Leucine rich repeat-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein

Species:

Leishmania mexicana

UniProt:

E9AZT5_LEIMU

TriTrypDb:

LmxM.28.1165

Length:

645

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 4
NetGPI	no	yes: 0, no: 4

Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	5
GO:0042995	cell projection	2	5
GO:0043226	organelle	2	5
GO:0043227	membrane-bounded organelle	3	5
GO:0110165	cellular anatomical entity	1	5
GO:0120025	plasma membrane bounded cell projection	3	5

Expansion

Sequence features

E9AZT5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AZT5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	33	37	PF00656	0.648
CLV_C14_Caspase3-7	448	452	PF00656	0.522
CLV_NRD_NRD_1	21	23	PF00675	0.718
CLV_NRD_NRD_1	349	351	PF00675	0.541
CLV_NRD_NRD_1	501	503	PF00675	0.545
CLV_NRD_NRD_1	551	553	PF00675	0.558
CLV_PCSK_KEX2_1	21	23	PF00082	0.718
CLV_PCSK_KEX2_1	349	351	PF00082	0.541
CLV_PCSK_KEX2_1	501	503	PF00082	0.545
CLV_PCSK_KEX2_1	551	553	PF00082	0.558
CLV_PCSK_SKI1_1	188	192	PF00082	0.727
CLV_PCSK_SKI1_1	369	373	PF00082	0.610
CLV_PCSK_SKI1_1	497	501	PF00082	0.575
CLV_PCSK_SKI1_1	71	75	PF00082	0.700
CLV_PCSK_SKI1_1	99	103	PF00082	0.652
DEG_APCC_DBOX_1	21	29	PF00400	0.527
DEG_APCC_DBOX_1	98	106	PF00400	0.613
DOC_AGCK_PIF_1	217	222	PF00069	0.530
DOC_CDC14_PxL_1	220	228	PF14671	0.594
DOC_CYCLIN_RxL_1	185	193	PF00134	0.644
DOC_CYCLIN_yCln2_LP_2	308	314	PF00134	0.606
DOC_CYCLIN_yCln2_LP_2	74	77	PF00134	0.691
DOC_MAPK_DCC_7	71	80	PF00069	0.693
DOC_MAPK_gen_1	21	28	PF00069	0.704
DOC_MAPK_MEF2A_6	21	28	PF00069	0.529
DOC_MAPK_MEF2A_6	71	80	PF00069	0.693
DOC_PP1_RVXF_1	466	472	PF00149	0.782
DOC_PP2B_LxvP_1	308	311	PF13499	0.609
DOC_PP2B_LxvP_1	74	77	PF13499	0.691
DOC_USP7_MATH_1	121	125	PF00917	0.789
DOC_USP7_MATH_1	258	262	PF00917	0.717
DOC_USP7_MATH_1	384	388	PF00917	0.435
DOC_USP7_MATH_1	447	451	PF00917	0.744
DOC_USP7_MATH_1	493	497	PF00917	0.704
DOC_USP7_MATH_1	557	561	PF00917	0.631
DOC_USP7_MATH_1	586	590	PF00917	0.630
DOC_WW_Pin1_4	16	21	PF00397	0.715
DOC_WW_Pin1_4	215	220	PF00397	0.540
DOC_WW_Pin1_4	584	589	PF00397	0.708
DOC_WW_Pin1_4	611	616	PF00397	0.690
DOC_WW_Pin1_4	631	636	PF00397	0.780
DOC_WW_Pin1_4	65	70	PF00397	0.778
LIG_14-3-3_CanoR_1	116	120	PF00244	0.464
LIG_14-3-3_CanoR_1	252	256	PF00244	0.730
LIG_14-3-3_CanoR_1	259	265	PF00244	0.692
LIG_14-3-3_CanoR_1	328	336	PF00244	0.556
LIG_14-3-3_CanoR_1	349	354	PF00244	0.724
LIG_14-3-3_CanoR_1	377	385	PF00244	0.594
LIG_14-3-3_CanoR_1	38	47	PF00244	0.718
LIG_14-3-3_CanoR_1	468	472	PF00244	0.734
LIG_14-3-3_CanoR_1	520	527	PF00244	0.633
LIG_14-3-3_CanoR_1	541	549	PF00244	0.568
LIG_14-3-3_CanoR_1	551	556	PF00244	0.520
LIG_14-3-3_CanoR_1	621	629	PF00244	0.689
LIG_14-3-3_CanoR_1	99	108	PF00244	0.611
LIG_Actin_WH2_2	125	140	PF00022	0.741
LIG_Actin_WH2_2	238	254	PF00022	0.692
