C3H1-type domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein

Species:

Leishmania mexicana

UniProt:

E9AZW0_LEIMU

TriTrypDb:

LmxM.28.1405

Length:

398

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AZW0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AZW0

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	7
GO:0043167	ion binding	2	7
GO:0043169	cation binding	3	7
GO:0046872	metal ion binding	4	7
GO:0003676	nucleic acid binding	3	1
GO:0003723	RNA binding	4	1
GO:0097159	organic cyclic compound binding	2	1
GO:1901363	heterocyclic compound binding	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	53	57	PF00656	0.644
CLV_PCSK_SKI1_1	149	153	PF00082	0.546
CLV_PCSK_SKI1_1	356	360	PF00082	0.635
CLV_PCSK_SKI1_1	36	40	PF00082	0.772
DEG_SPOP_SBC_1	4	8	PF00917	0.716
DOC_CKS1_1	137	142	PF01111	0.574
DOC_CKS1_1	143	148	PF01111	0.579
DOC_CKS1_1	150	155	PF01111	0.578
DOC_CKS1_1	98	103	PF01111	0.488
DOC_CYCLIN_yCln2_LP_2	383	389	PF00134	0.628
DOC_PP2B_LxvP_1	270	273	PF13499	0.660
DOC_PP4_FxxP_1	128	131	PF00568	0.315
DOC_PP4_FxxP_1	183	186	PF00568	0.754
DOC_PP4_FxxP_1	206	209	PF00568	0.612
DOC_PP4_MxPP_1	296	299	PF00568	0.494
DOC_USP7_MATH_1	158	162	PF00917	0.518
DOC_USP7_MATH_1	186	190	PF00917	0.604
DOC_USP7_MATH_1	213	217	PF00917	0.787
DOC_USP7_MATH_1	219	223	PF00917	0.696
DOC_USP7_MATH_1	287	291	PF00917	0.590
DOC_USP7_MATH_1	3	7	PF00917	0.650
DOC_USP7_MATH_1	336	340	PF00917	0.584
DOC_USP7_MATH_1	346	350	PF00917	0.544
DOC_USP7_MATH_1	351	355	PF00917	0.589
DOC_USP7_MATH_1	76	80	PF00917	0.724
DOC_USP7_MATH_1	81	85	PF00917	0.682
DOC_WW_Pin1_4	11	16	PF00397	0.584
DOC_WW_Pin1_4	136	141	PF00397	0.588
DOC_WW_Pin1_4	142	147	PF00397	0.593
DOC_WW_Pin1_4	149	154	PF00397	0.615
DOC_WW_Pin1_4	165	170	PF00397	0.581
DOC_WW_Pin1_4	182	187	PF00397	0.719
DOC_WW_Pin1_4	19	24	PF00397	0.569
DOC_WW_Pin1_4	205	210	PF00397	0.603
DOC_WW_Pin1_4	225	230	PF00397	0.493
DOC_WW_Pin1_4	238	243	PF00397	0.559
DOC_WW_Pin1_4	301	306	PF00397	0.643
DOC_WW_Pin1_4	357	362	PF00397	0.773
DOC_WW_Pin1_4	372	377	PF00397	0.532
DOC_WW_Pin1_4	38	43	PF00397	0.632
DOC_WW_Pin1_4	385	390	PF00397	0.785
DOC_WW_Pin1_4	5	10	PF00397	0.615
DOC_WW_Pin1_4	97	102	PF00397	0.631
LIG_14-3-3_CanoR_1	122	131	PF00244	0.351
LIG_14-3-3_CanoR_1	187	191	PF00244	0.611
LIG_14-3-3_CanoR_1	221	229	PF00244	0.715
