Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AZW4_LEIMU

TriTrypDb:

LmxM.28.1440

Length:

725

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AZW4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AZW4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	139	143	PF00656	0.510
CLV_C14_Caspase3-7	209	213	PF00656	0.530
CLV_C14_Caspase3-7	234	238	PF00656	0.301
CLV_C14_Caspase3-7	355	359	PF00656	0.606
CLV_C14_Caspase3-7	640	644	PF00656	0.543
CLV_NRD_NRD_1	18	20	PF00675	0.643
CLV_NRD_NRD_1	244	246	PF00675	0.391
CLV_NRD_NRD_1	26	28	PF00675	0.569
CLV_NRD_NRD_1	276	278	PF00675	0.398
CLV_NRD_NRD_1	326	328	PF00675	0.516
CLV_NRD_NRD_1	332	334	PF00675	0.565
CLV_NRD_NRD_1	545	547	PF00675	0.615
CLV_NRD_NRD_1	683	685	PF00675	0.407
CLV_NRD_NRD_1	693	695	PF00675	0.594
CLV_NRD_NRD_1	712	714	PF00675	0.572
CLV_NRD_NRD_1	95	97	PF00675	0.671
CLV_PCSK_KEX2_1	18	20	PF00082	0.643
CLV_PCSK_KEX2_1	181	183	PF00082	0.467
CLV_PCSK_KEX2_1	244	246	PF00082	0.459
CLV_PCSK_KEX2_1	26	28	PF00082	0.569
CLV_PCSK_KEX2_1	276	278	PF00082	0.398
CLV_PCSK_KEX2_1	292	294	PF00082	0.474
CLV_PCSK_KEX2_1	326	328	PF00082	0.516
CLV_PCSK_KEX2_1	332	334	PF00082	0.565
CLV_PCSK_KEX2_1	42	44	PF00082	0.634
CLV_PCSK_KEX2_1	468	470	PF00082	0.397
CLV_PCSK_KEX2_1	683	685	PF00082	0.427
CLV_PCSK_KEX2_1	697	699	PF00082	0.602
CLV_PCSK_KEX2_1	95	97	PF00082	0.671
CLV_PCSK_PC1ET2_1	181	183	PF00082	0.498
CLV_PCSK_PC1ET2_1	292	294	PF00082	0.499
CLV_PCSK_PC1ET2_1	42	44	PF00082	0.634
CLV_PCSK_PC1ET2_1	468	470	PF00082	0.397
CLV_PCSK_PC1ET2_1	697	699	PF00082	0.562
CLV_PCSK_PC1ET2_1	95	97	PF00082	0.671
CLV_PCSK_SKI1_1	19	23	PF00082	0.640
CLV_PCSK_SKI1_1	26	30	PF00082	0.538
CLV_PCSK_SKI1_1	327	331	PF00082	0.509
CLV_PCSK_SKI1_1	39	43	PF00082	0.612
CLV_PCSK_SKI1_1	425	429	PF00082	0.468
CLV_PCSK_SKI1_1	469	473	PF00082	0.488
CLV_PCSK_SKI1_1	588	592	PF00082	0.437
CLV_PCSK_SKI1_1	630	634	PF00082	0.460
CLV_PCSK_SKI1_1	649	653	PF00082	0.433
CLV_PCSK_SKI1_1	683	687	PF00082	0.574
CLV_PCSK_SKI1_1	697	701	PF00082	0.518
CLV_PCSK_SKI1_1	96	100	PF00082	0.657
DEG_APCC_DBOX_1	600	608	PF00400	0.476
DEG_APCC_DBOX_1	712	720	PF00400	0.457
DEG_COP1_1	135	143	PF00400	0.510
DEG_Nend_Nbox_1	1	3	PF02207	0.635
DEG_ODPH_VHL_1	512	525	PF01847	0.473
DEG_SPOP_SBC_1	217	221	PF00917	0.639
DEG_SPOP_SBC_1	353	357	PF00917	0.646
DOC_CKS1_1	311	316	PF01111	0.524
DOC_CKS1_1	444	449	PF01111	0.430
DOC_CYCLIN_RxL_1	160	173	PF00134	0.410
DOC_CYCLIN_RxL_1	24	34	PF00134	0.494
DOC_MAPK_DCC_7	409	417	PF00069	0.416
