Putative ATP-dependent RNA helicase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

ATP-dependent RNA helicase, putative

Species:

Leishmania mexicana

UniProt:

E9AZV0_LEIMU

TriTrypDb:

LmxM.28.1310

Length:

894

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 10
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0005730	nucleolus	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AZV0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AZV0

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	1
GO:0006364	rRNA processing	8	1
GO:0006396	RNA processing	6	1
GO:0006725	cellular aromatic compound metabolic process	3	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0009987	cellular process	1	1
GO:0016070	RNA metabolic process	5	1
GO:0016072	rRNA metabolic process	7	1
GO:0034470	ncRNA processing	7	1
GO:0034641	cellular nitrogen compound metabolic process	3	1
GO:0034660	ncRNA metabolic process	6	1
GO:0043170	macromolecule metabolic process	3	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0046483	heterocycle metabolic process	3	1
GO:0071704	organic substance metabolic process	2	1
GO:0090304	nucleic acid metabolic process	4	1
GO:1901360	organic cyclic compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	12
GO:0003676	nucleic acid binding	3	12
GO:0003723	RNA binding	4	12
GO:0003724	RNA helicase activity	3	11
GO:0003743	translation initiation factor activity	4	11
GO:0003824	catalytic activity	1	12
GO:0004386	helicase activity	2	12
GO:0005488	binding	1	12
GO:0005524	ATP binding	5	12
GO:0008135	translation factor activity, RNA binding	3	11
GO:0008186	ATP-dependent activity, acting on RNA	2	11
GO:0016787	hydrolase activity	2	11
GO:0017076	purine nucleotide binding	4	12
GO:0030554	adenyl nucleotide binding	5	12
GO:0032553	ribonucleotide binding	3	12
GO:0032555	purine ribonucleotide binding	4	12
GO:0032559	adenyl ribonucleotide binding	5	12
GO:0035639	purine ribonucleoside triphosphate binding	4	12
GO:0036094	small molecule binding	2	12
GO:0043167	ion binding	2	12
GO:0043168	anion binding	3	12
GO:0045182	translation regulator activity	1	11
GO:0090079	translation regulator activity, nucleic acid binding	2	11
GO:0097159	organic cyclic compound binding	2	12
GO:0097367	carbohydrate derivative binding	2	12
GO:0140098	catalytic activity, acting on RNA	3	11
GO:0140640	catalytic activity, acting on a nucleic acid	2	12
GO:0140657	ATP-dependent activity	1	12
GO:1901265	nucleoside phosphate binding	3	12
GO:1901363	heterocyclic compound binding	2	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	399	403	PF00656	0.339
CLV_C14_Caspase3-7	587	591	PF00656	0.702
CLV_C14_Caspase3-7	592	596	PF00656	0.650
CLV_C14_Caspase3-7	705	709	PF00656	0.608
