Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AZU8_LEIMU

TriTrypDb:

LmxM.28.1290

Length:

439

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AZU8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AZU8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	141	145	PF00656	0.398
CLV_C14_Caspase3-7	86	90	PF00656	0.461
CLV_NRD_NRD_1	18	20	PF00675	0.482
CLV_NRD_NRD_1	291	293	PF00675	0.593
CLV_NRD_NRD_1	404	406	PF00675	0.466
CLV_NRD_NRD_1	423	425	PF00675	0.621
CLV_NRD_NRD_1	8	10	PF00675	0.536
CLV_NRD_NRD_1	83	85	PF00675	0.395
CLV_PCSK_KEX2_1	114	116	PF00082	0.516
CLV_PCSK_KEX2_1	306	308	PF00082	0.672
CLV_PCSK_KEX2_1	423	425	PF00082	0.579
CLV_PCSK_KEX2_1	8	10	PF00082	0.552
CLV_PCSK_KEX2_1	83	85	PF00082	0.395
CLV_PCSK_PC1ET2_1	114	116	PF00082	0.435
CLV_PCSK_PC1ET2_1	306	308	PF00082	0.539
CLV_PCSK_PC7_1	4	10	PF00082	0.672
CLV_PCSK_SKI1_1	114	118	PF00082	0.503
CLV_PCSK_SKI1_1	147	151	PF00082	0.456
CLV_PCSK_SKI1_1	19	23	PF00082	0.489
DEG_APCC_KENBOX_2	214	218	PF00400	0.444
DEG_SPOP_SBC_1	273	277	PF00917	0.700
DOC_MAPK_gen_1	114	124	PF00069	0.456
DOC_MAPK_MEF2A_6	118	126	PF00069	0.452
DOC_USP7_MATH_1	103	107	PF00917	0.332
DOC_USP7_MATH_1	185	189	PF00917	0.516
DOC_USP7_MATH_1	190	194	PF00917	0.581
DOC_USP7_MATH_1	272	276	PF00917	0.668
DOC_USP7_MATH_1	31	35	PF00917	0.481
DOC_USP7_MATH_1	361	365	PF00917	0.723
DOC_USP7_UBL2_3	114	118	PF12436	0.433
DOC_WW_Pin1_4	231	236	PF00397	0.394
DOC_WW_Pin1_4	268	273	PF00397	0.431
DOC_WW_Pin1_4	348	353	PF00397	0.495
DOC_WW_Pin1_4	382	387	PF00397	0.544
DOC_WW_Pin1_4	430	435	PF00397	0.524
LIG_14-3-3_CanoR_1	147	153	PF00244	0.426
LIG_CSL_BTD_1	431	434	PF09270	0.521
LIG_FHA_1	251	257	PF00498	0.391
LIG_FHA_1	41	47	PF00498	0.484
LIG_FHA_1	5	11	PF00498	0.551
LIG_FHA_2	153	159	PF00498	0.487
LIG_FHA_2	174	180	PF00498	0.488
LIG_FHA_2	345	351	PF00498	0.558
LIG_Integrin_RGD_1	328	330	PF01839	0.520
LIG_LIR_Gen_1	158	167	PF02991	0.416
LIG_LIR_Gen_1	67	77	PF02991	0.328
LIG_LIR_Gen_1	89	99	PF02991	0.465
LIG_LIR_Nem_3	158	162	PF02991	0.389
LIG_LIR_Nem_3	216	222	PF02991	0.553
LIG_LIR_Nem_3	330	336	PF02991	0.487
LIG_LIR_Nem_3	67	72	PF02991	0.332
LIG_LIR_Nem_3	89	94	PF02991	0.485
LIG_LYPXL_S_1	109	113	PF13949	0.433
LIG_LYPXL_yS_3	110	113	PF13949	0.440
LIG_PCNA_yPIPBox_3	93	107	PF02747	0.475
LIG_PDZ_Class_3	434	439	PF00595	0.552
LIG_Pex14_2	333	337	PF04695	0.426
LIG_SH2_CRK	159	163	PF00017	0.327
LIG_SH2_CRK	75	79	PF00017	0.343
LIG_SH2_CRK	91	95	PF00017	0.342
LIG_SH2_GRB2like	91	94	PF00017	0.557
LIG_SH2_STAP1	148	152	PF00017	0.418
LIG_SH2_STAP1	159	163	PF00017	0.280
LIG_SH3_1	75	81	PF00018	0.344
LIG_SH3_2	78	83	PF14604	0.356
LIG_SH3_3	113	119	PF00018	0.525
LIG_SH3_3	186	192	PF00018	0.404
LIG_SH3_3	71	77	PF00018	0.358
LIG_Sin3_3	203	210	PF02671	0.448
LIG_SUMO_SIM_par_1	135	141	PF11976	0.303
LIG_TRAF2_1	61	64	PF00917	0.526
