Putative long-chain-fatty-acid-CoA ligase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

long-chain-fatty-acid-CoA ligase, putative

Species:

Leishmania mexicana

UniProt:

E9AZT3_LEIMU

TriTrypDb:

LmxM.28.1150

Length:

741

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 15

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 8

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 14
NetGPI	no	yes: 0, no: 14

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AZT3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AZT3

Function

Biological processes
Term	Name	Level	Count
GO:0006082	organic acid metabolic process	3	1
GO:0006629	lipid metabolic process	3	1
GO:0006631	fatty acid metabolic process	4	1
GO:0006633	fatty acid biosynthetic process	5	1
GO:0008152	metabolic process	1	1
GO:0008610	lipid biosynthetic process	4	1
GO:0009058	biosynthetic process	2	1
GO:0009987	cellular process	1	1
GO:0016053	organic acid biosynthetic process	4	1
GO:0019752	carboxylic acid metabolic process	5	1
GO:0032787	monocarboxylic acid metabolic process	6	1
GO:0043436	oxoacid metabolic process	4	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0044249	cellular biosynthetic process	3	1
GO:0044255	cellular lipid metabolic process	3	1
GO:0044281	small molecule metabolic process	2	1
GO:0044283	small molecule biosynthetic process	3	1
GO:0046394	carboxylic acid biosynthetic process	5	1
GO:0071704	organic substance metabolic process	2	1
GO:0072330	monocarboxylic acid biosynthetic process	6	1
GO:1901576	organic substance biosynthetic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	15
GO:0016874	ligase activity	2	15
GO:0004467	long-chain fatty acid-CoA ligase activity	3	4
GO:0015645	fatty acid ligase activity	2	4
GO:0016405	CoA-ligase activity	4	8
GO:0016877	ligase activity, forming carbon-sulfur bonds	3	8
GO:0016878	acid-thiol ligase activity	4	8
GO:0031957	very long-chain fatty acid-CoA ligase activity	3	1
GO:0140657	ATP-dependent activity	1	4
GO:0016207	4-coumarate-CoA ligase activity	5	4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	310	314	PF00656	0.319
CLV_NRD_NRD_1	454	456	PF00675	0.365
CLV_NRD_NRD_1	465	467	PF00675	0.373
CLV_NRD_NRD_1	607	609	PF00675	0.188
CLV_NRD_NRD_1	68	70	PF00675	0.453
CLV_PCSK_KEX2_1	234	236	PF00082	0.246
CLV_PCSK_KEX2_1	266	268	PF00082	0.366
CLV_PCSK_KEX2_1	68	70	PF00082	0.440
CLV_PCSK_PC1ET2_1	234	236	PF00082	0.273
CLV_PCSK_PC1ET2_1	266	268	PF00082	0.343
CLV_PCSK_SKI1_1	229	233	PF00082	0.382
CLV_PCSK_SKI1_1	26	30	PF00082	0.534
CLV_PCSK_SKI1_1	3	7	PF00082	0.431
CLV_PCSK_SKI1_1	35	39	PF00082	0.505
CLV_PCSK_SKI1_1	700	704	PF00082	0.322
CLV_PCSK_SKI1_1	723	727	PF00082	0.293
CLV_PCSK_SKI1_1	732	736	PF00082	0.355
