Haloacid dehalogenase-like hydrolase-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

haloacid dehalogenase-like hydrolase-like protein

Species:

Leishmania mexicana

UniProt:

E9AZV7_LEIMU

TriTrypDb:

LmxM.28.1380

Length:

401

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 25

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 8

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 33
NetGPI	no	yes: 0, no: 33

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AZV7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AZV7

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	30
GO:0016787	hydrolase activity	2	30

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	2	6	PF00656	0.470
CLV_NRD_NRD_1	15	17	PF00675	0.633
CLV_NRD_NRD_1	377	379	PF00675	0.303
CLV_NRD_NRD_1	81	83	PF00675	0.275
CLV_PCSK_FUR_1	78	82	PF00082	0.346
CLV_PCSK_KEX2_1	15	17	PF00082	0.465
CLV_PCSK_KEX2_1	277	279	PF00082	0.259
CLV_PCSK_KEX2_1	80	82	PF00082	0.263
CLV_PCSK_PC1ET2_1	277	279	PF00082	0.303
CLV_PCSK_PC1ET2_1	80	82	PF00082	0.284
CLV_PCSK_SKI1_1	267	271	PF00082	0.271
CLV_PCSK_SKI1_1	277	281	PF00082	0.290
CLV_PCSK_SKI1_1	359	363	PF00082	0.209
CLV_PCSK_SKI1_1	52	56	PF00082	0.320
CLV_PCSK_SKI1_1	71	75	PF00082	0.194
DEG_APCC_DBOX_1	51	59	PF00400	0.525
DEG_SCF_FBW7_1	123	130	PF00400	0.509
DEG_SCF_FBW7_1	99	105	PF00400	0.410
DOC_CKS1_1	124	129	PF01111	0.506
DOC_CKS1_1	92	97	PF01111	0.651
DOC_CKS1_1	99	104	PF01111	0.653
DOC_CYCLIN_RxL_1	356	366	PF00134	0.400
DOC_MAPK_DCC_7	357	367	PF00069	0.422
DOC_MAPK_gen_1	15	22	PF00069	0.631
DOC_MAPK_gen_1	357	367	PF00069	0.485
DOC_MAPK_gen_1	78	85	PF00069	0.539
DOC_MAPK_MEF2A_6	359	367	PF00069	0.448
DOC_MAPK_MEF2A_6	90	99	PF00069	0.640
DOC_USP7_MATH_1	102	106	PF00917	0.768
DOC_USP7_MATH_1	116	120	PF00917	0.722
DOC_USP7_MATH_1	125	129	PF00917	0.681
DOC_USP7_MATH_1	148	152	PF00917	0.539
DOC_USP7_MATH_1	265	269	PF00917	0.565
DOC_USP7_MATH_1	396	400	PF00917	0.718
DOC_WW_Pin1_4	112	117	PF00397	0.737
DOC_WW_Pin1_4	123	128	PF00397	0.645
DOC_WW_Pin1_4	91	96	PF00397	0.619
DOC_WW_Pin1_4	98	103	PF00397	0.624
LIG_14-3-3_CanoR_1	237	241	PF00244	0.484
LIG_14-3-3_CanoR_1	254	261	PF00244	0.564
LIG_14-3-3_CanoR_1	378	386	PF00244	0.596
LIG_14-3-3_CanoR_1	71	79	PF00244	0.499
LIG_14-3-3_CterR_2	398	401	PF00244	0.438
LIG_Actin_WH2_2	383	400	PF00022	0.344
LIG_APCC_ABBA_1	361	366	PF00400	0.387
LIG_BRCT_BRCA1_1	255	259	PF00533	0.546
LIG_BRCT_BRCA1_1	380	384	PF00533	0.300
LIG_EVH1_1	123	127	PF00568	0.503
LIG_FHA_1	137	143	PF00498	0.678
LIG_FHA_1	237	243	PF00498	0.545
LIG_FHA_1	247	253	PF00498	0.443
LIG_FHA_1	297	303	PF00498	0.522
LIG_FHA_1	49	55	PF00498	0.479
LIG_FHA_1	87	93	PF00498	0.585
LIG_FHA_2	323	329	PF00498	0.482
LIG_FHA_2	99	105	PF00498	0.653
LIG_IBAR_NPY_1	27	29	PF08397	0.342
LIG_LIR_Gen_1	176	185	PF02991	0.498
LIG_LIR_Nem_3	176	181	PF02991	0.498
LIG_LIR_Nem_3	239	243	PF02991	0.518
LIG_LIR_Nem_3	257	263	PF02991	0.485
LIG_MYND_3	362	366	PF01753	0.437
LIG_NRBOX	54	60	PF00104	0.541
LIG_Pex14_1	220	224	PF04695	0.503
LIG_SH2_CRK	205	209	PF00017	0.537
LIG_SH2_CRK	29	33	PF00017	0.342
LIG_SH2_GRB2like	205	208	PF00017	0.559
LIG_SH2_NCK_1	157	161	PF00017	0.541
LIG_SH2_NCK_1	205	209	PF00017	0.587
LIG_SH2_STAP1	165	169	PF00017	0.526
LIG_SH2_STAP1	178	182	PF00017	0.463
LIG_SH2_STAP1	50	54	PF00017	0.548
LIG_SH2_STAT5	205	208	PF00017	0.504
LIG_SH2_STAT5	300	303	PF00017	0.580
LIG_SH2_STAT5	50	53	PF00017	0.476
LIG_SH3_3	119	125	PF00018	0.507
LIG_SH3_3	17	23	PF00018	0.651
LIG_SH3_3	96	102	PF00018	0.628
LIG_SUMO_SIM_anti_2	338	344	PF11976	0.509
LIG_TRAF2_1	216	219	PF00917	0.491
MOD_CDK_SPxxK_3	103	110	PF00069	0.519
MOD_CK1_1	105	111	PF00069	0.738
MOD_CK1_1	115	121	PF00069	0.720
MOD_CK1_1	129	135	PF00069	0.580
MOD_CK1_1	236	242	PF00069	0.535
MOD_CK1_1	307	313	PF00069	0.479
MOD_CK1_1	43	49	PF00069	0.479
MOD_CK2_1	191	197	PF00069	0.585
MOD_CK2_1	241	247	PF00069	0.458
MOD_CK2_1	98	104	PF00069	0.650
MOD_GlcNHglycan	112	115	PF01048	0.739
MOD_GlcNHglycan	131	134	PF01048	0.613
MOD_GlcNHglycan	266	270	PF01048	0.186
MOD_GlcNHglycan	296	299	PF01048	0.304
MOD_GlcNHglycan	312	315	PF01048	0.240
MOD_GSK3_1	106	113	PF00069	0.741
MOD_GSK3_1	123	130	PF00069	0.655
MOD_GSK3_1	36	43	PF00069	0.502
MOD_GSK3_1	98	105	PF00069	0.641
MOD_N-GLC_1	116	121	PF02516	0.530
MOD_N-GLC_1	136	141	PF02516	0.487
MOD_N-GLC_1	43	48	PF02516	0.310
MOD_NEK2_1	147	152	PF00069	0.501
MOD_NEK2_1	246	251	PF00069	0.555
MOD_NEK2_1	288	293	PF00069	0.531
MOD_NEK2_1	322	327	PF00069	0.489
MOD_NEK2_1	341	346	PF00069	0.538
MOD_NEK2_1	36	41	PF00069	0.473
MOD_NEK2_1	86	91	PF00069	0.410
MOD_PKA_1	378	384	PF00069	0.456
MOD_PKA_2	236	242	PF00069	0.500
MOD_PKA_2	253	259	PF00069	0.543
MOD_Plk_1	165	171	PF00069	0.552
MOD_Plk_1	246	252	PF00069	0.386
MOD_Plk_1	265	271	PF00069	0.421
MOD_Plk_1	288	294	PF00069	0.531
MOD_Plk_1	322	328	PF00069	0.491
MOD_Plk_1	43	49	PF00069	0.451
MOD_Plk_2-3	214	220	PF00069	0.541
MOD_Plk_4	118	124	PF00069	0.529
MOD_Plk_4	176	182	PF00069	0.484
MOD_Plk_4	36	42	PF00069	0.479
MOD_Plk_4	8	14	PF00069	0.586
MOD_ProDKin_1	112	118	PF00069	0.738
MOD_ProDKin_1	123	129	PF00069	0.646
MOD_ProDKin_1	91	97	PF00069	0.624
MOD_ProDKin_1	98	104	PF00069	0.634
MOD_SUMO_for_1	286	289	PF00179	0.382
MOD_SUMO_rev_2	209	217	PF00179	0.556
MOD_SUMO_rev_2	281	288	PF00179	0.559
TRG_DiLeu_BaEn_1	266	271	PF01217	0.389
TRG_ENDOCYTIC_2	178	181	PF00928	0.451
TRG_ENDOCYTIC_2	29	32	PF00928	0.344
TRG_ER_diArg_1	15	17	PF00400	0.468
TRG_ER_diArg_1	81	83	PF00400	0.420
TRG_NLS_MonoExtN_4	78	84	PF00514	0.546
TRG_Pf-PMV_PEXEL_1	378	382	PF00026	0.277

