Amastin-like protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

amastin-like protein

Species:

Leishmania mexicana

UniProt:

E9AZV9_LEIMU

TriTrypDb:

LmxM.28.1400

Length:

546

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	6
GO:0110165	cellular anatomical entity	1	6

Expansion

Sequence features

E9AZV9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AZV9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	60	64	PF00656	0.617
CLV_NRD_NRD_1	194	196	PF00675	0.579
CLV_NRD_NRD_1	199	201	PF00675	0.549
CLV_NRD_NRD_1	423	425	PF00675	0.540
CLV_PCSK_KEX2_1	198	200	PF00082	0.566
CLV_PCSK_KEX2_1	423	425	PF00082	0.540
CLV_PCSK_PC7_1	195	201	PF00082	0.520
CLV_PCSK_SKI1_1	153	157	PF00082	0.621
CLV_PCSK_SKI1_1	466	470	PF00082	0.363
CLV_PCSK_SKI1_1	8	12	PF00082	0.538
DEG_APCC_DBOX_1	465	473	PF00400	0.563
DEG_COP1_1	213	223	PF00400	0.637
DEG_SCF_FBW7_1	104	111	PF00400	0.831
DOC_CKS1_1	201	206	PF01111	0.712
DOC_CKS1_1	268	273	PF01111	0.834
DOC_MAPK_MEF2A_6	364	373	PF00069	0.389
DOC_PP2B_LxvP_1	138	141	PF13499	0.602
DOC_PP4_FxxP_1	531	534	PF00568	0.644
DOC_USP7_MATH_1	100	104	PF00917	0.833
DOC_USP7_MATH_1	118	122	PF00917	0.618
DOC_USP7_MATH_1	170	174	PF00917	0.784
DOC_USP7_MATH_1	258	262	PF00917	0.805
DOC_USP7_MATH_1	314	318	PF00917	0.713
DOC_USP7_MATH_1	335	339	PF00917	0.581
DOC_USP7_MATH_1	37	41	PF00917	0.671
DOC_USP7_MATH_1	46	50	PF00917	0.689
DOC_WW_Pin1_4	104	109	PF00397	0.830
DOC_WW_Pin1_4	113	118	PF00397	0.799
DOC_WW_Pin1_4	166	171	PF00397	0.685
DOC_WW_Pin1_4	180	185	PF00397	0.833
DOC_WW_Pin1_4	200	205	PF00397	0.724
DOC_WW_Pin1_4	224	229	PF00397	0.770
DOC_WW_Pin1_4	267	272	PF00397	0.703
DOC_WW_Pin1_4	31	36	PF00397	0.775
DOC_WW_Pin1_4	526	531	PF00397	0.359
LIG_14-3-3_CanoR_1	101	107	PF00244	0.832
LIG_14-3-3_CanoR_1	171	175	PF00244	0.773
LIG_14-3-3_CanoR_1	276	284	PF00244	0.739
LIG_14-3-3_CanoR_1	423	429	PF00244	0.211
LIG_14-3-3_CanoR_1	489	497	PF00244	0.289
LIG_Actin_WH2_2	441	457	PF00022	0.412
LIG_BIR_II_1	1	5	PF00653	0.732
LIG_BRCT_BRCA1_1	316	320	PF00533	0.661
LIG_BRCT_BRCA1_1	417	421	PF00533	0.211
LIG_EH1_1	431	439	PF00400	0.513
LIG_FHA_1	201	207	PF00498	0.784
LIG_FHA_1	383	389	PF00498	0.346
LIG_FHA_1	407	413	PF00498	0.359
LIG_FHA_1	434	440	PF00498	0.297
LIG_FHA_1	444	450	PF00498	0.333
LIG_FHA_1	496	502	PF00498	0.395
LIG_FHA_2	105	111	PF00498	0.767
LIG_FHA_2	219	225	PF00498	0.767
