LeishMANIAdb
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Putative phenylalanine-4-hydroxylase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Putative phenylalanine-4-hydroxylase
Gene product:
phenylalanine-4-hydroxylase, putative
Species:
Leishmania mexicana
UniProt:
E9AZU7_LEIMU
TriTrypDb:
LmxM.28.1280
Length:
452

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. yes yes: 25
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 8
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 8
NetGPI no yes: 0, no: 8
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AZU7
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AZU7

Function

Biological processes
Term Name Level Count
GO:0006082 organic acid metabolic process 3 4
GO:0006520 amino acid metabolic process 3 4
GO:0006558 L-phenylalanine metabolic process 5 1
GO:0006725 cellular aromatic compound metabolic process 3 4
GO:0006807 nitrogen compound metabolic process 2 4
GO:0008152 metabolic process 1 4
GO:0009072 aromatic amino acid metabolic process 4 4
GO:0009987 cellular process 1 4
GO:0019752 carboxylic acid metabolic process 5 4
GO:0043436 oxoacid metabolic process 4 4
GO:0044237 cellular metabolic process 2 4
GO:0044238 primary metabolic process 2 4
GO:0044281 small molecule metabolic process 2 4
GO:0071704 organic substance metabolic process 2 4
GO:1901360 organic cyclic compound metabolic process 3 4
GO:1901564 organonitrogen compound metabolic process 3 4
GO:1901605 alpha-amino acid metabolic process 4 1
GO:1902221 erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process 5 1
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 9
GO:0004497 monooxygenase activity 3 9
GO:0004505 phenylalanine 4-monooxygenase activity 5 6
GO:0005488 binding 1 9
GO:0005506 iron ion binding 6 9
GO:0016491 oxidoreductase activity 2 9
GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen 3 9
GO:0016714 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen 4 9
GO:0043167 ion binding 2 9
GO:0043169 cation binding 3 9
GO:0046872 metal ion binding 4 9
GO:0046914 transition metal ion binding 5 9