CLV_PCSK_SKI1_1	94	98	PF00082	0.536
CLV_Separin_Metazoa	720	724	PF03568	0.305
DEG_Nend_Nbox_1	1	3	PF02207	0.484
DEG_ODPH_VHL_1	706	718	PF01847	0.261
DOC_ANK_TNKS_1	38	45	PF00023	0.365
DOC_CKS1_1	140	145	PF01111	0.261
DOC_CYCLIN_yCln2_LP_2	140	146	PF00134	0.274
DOC_CYCLIN_yCln2_LP_2	512	518	PF00134	0.246
DOC_MAPK_gen_1	149	157	PF00069	0.233
DOC_MAPK_gen_1	342	352	PF00069	0.268
DOC_MAPK_gen_1	627	636	PF00069	0.348
DOC_MAPK_gen_1	699	705	PF00069	0.317
DOC_MAPK_gen_1	731	740	PF00069	0.439
DOC_PP1_RVXF_1	676	683	PF00149	0.261
DOC_PP2B_LxvP_1	483	486	PF13499	0.246
DOC_PP2B_LxvP_1	705	708	PF13499	0.261
DOC_PP2B_LxvP_1	738	741	PF13499	0.303
DOC_PP4_FxxP_1	5	8	PF00568	0.491
DOC_USP7_MATH_1	206	210	PF00917	0.291
DOC_USP7_MATH_1	250	254	PF00917	0.427
DOC_USP7_MATH_1	257	261	PF00917	0.401
DOC_USP7_MATH_1	307	311	PF00917	0.305
DOC_USP7_MATH_1	31	35	PF00917	0.401
DOC_USP7_MATH_1	409	413	PF00917	0.367
DOC_USP7_MATH_1	566	570	PF00917	0.247
DOC_USP7_UBL2_3	234	238	PF12436	0.404
DOC_USP7_UBL2_3	272	276	PF12436	0.233
DOC_USP7_UBL2_3	728	732	PF12436	0.379
DOC_WW_Pin1_4	100	105	PF00397	0.720
DOC_WW_Pin1_4	139	144	PF00397	0.261
DOC_WW_Pin1_4	4	9	PF00397	0.461
DOC_WW_Pin1_4	455	460	PF00397	0.231
DOC_WW_Pin1_4	526	531	PF00397	0.352
LIG_14-3-3_CanoR_1	3	8	PF00244	0.569
LIG_14-3-3_CanoR_1	502	512	PF00244	0.248
LIG_14-3-3_CanoR_1	618	622	PF00244	0.360
LIG_APCC_ABBAyCdc20_2	643	649	PF00400	0.268
LIG_BRCT_BRCA1_1	212	216	PF00533	0.261
LIG_Clathr_ClatBox_1	317	321	PF01394	0.261
LIG_deltaCOP1_diTrp_1	380	384	PF00928	0.332
LIG_EH1_1	396	404	PF00400	0.246
LIG_eIF4E_1	222	228	PF01652	0.333
LIG_FHA_1	114	120	PF00498	0.493
LIG_FHA_1	124	130	PF00498	0.248
LIG_FHA_1	168	174	PF00498	0.432
LIG_FHA_1	213	219	PF00498	0.244
LIG_FHA_1	223	229	PF00498	0.230
LIG_FHA_1	238	244	PF00498	0.200
LIG_FHA_1	370	376	PF00498	0.198
LIG_FHA_1	385	391	PF00498	0.312
LIG_FHA_1	4	10	PF00498	0.427
LIG_FHA_1	598	604	PF00498	0.306
LIG_FHA_1	618	624	PF00498	0.389
LIG_FHA_1	693	699	PF00498	0.366
LIG_FHA_1	724	730	PF00498	0.262
LIG_FHA_2	15	21	PF00498	0.552
LIG_FHA_2	218	224	PF00498	0.300
LIG_FHA_2	342	348	PF00498	0.394
LIG_FHA_2	417	423	PF00498	0.246
LIG_FHA_2	496	502	PF00498	0.246
LIG_FHA_2	579	585	PF00498	0.246
LIG_LIR_Apic_2	244	250	PF02991	0.228
LIG_LIR_Apic_2	81	87	PF02991	0.588
LIG_LIR_Gen_1	180	188	PF02991	0.273
LIG_LIR_Gen_1	20	29	PF02991	0.438
LIG_LIR_Gen_1	437	447	PF02991	0.285
LIG_LIR_Gen_1	554	565	PF02991	0.251
LIG_LIR_Gen_1	713	722	PF02991	0.268
LIG_LIR_Nem_3	180	184	PF02991	0.305
LIG_LIR_Nem_3	20	24	PF02991	0.461
LIG_LIR_Nem_3	437	442	PF02991	0.289
LIG_LIR_Nem_3	444	449	PF02991	0.248
LIG_LIR_Nem_3	51	55	PF02991	0.358
LIG_LIR_Nem_3	554	560	PF02991	0.252
LIG_LIR_Nem_3	568	574	PF02991	0.263