LIG_LIR_Apic_2	160	165	PF02991	0.751
LIG_LIR_Apic_2	317	321	PF02991	0.672
LIG_LIR_Apic_2	409	413	PF02991	0.356
LIG_LIR_Apic_2	529	534	PF02991	0.586
LIG_LIR_Gen_1	483	491	PF02991	0.411
LIG_LIR_Nem_3	312	318	PF02991	0.677
LIG_LIR_Nem_3	397	401	PF02991	0.304
LIG_LIR_Nem_3	483	487	PF02991	0.404
LIG_MYND_1	321	325	PF01753	0.646
LIG_NRBOX	436	442	PF00104	0.436
LIG_SH2_CRK	130	134	PF00017	0.607
LIG_SH2_CRK	162	166	PF00017	0.753
LIG_SH2_CRK	410	414	PF00017	0.330
LIG_SH2_CRK	417	421	PF00017	0.330
LIG_SH2_NCK_1	130	134	PF00017	0.607
LIG_SH2_NCK_1	162	166	PF00017	0.753
LIG_SH2_NCK_1	269	273	PF00017	0.831
LIG_SH2_NCK_1	417	421	PF00017	0.211
LIG_SH2_PTP2	318	321	PF00017	0.673
LIG_SH2_SRC	357	360	PF00017	0.517
LIG_SH2_STAP1	130	134	PF00017	0.607
LIG_SH2_STAT5	202	205	PF00017	0.785
LIG_SH2_STAT5	269	272	PF00017	0.835
LIG_SH2_STAT5	318	321	PF00017	0.673
LIG_SH2_STAT5	357	360	PF00017	0.619
LIG_SH2_STAT5	368	371	PF00017	0.405
LIG_SH2_STAT5	410	413	PF00017	0.372
LIG_SH2_STAT5	452	455	PF00017	0.249
LIG_SH3_1	198	204	PF00018	0.715
LIG_SH3_2	527	532	PF14604	0.381
LIG_SH3_3	114	120	PF00018	0.809
LIG_SH3_3	178	184	PF00018	0.740
LIG_SH3_3	198	204	PF00018	0.697
LIG_SH3_3	29	35	PF00018	0.781
LIG_SH3_3	378	384	PF00018	0.389
LIG_SH3_3	521	527	PF00018	0.222
LIG_SH3_3	79	85	PF00018	0.776
LIG_SUMO_SIM_anti_2	375	380	PF11976	0.456
LIG_SUMO_SIM_anti_2	433	439	PF11976	0.424
LIG_SUMO_SIM_anti_2	446	452	PF11976	0.378
LIG_SUMO_SIM_par_1	377	382	PF11976	0.416
LIG_TYR_ITIM	128	133	PF00017	0.692
LIG_WRC_WIRS_1	14	19	PF05994	0.821
MOD_CDC14_SPxK_1	529	532	PF00782	0.535
MOD_CDK_SPK_2	104	109	PF00069	0.830
MOD_CDK_SPK_2	166	171	PF00069	0.623
MOD_CDK_SPxK_1	526	532	PF00069	0.367
MOD_CK1_1	15	21	PF00069	0.767
MOD_CK1_1	160	166	PF00069	0.787
MOD_CK1_1	194	200	PF00069	0.641
MOD_CK1_1	305	311	PF00069	0.744
MOD_CK1_1	382	388	PF00069	0.411
MOD_CK1_1	433	439	PF00069	0.353
MOD_CK1_1	462	468	PF00069	0.530
MOD_CK1_1	49	55	PF00069	0.762
MOD_CK1_1	495	501	PF00069	0.243
MOD_CK1_1	75	81	PF00069	0.817
MOD_CK2_1	113	119	PF00069	0.825
MOD_CK2_1	13	19	PF00069	0.752
MOD_CK2_1	218	224	PF00069	0.767
MOD_CK2_1	229	235	PF00069	0.749
MOD_CK2_1	240	246	PF00069	0.846
MOD_CK2_1	258	264	PF00069	0.752
MOD_CK2_1	282	288	PF00069	0.816
MOD_CK2_1	300	306	PF00069	0.597
MOD_DYRK1A_RPxSP_1	113	117	PF00069	0.786
MOD_DYRK1A_RPxSP_1	200	204	PF00069	0.780
MOD_GlcNHglycan	119	123	PF01048	0.595