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 400 404 PF00656 0.464
CLV_NRD_NRD_1 167 169 PF00675 0.266
CLV_NRD_NRD_1 348 350 PF00675 0.315
CLV_NRD_NRD_1 405 407 PF00675 0.315
CLV_PCSK_FUR_1 164 168 PF00082 0.331
CLV_PCSK_KEX2_1 166 168 PF00082 0.266
CLV_PCSK_KEX2_1 348 350 PF00082 0.315
CLV_PCSK_KEX2_1 446 448 PF00082 0.644
CLV_PCSK_PC1ET2_1 446 448 PF00082 0.558
CLV_PCSK_SKI1_1 172 176 PF00082 0.189
CLV_PCSK_SKI1_1 252 256 PF00082 0.286
CLV_PCSK_SKI1_1 261 265 PF00082 0.241
CLV_PCSK_SKI1_1 329 333 PF00082 0.331
CLV_Separin_Metazoa 169 173 PF03568 0.389
DEG_APCC_DBOX_1 260 268 PF00400 0.531
DEG_Nend_Nbox_1 1 3 PF02207 0.554
DOC_CDC14_PxL_1 297 305 PF14671 0.531
DOC_CKS1_1 285 290 PF01111 0.464
DOC_MAPK_gen_1 164 173 PF00069 0.519
DOC_MAPK_gen_1 175 185 PF00069 0.553
DOC_MAPK_gen_1 35 45 PF00069 0.446
DOC_MAPK_MEF2A_6 38 47 PF00069 0.421
DOC_PP1_RVXF_1 330 336 PF00149 0.464
DOC_USP7_UBL2_3 131 135 PF12436 0.389
DOC_USP7_UBL2_3 31 35 PF12436 0.579
DOC_WW_Pin1_4 284 289 PF00397 0.479
DOC_WW_Pin1_4 381 386 PF00397 0.531
LIG_14-3-3_CanoR_1 194 199 PF00244 0.540
LIG_14-3-3_CanoR_1 270 278 PF00244 0.464
LIG_14-3-3_CanoR_1 38 44 PF00244 0.390
LIG_14-3-3_CanoR_1 417 423 PF00244 0.539
LIG_14-3-3_CanoR_1 428 434 PF00244 0.528
LIG_14-3-3_CterR_2 447 452 PF00244 0.610
LIG_BRCT_BRCA1_1 259 263 PF00533 0.464
LIG_BRCT_BRCA1_1 336 340 PF00533 0.489
LIG_BRCT_BRCA1_1 4 8 PF00533 0.558
LIG_Dynein_DLC8_1 308 314 PF01221 0.468
LIG_eIF4E_1 217 223 PF01652 0.531
LIG_FHA_1 253 259 PF00498 0.494
LIG_FHA_1 273 279 PF00498 0.396
LIG_FHA_1 310 316 PF00498 0.532
LIG_FHA_1 62 68 PF00498 0.341
LIG_FHA_1 85 91 PF00498 0.434
LIG_FHA_2 187 193 PF00498 0.464
LIG_FHA_2 257 263 PF00498 0.544
LIG_LIR_Apic_2 118 124 PF02991 0.370
LIG_LIR_Gen_1 197 208 PF02991 0.473
LIG_LIR_Gen_1 305 315 PF02991 0.473
LIG_LIR_Gen_1 437 445 PF02991 0.517
LIG_LIR_Gen_1 87 96 PF02991 0.375
LIG_LIR_Nem_3 197 203 PF02991 0.499
LIG_LIR_Nem_3 305 311 PF02991 0.477
LIG_LIR_Nem_3 421 426 PF02991 0.466
LIG_LIR_Nem_3 437 441 PF02991 0.403
LIG_LIR_Nem_3 60 65 PF02991 0.497
LIG_LIR_Nem_3 87 92 PF02991 0.368
LIG_NRBOX 54 60 PF00104 0.382
LIG_PCNA_yPIPBox_3 405 417 PF02747 0.499
LIG_PDZ_Class_2 447 452 PF00595 0.641
LIG_Pex14_1 196 200 PF04695 0.556
LIG_SH2_CRK 215 219 PF00017 0.531
LIG_SH2_GRB2like 79 82 PF00017 0.584
LIG_SH2_PTP2 217 220 PF00017 0.531
LIG_SH2_SRC 95 98 PF00017 0.288
LIG_SH2_STAP1 200 204 PF00017 0.436
LIG_SH2_STAP1 273 277 PF00017 0.489
LIG_SH2_STAP1 336 340 PF00017 0.464
LIG_SH2_STAP1 426 430 PF00017 0.464
LIG_SH2_STAP1 65 69 PF00017 0.561
LIG_SH2_STAP1 79 83 PF00017 0.494
LIG_SH2_STAT3 273 276 PF00017 0.489
LIG_SH2_STAT5 188 191 PF00017 0.464
LIG_SH2_STAT5 217 220 PF00017 0.534
LIG_SH2_STAT5 23 26 PF00017 0.364
LIG_SH2_STAT5 277 280 PF00017 0.464
LIG_SH2_STAT5 286 289 PF00017 0.464
LIG_SH2_STAT5 395 398 PF00017 0.464
LIG_SH2_STAT5 420 423 PF00017 0.511
LIG_SH2_STAT5 95 98 PF00017 0.407
LIG_SH3_3 121 127 PF00018 0.301
LIG_SH3_3 148 154 PF00018 0.486
LIG_SH3_3 372 378 PF00018 0.464
LIG_SUMO_SIM_par_1 219 224 PF11976 0.519
LIG_TRAF2_1 143 146 PF00917 0.531
LIG_TRAF2_1 189 192 PF00917 0.464
LIG_TRAF2_1 413 416 PF00917 0.519
LIG_TYR_ITIM 198 203 PF00017 0.519
LIG_UBA3_1 326 332 PF00899 0.531
MOD_CK1_1 25 31 PF00069 0.462
MOD_CK1_1 46 52 PF00069 0.556
MOD_CK2_1 186 192 PF00069 0.472
MOD_CK2_1 356 362 PF00069 0.493
MOD_CK2_1 410 416 PF00069 0.553
MOD_Cter_Amidation 346 349 PF01082 0.315
MOD_GlcNHglycan 117 120 PF01048 0.286
MOD_GSK3_1 21 28 PF00069 0.604
MOD_GSK3_1 252 259 PF00069 0.547
MOD_GSK3_1 316 323 PF00069 0.489
MOD_GSK3_1 34 41 PF00069 0.427
MOD_GSK3_1 407 414 PF00069 0.556
MOD_GSK3_1 418 425 PF00069 0.488
MOD_GSK3_1 57 64 PF00069 0.365
MOD_N-GLC_1 186 191 PF02516 0.289
MOD_N-GLC_1 67 72 PF02516 0.407
MOD_NEK2_1 136 141 PF00069 0.464
MOD_NEK2_1 2 7 PF00069 0.534
MOD_NEK2_1 228 233 PF00069 0.502
MOD_NEK2_1 272 277 PF00069 0.474
MOD_NEK2_1 311 316 PF00069 0.531
MOD_NEK2_1 43 48 PF00069 0.392
MOD_NEK2_1 445 450 PF00069 0.600
MOD_NEK2_2 15 20 PF00069 0.579
MOD_NEK2_2 418 423 PF00069 0.531
MOD_NEK2_2 84 89 PF00069 0.487
MOD_PIKK_1 228 234 PF00454 0.475
MOD_PIKK_1 272 278 PF00454 0.464
MOD_PIKK_1 309 315 PF00454 0.531
MOD_PIKK_1 411 417 PF00454 0.519
MOD_PIKK_1 67 73 PF00454 0.486
MOD_PK_1 63 69 PF00069 0.451
MOD_PKA_2 39 45 PF00069 0.577
MOD_Plk_1 136 142 PF00069 0.482
MOD_Plk_1 67 73 PF00069 0.418
MOD_Plk_4 117 123 PF00069 0.382
MOD_Plk_4 407 413 PF00069 0.561
MOD_Plk_4 418 424 PF00069 0.589
MOD_Plk_4 57 63 PF00069 0.565
MOD_Plk_4 84 90 PF00069 0.318
MOD_ProDKin_1 284 290 PF00069 0.479
MOD_ProDKin_1 381 387 PF00069 0.531
MOD_SUMO_rev_2 28 37 PF00179 0.550
TRG_DiLeu_BaEn_1 54 59 PF01217 0.459
TRG_DiLeu_BaLyEn_6 217 222 PF01217 0.539
TRG_DiLeu_BaLyEn_6 298 303 PF01217 0.531
TRG_ENDOCYTIC_2 200 203 PF00928 0.531
TRG_ENDOCYTIC_2 215 218 PF00928 0.464
TRG_ER_diArg_1 163 166 PF00400 0.531
TRG_ER_diArg_1 3 6 PF00400 0.554
TRG_NES_CRM1_1 291 305 PF08389 0.531