CLV_C14_Caspase3-7	806	810	PF00656	0.611
CLV_C14_Caspase3-7	865	869	PF00656	0.623
CLV_C14_Caspase3-7	872	876	PF00656	0.723
CLV_NRD_NRD_1	18	20	PF00675	0.450
CLV_NRD_NRD_1	190	192	PF00675	0.248
CLV_NRD_NRD_1	361	363	PF00675	0.237
CLV_NRD_NRD_1	4	6	PF00675	0.607
CLV_NRD_NRD_1	54	56	PF00675	0.449
CLV_NRD_NRD_1	553	555	PF00675	0.552
CLV_NRD_NRD_1	649	651	PF00675	0.554
CLV_NRD_NRD_1	766	768	PF00675	0.503
CLV_NRD_NRD_1	769	771	PF00675	0.509
CLV_NRD_NRD_1	851	853	PF00675	0.669
CLV_PCSK_FUR_1	767	771	PF00082	0.534
CLV_PCSK_KEX2_1	18	20	PF00082	0.434
CLV_PCSK_KEX2_1	192	194	PF00082	0.237
CLV_PCSK_KEX2_1	315	317	PF00082	0.227
CLV_PCSK_KEX2_1	361	363	PF00082	0.237
CLV_PCSK_KEX2_1	4	6	PF00082	0.587
CLV_PCSK_KEX2_1	54	56	PF00082	0.479
CLV_PCSK_KEX2_1	606	608	PF00082	0.498
CLV_PCSK_KEX2_1	648	650	PF00082	0.550
CLV_PCSK_KEX2_1	766	768	PF00082	0.510
CLV_PCSK_KEX2_1	769	771	PF00082	0.517
CLV_PCSK_KEX2_1	853	855	PF00082	0.642
CLV_PCSK_KEX2_1	888	890	PF00082	0.739
CLV_PCSK_PC1ET2_1	192	194	PF00082	0.237
CLV_PCSK_PC1ET2_1	315	317	PF00082	0.237
CLV_PCSK_PC1ET2_1	606	608	PF00082	0.526
CLV_PCSK_PC1ET2_1	648	650	PF00082	0.550
CLV_PCSK_PC1ET2_1	853	855	PF00082	0.665
CLV_PCSK_PC1ET2_1	888	890	PF00082	0.725
CLV_PCSK_SKI1_1	173	177	PF00082	0.312
CLV_PCSK_SKI1_1	18	22	PF00082	0.452
CLV_PCSK_SKI1_1	341	345	PF00082	0.237
CLV_PCSK_SKI1_1	491	495	PF00082	0.289
CLV_PCSK_SKI1_1	524	528	PF00082	0.505
CLV_PCSK_SKI1_1	578	582	PF00082	0.645
CLV_PCSK_SKI1_1	668	672	PF00082	0.706
CLV_PCSK_SKI1_1	818	822	PF00082	0.601
DEG_APCC_DBOX_1	190	198	PF00400	0.449
DEG_APCC_DBOX_1	53	61	PF00400	0.421
DEG_SCF_FBW7_1	425	432	PF00400	0.350
DEG_SPOP_SBC_1	66	70	PF00917	0.697
DOC_CKS1_1	201	206	PF01111	0.437
DOC_CKS1_1	426	431	PF01111	0.338
DOC_CKS1_1	97	102	PF01111	0.398
DOC_CYCLIN_yCln2_LP_2	387	393	PF00134	0.437
DOC_CYCLIN_yCln2_LP_2	508	514	PF00134	0.358
DOC_MAPK_gen_1	191	199	PF00069	0.437
DOC_MAPK_gen_1	305	313	PF00069	0.289
DOC_MAPK_gen_1	344	353	PF00069	0.444
DOC_MAPK_gen_1	358	367	PF00069	0.416
DOC_MAPK_gen_1	371	378	PF00069	0.437
DOC_MAPK_MEF2A_6	103	110	PF00069	0.523
DOC_MAPK_MEF2A_6	192	201	PF00069	0.437
DOC_MAPK_MEF2A_6	361	369	PF00069	0.448
DOC_MAPK_NFAT4_5	103	111	PF00069	0.523
DOC_PP1_RVXF_1	123	130	PF00149	0.437
DOC_PP1_RVXF_1	319	326	PF00149	0.437
DOC_PP1_RVXF_1	383	390	PF00149	0.437
DOC_PP1_RVXF_1	481	488	PF00149	0.289
DOC_PP1_RVXF_1	666	672	PF00149	0.675
DOC_PP2B_LxvP_1	508	511	PF13499	0.316
DOC_PP4_FxxP_1	129	132	PF00568	0.437
DOC_PP4_FxxP_1	426	429	PF00568	0.331
DOC_USP7_MATH_1	241	245	PF00917	0.542
DOC_USP7_MATH_1	270	274	PF00917	0.397
DOC_USP7_MATH_1	514	518	PF00917	0.346
DOC_USP7_MATH_1	610	614	PF00917	0.710
DOC_USP7_MATH_1	617	621	PF00917	0.748
DOC_USP7_MATH_1	66	70	PF00917	0.671
