Amastin-like protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AZT0_LEIMU

TriTrypDb:

LmxM.28.1120

Length:

250

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	5
GO:0110165	cellular anatomical entity	1	5

Expansion

Sequence features

E9AZT0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AZT0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	70	72	PF00675	0.454
CLV_PCSK_KEX2_1	70	72	PF00082	0.454
CLV_PCSK_SKI1_1	105	109	PF00082	0.463
CLV_PCSK_SKI1_1	173	177	PF00082	0.285
CLV_PCSK_SKI1_1	244	248	PF00082	0.329
DEG_Nend_UBRbox_3	1	3	PF02207	0.589
DOC_CDC14_PxL_1	95	103	PF14671	0.208
DOC_CYCLIN_RxL_1	170	178	PF00134	0.482
DOC_CYCLIN_yCln2_LP_2	97	100	PF00134	0.362
DOC_MAPK_gen_1	74	83	PF00069	0.536
DOC_MAPK_MEF2A_6	143	152	PF00069	0.337
DOC_PP1_RVXF_1	212	219	PF00149	0.308
DOC_PP2B_LxvP_1	97	100	PF13499	0.208
DOC_USP7_MATH_1	141	145	PF00917	0.436
DOC_USP7_MATH_1	4	8	PF00917	0.629
DOC_WW_Pin1_4	62	67	PF00397	0.635
LIG_Actin_WH2_2	229	246	PF00022	0.362
LIG_APCC_ABBA_1	200	205	PF00400	0.297
LIG_EH1_1	178	186	PF00400	0.521
LIG_EH1_1	190	198	PF00400	0.240
LIG_eIF4E_1	179	185	PF01652	0.362
LIG_FHA_1	106	112	PF00498	0.356
LIG_FHA_1	147	153	PF00498	0.199
LIG_FHA_1	155	161	PF00498	0.196
LIG_FHA_1	176	182	PF00498	0.500
LIG_FHA_1	21	27	PF00498	0.632
LIG_FHA_2	119	125	PF00498	0.337
LIG_FHA_2	22	28	PF00498	0.621
LIG_GBD_Chelix_1	194	202	PF00786	0.358
LIG_LIR_Gen_1	144	155	PF02991	0.268
LIG_LIR_Gen_1	78	88	PF02991	0.447
LIG_LIR_Gen_1	93	103	PF02991	0.364
LIG_LIR_Nem_3	144	150	PF02991	0.294
LIG_LIR_Nem_3	154	158	PF02991	0.292
LIG_LIR_Nem_3	165	170	PF02991	0.346
LIG_LIR_Nem_3	78	83	PF02991	0.447
LIG_LIR_Nem_3	85	91	PF02991	0.297
LIG_LIR_Nem_3	93	98	PF02991	0.364
LIG_NRBOX	237	243	PF00104	0.300
LIG_SH2_GRB2like	56	59	PF00017	0.682
LIG_SH2_STAP1	203	207	PF00017	0.243
LIG_SH2_STAT3	130	133	PF00017	0.254
LIG_SH2_STAT5	147	150	PF00017	0.355
LIG_SH2_STAT5	151	154	PF00017	0.360
LIG_SH2_STAT5	179	182	PF00017	0.299
LIG_SH2_STAT5	56	59	PF00017	0.659
LIG_SH3_2	66	71	PF14604	0.616
LIG_SH3_3	63	69	PF00018	0.649
LIG_SUMO_SIM_anti_2	232	238	PF11976	0.210
LIG_TRAF2_1	34	37	PF00917	0.590
LIG_TRFH_1	95	99	PF08558	0.208
LIG_UBA3_1	238	247	PF00899	0.362
LIG_UBA3_1	97	105	PF00899	0.266
LIG_WRC_WIRS_1	152	157	PF05994	0.208
MOD_CK1_1	20	26	PF00069	0.624
MOD_CK1_1	232	238	PF00069	0.362
MOD_CK1_1	8	14	PF00069	0.705
MOD_CK2_1	118	124	PF00069	0.379
MOD_CK2_1	21	27	PF00069	0.577
MOD_CK2_1	8	14	PF00069	0.588
MOD_GlcNHglycan	105	108	PF01048	0.495
MOD_GSK3_1	103	110	PF00069	0.368
MOD_GSK3_1	13	20	PF00069	0.593
MOD_GSK3_1	4	11	PF00069	0.735
MOD_LATS_1	129	135	PF00433	0.259
MOD_N-GLC_1	20	25	PF02516	0.397
MOD_N-GLC_2	206	208	PF02516	0.562
MOD_N-GLC_2	73	75	PF02516	0.321
MOD_NEK2_1	136	141	PF00069	0.243
MOD_NEK2_1	162	167	PF00069	0.310
MOD_NEK2_1	175	180	PF00069	0.630
MOD_NEK2_1	224	229	PF00069	0.461
MOD_NEK2_1	242	247	PF00069	0.591
MOD_NEK2_1	90	95	PF00069	0.362
MOD_NEK2_2	107	112	PF00069	0.258
MOD_NEK2_2	146	151	PF00069	0.199
MOD_Plk_1	13	19	PF00069	0.610
MOD_Plk_1	209	215	PF00069	0.305
MOD_Plk_1	5	11	PF00069	0.694
MOD_Plk_1	52	58	PF00069	0.635
MOD_Plk_4	131	137	PF00069	0.366
MOD_Plk_4	146	152	PF00069	0.212
MOD_Plk_4	162	168	PF00069	0.339
MOD_Plk_4	175	181	PF00069	0.478
MOD_Plk_4	232	238	PF00069	0.272
MOD_Plk_4	52	58	PF00069	0.683
MOD_Plk_4	82	88	PF00069	0.362
MOD_Plk_4	90	96	PF00069	0.288
MOD_ProDKin_1	62	68	PF00069	0.632
MOD_SUMO_for_1	34	37	PF00179	0.590
TRG_ENDOCYTIC_2	147	150	PF00928	0.310
TRG_ER_diArg_1	69	71	PF00400	0.630
TRG_ER_diArg_1	74	77	PF00400	0.556

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I1D0	Leptomonas seymouri	43%	100%
A0A3Q8IEK1	Leishmania donovani	70%	98%
A4I3I8	Leishmania infantum	71%	98%
Q4Q8F4	Leishmania major	69%	100%