Homologs

Protein Taxonomy Sequence identity Coverage
A0A060X6Z0 Oncorhynchus mykiss 42% 92%
A0A0N1HZV2 Leptomonas seymouri 81% 100%
A0A0S4JDM5 Bodo saltans 56% 100%
A0A3S5H7J2 Leishmania donovani 94% 100%
A4HGH5 Leishmania braziliensis 90% 100%
A4I3K7 Leishmania infantum 94% 100%
A8X3V8 Caenorhabditis briggsae 45% 87%
B6DT73 Bodo saltans 56% 100%
O17446 Schistosoma mansoni 41% 97%
O42091 Anguilla anguilla 43% 93%
P00439 Homo sapiens 43% 100%
P04176 Rattus norvegicus 44% 100%
P04177 Rattus norvegicus 43% 91%
P07101 Homo sapiens 42% 86%
P09810 Rattus norvegicus 43% 100%
P11982 Phasianidae sp. 43% 92%
P16331 Mus musculus 44% 100%
P17276 Drosophila melanogaster 43% 100%
P17289 Bos taurus 42% 92%
P17290 Oryctolagus cuniculus 42% 100%
P17532 Mus musculus 43% 100%
P17752 Homo sapiens 43% 100%
P18459 Drosophila melanogaster 48% 78%
P24529 Mus musculus 43% 91%
P70080 Gallus gallus 44% 100%
P90925 Caenorhabditis elegans 45% 99%
P90986 Caenorhabditis elegans 45% 87%
Q0EAB8 Equus caballus 47% 92%
Q2HZ26 Macaca mulatta 47% 92%
Q2KIH7 Bos taurus 44% 100%
Q54XS1 Dictyostelium discoideum 47% 100%
Q6WRI4 Leishmania major 93% 100%
Q76IQ3 Canis lupus familiaris 41% 91%
Q8CGU9 Rattus norvegicus 41% 93%
Q8CGV2 Mus musculus 40% 93%
Q8IWU9 Homo sapiens 47% 92%
Q92142 Xenopus laevis 42% 94%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS