FHA domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AZU1_LEIMU

TriTrypDb:

LmxM.28.1220

Length:

470

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AZU1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AZU1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	209	213	PF00656	0.587
CLV_C14_Caspase3-7	321	325	PF00656	0.461
CLV_C14_Caspase3-7	424	428	PF00656	0.650
CLV_C14_Caspase3-7	434	438	PF00656	0.731
CLV_NRD_NRD_1	328	330	PF00675	0.441
CLV_NRD_NRD_1	397	399	PF00675	0.434
CLV_NRD_NRD_1	407	409	PF00675	0.581
CLV_NRD_NRD_1	467	469	PF00675	0.642
CLV_PCSK_KEX2_1	397	399	PF00082	0.434
CLV_PCSK_KEX2_1	406	408	PF00082	0.579
CLV_PCSK_KEX2_1	465	467	PF00082	0.653
CLV_PCSK_PC1ET2_1	465	467	PF00082	0.656
CLV_PCSK_PC7_1	461	467	PF00082	0.543
CLV_PCSK_SKI1_1	116	120	PF00082	0.594
CLV_PCSK_SKI1_1	19	23	PF00082	0.381
CLV_PCSK_SKI1_1	243	247	PF00082	0.586
CLV_PCSK_SKI1_1	407	411	PF00082	0.605
CLV_Separin_Metazoa	273	277	PF03568	0.507
DEG_APCC_DBOX_1	51	59	PF00400	0.380
DEG_COP1_1	187	197	PF00400	0.640
DEG_Nend_Nbox_1	1	3	PF02207	0.469
DEG_SPOP_SBC_1	442	446	PF00917	0.680
DOC_CYCLIN_yCln2_LP_2	134	140	PF00134	0.562
DOC_MAPK_gen_1	16	24	PF00069	0.396
DOC_MAPK_gen_1	326	335	PF00069	0.474
DOC_MAPK_gen_1	406	417	PF00069	0.415
DOC_MAPK_MEF2A_6	16	24	PF00069	0.396
DOC_MAPK_MEF2A_6	243	250	PF00069	0.551
DOC_PP2B_LxvP_1	160	163	PF13499	0.424
DOC_PP2B_LxvP_1	192	195	PF13499	0.613
DOC_PP4_FxxP_1	359	362	PF00568	0.444
DOC_USP7_MATH_1	120	124	PF00917	0.595
DOC_USP7_MATH_1	193	197	PF00917	0.703
DOC_USP7_MATH_1	234	238	PF00917	0.642
DOC_USP7_MATH_1	288	292	PF00917	0.593
DOC_USP7_MATH_1	418	422	PF00917	0.513
DOC_USP7_MATH_1	438	442	PF00917	0.645
DOC_USP7_MATH_1	91	95	PF00917	0.589
DOC_USP7_UBL2_3	235	239	PF12436	0.504
DOC_USP7_UBL2_3	361	365	PF12436	0.443
DOC_USP7_UBL2_3	388	392	PF12436	0.630
DOC_WW_Pin1_4	1	6	PF00397	0.440
DOC_WW_Pin1_4	259	264	PF00397	0.705
DOC_WW_Pin1_4	78	83	PF00397	0.584
LIG_14-3-3_CanoR_1	19	25	PF00244	0.398
LIG_AP_GAE_1	429	435	PF02883	0.495
LIG_BRCT_BRCA1_1	355	359	PF00533	0.507
LIG_BRCT_BRCA1_2	355	361	PF00533	0.516
LIG_CSL_BTD_1	58	61	PF09270	0.398
LIG_CtBP_PxDLS_1	157	161	PF00389	0.480
LIG_FHA_1	127	133	PF00498	0.504
LIG_FHA_1	162	168	PF00498	0.495
LIG_FHA_1	348	354	PF00498	0.416
LIG_FHA_1	366	372	PF00498	0.393
LIG_FHA_1	4	10	PF00498	0.490
LIG_FHA_2	173	179	PF00498	0.668
LIG_FHA_2	185	191	PF00498	0.566
LIG_HCF-1_HBM_1	28	31	PF13415	0.394
LIG_LIR_Apic_2	356	362	PF02991	0.477
LIG_LIR_Apic_2	56	62	PF02991	0.290
LIG_LIR_Nem_3	325	331	PF02991	0.419
LIG_LIR_Nem_3	391	396	PF02991	0.449
LIG_PCNA_yPIPBox_3	326	339	PF02747	0.417
LIG_PTAP_UEV_1	4	9	PF05743	0.383
LIG_PTB_Apo_2	69	76	PF02174	0.416
LIG_SH2_STAT3	65	68	PF00017	0.405
LIG_SH2_STAT5	31	34	PF00017	0.375
LIG_SH3_3	127	133	PF00018	0.484
LIG_SH3_3	151	157	PF00018	0.520