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P7I9	Leptomonas seymouri	30%	100%
A0A0N0P7W9	Leptomonas seymouri	25%	100%
A0A0N1I1D8	Leptomonas seymouri	31%	100%
A0A0N1ILU0	Leptomonas seymouri	28%	100%
A0A0N1PEM6	Leptomonas seymouri	65%	100%
A0A1X0NRL0	Trypanosomatidae	26%	100%
A0A1X0NYN3	Trypanosomatidae	30%	100%
A0A1X0NYY3	Trypanosomatidae	30%	100%
A0A1X0P2Q4	Trypanosomatidae	39%	100%
A0A3Q8IDX0	Leishmania donovani	28%	100%
A0A3Q8IEU6	Leishmania donovani	93%	100%
A0A3Q8IGR3	Leishmania donovani	29%	100%
A0A3R7M7Z1	Trypanosoma rangeli	27%	100%
A0A3S7X1G8	Leishmania donovani	29%	100%
A0A422MX56	Trypanosoma rangeli	28%	100%
A0A422N4F0	Trypanosoma rangeli	30%	100%
A4HGI1	Leishmania braziliensis	27%	90%
A4HGI6	Leishmania braziliensis	29%	83%
A4HGI9	Leishmania braziliensis	28%	100%
A4HGJ0	Leishmania braziliensis	31%	93%
A4I3L4	Leishmania infantum	28%	100%
A4I3L6	Leishmania infantum	32%	100%
A4I3L7	Leishmania infantum	93%	100%
D0A7S2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	33%	100%
D0A841	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	31%	100%
E9AZV4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	29%	86%
E9AZV6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	30%	100%
Q4Q8C8	Leishmania major	93%	100%
Q4Q8C9	Leishmania major	29%	100%
Q4Q8D0	Leishmania major	24%	79%
Q4Q8D1	Leishmania major	30%	86%
V5BGL5	Trypanosoma cruzi	32%	100%