DOC_USP7_MATH_1	693	697	PF00917	0.718
DOC_USP7_MATH_1	797	801	PF00917	0.682
DOC_USP7_MATH_1	887	891	PF00917	0.483
DOC_USP7_UBL2_3	21	25	PF12436	0.604
DOC_USP7_UBL2_3	341	345	PF12436	0.448
DOC_WW_Pin1_4	151	156	PF00397	0.437
DOC_WW_Pin1_4	200	205	PF00397	0.437
DOC_WW_Pin1_4	287	292	PF00397	0.405
DOC_WW_Pin1_4	425	430	PF00397	0.338
DOC_WW_Pin1_4	698	703	PF00397	0.780
DOC_WW_Pin1_4	878	883	PF00397	0.689
DOC_WW_Pin1_4	96	101	PF00397	0.398
LIG_14-3-3_CanoR_1	253	257	PF00244	0.437
LIG_14-3-3_CanoR_1	278	283	PF00244	0.491
LIG_14-3-3_CanoR_1	371	378	PF00244	0.497
LIG_14-3-3_CanoR_1	4	8	PF00244	0.630
LIG_14-3-3_CanoR_1	420	425	PF00244	0.359
LIG_14-3-3_CanoR_1	776	783	PF00244	0.583
LIG_Actin_WH2_2	431	448	PF00022	0.325
LIG_APCC_ABBAyCdc20_2	824	830	PF00400	0.640
LIG_BIR_II_1	1	5	PF00653	0.443
LIG_BRCT_BRCA1_1	254	258	PF00533	0.542
LIG_BRCT_BRCA1_1	422	426	PF00533	0.340
LIG_BRCT_BRCA1_1	483	487	PF00533	0.289
LIG_Clathr_ClatBox_1	224	228	PF01394	0.477
LIG_DLG_GKlike_1	420	427	PF00625	0.351
LIG_EH1_1	163	171	PF00400	0.448
LIG_EH1_1	194	202	PF00400	0.497
LIG_FAT_LD_1	307	315	PF03623	0.437
LIG_FHA_1	154	160	PF00498	0.437
LIG_FHA_1	241	247	PF00498	0.497
LIG_FHA_1	261	267	PF00498	0.306
LIG_FHA_1	430	436	PF00498	0.367
LIG_FHA_1	742	748	PF00498	0.654
LIG_FHA_1	811	817	PF00498	0.661
LIG_FHA_2	4	10	PF00498	0.463
LIG_FHA_2	426	432	PF00498	0.341
LIG_FHA_2	551	557	PF00498	0.546
LIG_FHA_2	634	640	PF00498	0.562
LIG_FHA_2	66	72	PF00498	0.689
LIG_FHA_2	780	786	PF00498	0.583
LIG_GBD_Chelix_1	159	167	PF00786	0.237
LIG_GBD_Chelix_1	299	307	PF00786	0.345
LIG_HCF-1_HBM_1	71	74	PF13415	0.641
LIG_Integrin_RGD_1	588	590	PF01839	0.709
LIG_IRF3_LxIS_1	77	83	PF10401	0.504
LIG_LIR_Apic_2	126	132	PF02991	0.437
LIG_LIR_Apic_2	423	429	PF02991	0.343
LIG_LIR_Gen_1	460	470	PF02991	0.356
LIG_LIR_Gen_1	71	82	PF02991	0.443
LIG_LIR_Nem_3	363	369	PF02991	0.431
LIG_LIR_Nem_3	388	392	PF02991	0.437
LIG_LIR_Nem_3	460	465	PF02991	0.342
LIG_LIR_Nem_3	71	77	PF02991	0.472
LIG_MAD2	341	349	PF02301	0.448
LIG_MLH1_MIPbox_1	483	487	PF16413	0.305
LIG_NRBOX	306	312	PF00104	0.437
LIG_NRP_CendR_1	891	894	PF00754	0.774
LIG_Pex14_1	394	398	PF04695	0.437
LIG_PTB_Apo_2	273	280	PF02174	0.415
LIG_PTB_Phospho_1	273	279	PF10480	0.418
LIG_SH2_CRK	95	99	PF00017	0.456
LIG_SH2_NCK_1	398	402	PF00017	0.461
LIG_SH2_SRC	248	251	PF00017	0.523
LIG_SH2_SRC	437	440	PF00017	0.512
LIG_SH2_STAT3	472	475	PF00017	0.289
LIG_SH2_STAT5	248	251	PF00017	0.504
LIG_SH2_STAT5	279	282	PF00017	0.408
LIG_SH2_STAT5	407	410	PF00017	0.437
LIG_SH2_STAT5	437	440	PF00017	0.512
LIG_SH2_STAT5	454	457	PF00017	0.209
LIG_SH2_STAT5	481	484	PF00017	0.289
LIG_SH2_STAT5	486	489	PF00017	0.289
LIG_SH2_STAT5	95	98	PF00017	0.531
LIG_SH3_2	883	888	PF14604	0.671
