RING-type domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AZU9_LEIMU

TriTrypDb:

LmxM.28.1300

Length:

398

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AZU9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AZU9

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	6
GO:0043167	ion binding	2	6
GO:0043169	cation binding	3	6
GO:0046872	metal ion binding	4	6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	44	48	PF00656	0.643
CLV_NRD_NRD_1	104	106	PF00675	0.461
CLV_NRD_NRD_1	387	389	PF00675	0.420
CLV_NRD_NRD_1	80	82	PF00675	0.463
CLV_NRD_NRD_1	9	11	PF00675	0.613
CLV_PCSK_KEX2_1	104	106	PF00082	0.418
CLV_PCSK_KEX2_1	114	116	PF00082	0.486
CLV_PCSK_KEX2_1	125	127	PF00082	0.453
CLV_PCSK_KEX2_1	63	65	PF00082	0.515
CLV_PCSK_KEX2_1	80	82	PF00082	0.505
CLV_PCSK_KEX2_1	88	90	PF00082	0.521
CLV_PCSK_KEX2_1	9	11	PF00082	0.619
CLV_PCSK_PC1ET2_1	114	116	PF00082	0.592
CLV_PCSK_PC1ET2_1	125	127	PF00082	0.500
CLV_PCSK_PC1ET2_1	63	65	PF00082	0.569
CLV_PCSK_PC1ET2_1	88	90	PF00082	0.542
CLV_PCSK_SKI1_1	122	126	PF00082	0.346
CLV_PCSK_SKI1_1	330	334	PF00082	0.389
CLV_PCSK_SKI1_1	95	99	PF00082	0.650
DEG_APCC_DBOX_1	243	251	PF00400	0.468
DEG_APCC_DBOX_1	79	87	PF00400	0.358
DEG_APCC_KENBOX_2	163	167	PF00400	0.294
DEG_Nend_UBRbox_2	1	3	PF02207	0.511
DOC_CDC14_PxL_1	298	306	PF14671	0.271
DOC_CYCLIN_RxL_1	122	132	PF00134	0.448
DOC_CYCLIN_RxL_1	60	70	PF00134	0.384
DOC_MAPK_gen_1	208	217	PF00069	0.493
DOC_PP1_RVXF_1	123	130	PF00149	0.603
DOC_PP4_FxxP_1	290	293	PF00568	0.370
DOC_USP7_UBL2_3	110	114	PF12436	0.421
DOC_USP7_UBL2_3	330	334	PF12436	0.389
DOC_WW_Pin1_4	340	345	PF00397	0.369
DOC_WW_Pin1_4	377	382	PF00397	0.639
DOC_WW_Pin1_4	9	14	PF00397	0.568
LIG_14-3-3_CanoR_1	126	130	PF00244	0.436
LIG_14-3-3_CanoR_1	363	371	PF00244	0.449
LIG_Actin_WH2_2	357	374	PF00022	0.533
LIG_BRCT_BRCA1_1	314	318	PF00533	0.437
LIG_FHA_1	221	227	PF00498	0.503
LIG_FHA_1	267	273	PF00498	0.245
LIG_FHA_1	32	38	PF00498	0.628
LIG_FHA_1	345	351	PF00498	0.301
LIG_FHA_1	54	60	PF00498	0.591
LIG_FHA_2	199	205	PF00498	0.460
LIG_FHA_2	39	45	PF00498	0.616
LIG_GBD_Chelix_1	260	268	PF00786	0.265
LIG_GBD_Chelix_1	68	76	PF00786	0.390
LIG_LIR_Apic_2	289	293	PF02991	0.360
LIG_LIR_Nem_3	394	398	PF02991	0.549
LIG_Rb_LxCxE_1	289	309	PF01857	0.335
LIG_SH2_CRK	212	216	PF00017	0.502
LIG_SH2_CRK	305	309	PF00017	0.404
LIG_SH2_STAT3	225	228	PF00017	0.508
LIG_SH2_STAT5	174	177	PF00017	0.424
LIG_SH2_STAT5	225	228	PF00017	0.508
LIG_SH3_3	347	353	PF00018	0.494
