Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AZT7_LEIMU

TriTrypDb:

LmxM.28.1180

Length:

226

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AZT7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AZT7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	116	120	PF00656	0.618
CLV_NRD_NRD_1	142	144	PF00675	0.660
CLV_PCSK_KEX2_1	142	144	PF00082	0.660
CLV_PCSK_SKI1_1	216	220	PF00082	0.622
CLV_PCSK_SKI1_1	40	44	PF00082	0.474
CLV_PCSK_SKI1_1	67	71	PF00082	0.639
DOC_CYCLIN_RxL_1	37	47	PF00134	0.470
DOC_CYCLIN_RxL_1	64	73	PF00134	0.639
DOC_PP1_RVXF_1	214	221	PF00149	0.623
DOC_USP7_MATH_1	175	179	PF00917	0.584
DOC_USP7_MATH_1	186	190	PF00917	0.481
DOC_WW_Pin1_4	59	64	PF00397	0.648
LIG_14-3-3_CanoR_1	40	46	PF00244	0.562
LIG_BIR_II_1	1	5	PF00653	0.638
LIG_BIR_III_2	204	208	PF00653	0.635
LIG_BRCT_BRCA1_1	60	64	PF00533	0.471
LIG_BRCT_MDC1_1	222	226	PF00533	0.563
LIG_FHA_1	149	155	PF00498	0.606
LIG_FHA_1	52	58	PF00498	0.697
LIG_FHA_1	75	81	PF00498	0.636
LIG_FHA_2	114	120	PF00498	0.642
LIG_FHA_2	126	132	PF00498	0.546
LIG_FHA_2	150	156	PF00498	0.725
LIG_FHA_2	210	216	PF00498	0.661
LIG_LIR_Apic_2	168	173	PF02991	0.559
LIG_LIR_Nem_3	161	166	PF02991	0.652
LIG_LIR_Nem_3	17	22	PF02991	0.554
LIG_LIR_Nem_3	2	8	PF02991	0.710
LIG_REV1ctd_RIR_1	34	44	PF16727	0.637
LIG_SH2_CRK	163	167	PF00017	0.658
LIG_SH2_GRB2like	9	12	PF00017	0.597
LIG_SH2_STAP1	201	205	PF00017	0.657
LIG_SH2_STAT5	201	204	PF00017	0.572
LIG_SH3_3	134	140	PF00018	0.707
LIG_SH3_3	163	169	PF00018	0.651
LIG_SH3_3	43	49	PF00018	0.650
LIG_WRC_WIRS_1	5	10	PF05994	0.486
MOD_CK1_1	106	112	PF00069	0.724
MOD_CK1_1	47	53	PF00069	0.686
MOD_CK1_1	96	102	PF00069	0.680
MOD_CK2_1	125	131	PF00069	0.636
MOD_CK2_1	135	141	PF00069	0.552
MOD_CK2_1	149	155	PF00069	0.627
MOD_CK2_1	4	10	PF00069	0.617
MOD_GlcNHglycan	105	108	PF01048	0.616
MOD_GlcNHglycan	12	16	PF01048	0.684
MOD_GlcNHglycan	95	98	PF01048	0.641
MOD_GSK3_1	101	108	PF00069	0.633
MOD_GSK3_1	11	18	PF00069	0.566
MOD_GSK3_1	131	138	PF00069	0.648
MOD_GSK3_1	154	161	PF00069	0.667
MOD_GSK3_1	216	223	PF00069	0.651
MOD_GSK3_1	32	39	PF00069	0.555
MOD_GSK3_1	47	54	PF00069	0.539
MOD_GSK3_1	70	77	PF00069	0.602
MOD_NEK2_1	102	107	PF00069	0.818
MOD_NEK2_1	135	140	PF00069	0.651
MOD_NEK2_1	154	159	PF00069	0.629
MOD_NEK2_1	36	41	PF00069	0.672
MOD_NEK2_1	58	63	PF00069	0.636
MOD_NEK2_1	70	75	PF00069	0.500
MOD_NEK2_2	187	192	PF00069	0.607
MOD_NEK2_2	32	37	PF00069	0.622
MOD_NEK2_2	65	70	PF00069	0.642
MOD_PIKK_1	41	47	PF00454	0.596
MOD_PIKK_1	91	97	PF00454	0.664
MOD_PKA_2	15	21	PF00069	0.589
MOD_Plk_1	125	131	PF00069	0.636
MOD_Plk_1	176	182	PF00069	0.576
MOD_Plk_1	209	215	PF00069	0.661
MOD_Plk_2-3	131	137	PF00069	0.622
MOD_Plk_4	15	21	PF00069	0.519
MOD_Plk_4	176	182	PF00069	0.561
MOD_Plk_4	32	38	PF00069	0.435
MOD_Plk_4	4	10	PF00069	0.574
MOD_Plk_4	52	58	PF00069	0.469
MOD_Plk_4	75	81	PF00069	0.636
MOD_ProDKin_1	59	65	PF00069	0.647
TRG_ENDOCYTIC_2	163	166	PF00928	0.659
TRG_ENDOCYTIC_2	5	8	PF00928	0.557
TRG_ER_diArg_1	142	145	PF00400	0.671
TRG_ER_diArg_1	222	225	PF00400	0.610
TRG_Pf-PMV_PEXEL_1	142	146	PF00026	0.778
TRG_Pf-PMV_PEXEL_1	40	45	PF00026	0.472

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A1X0NYM4	Trypanosomatidae	44%	94%
A0A3Q8IDW1	Leishmania donovani	94%	100%
A0A422N2Z7	Trypanosoma rangeli	38%	89%
A4HGG5	Leishmania braziliensis	84%	100%
A4I3J7	Leishmania infantum	94%	100%
D0A7U6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	37%	91%
Q4Q8E8	Leishmania major	92%	100%