Amastin surface glycofamily protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Amastin surface glycoprotein, putative

Species:

Leishmania mexicana

UniProt:

E9AZT1_LEIMU

TriTrypDb:

LmxM.28.1130

Length:

522

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 18
NetGPI	no	yes: 0, no: 18

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	16
GO:0110165	cellular anatomical entity	1	16

Expansion

Sequence features

E9AZT1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AZT1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	120	122	PF00675	0.481
CLV_NRD_NRD_1	360	362	PF00675	0.533
CLV_NRD_NRD_1	56	58	PF00675	0.638
CLV_PCSK_KEX2_1	122	124	PF00082	0.474
CLV_PCSK_KEX2_1	359	361	PF00082	0.522
CLV_PCSK_KEX2_1	401	403	PF00082	0.480
CLV_PCSK_KEX2_1	6	8	PF00082	0.456
CLV_PCSK_PC1ET2_1	122	124	PF00082	0.335
CLV_PCSK_PC1ET2_1	359	361	PF00082	0.522
CLV_PCSK_PC1ET2_1	401	403	PF00082	0.505
CLV_PCSK_PC1ET2_1	6	8	PF00082	0.431
CLV_PCSK_SKI1_1	151	155	PF00082	0.329
CLV_PCSK_SKI1_1	401	405	PF00082	0.492
CLV_Separin_Metazoa	118	122	PF03568	0.544
DEG_APCC_KENBOX_2	30	34	PF00400	0.646
DOC_CYCLIN_yCln2_LP_2	423	429	PF00134	0.293
DOC_MAPK_gen_1	148	156	PF00069	0.422
DOC_MAPK_gen_1	401	409	PF00069	0.340
DOC_MAPK_gen_1	431	440	PF00069	0.498
DOC_MAPK_MEF2A_6	151	158	PF00069	0.453
DOC_MAPK_RevD_3	347	361	PF00069	0.313
DOC_PP2B_LxvP_1	379	382	PF13499	0.261
DOC_PP2B_LxvP_1	423	426	PF13499	0.293
DOC_PP2B_LxvP_1	517	520	PF13499	0.361
DOC_USP7_MATH_1	17	21	PF00917	0.769
DOC_USP7_MATH_1	62	66	PF00917	0.655
LIG_14-3-3_CanoR_1	121	126	PF00244	0.633
LIG_14-3-3_CanoR_1	193	198	PF00244	0.311
LIG_14-3-3_CanoR_1	371	375	PF00244	0.317
LIG_14-3-3_CanoR_1	395	403	PF00244	0.361
LIG_14-3-3_CanoR_1	492	496	PF00244	0.224
LIG_14-3-3_CanoR_1	7	17	PF00244	0.665
LIG_14-3-3_CanoR_1	70	75	PF00244	0.635
LIG_BIR_III_4	184	188	PF00653	0.192
LIG_BRCT_BRCA1_1	274	278	PF00533	0.389
LIG_BRCT_BRCA1_1	344	348	PF00533	0.467
LIG_BRCT_BRCA1_1	405	409	PF00533	0.325
LIG_BRCT_BRCA1_1	436	440	PF00533	0.384
LIG_CaM_NSCaTE_8	506	513	PF13499	0.293
LIG_EH1_1	439	447	PF00400	0.293
LIG_eIF4E_1	254	260	PF01652	0.378
LIG_eIF4E_1	374	380	PF01652	0.322
LIG_FHA_1	122	128	PF00498	0.694
LIG_FHA_1	241	247	PF00498	0.383
LIG_FHA_1	290	296	PF00498	0.377
LIG_FHA_1	352	358	PF00498	0.407
LIG_FHA_1	362	368	PF00498	0.302
LIG_FHA_1	375	381	PF00498	0.260
LIG_FHA_1	463	469	PF00498	0.319
LIG_FHA_2	112	118	PF00498	0.670
LIG_GBD_Chelix_1	310	318	PF00786	0.273
LIG_Integrin_RGD_1	391	393	PF01839	0.392
LIG_IRF3_LxIS_1	445	451	PF10401	0.359
