Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AZU0_LEIMU

TriTrypDb:

LmxM.28.1210

Length:

784

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AZU0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AZU0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	19	23	PF00656	0.709
CLV_C14_Caspase3-7	480	484	PF00656	0.728
CLV_C14_Caspase3-7	492	496	PF00656	0.735
CLV_NRD_NRD_1	162	164	PF00675	0.545
CLV_NRD_NRD_1	220	222	PF00675	0.741
CLV_NRD_NRD_1	259	261	PF00675	0.711
CLV_NRD_NRD_1	293	295	PF00675	0.498
CLV_NRD_NRD_1	386	388	PF00675	0.789
CLV_NRD_NRD_1	435	437	PF00675	0.510
CLV_NRD_NRD_1	464	466	PF00675	0.689
CLV_NRD_NRD_1	569	571	PF00675	0.751
CLV_NRD_NRD_1	595	597	PF00675	0.566
CLV_NRD_NRD_1	72	74	PF00675	0.664
CLV_PCSK_FUR_1	291	295	PF00082	0.616
CLV_PCSK_FUR_1	593	597	PF00082	0.592
CLV_PCSK_KEX2_1	143	145	PF00082	0.523
CLV_PCSK_KEX2_1	162	164	PF00082	0.550
CLV_PCSK_KEX2_1	220	222	PF00082	0.741
CLV_PCSK_KEX2_1	259	261	PF00082	0.690
CLV_PCSK_KEX2_1	293	295	PF00082	0.498
CLV_PCSK_KEX2_1	385	387	PF00082	0.736
CLV_PCSK_KEX2_1	464	466	PF00082	0.689
CLV_PCSK_KEX2_1	569	571	PF00082	0.853
CLV_PCSK_KEX2_1	595	597	PF00082	0.534
CLV_PCSK_KEX2_1	72	74	PF00082	0.664
CLV_PCSK_PC1ET2_1	143	145	PF00082	0.523
CLV_PCSK_PC1ET2_1	385	387	PF00082	0.736
CLV_PCSK_PC1ET2_1	569	571	PF00082	0.831
CLV_PCSK_SKI1_1	174	178	PF00082	0.772
CLV_PCSK_SKI1_1	230	234	PF00082	0.659
CLV_PCSK_SKI1_1	286	290	PF00082	0.511
CLV_PCSK_SKI1_1	322	326	PF00082	0.682
CLV_PCSK_SKI1_1	372	376	PF00082	0.579
CLV_PCSK_SKI1_1	639	643	PF00082	0.525
DEG_Nend_UBRbox_3	1	3	PF02207	0.697
DEG_SPOP_SBC_1	231	235	PF00917	0.828
DEG_SPOP_SBC_1	238	242	PF00917	0.703
DEG_SPOP_SBC_1	37	41	PF00917	0.801
DEG_SPOP_SBC_1	583	587	PF00917	0.747
DEG_SPOP_SBC_1	698	702	PF00917	0.491
DEG_SPOP_SBC_1	81	85	PF00917	0.694
DOC_ANK_TNKS_1	629	636	PF00023	0.710
DOC_CYCLIN_RxL_1	316	327	PF00134	0.448
DOC_CYCLIN_yCln2_LP_2	689	695	PF00134	0.714
DOC_MAPK_gen_1	593	602	PF00069	0.559
DOC_MAPK_gen_1	72	78	PF00069	0.671
DOC_MAPK_RevD_3	60	73	PF00069	0.707
DOC_PP2B_LxvP_1	689	692	PF13499	0.754
DOC_PP2B_LxvP_1	695	698	PF13499	0.679
DOC_USP7_MATH_1	117	121	PF00917	0.786
DOC_USP7_MATH_1	123	127	PF00917	0.731
DOC_USP7_MATH_1	186	190	PF00917	0.695
DOC_USP7_MATH_1	215	219	PF00917	0.815
DOC_USP7_MATH_1	232	236	PF00917	0.685
DOC_USP7_MATH_1	238	242	PF00917	0.744
DOC_USP7_MATH_1	275	279	PF00917	0.441
DOC_USP7_MATH_1	331	335	PF00917	0.577
DOC_USP7_MATH_1	346	350	PF00917	0.763
DOC_USP7_MATH_1	35	39	PF00917	0.801
DOC_USP7_MATH_1	431	435	PF00917	0.726
DOC_USP7_MATH_1	534	538	PF00917	0.690
DOC_USP7_MATH_1	561	565	PF00917	0.657
DOC_USP7_MATH_1	698	702	PF00917	0.750
DOC_USP7_MATH_1	723	727	PF00917	0.700
DOC_USP7_MATH_1	729	733	PF00917	0.717
DOC_USP7_MATH_1	81	85	PF00917	0.715
DOC_USP7_MATH_1	9	13	PF00917	0.556
DOC_USP7_MATH_1	94	98	PF00917	0.619
DOC_WW_Pin1_4	209	214	PF00397	0.689
DOC_WW_Pin1_4	224	229	PF00397	0.647
DOC_WW_Pin1_4	33	38	PF00397	0.711
DOC_WW_Pin1_4	389	394	PF00397	0.760
DOC_WW_Pin1_4	44	49	PF00397	0.834
DOC_WW_Pin1_4	504	509	PF00397	0.739
DOC_WW_Pin1_4	552	557	PF00397	0.752
DOC_WW_Pin1_4	564	569	PF00397	0.798
DOC_WW_Pin1_4	588	593	PF00397	0.468
DOC_WW_Pin1_4	84	89	PF00397	0.716
LIG_14-3-3_CanoR_1	101	107	PF00244	0.565
LIG_14-3-3_CanoR_1	144	150	PF00244	0.714
LIG_14-3-3_CanoR_1	174	179	PF00244	0.685
LIG_14-3-3_CanoR_1	248	256	PF00244	0.609
LIG_14-3-3_CanoR_1	269	276	PF00244	0.685
LIG_14-3-3_CanoR_1	358	362	PF00244	0.574
LIG_14-3-3_CanoR_1	370	379	PF00244	0.711
LIG_14-3-3_CanoR_1	386	395	PF00244	0.814
LIG_14-3-3_CanoR_1	520	526	PF00244	0.830
LIG_14-3-3_CanoR_1	639	644	PF00244	0.520
LIG_14-3-3_CanoR_1	746	755	PF00244	0.535
LIG_BRCT_BRCA1_1	498	502	PF00533	0.578
LIG_CtBP_PxDLS_1	560	564	PF00389	0.537
LIG_deltaCOP1_diTrp_1	545	552	PF00928	0.626
LIG_FHA_1	140	146	PF00498	0.714
LIG_FHA_1	25	31	PF00498	0.507
LIG_FHA_1	251	257	PF00498	0.518
LIG_FHA_1	37	43	PF00498	0.505
LIG_FHA_1	373	379	PF00498	0.507
LIG_FHA_1	400	406	PF00498	0.688
LIG_FHA_1	473	479	PF00498	0.800
LIG_FHA_1	762	768	PF00498	0.667
LIG_FHA_2	414	420	PF00498	0.585
LIG_FHA_2	485	491	PF00498	0.753
LIG_FHA_2	771	777	PF00498	0.693
LIG_LIR_Apic_2	606	611	PF02991	0.541
LIG_LIR_Nem_3	205	211	PF02991	0.498
LIG_LIR_Nem_3	284	288	PF02991	0.510
LIG_LIR_Nem_3	413	417	PF02991	0.552
LIG_LIR_Nem_3	750	755	PF02991	0.472
LIG_SH2_CRK	208	212	PF00017	0.581
LIG_SH2_CRK	597	601	PF00017	0.568
LIG_SH2_STAT3	615	618	PF00017	0.647
LIG_SH2_STAT5	538	541	PF00017	0.696
LIG_SH3_2	459	464	PF14604	0.618
LIG_SH3_3	128	134	PF00018	0.584
LIG_SH3_3	31	37	PF00018	0.774
LIG_SH3_3	347	353	PF00018	0.555
LIG_SH3_3	375	381	PF00018	0.681
LIG_SH3_3	453	459	PF00018	0.716
LIG_SH3_3	553	559	PF00018	0.726
LIG_SH3_3	681	687	PF00018	0.587
LIG_SH3_3	716	722	PF00018	0.649
LIG_SH3_3	75	81	PF00018	0.601
LIG_SUMO_SIM_anti_2	402	408	PF11976	0.515
LIG_SUMO_SIM_par_1	402	408	PF11976	0.446
LIG_SUMO_SIM_par_1	475	484	PF11976	0.665
LIG_TRAF2_1	773	776	PF00917	0.653
LIG_TYR_ITIM	206	211	PF00017	0.575
MOD_CDC14_SPxK_1	227	230	PF00782	0.661
MOD_CDC14_SPxK_1	555	558	PF00782	0.779
MOD_CDC14_SPxK_1	567	570	PF00782	0.681
MOD_CDK_SPK_2	564	569	PF00069	0.843
MOD_CDK_SPK_2	588	593	PF00069	0.417
MOD_CDK_SPxK_1	224	230	PF00069	0.666
MOD_CDK_SPxK_1	552	558	PF00069	0.785
MOD_CDK_SPxK_1	564	570	PF00069	0.681
MOD_CDK_SPxxK_3	564	571	PF00069	0.810
MOD_CDK_SPxxK_3	588	595	PF00069	0.406
MOD_CK1_1	109	115	PF00069	0.723
MOD_CK1_1	136	142	PF00069	0.821
MOD_CK1_1	168	174	PF00069	0.601
MOD_CK1_1	237	243	PF00069	0.769
MOD_CK1_1	249	255	PF00069	0.588
MOD_CK1_1	26	32	PF00069	0.692
MOD_CK1_1	265	271	PF00069	0.602
MOD_CK1_1	334	340	PF00069	0.685
MOD_CK1_1	36	42	PF00069	0.770
MOD_CK1_1	484	490	PF00069	0.688
MOD_CK1_1	496	502	PF00069	0.760
MOD_CK1_1	504	510	PF00069	0.698
MOD_CK1_1	537	543	PF00069	0.692
MOD_CK1_1	544	550	PF00069	0.708
MOD_CK1_1	551	557	PF00069	0.734
MOD_CK1_1	562	568	PF00069	0.746
MOD_CK1_1	702	708	PF00069	0.665
MOD_CK1_1	84	90	PF00069	0.663
MOD_CK2_1	370	376	PF00069	0.801
MOD_CK2_1	413	419	PF00069	0.578
MOD_CK2_1	504	510	PF00069	0.537
MOD_CK2_1	770	776	PF00069	0.646
MOD_Cter_Amidation	291	294	PF01082	0.531
MOD_Cter_Amidation	70	73	PF01082	0.656
MOD_GlcNHglycan	108	111	PF01048	0.555
MOD_GlcNHglycan	114	117	PF01048	0.458
MOD_GlcNHglycan	170	173	PF01048	0.661
MOD_GlcNHglycan	234	237	PF01048	0.758
MOD_GlcNHglycan	248	251	PF01048	0.727
MOD_GlcNHglycan	264	267	PF01048	0.587
MOD_GlcNHglycan	306	309	PF01048	0.626
MOD_GlcNHglycan	367	370	PF01048	0.787
MOD_GlcNHglycan	372	375	PF01048	0.724
MOD_GlcNHglycan	468	471	PF01048	0.702
MOD_GlcNHglycan	53	56	PF01048	0.817
MOD_GlcNHglycan	57	60	PF01048	0.661
MOD_GlcNHglycan	653	656	PF01048	0.755
MOD_GlcNHglycan	689	692	PF01048	0.674
MOD_GlcNHglycan	69	72	PF01048	0.517
MOD_GlcNHglycan	704	707	PF01048	0.588
MOD_GlcNHglycan	713	716	PF01048	0.587
MOD_GlcNHglycan	726	729	PF01048	0.639
MOD_GlcNHglycan	749	752	PF01048	0.648
MOD_GlcNHglycan	84	87	PF01048	0.665
MOD_GlcNHglycan	94	97	PF01048	0.778
MOD_GSK3_1	102	109	PF00069	0.692
MOD_GSK3_1	112	119	PF00069	0.707
MOD_GSK3_1	133	140	PF00069	0.773
MOD_GSK3_1	186	193	PF00069	0.689
MOD_GSK3_1	215	222	PF00069	0.759
MOD_GSK3_1	22	29	PF00069	0.641
MOD_GSK3_1	226	233	PF00069	0.650
MOD_GSK3_1	234	241	PF00069	0.660
MOD_GSK3_1	246	253	PF00069	0.496
MOD_GSK3_1	261	268	PF00069	0.557
MOD_GSK3_1	299	306	PF00069	0.475
MOD_GSK3_1	33	40	PF00069	0.760
MOD_GSK3_1	381	388	PF00069	0.808
MOD_GSK3_1	468	475	PF00069	0.720
MOD_GSK3_1	479	486	PF00069	0.805
MOD_GSK3_1	491	498	PF00069	0.642
MOD_GSK3_1	500	507	PF00069	0.505
MOD_GSK3_1	51	58	PF00069	0.682
MOD_GSK3_1	533	540	PF00069	0.691
MOD_GSK3_1	541	548	PF00069	0.696
MOD_GSK3_1	584	591	PF00069	0.632
MOD_GSK3_1	635	642	PF00069	0.768
MOD_GSK3_1	698	705	PF00069	0.782
MOD_GSK3_1	729	736	PF00069	0.583
MOD_GSK3_1	80	87	PF00069	0.667
MOD_GSK3_1	9	16	PF00069	0.722
MOD_N-GLC_1	145	150	PF02516	0.643
MOD_N-GLC_1	484	489	PF02516	0.699
MOD_N-GLC_1	648	653	PF02516	0.735
MOD_N-GLC_2	735	737	PF02516	0.480
MOD_NEK2_1	121	126	PF00069	0.682
MOD_NEK2_1	137	142	PF00069	0.703
MOD_NEK2_1	324	329	PF00069	0.493
MOD_NEK2_1	405	410	PF00069	0.591
MOD_NEK2_1	468	473	PF00069	0.691
MOD_NEK2_1	502	507	PF00069	0.759
MOD_NEK2_1	699	704	PF00069	0.615
MOD_NEK2_1	733	738	PF00069	0.739
MOD_NEK2_1	82	87	PF00069	0.700
MOD_NEK2_2	186	191	PF00069	0.523
MOD_NEK2_2	452	457	PF00069	0.662
MOD_PIKK_1	215	221	PF00454	0.747
MOD_PIKK_1	324	330	PF00454	0.495
MOD_PIKK_1	405	411	PF00454	0.613
MOD_PIKK_1	444	450	PF00454	0.715
MOD_PIKK_1	614	620	PF00454	0.555
MOD_PKA_1	385	391	PF00069	0.740
MOD_PKA_2	156	162	PF00069	0.582
MOD_PKA_2	219	225	PF00069	0.696
MOD_PKA_2	261	267	PF00069	0.759
MOD_PKA_2	268	274	PF00069	0.653
MOD_PKA_2	334	340	PF00069	0.693
MOD_PKA_2	357	363	PF00069	0.605
MOD_PKA_2	385	391	PF00069	0.814
MOD_PKA_2	576	582	PF00069	0.718
MOD_PKA_2	623	629	PF00069	0.628
MOD_PKA_2	678	684	PF00069	0.513
MOD_PKA_2	711	717	PF00069	0.487
MOD_PKB_1	260	268	PF00069	0.795
MOD_PKB_1	370	378	PF00069	0.582
MOD_Plk_1	145	151	PF00069	0.493
MOD_Plk_1	346	352	PF00069	0.802
MOD_Plk_2-3	413	419	PF00069	0.578
MOD_Plk_4	29	35	PF00069	0.725
MOD_Plk_4	534	540	PF00069	0.654
MOD_Plk_4	706	712	PF00069	0.786
MOD_Plk_4	729	735	PF00069	0.624
MOD_ProDKin_1	209	215	PF00069	0.691
MOD_ProDKin_1	224	230	PF00069	0.648
MOD_ProDKin_1	33	39	PF00069	0.715
MOD_ProDKin_1	389	395	PF00069	0.760
MOD_ProDKin_1	44	50	PF00069	0.835
MOD_ProDKin_1	504	510	PF00069	0.741
MOD_ProDKin_1	552	558	PF00069	0.751
MOD_ProDKin_1	564	570	PF00069	0.800
MOD_ProDKin_1	588	594	PF00069	0.462
MOD_ProDKin_1	84	90	PF00069	0.717
TRG_DiLeu_BaEn_1	413	418	PF01217	0.548
TRG_ENDOCYTIC_2	208	211	PF00928	0.580
TRG_ENDOCYTIC_2	285	288	PF00928	0.528
TRG_ENDOCYTIC_2	597	600	PF00928	0.574
TRG_ER_diArg_1	161	163	PF00400	0.586
TRG_ER_diArg_1	220	223	PF00400	0.741
TRG_ER_diArg_1	259	262	PF00400	0.694
TRG_ER_diArg_1	291	294	PF00400	0.633
TRG_ER_diArg_1	319	322	PF00400	0.366
TRG_ER_diArg_1	592	595	PF00400	0.522
TRG_ER_diArg_1	72	74	PF00400	0.664
TRG_NLS_MonoCore_2	568	573	PF00514	0.630
TRG_NLS_MonoExtC_3	569	574	PF00514	0.744
TRG_NLS_MonoExtN_4	568	575	PF00514	0.747
TRG_Pf-PMV_PEXEL_1	415	419	PF00026	0.569

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I844	Leptomonas seymouri	35%	100%
A0A3S7X1G0	Leishmania donovani	82%	100%
A4HGG8	Leishmania braziliensis	60%	98%
A4I3K0	Leishmania infantum	82%	100%
Q4Q8E5	Leishmania major	83%	100%