LIG_SH3_3	198	204	PF00018	0.448
LIG_SH3_3	508	514	PF00018	0.358
LIG_SH3_3	879	885	PF00018	0.676
LIG_Sin3_3	215	222	PF02671	0.511
LIG_TRAF2_1	39	42	PF00917	0.556
LIG_TRAF2_1	636	639	PF00917	0.647
LIG_TYR_ITIM	170	175	PF00017	0.477
LIG_UBA3_1	268	275	PF00899	0.507
LIG_UBA3_1	310	315	PF00899	0.437
LIG_UBA3_1	434	441	PF00899	0.376
LIG_UBA3_1	97	103	PF00899	0.407
LIG_WRC_WIRS_1	366	371	PF05994	0.448
MOD_CDC14_SPxK_1	154	157	PF00782	0.437
MOD_CDK_SPK_2	425	430	PF00069	0.395
MOD_CDK_SPxK_1	151	157	PF00069	0.437
MOD_CDK_SPxK_1	200	206	PF00069	0.437
MOD_CDK_SPxxK_3	96	103	PF00069	0.409
MOD_CK1_1	123	129	PF00069	0.428
MOD_CK1_1	36	42	PF00069	0.496
MOD_CK1_1	403	409	PF00069	0.437
MOD_CK1_1	550	556	PF00069	0.699
MOD_CK1_1	615	621	PF00069	0.746
MOD_CK1_1	700	706	PF00069	0.743
MOD_CK1_1	75	81	PF00069	0.446
MOD_CK1_1	778	784	PF00069	0.578
MOD_CK1_1	812	818	PF00069	0.602
MOD_CK1_1	83	89	PF00069	0.336
MOD_CK1_1	866	872	PF00069	0.632
MOD_CK2_1	3	9	PF00069	0.405
MOD_CK2_1	36	42	PF00069	0.469
MOD_CK2_1	425	431	PF00069	0.335
MOD_CK2_1	454	460	PF00069	0.476
MOD_CK2_1	550	556	PF00069	0.552
MOD_CK2_1	633	639	PF00069	0.551
MOD_CK2_1	65	71	PF00069	0.697
MOD_CK2_1	779	785	PF00069	0.557
MOD_CK2_1	805	811	PF00069	0.663
MOD_Cter_Amidation	2	5	PF01082	0.436
MOD_GlcNHglycan	1	4	PF01048	0.584
MOD_GlcNHglycan	122	125	PF01048	0.237
MOD_GlcNHglycan	176	179	PF01048	0.237
MOD_GlcNHglycan	258	261	PF01048	0.245
MOD_GlcNHglycan	373	376	PF01048	0.297
MOD_GlcNHglycan	402	405	PF01048	0.237
MOD_GlcNHglycan	524	527	PF01048	0.628
MOD_GlcNHglycan	592	595	PF01048	0.765
MOD_GlcNHglycan	614	617	PF01048	0.715
MOD_GlcNHglycan	690	693	PF01048	0.731
MOD_GlcNHglycan	695	698	PF01048	0.732
MOD_GlcNHglycan	784	788	PF01048	0.597
MOD_GlcNHglycan	848	851	PF01048	0.749
MOD_GSK3_1	252	259	PF00069	0.448
MOD_GSK3_1	283	290	PF00069	0.467
MOD_GSK3_1	347	354	PF00069	0.461
MOD_GSK3_1	377	384	PF00069	0.523
MOD_GSK3_1	425	432	PF00069	0.350
MOD_GSK3_1	611	618	PF00069	0.491
MOD_GSK3_1	629	636	PF00069	0.448
MOD_GSK3_1	693	700	PF00069	0.675
MOD_GSK3_1	742	749	PF00069	0.694
MOD_GSK3_1	775	782	PF00069	0.565
MOD_GSK3_1	783	790	PF00069	0.576
MOD_GSK3_1	805	812	PF00069	0.657
MOD_N-GLC_1	66	71	PF02516	0.669
MOD_N-GLC_1	869	874	PF02516	0.714
MOD_NEK2_1	256	261	PF00069	0.436
MOD_NEK2_1	325	330	PF00069	0.437
MOD_NEK2_1	337	342	PF00069	0.413
MOD_NEK2_1	351	356	PF00069	0.411
MOD_NEK2_1	504	509	PF00069	0.296
MOD_NEK2_1	522	527	PF00069	0.504
MOD_NEK2_2	270	275	PF00069	0.402
MOD_NEK2_2	3	8	PF00069	0.428
MOD_NEK2_2	481	486	PF00069	0.305
MOD_NEK2_2	617	622	PF00069	0.748
MOD_PIKK_1	258	264	PF00454	0.442
MOD_PIKK_1	80	86	PF00454	0.374
MOD_PKA_1	852	858	PF00069	0.759
MOD_PKA_2	252	258	PF00069	0.444
MOD_PKA_2	3	9	PF00069	0.624
MOD_PKA_2	775	781	PF00069	0.585