LIG_SH3_3	2	8	PF00018	0.407
LIG_SH3_3	301	307	PF00018	0.541
LIG_SH3_3	55	61	PF00018	0.456
LIG_SH3_4	361	368	PF00018	0.425
LIG_SUMO_SIM_anti_2	53	59	PF11976	0.347
LIG_SUMO_SIM_par_1	126	131	PF11976	0.524
LIG_SUMO_SIM_par_1	190	196	PF11976	0.640
LIG_SUMO_SIM_par_1	20	25	PF11976	0.388
LIG_TRAF2_1	227	230	PF00917	0.546
LIG_WW_3	273	277	PF00397	0.507
MOD_CDK_SPxxK_3	78	85	PF00069	0.560
MOD_CK1_1	218	224	PF00069	0.693
MOD_CK1_1	259	265	PF00069	0.779
MOD_CK1_1	347	353	PF00069	0.380
MOD_CK1_1	421	427	PF00069	0.617
MOD_CK1_1	428	434	PF00069	0.660
MOD_CK1_1	441	447	PF00069	0.661
MOD_CK1_1	448	454	PF00069	0.511
MOD_CK1_1	94	100	PF00069	0.609
MOD_CK2_1	184	190	PF00069	0.613
MOD_CK2_1	208	214	PF00069	0.630
MOD_CK2_1	224	230	PF00069	0.638
MOD_CK2_1	416	422	PF00069	0.571
MOD_CK2_1	423	429	PF00069	0.609
MOD_CK2_1	433	439	PF00069	0.639
MOD_GlcNHglycan	109	112	PF01048	0.578
MOD_GlcNHglycan	122	125	PF01048	0.516
MOD_GlcNHglycan	195	198	PF01048	0.644
MOD_GlcNHglycan	226	229	PF01048	0.549
MOD_GlcNHglycan	236	239	PF01048	0.796
MOD_GlcNHglycan	257	261	PF01048	0.572
MOD_GlcNHglycan	283	286	PF01048	0.593
MOD_GlcNHglycan	290	293	PF01048	0.640
MOD_GlcNHglycan	355	358	PF01048	0.548
MOD_GlcNHglycan	40	43	PF01048	0.443
MOD_GlcNHglycan	439	443	PF01048	0.675
MOD_GlcNHglycan	95	99	PF01048	0.575
MOD_GSK3_1	116	123	PF00069	0.586
MOD_GSK3_1	177	184	PF00069	0.628
MOD_GSK3_1	218	225	PF00069	0.649
MOD_GSK3_1	255	262	PF00069	0.607
MOD_GSK3_1	320	327	PF00069	0.525
MOD_GSK3_1	343	350	PF00069	0.389
MOD_GSK3_1	417	424	PF00069	0.633
MOD_GSK3_1	438	445	PF00069	0.632
MOD_GSK3_1	446	453	PF00069	0.737
MOD_NEK2_1	109	114	PF00069	0.587
MOD_NEK2_1	138	143	PF00069	0.611
MOD_NEK2_1	76	81	PF00069	0.564
MOD_NEK2_2	150	155	PF00069	0.468
MOD_NEK2_2	163	168	PF00069	0.424
MOD_PIKK_1	138	144	PF00454	0.613
MOD_PKA_2	107	113	PF00069	0.559
MOD_PKA_2	218	224	PF00069	0.655
MOD_PKA_2	396	402	PF00069	0.450
MOD_Plk_1	343	349	PF00069	0.461
MOD_Plk_1	428	434	PF00069	0.565
MOD_Plk_2-3	126	132	PF00069	0.653
MOD_Plk_2-3	208	214	PF00069	0.630
MOD_Plk_2-3	423	429	PF00069	0.604
MOD_Plk_2-3	430	436	PF00069	0.625
MOD_Plk_4	53	59	PF00069	0.430
MOD_Plk_4	71	77	PF00069	0.417
MOD_ProDKin_1	1	7	PF00069	0.430
MOD_ProDKin_1	259	265	PF00069	0.706
MOD_ProDKin_1	78	84	PF00069	0.581
TRG_ER_diArg_1	396	398	PF00400	0.418
TRG_ER_diArg_1	406	408	PF00400	0.577
TRG_ER_diArg_1	466	468	PF00400	0.775
TRG_ER_diArg_1	84	87	PF00400	0.427
TRG_NLS_MonoCore_2	463	468	PF00514	0.628
TRG_NLS_MonoExtC_3	463	468	PF00514	0.665
TRG_NLS_MonoExtN_4	461	468	PF00514	0.564
TRG_Pf-PMV_PEXEL_1	243	247	PF00026	0.562

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P7J3	Leptomonas seymouri	54%	98%
A0A3Q8IQI6	Leishmania donovani	85%	100%
A4HGG9	Leishmania braziliensis	71%	99%
A4I3K1	Leishmania infantum	85%	100%
Q4Q8E4	Leishmania major	85%	99%