LIG_Actin_WH2_2	303	320	PF00022	0.616
LIG_Actin_WH2_2	454	470	PF00022	0.517
LIG_BIR_II_1	1	5	PF00653	0.542
LIG_Clathr_ClatBox_1	105	109	PF01394	0.706
LIG_CSL_BTD_1	118	121	PF09270	0.695
LIG_eIF4E_1	41	47	PF01652	0.627
LIG_FHA_1	109	115	PF00498	0.718
LIG_FHA_1	141	147	PF00498	0.731
LIG_FHA_1	303	309	PF00498	0.436
LIG_FHA_1	350	356	PF00498	0.627
LIG_FHA_1	370	376	PF00498	0.695
LIG_FHA_1	511	517	PF00498	0.695
LIG_FHA_1	593	599	PF00498	0.679
LIG_FHA_2	187	193	PF00498	0.561
LIG_FHA_2	285	291	PF00498	0.594
LIG_FHA_2	401	407	PF00498	0.827
LIG_FHA_2	429	435	PF00498	0.596
LIG_FHA_2	458	464	PF00498	0.513
LIG_FHA_2	534	540	PF00498	0.734
LIG_FHA_2	551	557	PF00498	0.526
LIG_FHA_2	81	87	PF00498	0.734
LIG_LIR_Apic_2	254	258	PF02991	0.494
LIG_LIR_Gen_1	218	228	PF02991	0.511
LIG_LIR_Gen_1	470	478	PF02991	0.654
LIG_LIR_Nem_3	117	122	PF02991	0.706
LIG_LIR_Nem_3	215	220	PF02991	0.540
LIG_LIR_Nem_3	426	430	PF02991	0.678
LIG_LIR_Nem_3	470	474	PF02991	0.656
LIG_LIR_Nem_3	543	549	PF02991	0.597
LIG_NRBOX	101	107	PF00104	0.693
LIG_Pex14_2	45	49	PF04695	0.660
LIG_Pex14_2	454	458	PF04695	0.515
LIG_Rb_LxCxE_1	103	118	PF01857	0.631
LIG_RPA_C_Fungi	190	202	PF08784	0.567
LIG_SH2_CRK	255	259	PF00017	0.514
LIG_SH2_NCK_1	478	482	PF00017	0.691
LIG_SH2_SRC	222	225	PF00017	0.768
LIG_SH2_SRC	255	258	PF00017	0.767
LIG_SH2_SRC	324	327	PF00017	0.693
LIG_SH2_SRC	563	566	PF00017	0.544
LIG_SH2_STAP1	237	241	PF00017	0.628
LIG_SH2_STAP1	567	571	PF00017	0.540
LIG_SH2_STAT5	222	225	PF00017	0.759
LIG_SH2_STAT5	391	394	PF00017	0.743
LIG_SH2_STAT5	41	44	PF00017	0.629
LIG_SH3_2	515	520	PF14604	0.535
LIG_SH3_3	337	343	PF00018	0.803
LIG_SH3_3	512	518	PF00018	0.552
LIG_SH3_3	532	538	PF00018	0.505
LIG_SH3_3	70	76	PF00018	0.699
LIG_SUMO_SIM_anti_2	23	29	PF11976	0.522
LIG_SUMO_SIM_anti_2	361	367	PF11976	0.448
LIG_SUMO_SIM_par_1	227	233	PF11976	0.733
LIG_TRAF2_1	13	16	PF00917	0.722
LIG_TRAF2_1	407	410	PF00917	0.639
LIG_UBA3_1	365	373	PF00899	0.704
LIG_WW_3	256	260	PF00397	0.519
MOD_CDC14_SPxK_1	19	22	PF00782	0.708
MOD_CDC14_SPxK_1	68	71	PF00782	0.790
MOD_CDK_SPK_2	16	21	PF00069	0.548
MOD_CDK_SPxK_1	16	22	PF00069	0.714
MOD_CDK_SPxK_1	65	71	PF00069	0.780
MOD_CK1_1	115	121	PF00069	0.532
MOD_CK1_1	232	238	PF00069	0.722
MOD_CK1_1	263	269	PF00069	0.760
MOD_CK1_1	330	336	PF00069	0.560
MOD_CK1_1	423	429	PF00069	0.716
MOD_CK1_1	550	556	PF00069	0.810
MOD_CK1_1	587	593	PF00069	0.774
MOD_CK1_1	65	71	PF00069	0.535
MOD_CK2_1	1	7	PF00069	0.702
MOD_CK2_1	127	133	PF00069	0.484
MOD_CK2_1	173	179	PF00069	0.705
MOD_CK2_1	284	290	PF00069	0.604
MOD_CK2_1	400	406	PF00069	0.823
MOD_CK2_1	428	434	PF00069	0.766
MOD_CK2_1	533	539	PF00069	0.749
MOD_CK2_1	550	556	PF00069	0.616
MOD_CK2_1	639	645	PF00069	0.743
MOD_GlcNHglycan	102	105	PF01048	0.608
MOD_GlcNHglycan	123	126	PF01048	0.698
MOD_GlcNHglycan	129	132	PF01048	0.502