LIG_LIR_Nem_3	713	718	PF02991	0.287
LIG_PCNA_yPIPBox_3	22	35	PF02747	0.396
LIG_Pex14_2	571	575	PF04695	0.230
LIG_PTB_Apo_2	326	333	PF02174	0.156
LIG_PTB_Phospho_1	326	332	PF10480	0.156
LIG_SH2_CRK	15	19	PF00017	0.425
LIG_SH2_CRK	446	450	PF00017	0.187
LIG_SH2_CRK	52	56	PF00017	0.394
LIG_SH2_CRK	613	617	PF00017	0.362
LIG_SH2_CRK	709	713	PF00017	0.265
LIG_SH2_GRB2like	574	577	PF00017	0.362
LIG_SH2_NCK_1	557	561	PF00017	0.227
LIG_SH2_PTP2	715	718	PF00017	0.302
LIG_SH2_SRC	557	560	PF00017	0.247
LIG_SH2_STAP1	115	119	PF00017	0.470
LIG_SH2_STAP1	125	129	PF00017	0.192
LIG_SH2_STAP1	15	19	PF00017	0.430
LIG_SH2_STAP1	181	185	PF00017	0.287
LIG_SH2_STAP1	222	226	PF00017	0.261
LIG_SH2_STAP1	346	350	PF00017	0.261
LIG_SH2_STAP1	648	652	PF00017	0.362
LIG_SH2_STAT3	537	540	PF00017	0.261
LIG_SH2_STAT5	115	118	PF00017	0.522
LIG_SH2_STAT5	125	128	PF00017	0.233
LIG_SH2_STAT5	156	159	PF00017	0.251
LIG_SH2_STAT5	185	188	PF00017	0.334
LIG_SH2_STAT5	353	356	PF00017	0.230
LIG_SH2_STAT5	537	540	PF00017	0.362
LIG_SH2_STAT5	613	616	PF00017	0.362
LIG_SH2_STAT5	715	718	PF00017	0.302
LIG_SH3_3	200	206	PF00018	0.191
LIG_SH3_3	40	46	PF00018	0.480
LIG_SH3_3	512	518	PF00018	0.292
LIG_SH3_3	524	530	PF00018	0.249
LIG_SH3_3	535	541	PF00018	0.246
LIG_SH3_3	716	722	PF00018	0.246
LIG_SH3_3	84	90	PF00018	0.554
LIG_SH3_5	104	108	PF00018	0.510
LIG_SUMO_SIM_anti_2	619	626	PF11976	0.369
LIG_SUMO_SIM_anti_2	662	669	PF11976	0.310
LIG_SUMO_SIM_par_1	223	230	PF11976	0.339
LIG_TYR_ITIM	13	18	PF00017	0.441
LIG_UBA3_1	154	159	PF00899	0.191
LIG_WRC_WIRS_1	418	423	PF05994	0.261
MOD_CDK_SPxxK_3	455	462	PF00069	0.302
MOD_CK1_1	209	215	PF00069	0.247
MOD_CK1_1	355	361	PF00069	0.324
MOD_CK1_1	495	501	PF00069	0.246
MOD_CK1_1	564	570	PF00069	0.290
MOD_CK2_1	14	20	PF00069	0.515
MOD_CK2_1	455	461	PF00069	0.231
MOD_CK2_1	495	501	PF00069	0.262
MOD_CK2_1	548	554	PF00069	0.409
MOD_CK2_1	578	584	PF00069	0.259
MOD_CK2_1	629	635	PF00069	0.322
MOD_GlcNHglycan	160	163	PF01048	0.333
MOD_GlcNHglycan	197	200	PF01048	0.357
MOD_GlcNHglycan	252	255	PF01048	0.248
MOD_GlcNHglycan	259	262	PF01048	0.233
MOD_GlcNHglycan	321	324	PF01048	0.387
MOD_GlcNHglycan	354	357	PF01048	0.288
MOD_GlcNHglycan	479	482	PF01048	0.297
MOD_GlcNHglycan	493	497	PF01048	0.248
MOD_GlcNHglycan	550	553	PF01048	0.485
MOD_GlcNHglycan	631	634	PF01048	0.311
MOD_GlcNHglycan	690	693	PF01048	0.243
MOD_GSK3_1	109	116	PF00069	0.619
MOD_GSK3_1	123	130	PF00069	0.179
MOD_GSK3_1	158	165	PF00069	0.364
MOD_GSK3_1	206	213	PF00069	0.275
MOD_GSK3_1	351	358	PF00069	0.263
MOD_GSK3_1	526	533	PF00069	0.299
MOD_GSK3_1	688	695	PF00069	0.316
MOD_N-GLC_1	207	212	PF02516	0.228
MOD_N-GLC_1	576	581	PF02516	0.421
MOD_N-GLC_1	723	728	PF02516	0.273
MOD_NEK2_1	109	114	PF00069	0.600