LIG_LIR_Apic_2	124	128	PF02991	0.634
LIG_LIR_Gen_1	204	213	PF02991	0.252
LIG_LIR_Gen_1	253	264	PF02991	0.485
LIG_LIR_Gen_1	335	346	PF02991	0.378
LIG_LIR_Gen_1	406	417	PF02991	0.371
LIG_LIR_Gen_1	437	448	PF02991	0.468
LIG_LIR_Gen_1	505	514	PF02991	0.211
LIG_LIR_Nem_3	204	208	PF02991	0.301
LIG_LIR_Nem_3	253	259	PF02991	0.476
LIG_LIR_Nem_3	261	265	PF02991	0.361
LIG_LIR_Nem_3	335	341	PF02991	0.392
LIG_LIR_Nem_3	345	351	PF02991	0.359
LIG_LIR_Nem_3	406	412	PF02991	0.399
LIG_LIR_Nem_3	437	443	PF02991	0.373
LIG_LIR_Nem_3	444	450	PF02991	0.360
LIG_LIR_Nem_3	471	476	PF02991	0.313
LIG_LIR_Nem_3	488	493	PF02991	0.288
LIG_LIR_Nem_3	505	509	PF02991	0.342
LIG_LYPXL_yS_3	476	479	PF13949	0.305
LIG_NRBOX	237	243	PF00104	0.352
LIG_NRBOX	309	315	PF00104	0.354
LIG_PAM2_1	258	270	PF00658	0.378
LIG_PAM2_1	299	311	PF00658	0.293
LIG_PDZ_Wminus1_1	520	522	PF00595	0.574
LIG_Pex14_1	256	260	PF04695	0.378
LIG_Pex14_1	358	362	PF04695	0.318
LIG_Pex14_2	161	165	PF04695	0.422
LIG_SH2_CRK	125	129	PF00017	0.672
LIG_SH2_CRK	223	227	PF00017	0.261
LIG_SH2_CRK	338	342	PF00017	0.390
LIG_SH2_STAP1	205	209	PF00017	0.203
LIG_SH2_STAP1	399	403	PF00017	0.243
LIG_SH2_STAT3	18	21	PF00017	0.661
LIG_SH2_STAT3	23	26	PF00017	0.654
LIG_SH2_STAT3	493	496	PF00017	0.322
LIG_SH2_STAT5	125	128	PF00017	0.617
LIG_SH3_3	474	480	PF00018	0.326
LIG_SUMO_SIM_anti_2	237	244	PF11976	0.261
LIG_SUMO_SIM_anti_2	441	447	PF11976	0.329
LIG_SUMO_SIM_anti_2	454	460	PF11976	0.240
LIG_SUMO_SIM_anti_2	505	511	PF11976	0.379
LIG_SUMO_SIM_par_1	234	240	PF11976	0.338
LIG_SUMO_SIM_par_1	314	320	PF11976	0.237
LIG_TRAF2_1	115	118	PF00917	0.776
LIG_TRAF2_1	494	497	PF00917	0.192
LIG_TYR_ITIM	252	257	PF00017	0.392
LIG_UBA3_1	194	199	PF00899	0.192
LIG_UBA3_1	313	321	PF00899	0.290
LIG_WRC_WIRS_1	259	264	PF05994	0.342
MOD_CK1_1	237	243	PF00069	0.461
MOD_CK1_1	397	403	PF00069	0.399
MOD_CK1_1	441	447	PF00069	0.374
MOD_CK1_1	451	457	PF00069	0.343
MOD_CK1_1	502	508	PF00069	0.236
MOD_CK1_1	8	14	PF00069	0.787
MOD_CK2_1	111	117	PF00069	0.670
MOD_CK2_1	491	497	PF00069	0.320
MOD_CK2_1	62	68	PF00069	0.751
MOD_CK2_1	70	76	PF00069	0.704
MOD_GlcNHglycan	243	246	PF01048	0.383
MOD_GlcNHglycan	396	399	PF01048	0.459
MOD_GlcNHglycan	480	483	PF01048	0.587
MOD_GlcNHglycan	59	62	PF01048	0.626
MOD_GlcNHglycan	90	93	PF01048	0.447
MOD_GSK3_1	1	8	PF00069	0.657
MOD_GSK3_1	237	244	PF00069	0.388
MOD_GSK3_1	274	281	PF00069	0.357
MOD_GSK3_1	349	356	PF00069	0.452
MOD_GSK3_1	370	377	PF00069	0.384
MOD_GSK3_1	38	45	PF00069	0.758
MOD_GSK3_1	434	441	PF00069	0.536
MOD_GSK3_1	462	469	PF00069	0.374