MOD_GlcNHglycan	237	240	PF01048	0.715
MOD_GlcNHglycan	262	265	PF01048	0.738
MOD_GlcNHglycan	284	287	PF01048	0.658
MOD_GlcNHglycan	3	6	PF01048	0.629
MOD_GlcNHglycan	379	382	PF01048	0.484
MOD_GlcNHglycan	447	450	PF01048	0.583
MOD_GlcNHglycan	521	524	PF01048	0.740
MOD_GlcNHglycan	624	627	PF01048	0.766
MOD_GlcNHglycan	641	644	PF01048	0.561
MOD_GSK3_1	108	115	PF00069	0.718
MOD_GSK3_1	16	23	PF00069	0.678
MOD_GSK3_1	163	170	PF00069	0.535
MOD_GSK3_1	218	225	PF00069	0.736
MOD_GSK3_1	330	337	PF00069	0.629
MOD_GSK3_1	341	348	PF00069	0.749
MOD_GSK3_1	400	407	PF00069	0.741
MOD_GSK3_1	533	540	PF00069	0.587
MOD_GSK3_1	547	554	PF00069	0.698
MOD_GSK3_1	587	594	PF00069	0.611
MOD_GSK3_1	627	634	PF00069	0.740
MOD_N-GLC_1	213	218	PF02516	0.552
MOD_N-GLC_2	90	92	PF02516	0.487
MOD_NEK2_1	1	6	PF00069	0.803
MOD_NEK2_1	153	158	PF00069	0.587
MOD_NEK2_1	251	256	PF00069	0.579
MOD_NEK2_1	282	287	PF00069	0.661
MOD_NEK2_1	302	307	PF00069	0.383
MOD_NEK2_1	371	376	PF00069	0.477
MOD_NEK2_1	428	433	PF00069	0.601
MOD_NEK2_1	467	472	PF00069	0.607
MOD_NEK2_1	591	596	PF00069	0.698
MOD_NEK2_1	80	85	PF00069	0.692
MOD_PIKK_1	341	347	PF00454	0.559
MOD_PIKK_1	540	546	PF00454	0.563
MOD_PIKK_1	62	68	PF00454	0.523
MOD_PK_1	167	173	PF00069	0.531
MOD_PK_1	551	557	PF00069	0.549
MOD_PKA_1	349	355	PF00069	0.550
MOD_PKA_1	551	557	PF00069	0.549
MOD_PKA_2	115	121	PF00069	0.509
MOD_PKA_2	251	257	PF00069	0.730
MOD_PKA_2	258	264	PF00069	0.687
MOD_PKA_2	327	333	PF00069	0.542
MOD_PKA_2	349	355	PF00069	0.725
MOD_PKA_2	376	382	PF00069	0.599
MOD_PKA_2	404	410	PF00069	0.572
MOD_PKA_2	467	473	PF00069	0.734
MOD_PKA_2	519	525	PF00069	0.735
MOD_PKA_2	540	546	PF00069	0.690
MOD_PKA_2	547	553	PF00069	0.765
MOD_PKB_1	367	375	PF00069	0.703
MOD_Plk_1	213	219	PF00069	0.641
MOD_Plk_1	232	238	PF00069	0.579
MOD_Plk_1	420	426	PF00069	0.519
MOD_Plk_1	462	468	PF00069	0.558
MOD_Plk_4	232	238	PF00069	0.538
MOD_Plk_4	349	355	PF00069	0.725
MOD_Plk_4	423	429	PF00069	0.685
MOD_Plk_4	473	479	PF00069	0.775
MOD_Plk_4	495	501	PF00069	0.594
MOD_ProDKin_1	16	22	PF00069	0.714
MOD_ProDKin_1	215	221	PF00069	0.538
MOD_ProDKin_1	584	590	PF00069	0.704
MOD_ProDKin_1	611	617	PF00069	0.690
MOD_ProDKin_1	631	637	PF00069	0.781
MOD_ProDKin_1	65	71	PF00069	0.780
MOD_SUMO_for_1	322	325	PF00179	0.685
TRG_DiLeu_BaEn_2	611	617	PF01217	0.690
TRG_DiLeu_BaLyEn_6	149	154	PF01217	0.725
TRG_DiLeu_BaLyEn_6	21	26	PF01217	0.533
TRG_DiLeu_BaLyEn_6	224	229	PF01217	0.755
TRG_ENDOCYTIC_2	58	61	PF00928	0.569
TRG_ER_diArg_1	20	22	PF00400	0.749
TRG_ER_diArg_1	366	369	PF00400	0.709
TRG_ER_diArg_1	500	502	PF00400	0.552
TRG_Pf-PMV_PEXEL_1	173	177	PF00026	0.691
TRG_Pf-PMV_PEXEL_1	188	192	PF00026	0.469
TRG_Pf-PMV_PEXEL_1	38	43	PF00026	0.724

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8IDR9	Leishmania donovani	78%	66%
A4HGG3	Leishmania braziliensis	60%	66%
A4I3J5	Leishmania infantum	79%	66%