MOD_PKA_2	846	852	PF00069	0.682
MOD_Plk_1	710	716	PF00069	0.677
MOD_Plk_2-3	495	501	PF00069	0.351
MOD_Plk_2-3	595	601	PF00069	0.631
MOD_Plk_2-3	735	741	PF00069	0.669
MOD_Plk_2-3	805	811	PF00069	0.508
MOD_Plk_2-3	826	832	PF00069	0.641
MOD_Plk_4	241	247	PF00069	0.483
MOD_Plk_4	252	258	PF00069	0.388
MOD_Plk_4	403	409	PF00069	0.434
MOD_Plk_4	420	426	PF00069	0.280
MOD_Plk_4	433	439	PF00069	0.331
MOD_Plk_4	622	628	PF00069	0.735
MOD_Plk_4	93	99	PF00069	0.561
MOD_ProDKin_1	151	157	PF00069	0.437
MOD_ProDKin_1	200	206	PF00069	0.437
MOD_ProDKin_1	287	293	PF00069	0.401
MOD_ProDKin_1	425	431	PF00069	0.335
MOD_ProDKin_1	698	704	PF00069	0.780
MOD_ProDKin_1	878	884	PF00069	0.686
MOD_ProDKin_1	96	102	PF00069	0.289
MOD_SUMO_for_1	470	473	PF00179	0.305
MOD_SUMO_for_1	605	608	PF00179	0.680
MOD_SUMO_rev_2	186	194	PF00179	0.437
MOD_SUMO_rev_2	728	734	PF00179	0.450
TRG_DiLeu_BaEn_1	229	234	PF01217	0.437
TRG_DiLeu_BaEn_4	189	195	PF01217	0.448
TRG_DiLeu_BaEn_4	41	47	PF01217	0.535
TRG_DiLeu_BaLyEn_6	815	820	PF01217	0.631
TRG_DiLeu_LyEn_5	229	234	PF01217	0.437
TRG_ENDOCYTIC_2	172	175	PF00928	0.477
TRG_ENDOCYTIC_2	279	282	PF00928	0.378
TRG_ENDOCYTIC_2	565	568	PF00928	0.547
TRG_ENDOCYTIC_2	74	77	PF00928	0.436
TRG_ENDOCYTIC_2	861	864	PF00928	0.742
TRG_ENDOCYTIC_2	95	98	PF00928	0.411
TRG_ER_diArg_1	17	19	PF00400	0.454
TRG_ER_diArg_1	191	194	PF00400	0.448
TRG_ER_diArg_1	360	362	PF00400	0.437
TRG_ER_diArg_1	53	55	PF00400	0.540
TRG_ER_diArg_1	658	661	PF00400	0.543
TRG_ER_diArg_1	724	727	PF00400	0.713
TRG_ER_diArg_1	765	767	PF00400	0.544
TRG_ER_diArg_1	768	770	PF00400	0.499
TRG_ER_diArg_1	891	894	PF00400	0.790
TRG_NLS_MonoCore_2	647	652	PF00514	0.619
TRG_NLS_MonoExtC_3	762	767	PF00514	0.528
TRG_NLS_MonoExtC_3	851	856	PF00514	0.734
TRG_NLS_MonoExtN_4	341	348	PF00514	0.448
TRG_NLS_MonoExtN_4	646	652	PF00514	0.537
TRG_NLS_MonoExtN_4	761	767	PF00514	0.529
TRG_NLS_MonoExtN_4	885	892	PF00514	0.717
TRG_Pf-PMV_PEXEL_1	157	162	PF00026	0.237
TRG_Pf-PMV_PEXEL_1	55	59	PF00026	0.538
TRG_Pf-PMV_PEXEL_1	650	654	PF00026	0.624
TRG_Pf-PMV_PEXEL_1	769	774	PF00026	0.561

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P7J1	Leptomonas seymouri	72%	100%
A0A0S4JDX4	Bodo saltans	57%	100%
A0A1X0P3K1	Trypanosomatidae	53%	95%
A0A3S7X1H1	Leishmania donovani	90%	100%
A0A422NYB4	Trypanosoma rangeli	60%	100%
A4HGH8	Leishmania braziliensis	84%	99%
A4HK20	Leishmania braziliensis	30%	100%
A4HKL3	Leishmania braziliensis	30%	100%
A4HP48	Leishmania braziliensis	39%	100%
A4I3L0	Leishmania infantum	90%	99%
C9ZPV9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	59%	100%
Q0UMB9	Phaeosphaeria nodorum (strain SN15 / ATCC MYA-4574 / FGSC 10173)	39%	100%
Q4Q8D5	Leishmania major	90%	100%
V5DAZ9	Trypanosoma cruzi	60%	94%