MOD_NEK2_1	131	136	PF00069	0.288
MOD_NEK2_1	144	149	PF00069	0.345
MOD_NEK2_1	158	163	PF00069	0.200
MOD_NEK2_1	217	222	PF00069	0.288
MOD_NEK2_1	351	356	PF00069	0.302
MOD_NEK2_1	510	515	PF00069	0.264
MOD_NEK2_1	616	621	PF00069	0.230
MOD_NEK2_2	14	19	PF00069	0.416
MOD_NEK2_2	434	439	PF00069	0.362
MOD_NEK2_2	469	474	PF00069	0.261
MOD_NEK2_2	566	571	PF00069	0.279
MOD_PIKK_1	144	150	PF00454	0.268
MOD_PIKK_1	510	516	PF00454	0.277
MOD_PKA_1	234	240	PF00069	0.156
MOD_PKA_2	234	240	PF00069	0.158
MOD_PKA_2	341	347	PF00069	0.268
MOD_PKA_2	384	390	PF00069	0.370
MOD_PKA_2	617	623	PF00069	0.347
MOD_PKB_1	294	302	PF00069	0.198
MOD_Plk_1	206	212	PF00069	0.264
MOD_Plk_1	222	228	PF00069	0.370
MOD_Plk_1	434	440	PF00069	0.250
MOD_Plk_1	636	642	PF00069	0.233
MOD_Plk_1	78	84	PF00069	0.456
MOD_Plk_4	115	121	PF00069	0.463
MOD_Plk_4	127	133	PF00069	0.188
MOD_Plk_4	14	20	PF00069	0.413
MOD_Plk_4	212	218	PF00069	0.268
MOD_Plk_4	222	228	PF00069	0.219
MOD_Plk_4	386	392	PF00069	0.282
MOD_Plk_4	441	447	PF00069	0.258
MOD_Plk_4	495	501	PF00069	0.246
MOD_Plk_4	533	539	PF00069	0.309
MOD_Plk_4	566	572	PF00069	0.244
MOD_Plk_4	611	617	PF00069	0.395
MOD_Plk_4	636	642	PF00069	0.254
MOD_Plk_4	660	666	PF00069	0.334
MOD_Plk_4	80	86	PF00069	0.438
MOD_ProDKin_1	100	106	PF00069	0.715
MOD_ProDKin_1	139	145	PF00069	0.261
MOD_ProDKin_1	4	10	PF00069	0.462
MOD_ProDKin_1	455	461	PF00069	0.231
MOD_ProDKin_1	526	532	PF00069	0.352
MOD_SUMO_rev_2	198	206	PF00179	0.156
MOD_SUMO_rev_2	230	240	PF00179	0.396
MOD_SUMO_rev_2	269	274	PF00179	0.284
MOD_SUMO_rev_2	691	701	PF00179	0.261
TRG_DiLeu_BaEn_1	471	476	PF01217	0.233
TRG_ENDOCYTIC_2	15	18	PF00928	0.430
TRG_ENDOCYTIC_2	181	184	PF00928	0.276
TRG_ENDOCYTIC_2	21	24	PF00928	0.384
TRG_ENDOCYTIC_2	446	449	PF00928	0.230
TRG_ENDOCYTIC_2	52	55	PF00928	0.374
TRG_ENDOCYTIC_2	557	560	PF00928	0.227
TRG_ENDOCYTIC_2	613	616	PF00928	0.386
TRG_ENDOCYTIC_2	715	718	PF00928	0.310
TRG_ER_diArg_1	293	296	PF00400	0.340
TRG_ER_diArg_1	603	606	PF00400	0.205
TRG_ER_diArg_1	67	69	PF00400	0.631

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0S4IL67	Bodo saltans	41%	96%
A0A1X0NYK4	Trypanosomatidae	51%	100%
A0A3Q8ID29	Leishmania donovani	91%	100%
A0A3R7KRF3	Trypanosoma rangeli	50%	100%
A0A3S7WVL1	Leishmania donovani	24%	100%
A4HGG0	Leishmania braziliensis	81%	100%
A4HYA8	Leishmania infantum	24%	100%
A4I3J3	Leishmania infantum	91%	100%
D0A7V2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	51%	100%
E9AGS6	Leishmania infantum	24%	100%
P63521	Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)	22%	100%
P63522	Salmonella typhi	22%	100%
Q4Q8F1	Leishmania major	91%	100%
Q4QDB5	Leishmania major	21%	100%
Q4QDB6	Leishmania major	23%	100%
V5AUI9	Trypanosoma cruzi	51%	100%