LIG_SUMO_SIM_par_1	136	143	PF11976	0.360
LIG_TRAF2_1	106	109	PF00917	0.525
LIG_TRAF2_1	201	204	PF00917	0.465
LIG_UBA3_1	137	141	PF00899	0.409
LIG_UBA3_1	152	157	PF00899	0.428
MOD_CDC14_SPxK_1	380	383	PF00782	0.641
MOD_CDK_SPxK_1	377	383	PF00069	0.628
MOD_CK1_1	12	18	PF00069	0.498
MOD_CK1_1	220	226	PF00069	0.627
MOD_CK1_1	312	318	PF00069	0.381
MOD_CK1_1	362	368	PF00069	0.353
MOD_CK2_1	198	204	PF00069	0.467
MOD_CK2_1	38	44	PF00069	0.720
MOD_DYRK1A_RPxSP_1	377	381	PF00069	0.473
MOD_GlcNHglycan	25	29	PF01048	0.778
MOD_GlcNHglycan	384	387	PF01048	0.611
MOD_GSK3_1	125	132	PF00069	0.386
MOD_GSK3_1	340	347	PF00069	0.369
MOD_GSK3_1	38	45	PF00069	0.757
MOD_NEK2_1	129	134	PF00069	0.439
MOD_NEK2_1	145	150	PF00069	0.327
MOD_NEK2_1	193	198	PF00069	0.467
MOD_NEK2_1	263	268	PF00069	0.524
MOD_NEK2_1	324	329	PF00069	0.428
MOD_NEK2_1	59	64	PF00069	0.510
MOD_NEK2_1	72	77	PF00069	0.331
MOD_NEK2_2	344	349	PF00069	0.491
MOD_PIKK_1	117	123	PF00454	0.527
MOD_PIKK_1	129	135	PF00454	0.515
MOD_PIKK_1	338	344	PF00454	0.510
MOD_PIKK_1	362	368	PF00454	0.608
MOD_PKA_1	125	131	PF00069	0.489
MOD_PKA_2	125	131	PF00069	0.409
MOD_PKA_2	362	368	PF00069	0.584
MOD_PKA_2	371	377	PF00069	0.528
MOD_Plk_1	264	270	PF00069	0.422
MOD_Plk_1	72	78	PF00069	0.457
MOD_Plk_2-3	155	161	PF00069	0.497
MOD_Plk_4	125	131	PF00069	0.410
MOD_ProDKin_1	340	346	PF00069	0.369
MOD_ProDKin_1	377	383	PF00069	0.643
MOD_ProDKin_1	9	15	PF00069	0.568
MOD_SUMO_for_1	113	116	PF00179	0.486
MOD_SUMO_for_1	140	143	PF00179	0.400
MOD_SUMO_rev_2	154	159	PF00179	0.448
MOD_SUMO_rev_2	384	391	PF00179	0.490
TRG_DiLeu_BaEn_4	154	160	PF01217	0.449
TRG_DiLeu_BaLyEn_6	148	153	PF01217	0.536
TRG_DiLeu_BaLyEn_6	245	250	PF01217	0.392
TRG_ENDOCYTIC_2	212	215	PF00928	0.550
TRG_ER_diArg_1	103	105	PF00400	0.578
TRG_ER_diArg_1	149	152	PF00400	0.563
TRG_ER_diArg_1	30	33	PF00400	0.581
TRG_ER_diArg_1	79	81	PF00400	0.371
TRG_ER_diArg_1	8	10	PF00400	0.619
TRG_Pf-PMV_PEXEL_1	151	155	PF00026	0.526
TRG_Pf-PMV_PEXEL_1	188	192	PF00026	0.399
TRG_Pf-PMV_PEXEL_1	369	373	PF00026	0.521

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I6L8	Leptomonas seymouri	63%	100%
A0A1X0P3W0	Trypanosomatidae	46%	100%
A0A3R7KVC5	Trypanosoma rangeli	45%	100%
A0A3S7X1G5	Leishmania donovani	87%	100%
A4HGH7	Leishmania braziliensis	77%	100%
A4I3K9	Leishmania infantum	87%	100%
C9ZPW1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	43%	98%
Q4Q8D6	Leishmania major	85%	100%
V5AUY7	Trypanosoma cruzi	46%	88%