LIG_14-3-3_CanoR_1	259	268	PF00244	0.468
LIG_14-3-3_CanoR_1	36	44	PF00244	0.657
LIG_14-3-3_CanoR_1	380	386	PF00244	0.676
LIG_14-3-3_CanoR_1	70	77	PF00244	0.511
LIG_14-3-3_CanoR_1	83	89	PF00244	0.479
LIG_BRCT_BRCA1_1	124	128	PF00533	0.315
LIG_BRCT_BRCA1_1	221	225	PF00533	0.796
LIG_BRCT_BRCA1_1	240	244	PF00533	0.613
LIG_FHA_1	176	182	PF00498	0.643
LIG_FHA_1	221	227	PF00498	0.579
LIG_FHA_1	332	338	PF00498	0.504
LIG_FHA_1	44	50	PF00498	0.568
LIG_FHA_2	290	296	PF00498	0.685
LIG_GSK3_LRP6_1	209	215	PF00069	0.493
LIG_IBAR_NPY_1	370	372	PF08397	0.679
LIG_LIR_Apic_2	125	131	PF02991	0.315
LIG_LIR_Apic_2	172	177	PF02991	0.456
LIG_LIR_Apic_2	204	209	PF02991	0.642
LIG_LIR_Gen_1	59	66	PF02991	0.566
LIG_LIR_Nem_3	22	28	PF02991	0.473
LIG_LIR_Nem_3	59	63	PF02991	0.611
LIG_Pex14_2	244	248	PF04695	0.686
LIG_SH2_CRK	311	315	PF00017	0.515
LIG_SH2_GRB2like	104	107	PF00017	0.570
LIG_SH2_PTP2	174	177	PF00017	0.459
LIG_SH2_SRC	372	375	PF00017	0.682
LIG_SH2_STAT5	174	177	PF00017	0.459
LIG_SH2_STAT5	275	278	PF00017	0.677
LIG_SH2_STAT5	316	319	PF00017	0.663
LIG_SH2_STAT5	43	46	PF00017	0.570
LIG_SH3_1	391	397	PF00018	0.488
LIG_SH3_2	386	391	PF14604	0.683
LIG_SH3_3	134	140	PF00018	0.584
LIG_SH3_3	147	153	PF00018	0.628
LIG_SH3_3	207	213	PF00018	0.508
LIG_SH3_3	223	229	PF00018	0.564
LIG_SH3_3	25	31	PF00018	0.469
LIG_SH3_3	296	302	PF00018	0.612
LIG_SH3_3	355	361	PF00018	0.633
LIG_SH3_3	383	389	PF00018	0.724
LIG_SH3_3	391	397	PF00018	0.611
MOD_CDC14_SPxK_1	375	378	PF00782	0.522
MOD_CDC14_SPxK_1	388	391	PF00782	0.682
MOD_CDK_SPK_2	182	187	PF00069	0.618
MOD_CDK_SPK_2	357	362	PF00069	0.689
MOD_CDK_SPxK_1	136	142	PF00069	0.651
MOD_CDK_SPxK_1	372	378	PF00069	0.513
MOD_CDK_SPxK_1	385	391	PF00069	0.680
MOD_CDK_SPxxK_3	11	18	PF00069	0.636
MOD_CDK_SPxxK_3	142	149	PF00069	0.579
MOD_CDK_SPxxK_3	169	176	PF00069	0.599
MOD_CK1_1	161	167	PF00069	0.501
MOD_CK1_1	198	204	PF00069	0.650
MOD_CK1_1	205	211	PF00069	0.665
MOD_CK1_1	212	218	PF00069	0.702
MOD_CK1_1	240	246	PF00069	0.653
MOD_CK1_1	249	255	PF00069	0.709
MOD_CK1_1	289	295	PF00069	0.621
MOD_CK1_1	304	310	PF00069	0.590
MOD_CK1_1	325	331	PF00069	0.680
MOD_CK1_1	354	360	PF00069	0.661
MOD_CK1_1	84	90	PF00069	0.629
MOD_CK1_1	91	97	PF00069	0.619
MOD_CK2_1	198	204	PF00069	0.679
MOD_DYRK1A_RPxSP_1	142	146	PF00069	0.668
MOD_DYRK1A_RPxSP_1	149	153	PF00069	0.513