DOC_MAPK_DCC_7	509	517	PF00069	0.419
DOC_MAPK_gen_1	3	13	PF00069	0.609
DOC_MAPK_gen_1	646	655	PF00069	0.422
DOC_MAPK_MEF2A_6	409	417	PF00069	0.454
DOC_MAPK_MEF2A_6	6	15	PF00069	0.615
DOC_MAPK_MEF2A_6	626	633	PF00069	0.282
DOC_MAPK_MEF2A_6	646	655	PF00069	0.422
DOC_MAPK_RevD_3	11	27	PF00069	0.493
DOC_PP1_RVXF_1	163	170	PF00149	0.411
DOC_PP1_RVXF_1	675	681	PF00149	0.465
DOC_PP2B_LxvP_1	13	16	PF13499	0.619
DOC_PP2B_LxvP_1	138	141	PF13499	0.515
DOC_PP2B_LxvP_1	502	505	PF13499	0.467
DOC_PP4_MxPP_1	663	666	PF00568	0.370
DOC_USP7_MATH_1	132	136	PF00917	0.454
DOC_USP7_MATH_1	196	200	PF00917	0.449
DOC_USP7_MATH_1	217	221	PF00917	0.636
DOC_USP7_MATH_1	304	308	PF00917	0.551
DOC_USP7_MATH_1	388	392	PF00917	0.301
DOC_USP7_MATH_1	413	417	PF00917	0.469
DOC_USP7_MATH_1	536	540	PF00917	0.466
DOC_USP7_MATH_1	577	581	PF00917	0.460
DOC_USP7_UBL2_3	405	409	PF12436	0.440
DOC_WW_Pin1_4	310	315	PF00397	0.468
DOC_WW_Pin1_4	371	376	PF00397	0.406
DOC_WW_Pin1_4	443	448	PF00397	0.368
DOC_WW_Pin1_4	707	712	PF00397	0.603
DOC_WW_Pin1_4	71	76	PF00397	0.502
LIG_14-3-3_CanoR_1	192	196	PF00244	0.526
LIG_14-3-3_CanoR_1	422	428	PF00244	0.438
LIG_14-3-3_CanoR_1	563	570	PF00244	0.445
LIG_14-3-3_CanoR_1	596	600	PF00244	0.454
LIG_14-3-3_CanoR_1	6	12	PF00244	0.630
LIG_14-3-3_CanoR_1	649	654	PF00244	0.431
LIG_BIR_III_4	212	216	PF00653	0.624
LIG_BRCT_BRCA1_1	105	109	PF00533	0.630
LIG_BRCT_BRCA1_1	198	202	PF00533	0.420
LIG_BRCT_BRCA1_1	429	433	PF00533	0.528
LIG_BRCT_BRCA1_1	79	83	PF00533	0.635
LIG_CtBP_PxDLS_1	505	509	PF00389	0.490
LIG_eIF4E_1	466	472	PF01652	0.489
LIG_FHA_1	143	149	PF00498	0.485
LIG_FHA_1	360	366	PF00498	0.499
LIG_FHA_1	371	377	PF00498	0.402
LIG_FHA_1	454	460	PF00498	0.394
LIG_FHA_1	650	656	PF00498	0.360
LIG_FHA_1	670	676	PF00498	0.256
LIG_FHA_1	72	78	PF00498	0.541
LIG_FHA_1	8	14	PF00498	0.616
LIG_FHA_2	151	157	PF00498	0.511
LIG_FHA_2	184	190	PF00498	0.482
LIG_FHA_2	311	317	PF00498	0.466
LIG_FHA_2	613	619	PF00498	0.596
LIG_FHA_2	97	103	PF00498	0.651
LIG_LIR_Apic_2	142	147	PF02991	0.507
LIG_LIR_Gen_1	199	210	PF02991	0.416
LIG_LIR_Gen_1	446	457	PF02991	0.359
LIG_LIR_Gen_1	647	658	PF02991	0.392
LIG_LIR_Nem_3	106	112	PF02991	0.620
LIG_LIR_Nem_3	199	205	PF02991	0.375
LIG_LIR_Nem_3	263	268	PF02991	0.381
LIG_LIR_Nem_3	446	452	PF02991	0.357
LIG_LIR_Nem_3	456	460	PF02991	0.355
LIG_LIR_Nem_3	467	473	PF02991	0.351
LIG_LIR_Nem_3	591	595	PF02991	0.492
LIG_LIR_Nem_3	647	653	PF02991	0.406
LIG_LRP6_Inhibitor_1	590	596	PF00058	0.260
