Amastin

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Amastin

Gene product:

Amastin surface glycoprotein, putative

Species:

Leishmania mexicana

UniProt:

E9AZV8_LEIMU

TriTrypDb:

LmxM.28.1390

Length:

338

Annotations

LeishMANIAdb annotations

Publication identifier(s): 26641088 15760660
Amastin, Kinetoplastid host adhesion protein. A host adhesion protein family greatly expanded in Leishmaniids.. Localization: Cell surface (experimental)

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	10
GO:0110165	cellular anatomical entity	1	10
GO:0020016	ciliary pocket	2	1

Expansion

Sequence features

E9AZV8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AZV8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	124	128	PF00656	0.556
CLV_C14_Caspase3-7	17	21	PF00656	0.680
CLV_PCSK_KEX2_1	76	78	PF00082	0.620
CLV_PCSK_PC1ET2_1	76	78	PF00082	0.479
CLV_PCSK_SKI1_1	121	125	PF00082	0.420
CLV_PCSK_SKI1_1	181	185	PF00082	0.501
CLV_PCSK_SKI1_1	192	196	PF00082	0.448
DOC_MAPK_gen_1	271	278	PF00069	0.527
DOC_MAPK_HePTP_8	123	135	PF00069	0.591
DOC_MAPK_MEF2A_6	126	135	PF00069	0.579
DOC_MAPK_MEF2A_6	271	280	PF00069	0.482
DOC_PP1_RVXF_1	179	186	PF00149	0.185
DOC_PP4_FxxP_1	113	116	PF00568	0.595
DOC_WW_Pin1_4	38	43	PF00397	0.589
DOC_WW_Pin1_4	68	73	PF00397	0.691
LIG_14-3-3_CanoR_1	43	49	PF00244	0.629
LIG_BIR_III_4	79	83	PF00653	0.642
LIG_CaM_IQ_9	182	198	PF13499	0.268
LIG_FHA_1	320	326	PF00498	0.282
LIG_FHA_1	63	69	PF00498	0.688
LIG_FHA_2	109	115	PF00498	0.525
LIG_FHA_2	122	128	PF00498	0.509
LIG_GBD_Chelix_1	278	286	PF00786	0.382
LIG_Integrin_RGD_1	77	79	PF01839	0.475
LIG_IRF3_LxIS_1	133	140	PF10401	0.190
LIG_LIR_Apic_2	111	116	PF02991	0.503
LIG_LIR_Gen_1	140	149	PF02991	0.303
LIG_LIR_Gen_1	199	207	PF02991	0.402
LIG_LIR_Gen_1	30	37	PF02991	0.674
LIG_LIR_Nem_3	140	145	PF02991	0.390
LIG_LIR_Nem_3	165	169	PF02991	0.264
LIG_LIR_Nem_3	199	204	PF02991	0.410
LIG_LIR_Nem_3	327	331	PF02991	0.313
LIG_PDZ_Class_1	333	338	PF00595	0.368
LIG_Pex14_1	324	328	PF04695	0.190
LIG_Pex14_2	142	146	PF04695	0.310
LIG_PTB_Apo_2	107	114	PF02174	0.502
LIG_SH2_GRB2like	236	239	PF00017	0.498
LIG_SH2_NCK_1	236	240	PF00017	0.385
LIG_SH2_PTP2	134	137	PF00017	0.190
LIG_SH2_SRC	236	239	PF00017	0.415
LIG_SH2_STAP1	33	37	PF00017	0.699
LIG_SH2_STAT5	134	137	PF00017	0.364
LIG_SH2_STAT5	164	167	PF00017	0.282
LIG_SH2_STAT5	26	29	PF00017	0.726
LIG_SH2_STAT5	300	303	PF00017	0.312
LIG_SH2_STAT5	331	334	PF00017	0.382
LIG_SUMO_SIM_anti_2	154	160	PF11976	0.278
LIG_SUMO_SIM_anti_2	202	209	PF11976	0.290
LIG_SUMO_SIM_par_1	202	209	PF11976	0.301
MOD_CDK_SPK_2	38	43	PF00069	0.587
MOD_CK1_1	162	168	PF00069	0.323
MOD_CK1_1	179	185	PF00069	0.187
MOD_CK1_1	199	205	PF00069	0.389
MOD_CK1_1	209	215	PF00069	0.314
MOD_CK1_1	308	314	PF00069	0.264
MOD_CK1_1	38	44	PF00069	0.709
MOD_CK2_1	108	114	PF00069	0.534
MOD_CK2_1	18	24	PF00069	0.733
MOD_GlcNHglycan	149	152	PF01048	0.388
MOD_GlcNHglycan	198	201	PF01048	0.494
MOD_GlcNHglycan	29	32	PF01048	0.517
MOD_GSK3_1	104	111	PF00069	0.509
MOD_GSK3_1	121	128	PF00069	0.558
MOD_GSK3_1	14	21	PF00069	0.746
MOD_GSK3_1	147	154	PF00069	0.389
MOD_GSK3_1	172	179	PF00069	0.271
MOD_GSK3_1	202	209	PF00069	0.377
MOD_GSK3_1	22	29	PF00069	0.723
MOD_GSK3_1	305	312	PF00069	0.282
MOD_GSK3_1	31	38	PF00069	0.755
MOD_GSK3_1	56	63	PF00069	0.799
MOD_NEK2_1	108	113	PF00069	0.508
MOD_NEK2_1	137	142	PF00069	0.249
MOD_NEK2_1	213	218	PF00069	0.383
MOD_NEK2_1	305	310	PF00069	0.296
MOD_NEK2_1	319	324	PF00069	0.321
MOD_PIKK_1	125	131	PF00454	0.595
MOD_PIKK_1	14	20	PF00454	0.687
MOD_PIKK_1	151	157	PF00454	0.297
MOD_PIKK_1	255	261	PF00454	0.430
MOD_PKA_2	125	131	PF00069	0.542
MOD_PKA_2	230	236	PF00069	0.414
MOD_PKB_1	119	127	PF00069	0.637
MOD_Plk_1	22	28	PF00069	0.673
MOD_Plk_2-3	35	41	PF00069	0.592
MOD_Plk_4	162	168	PF00069	0.284
MOD_Plk_4	213	219	PF00069	0.381
MOD_ProDKin_1	38	44	PF00069	0.588
MOD_ProDKin_1	68	74	PF00069	0.690
MOD_SUMO_for_1	57	60	PF00179	0.665
MOD_SUMO_rev_2	266	273	PF00179	0.430
TRG_ENDOCYTIC_2	134	137	PF00928	0.359
TRG_ENDOCYTIC_2	33	36	PF00928	0.673
TRG_ENDOCYTIC_2	331	334	PF00928	0.395
TRG_NLS_Bipartite_1	76	98	PF00514	0.666
TRG_Pf-PMV_PEXEL_1	192	196	PF00026	0.430
TRG_Pf-PMV_PEXEL_1	66	70	PF00026	0.520

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P7I8	Leptomonas seymouri	43%	100%
A0A3S7X1H6	Leishmania donovani	80%	99%
A0A422MVT4	Trypanosoma rangeli	28%	100%
A4HDI3	Leishmania braziliensis	26%	100%
A4HGJ1	Leishmania braziliensis	60%	100%
A4I0W6	Leishmania infantum	21%	100%
A4I3L8	Leishmania infantum	80%	99%
Q4Q8C7	Leishmania major	76%	100%
V5AQB9	Trypanosoma cruzi	35%	100%