J domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

DnaJ domain containing protein, putative

Species:

Leishmania mexicana

UniProt:

E9AZU6_LEIMU

TriTrypDb:

LmxM.28.1270

Length:

479

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AZU6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AZU6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_MEL_PAP_1	194	200	PF00089	0.583
CLV_NRD_NRD_1	109	111	PF00675	0.533
CLV_NRD_NRD_1	298	300	PF00675	0.548
CLV_PCSK_KEX2_1	298	300	PF00082	0.548
CLV_PCSK_KEX2_1	427	429	PF00082	0.602
CLV_PCSK_KEX2_1	72	74	PF00082	0.326
CLV_PCSK_PC1ET2_1	427	429	PF00082	0.602
CLV_PCSK_PC1ET2_1	72	74	PF00082	0.326
DEG_Nend_UBRbox_2	1	3	PF02207	0.630
DEG_SPOP_SBC_1	116	120	PF00917	0.701
DEG_SPOP_SBC_1	168	172	PF00917	0.541
DOC_CDC14_PxL_1	439	447	PF14671	0.581
DOC_MAPK_DCC_7	456	465	PF00069	0.525
DOC_MAPK_gen_1	205	212	PF00069	0.613
DOC_MAPK_gen_1	27	36	PF00069	0.315
DOC_MAPK_gen_1	427	437	PF00069	0.557
DOC_MAPK_MEF2A_6	190	198	PF00069	0.588
DOC_MAPK_MEF2A_6	27	36	PF00069	0.315
DOC_MAPK_MEF2A_6	430	439	PF00069	0.625
DOC_MAPK_MEF2A_6	456	465	PF00069	0.525
DOC_PP4_FxxP_1	224	227	PF00568	0.457
DOC_USP7_MATH_1	116	120	PF00917	0.726
DOC_USP7_MATH_1	168	172	PF00917	0.625
DOC_USP7_MATH_1	265	269	PF00917	0.643
DOC_USP7_MATH_1	337	341	PF00917	0.637
DOC_USP7_MATH_1	429	433	PF00917	0.641
DOC_USP7_MATH_1	470	474	PF00917	0.527
DOC_WW_Pin1_4	117	122	PF00397	0.714
DOC_WW_Pin1_4	223	228	PF00397	0.638
DOC_WW_Pin1_4	300	305	PF00397	0.641
DOC_WW_Pin1_4	333	338	PF00397	0.634
DOC_WW_Pin1_4	381	386	PF00397	0.579
DOC_WW_Pin1_4	454	459	PF00397	0.535
DOC_WW_Pin1_4	466	471	PF00397	0.550
LIG_14-3-3_CanoR_1	110	117	PF00244	0.552
LIG_14-3-3_CanoR_1	190	195	PF00244	0.755
LIG_14-3-3_CanoR_1	222	227	PF00244	0.565
LIG_14-3-3_CanoR_1	298	302	PF00244	0.577
LIG_14-3-3_CanoR_1	428	437	PF00244	0.505
LIG_14-3-3_CanoR_1	471	479	PF00244	0.487
LIG_14-3-3_CanoR_1	59	67	PF00244	0.344
LIG_Actin_WH2_2	184	199	PF00022	0.642
LIG_APCC_ABBA_1	34	39	PF00400	0.315
LIG_BIR_III_4	180	184	PF00653	0.634
LIG_BRCT_BRCA1_1	475	479	PF00533	0.484
LIG_Clathr_ClatBox_1	244	248	PF01394	0.676
LIG_FHA_1	215	221	PF00498	0.528
LIG_FHA_1	232	238	PF00498	0.713
LIG_FHA_1	274	280	PF00498	0.727
LIG_FHA_1	339	345	PF00498	0.640
LIG_FHA_2	120	126	PF00498	0.753
LIG_FHA_2	141	147	PF00498	0.664
LIG_GBD_Chelix_1	269	277	PF00786	0.574
LIG_LIR_Apic_2	221	227	PF02991	0.514
LIG_LIR_Gen_1	438	445	PF02991	0.628
LIG_LIR_Gen_1	61	70	PF02991	0.306
LIG_LIR_Gen_1	9	18	PF02991	0.208
LIG_LIR_Nem_3	234	238	PF02991	0.573
LIG_LIR_Nem_3	438	442	PF02991	0.628
LIG_LIR_Nem_3	61	67	PF02991	0.306
LIG_LIR_Nem_3	9	14	PF02991	0.208
LIG_LYPXL_SIV_4	349	357	PF13949	0.609
LIG_MYND_1	381	385	PF01753	0.491
LIG_PDZ_Class_2	474	479	PF00595	0.588
LIG_Pex14_1	235	239	PF04695	0.597
LIG_SH2_CRK	215	219	PF00017	0.545
LIG_SH2_CRK	29	33	PF00017	0.315
LIG_SH2_CRK	350	354	PF00017	0.592
LIG_SH2_CRK	355	359	PF00017	0.538
LIG_SH2_CRK	57	61	PF00017	0.315
LIG_SH2_CRK	64	68	PF00017	0.315