MOD_GSK3_1	68	75	PF00069	0.748
MOD_GSK3_1	84	91	PF00069	0.595
MOD_N-GLC_1	32	37	PF02516	0.625
MOD_N-GLC_1	382	387	PF02516	0.545
MOD_N-GLC_2	462	464	PF02516	0.443
MOD_NEK2_1	111	116	PF00069	0.722
MOD_NEK2_1	165	170	PF00069	0.374
MOD_NEK2_1	241	246	PF00069	0.305
MOD_NEK2_1	258	263	PF00069	0.309
MOD_NEK2_1	265	270	PF00069	0.355
MOD_NEK2_1	274	279	PF00069	0.304
MOD_NEK2_1	289	294	PF00069	0.281
MOD_NEK2_1	299	304	PF00069	0.277
MOD_NEK2_1	342	347	PF00069	0.453
MOD_NEK2_1	349	354	PF00069	0.486
MOD_NEK2_1	403	408	PF00069	0.342
MOD_NEK2_1	410	415	PF00069	0.411
MOD_NEK2_1	448	453	PF00069	0.485
MOD_NEK2_1	510	515	PF00069	0.453
MOD_PIKK_1	17	23	PF00454	0.745
MOD_PIKK_1	38	44	PF00454	0.859
MOD_PIKK_1	68	74	PF00454	0.782
MOD_PK_1	434	440	PF00069	0.461
MOD_PKA_1	121	127	PF00069	0.533
MOD_PKA_1	57	63	PF00069	0.639
MOD_PKA_2	287	293	PF00069	0.271
MOD_PKA_2	370	376	PF00069	0.389
MOD_PKA_2	394	400	PF00069	0.387
MOD_PKA_2	491	497	PF00069	0.224
MOD_PKA_2	8	14	PF00069	0.670
MOD_PKB_1	121	129	PF00069	0.541
MOD_Plk_4	227	233	PF00069	0.395
MOD_Plk_4	234	240	PF00069	0.419
MOD_Plk_4	299	305	PF00069	0.332
MOD_Plk_4	333	339	PF00069	0.436
MOD_Plk_4	342	348	PF00069	0.435
MOD_Plk_4	353	359	PF00069	0.348
MOD_Plk_4	370	376	PF00069	0.252
MOD_Plk_4	383	389	PF00069	0.378
MOD_Plk_4	434	440	PF00069	0.502
MOD_Plk_4	468	474	PF00069	0.277
MOD_Plk_4	502	508	PF00069	0.372
MOD_Plk_4	510	516	PF00069	0.392
MOD_Plk_4	84	90	PF00069	0.685
MOD_SUMO_for_1	115	118	PF00179	0.661
TRG_ENDOCYTIC_2	205	208	PF00928	0.261
TRG_ENDOCYTIC_2	223	226	PF00928	0.261
TRG_ENDOCYTIC_2	254	257	PF00928	0.357
TRG_ENDOCYTIC_2	338	341	PF00928	0.437
TRG_ENDOCYTIC_2	476	479	PF00928	0.322
TRG_ER_diArg_1	120	123	PF00400	0.575
TRG_ER_diArg_1	178	181	PF00400	0.243
TRG_ER_diArg_1	360	362	PF00400	0.238
TRG_NLS_Bipartite_1	104	125	PF00514	0.556

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6X2	Leptomonas seymouri	30%	100%
A0A0N1PC74	Leptomonas seymouri	57%	100%
A0A0N1PCA2	Leptomonas seymouri	26%	100%
A0A3Q8I8Q6	Leishmania donovani	29%	100%
A0A3S7WR28	Leishmania donovani	26%	100%
A0A3S7X1E1	Leishmania donovani	83%	100%
A4H605	Leishmania braziliensis	28%	100%
A4H606	Leishmania braziliensis	28%	100%
A4HGF8	Leishmania braziliensis	68%	100%
A4HUD2	Leishmania infantum	29%	100%
A4HUD3	Leishmania infantum	26%	100%
A4I3I9	Leishmania infantum	83%	100%
E9AN32	Leishmania mexicana (strain MHOM/GT/2001/U1103)	28%	100%
E9AN33	Leishmania mexicana (strain MHOM/GT/2001/U1103)	25%	98%
Q4Q8F3	Leishmania major	82%	100%
Q4QHJ3	Leishmania major	26%	100%
Q4QHJ4	Leishmania major	28%	100%