MOD_DYRK1A_RPxSP_1	301	305	PF00069	0.789
MOD_GlcNHglycan	161	164	PF01048	0.770
MOD_GlcNHglycan	178	181	PF01048	0.540
MOD_GlcNHglycan	193	196	PF01048	0.740
MOD_GlcNHglycan	197	200	PF01048	0.801
MOD_GlcNHglycan	217	220	PF01048	0.496
MOD_GlcNHglycan	289	292	PF01048	0.622
MOD_GlcNHglycan	327	330	PF01048	0.797
MOD_GlcNHglycan	78	81	PF01048	0.795
MOD_GlcNHglycan	83	86	PF01048	0.719
MOD_GlcNHglycan	93	96	PF01048	0.638
MOD_GSK3_1	138	145	PF00069	0.579
MOD_GSK3_1	159	166	PF00069	0.624
MOD_GSK3_1	182	189	PF00069	0.717
MOD_GSK3_1	191	198	PF00069	0.523
MOD_GSK3_1	205	212	PF00069	0.700
MOD_GSK3_1	215	222	PF00069	0.670
MOD_GSK3_1	246	253	PF00069	0.577
MOD_GSK3_1	297	304	PF00069	0.608
MOD_GSK3_1	352	359	PF00069	0.699
MOD_GSK3_1	38	45	PF00069	0.553
MOD_GSK3_1	381	388	PF00069	0.630
MOD_GSK3_1	84	91	PF00069	0.525
MOD_N-GLC_1	19	24	PF02516	0.640
MOD_N-GLC_1	88	93	PF02516	0.639
MOD_N-GLC_2	110	112	PF02516	0.315
MOD_NEK2_1	181	186	PF00069	0.636
MOD_NEK2_1	250	255	PF00069	0.659
MOD_NEK2_1	322	327	PF00069	0.673
MOD_NEK2_1	88	93	PF00069	0.592
MOD_NEK2_2	186	191	PF00069	0.606
MOD_NEK2_2	336	341	PF00069	0.500
MOD_OFUCOSY	120	126	PF10250	0.315
MOD_PIKK_1	144	150	PF00454	0.555
MOD_PIKK_1	163	169	PF00454	0.496
MOD_PIKK_1	381	387	PF00454	0.633
MOD_PIKK_1	69	75	PF00454	0.514
MOD_PK_1	362	368	PF00069	0.509
MOD_PKA_2	121	127	PF00069	0.347
MOD_PKA_2	186	192	PF00069	0.608
MOD_PKA_2	220	226	PF00069	0.721
MOD_PKA_2	69	75	PF00069	0.514
MOD_PKB_1	142	150	PF00069	0.609
MOD_PKB_1	257	265	PF00069	0.464
MOD_Plk_4	21	27	PF00069	0.612
MOD_ProDKin_1	136	142	PF00069	0.592
MOD_ProDKin_1	149	155	PF00069	0.613
MOD_ProDKin_1	165	171	PF00069	0.583
MOD_ProDKin_1	182	188	PF00069	0.720
MOD_ProDKin_1	19	25	PF00069	0.569
MOD_ProDKin_1	205	211	PF00069	0.606
MOD_ProDKin_1	225	231	PF00069	0.493
MOD_ProDKin_1	238	244	PF00069	0.558
MOD_ProDKin_1	301	307	PF00069	0.641
MOD_ProDKin_1	357	363	PF00069	0.775
MOD_ProDKin_1	372	378	PF00069	0.535
MOD_ProDKin_1	38	44	PF00069	0.630
MOD_ProDKin_1	385	391	PF00069	0.787
MOD_ProDKin_1	5	11	PF00069	0.618
MOD_ProDKin_1	97	103	PF00069	0.627
TRG_ER_diArg_1	378	381	PF00400	0.508

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P7W6	Leptomonas seymouri	40%	100%
A0A3S7X1G7	Leishmania donovani	88%	100%
A4HGJ2	Leishmania braziliensis	64%	100%
E9ADK0	Leishmania major	87%	100%
E9AHG4	Leishmania infantum	88%	100%