LIG_SH2_NCK_1	350	354	PF00017	0.608
LIG_SH2_NCK_1	355	359	PF00017	0.553
LIG_SH2_STAP1	350	354	PF00017	0.617
LIG_SH2_STAT5	187	190	PF00017	0.593
LIG_SH3_3	154	160	PF00018	0.704
LIG_SH3_3	224	230	PF00018	0.593
LIG_SH3_3	261	267	PF00018	0.705
LIG_SH3_3	298	304	PF00018	0.500
LIG_SH3_3	326	332	PF00018	0.699
LIG_SH3_3	382	388	PF00018	0.504
LIG_SH3_3	455	461	PF00018	0.561
LIG_SUMO_SIM_par_1	216	221	PF11976	0.426
LIG_TYR_ITIM	348	353	PF00017	0.610
LIG_WW_3	159	163	PF00397	0.662
MOD_CDK_SPK_2	466	471	PF00069	0.565
MOD_CK1_1	115	121	PF00069	0.655
MOD_CK1_1	169	175	PF00069	0.572
MOD_CK1_1	19	25	PF00069	0.390
MOD_CK1_1	226	232	PF00069	0.583
MOD_CK1_1	3	9	PF00069	0.616
MOD_CK1_1	300	306	PF00069	0.675
MOD_CK1_1	447	453	PF00069	0.612
MOD_CK1_1	473	479	PF00069	0.485
MOD_CK2_1	119	125	PF00069	0.777
MOD_CK2_1	399	405	PF00069	0.492
MOD_CK2_1	6	12	PF00069	0.364
MOD_Cter_Amidation	108	111	PF01082	0.532
MOD_GlcNHglycan	114	117	PF01048	0.527
MOD_GlcNHglycan	138	141	PF01048	0.780
MOD_GlcNHglycan	317	320	PF01048	0.572
MOD_GlcNHglycan	401	404	PF01048	0.492
MOD_GlcNHglycan	446	449	PF01048	0.570
MOD_GlcNHglycan	73	76	PF01048	0.320
MOD_GSK3_1	112	119	PF00069	0.684
MOD_GSK3_1	136	143	PF00069	0.648
MOD_GSK3_1	168	175	PF00069	0.715
MOD_GSK3_1	214	221	PF00069	0.560
MOD_GSK3_1	222	229	PF00069	0.615
MOD_GSK3_1	306	313	PF00069	0.671
MOD_GSK3_1	333	340	PF00069	0.641
MOD_GSK3_1	391	398	PF00069	0.530
MOD_GSK3_1	466	473	PF00069	0.610
MOD_N-GLC_1	273	278	PF02516	0.586
MOD_N-GLC_1	395	400	PF02516	0.601
MOD_NEK2_1	103	108	PF00069	0.541
MOD_NEK2_1	348	353	PF00069	0.678
MOD_NEK2_1	444	449	PF00069	0.637
MOD_PKA_1	30	36	PF00069	0.315
MOD_PKA_1	71	77	PF00069	0.208
MOD_PKA_2	109	115	PF00069	0.605
MOD_PKA_2	256	262	PF00069	0.537
MOD_PKA_2	297	303	PF00069	0.686
MOD_PKA_2	429	435	PF00069	0.552
MOD_PKA_2	470	476	PF00069	0.487
MOD_PKA_2	58	64	PF00069	0.330
MOD_Plk_1	273	279	PF00069	0.586
MOD_Plk_1	395	401	PF00069	0.537
MOD_Plk_1	419	425	PF00069	0.527
MOD_Plk_4	265	271	PF00069	0.544
MOD_Plk_4	273	279	PF00069	0.568
MOD_Plk_4	348	354	PF00069	0.422
MOD_Plk_4	473	479	PF00069	0.597
MOD_ProDKin_1	117	123	PF00069	0.715
MOD_ProDKin_1	223	229	PF00069	0.632
MOD_ProDKin_1	300	306	PF00069	0.643
MOD_ProDKin_1	333	339	PF00069	0.631
MOD_ProDKin_1	381	387	PF00069	0.578
MOD_ProDKin_1	454	460	PF00069	0.536
MOD_ProDKin_1	466	472	PF00069	0.546
TRG_DiLeu_BaEn_1	240	245	PF01217	0.596
TRG_DiLeu_BaEn_1	342	347	PF01217	0.541
TRG_DiLeu_BaLyEn_6	283	288	PF01217	0.621
TRG_ENDOCYTIC_2	11	14	PF00928	0.315
TRG_ENDOCYTIC_2	215	218	PF00928	0.552
TRG_ENDOCYTIC_2	29	32	PF00928	0.315
TRG_ENDOCYTIC_2	350	353	PF00928	0.592
TRG_ENDOCYTIC_2	355	358	PF00928	0.539
TRG_ENDOCYTIC_2	57	60	PF00928	0.315
TRG_ENDOCYTIC_2	64	67	PF00928	0.315
TRG_NLS_MonoExtN_4	70	75	PF00514	0.208

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1ILU4	Leptomonas seymouri	41%	100%
A0A3Q8IEL1	Leishmania donovani	85%	100%
A4HGH4	Leishmania braziliensis	71%	100%
A4I3K6	Leishmania infantum	85%	100%
Q4Q8D9	Leishmania major	80%	100%