LIG_WRC_WIRS_1	96	101	PF05994	0.341
MOD_CK1_1	151	157	PF00069	0.292
MOD_CK1_1	234	240	PF00069	0.498
MOD_CK1_1	276	282	PF00069	0.710
MOD_CK1_1	287	293	PF00069	0.706
MOD_CK1_1	348	354	PF00069	0.594
MOD_CK1_1	378	384	PF00069	0.600
MOD_CK1_1	419	425	PF00069	0.669
MOD_CK1_1	95	101	PF00069	0.338
MOD_CK2_1	152	158	PF00069	0.539
MOD_CK2_1	344	350	PF00069	0.539
MOD_CK2_1	351	357	PF00069	0.691
MOD_CK2_1	58	64	PF00069	0.440
MOD_CK2_1	95	101	PF00069	0.372
MOD_GlcNHglycan	101	104	PF01048	0.425
MOD_GlcNHglycan	134	137	PF01048	0.305
MOD_GlcNHglycan	201	206	PF01048	0.565
MOD_GlcNHglycan	279	282	PF01048	0.653
MOD_GlcNHglycan	289	292	PF01048	0.783
MOD_GlcNHglycan	302	305	PF01048	0.671
MOD_GlcNHglycan	346	350	PF01048	0.484
MOD_GlcNHglycan	353	356	PF01048	0.588
MOD_GlcNHglycan	380	383	PF01048	0.618
MOD_GSK3_1	147	154	PF00069	0.423
MOD_GSK3_1	169	176	PF00069	0.527
MOD_GSK3_1	197	204	PF00069	0.653
MOD_GSK3_1	231	238	PF00069	0.387
MOD_GSK3_1	268	275	PF00069	0.554
MOD_GSK3_1	276	283	PF00069	0.657
MOD_GSK3_1	287	294	PF00069	0.644
MOD_GSK3_1	344	351	PF00069	0.498
MOD_GSK3_1	378	385	PF00069	0.603
MOD_GSK3_1	95	102	PF00069	0.471
MOD_N-GLC_1	173	178	PF02516	0.539
MOD_N-GLC_1	416	421	PF02516	0.528
MOD_N-GLC_1	92	97	PF02516	0.505
MOD_NEK2_1	152	157	PF00069	0.393
MOD_NEK2_1	251	256	PF00069	0.488
MOD_NEK2_1	375	380	PF00069	0.591
MOD_NEK2_1	416	421	PF00069	0.609
MOD_NEK2_1	428	433	PF00069	0.550
MOD_NEK2_1	99	104	PF00069	0.479
MOD_NEK2_2	218	223	PF00069	0.440
MOD_PIKK_1	235	241	PF00454	0.516
MOD_PKA_2	277	283	PF00069	0.685
MOD_PKA_2	291	297	PF00069	0.735
MOD_Plk_1	173	179	PF00069	0.489
MOD_Plk_1	201	207	PF00069	0.642
MOD_Plk_1	92	98	PF00069	0.502
MOD_Plk_4	173	179	PF00069	0.414
MOD_Plk_4	223	229	PF00069	0.349
MOD_Plk_4	251	257	PF00069	0.279
MOD_Plk_4	95	101	PF00069	0.341
MOD_ProDKin_1	231	237	PF00069	0.397
MOD_ProDKin_1	268	274	PF00069	0.438
MOD_ProDKin_1	348	354	PF00069	0.508
MOD_ProDKin_1	382	388	PF00069	0.544
MOD_ProDKin_1	430	436	PF00069	0.527
TRG_DiLeu_BaEn_1	158	163	PF01217	0.471
TRG_ENDOCYTIC_2	110	113	PF00928	0.440
TRG_ENDOCYTIC_2	159	162	PF00928	0.372
TRG_ENDOCYTIC_2	219	222	PF00928	0.431
TRG_ENDOCYTIC_2	91	94	PF00928	0.439
TRG_ER_diArg_1	122	125	PF00400	0.546
TRG_ER_diArg_1	423	425	PF00400	0.589
TRG_ER_diArg_1	8	10	PF00400	0.583
TRG_ER_diArg_1	82	84	PF00400	0.363
TRG_Pf-PMV_PEXEL_1	44	49	PF00026	0.491
TRG_Pf-PMV_PEXEL_1	8	12	PF00026	0.531

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PFK1	Leptomonas seymouri	63%	100%
A0A0S4JAC2	Bodo saltans	28%	100%
A0A1X0P2Q2	Trypanosomatidae	41%	100%
A0A3Q8ID39	Leishmania donovani	92%	100%
A0A422NY97	Trypanosoma rangeli	41%	100%
A4HGH6	Leishmania braziliensis	82%	97%
A4I3K8	Leishmania infantum	92%	100%
C9ZPW2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	40%	100%
Q4Q8D7	Leishmania major	93%	100%
V5BAD6	Trypanosoma cruzi	43%	100%