LIG_MLH1_MIPbox_1	198	202	PF16413	0.420
LIG_PCNA_PIPBox_1	578	587	PF02747	0.358
LIG_PDZ_Class_2	720	725	PF00595	0.521
LIG_Pex14_2	433	437	PF04695	0.468
LIG_Pex14_2	445	449	PF04695	0.293
LIG_SH2_CRK	144	148	PF00017	0.496
LIG_SH2_CRK	592	596	PF00017	0.438
LIG_SH2_NCK_1	485	489	PF00017	0.412
LIG_SH2_STAP1	265	269	PF00017	0.455
LIG_SH2_STAP1	466	470	PF00017	0.449
LIG_SH2_STAP1	84	88	PF00017	0.632
LIG_SH2_STAT3	64	67	PF00017	0.650
LIG_SH2_STAT5	116	119	PF00017	0.502
LIG_SH2_STAT5	125	128	PF00017	0.514
LIG_SH2_STAT5	144	147	PF00017	0.323
LIG_SH2_STAT5	178	181	PF00017	0.583
LIG_SH2_STAT5	201	204	PF00017	0.355
LIG_SH2_STAT5	246	249	PF00017	0.541
LIG_SH2_STAT5	268	271	PF00017	0.562
LIG_SH2_STAT5	470	473	PF00017	0.404
LIG_SH2_STAT5	474	477	PF00017	0.415
LIG_SH2_STAT5	493	496	PF00017	0.300
LIG_SH2_STAT5	650	653	PF00017	0.426
LIG_SH2_STAT5	679	682	PF00017	0.463
LIG_SH3_3	308	314	PF00018	0.666
LIG_SH3_3	441	447	PF00018	0.383
LIG_SH3_3	495	501	PF00018	0.318
LIG_SH3_3	594	600	PF00018	0.396
LIG_SH3_3	60	66	PF00018	0.653
LIG_SH3_3	659	665	PF00018	0.556
LIG_SUMO_SIM_anti_2	385	391	PF11976	0.455
LIG_SUMO_SIM_par_1	135	142	PF11976	0.516
LIG_SUMO_SIM_par_1	385	391	PF11976	0.280
LIG_SUMO_SIM_par_1	413	419	PF11976	0.397
LIG_SUMO_SIM_par_1	665	672	PF11976	0.536
LIG_SUMO_SIM_par_1	9	14	PF11976	0.618
LIG_TRAF2_1	615	618	PF00917	0.471
LIG_TYR_ITIM	590	595	PF00017	0.482
LIG_UBA3_1	541	548	PF00899	0.573
LIG_WRC_WIRS_1	417	422	PF05994	0.477
MOD_CDC14_SPxK_1	710	713	PF00782	0.599
MOD_CDK_SPxK_1	707	713	PF00069	0.603
MOD_CDK_SPxxK_3	707	714	PF00069	0.603
MOD_CK1_1	361	367	PF00069	0.466
MOD_CK1_1	37	43	PF00069	0.601
MOD_CK1_1	416	422	PF00069	0.384
MOD_CK1_1	477	483	PF00069	0.362
MOD_CK2_1	150	156	PF00069	0.465
MOD_CK2_1	302	308	PF00069	0.578
MOD_CK2_1	310	316	PF00069	0.481
MOD_CK2_1	603	609	PF00069	0.413
MOD_CK2_1	612	618	PF00069	0.482
MOD_Cter_Amidation	711	714	PF01082	0.657
MOD_GlcNHglycan	206	209	PF01048	0.571
MOD_GlcNHglycan	337	340	PF01048	0.811
MOD_GlcNHglycan	39	42	PF01048	0.730
MOD_GlcNHglycan	409	412	PF01048	0.519
MOD_GlcNHglycan	47	50	PF01048	0.631
MOD_GlcNHglycan	646	649	PF01048	0.544
MOD_GSK3_1	260	267	PF00069	0.400
MOD_GSK3_1	354	361	PF00069	0.632
MOD_GSK3_1	423	430	PF00069	0.480
MOD_GSK3_1	433	440	PF00069	0.334
MOD_GSK3_1	517	524	PF00069	0.404
MOD_GSK3_1	55	62	PF00069	0.616
MOD_GSK3_1	7	14	PF00069	0.633
MOD_N-GLC_1	272	277	PF02516	0.388
MOD_N-GLC_1	690	695	PF02516	0.355
MOD_N-GLC_2	552	554	PF02516	0.502