MOD_GlcNHglycan	161	165	PF01048	0.513
MOD_GlcNHglycan	213	217	PF01048	0.578
MOD_GlcNHglycan	252	255	PF01048	0.445
MOD_GlcNHglycan	337	340	PF01048	0.414
MOD_GlcNHglycan	35	38	PF01048	0.606
MOD_GlcNHglycan	39	42	PF01048	0.635
MOD_GlcNHglycan	494	497	PF01048	0.548
MOD_GlcNHglycan	54	57	PF01048	0.446
MOD_GlcNHglycan	74	77	PF01048	0.520
MOD_GSK3_1	100	107	PF00069	0.765
MOD_GSK3_1	166	173	PF00069	0.781
MOD_GSK3_1	190	197	PF00069	0.661
MOD_GSK3_1	33	40	PF00069	0.723
MOD_GSK3_1	379	386	PF00069	0.411
MOD_GSK3_1	453	460	PF00069	0.222
MOD_GSK3_1	495	502	PF00069	0.263
MOD_GSK3_1	57	64	PF00069	0.715
MOD_N-GLC_1	157	162	PF02516	0.555
MOD_N-GLC_1	406	411	PF02516	0.547
MOD_N-GLC_1	509	514	PF02516	0.546
MOD_NEK2_1	102	107	PF00069	0.623
MOD_NEK2_1	372	377	PF00069	0.369
MOD_NEK2_1	379	384	PF00069	0.349
MOD_NEK2_1	509	514	PF00069	0.333
MOD_NEK2_1	54	59	PF00069	0.757
MOD_PIKK_1	383	389	PF00454	0.304
MOD_PIKK_1	57	63	PF00454	0.742
MOD_PK_1	424	430	PF00069	0.211
MOD_PK_1	532	538	PF00069	0.528
MOD_PKA_2	100	106	PF00069	0.832
MOD_PKA_2	170	176	PF00069	0.769
MOD_PKA_2	194	200	PF00069	0.714
MOD_PKA_2	275	281	PF00069	0.741
MOD_PKA_2	49	55	PF00069	0.617
MOD_Plk_1	12	18	PF00069	0.820
MOD_Plk_1	24	30	PF00069	0.705
MOD_Plk_1	406	412	PF00069	0.353
MOD_Plk_1	499	505	PF00069	0.288
MOD_Plk_1	509	515	PF00069	0.382
MOD_Plk_2-3	13	19	PF00069	0.749
MOD_Plk_2-3	283	289	PF00069	0.607
MOD_Plk_4	314	320	PF00069	0.677
MOD_Plk_4	94	100	PF00069	0.823
MOD_ProDKin_1	104	110	PF00069	0.830
MOD_ProDKin_1	113	119	PF00069	0.799
MOD_ProDKin_1	166	172	PF00069	0.685
MOD_ProDKin_1	180	186	PF00069	0.834
MOD_ProDKin_1	200	206	PF00069	0.725
MOD_ProDKin_1	224	230	PF00069	0.772
MOD_ProDKin_1	267	273	PF00069	0.701
MOD_ProDKin_1	31	37	PF00069	0.774
MOD_ProDKin_1	526	532	PF00069	0.367
MOD_SUMO_rev_2	173	181	PF00179	0.622
MOD_SUMO_rev_2	246	254	PF00179	0.786
TRG_ENDOCYTIC_2	130	133	PF00928	0.692
TRG_ENDOCYTIC_2	357	360	PF00928	0.621
TRG_ENDOCYTIC_2	368	371	PF00928	0.411
TRG_ER_diArg_1	198	200	PF00400	0.852
TRG_ER_diArg_1	331	334	PF00400	0.570
TRG_ER_diArg_1	422	424	PF00400	0.341
TRG_ER_diArg_1	540	543	PF00400	0.536
TRG_NLS_MonoExtC_3	194	199	PF00514	0.724

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HZU6	Leptomonas seymouri	37%	100%
A0A3S7X1I0	Leishmania donovani	77%	100%
A4I3L9	Leishmania infantum	77%	100%
E9AIT0	Leishmania braziliensis	56%	99%
Q4Q8C6	Leishmania major	74%	100%