MOD_NEK2_1	191	196	PF00069	0.468
MOD_NEK2_1	204	209	PF00069	0.374
MOD_NEK2_1	216	221	PF00069	0.570
MOD_NEK2_1	272	277	PF00069	0.407
MOD_NEK2_1	31	36	PF00069	0.609
MOD_NEK2_1	433	438	PF00069	0.466
MOD_NEK2_1	453	458	PF00069	0.238
MOD_NEK2_1	508	513	PF00069	0.396
MOD_NEK2_1	517	522	PF00069	0.386
MOD_NEK2_1	656	661	PF00069	0.445
MOD_NEK2_1	678	683	PF00069	0.462
MOD_NEK2_1	699	704	PF00069	0.525
MOD_NEK2_1	83	88	PF00069	0.752
MOD_NEK2_2	196	201	PF00069	0.443
MOD_NEK2_2	413	418	PF00069	0.399
MOD_NEK2_2	577	582	PF00069	0.456
MOD_PIKK_1	55	61	PF00454	0.753
MOD_PIKK_1	554	560	PF00454	0.499
MOD_PKA_1	96	102	PF00069	0.655
MOD_PKA_2	191	197	PF00069	0.552
MOD_PKA_2	335	341	PF00069	0.661
MOD_PKA_2	477	483	PF00069	0.434
MOD_PKA_2	508	514	PF00069	0.440
MOD_PKA_2	521	527	PF00069	0.401
MOD_PKA_2	562	568	PF00069	0.460
MOD_PKA_2	595	601	PF00069	0.392
MOD_Plk_1	260	266	PF00069	0.394
MOD_Plk_1	77	83	PF00069	0.618
MOD_Plk_1	84	90	PF00069	0.564
MOD_Plk_4	196	202	PF00069	0.367
MOD_Plk_4	264	270	PF00069	0.446
MOD_Plk_4	59	65	PF00069	0.685
MOD_Plk_4	603	609	PF00069	0.348
MOD_Plk_4	718	724	PF00069	0.592
MOD_Plk_4	78	84	PF00069	0.640
MOD_ProDKin_1	310	316	PF00069	0.465
MOD_ProDKin_1	371	377	PF00069	0.405
MOD_ProDKin_1	443	449	PF00069	0.362
MOD_ProDKin_1	707	713	PF00069	0.603
MOD_ProDKin_1	71	77	PF00069	0.500
MOD_SUMO_for_1	117	120	PF00179	0.507
MOD_SUMO_for_1	41	44	PF00179	0.662
MOD_SUMO_rev_2	225	235	PF00179	0.472
TRG_DiLeu_BaEn_1	467	472	PF01217	0.501
TRG_DiLeu_BaLyEn_6	267	272	PF01217	0.453
TRG_ENDOCYTIC_2	125	128	PF00928	0.524
TRG_ENDOCYTIC_2	171	174	PF00928	0.441
TRG_ENDOCYTIC_2	201	204	PF00928	0.355
TRG_ENDOCYTIC_2	268	271	PF00928	0.394
TRG_ENDOCYTIC_2	473	476	PF00928	0.472
TRG_ENDOCYTIC_2	592	595	PF00928	0.460
TRG_ENDOCYTIC_2	650	653	PF00928	0.426
TRG_ER_diArg_1	243	245	PF00400	0.386
TRG_ER_diArg_1	25	27	PF00400	0.497
TRG_ER_diArg_1	325	327	PF00400	0.497
TRG_ER_diArg_1	332	334	PF00400	0.555
TRG_ER_diArg_1	635	638	PF00400	0.461
TRG_ER_diArg_1	683	685	PF00400	0.376
TRG_NLS_Bipartite_1	683	698	PF00514	0.369
TRG_NLS_MonoExtC_3	545	550	PF00514	0.534
TRG_NLS_MonoExtC_3	693	698	PF00514	0.463
TRG_NLS_MonoExtN_4	692	698	PF00514	0.414
TRG_NLS_MonoExtN_4	711	717	PF00514	0.608
TRG_Pf-PMV_PEXEL_1	96	101	PF00026	0.609

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I1D3	Leptomonas seymouri	33%	86%
A0A3S5H7J3	Leishmania donovani	90%	100%
A4HGJ6	Leishmania braziliensis	76%	99%
A4I3M3	Leishmania infantum	89%	100%
Q4Q8C2	Leishmania major	89%	100%