Ubiquitin-like domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AZS8_LEIMU

TriTrypDb:

LmxM.28.1100

Length:

848

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AZS8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AZS8

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	7
GO:0004842	ubiquitin-protein transferase activity	4	7
GO:0005488	binding	1	7
GO:0008270	zinc ion binding	6	7
GO:0016740	transferase activity	2	7
GO:0019787	ubiquitin-like protein transferase activity	3	7
GO:0043167	ion binding	2	7
GO:0043169	cation binding	3	7
GO:0046872	metal ion binding	4	7
GO:0046914	transition metal ion binding	5	7
GO:0061630	ubiquitin protein ligase activity	5	7
GO:0061659	ubiquitin-like protein ligase activity	4	7
GO:0140096	catalytic activity, acting on a protein	2	7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	303	307	PF00656	0.521
CLV_C14_Caspase3-7	329	333	PF00656	0.649
CLV_C14_Caspase3-7	503	507	PF00656	0.517
CLV_C14_Caspase3-7	609	613	PF00656	0.412
CLV_NRD_NRD_1	212	214	PF00675	0.512
CLV_NRD_NRD_1	245	247	PF00675	0.629
CLV_NRD_NRD_1	4	6	PF00675	0.360
CLV_NRD_NRD_1	453	455	PF00675	0.451
CLV_NRD_NRD_1	846	848	PF00675	0.633
CLV_PCSK_KEX2_1	212	214	PF00082	0.509
CLV_PCSK_KEX2_1	247	249	PF00082	0.650
CLV_PCSK_KEX2_1	258	260	PF00082	0.641
CLV_PCSK_KEX2_1	346	348	PF00082	0.706
CLV_PCSK_KEX2_1	4	6	PF00082	0.542
CLV_PCSK_KEX2_1	453	455	PF00082	0.426
CLV_PCSK_PC1ET2_1	247	249	PF00082	0.650
CLV_PCSK_PC1ET2_1	258	260	PF00082	0.641
CLV_PCSK_PC1ET2_1	346	348	PF00082	0.706
CLV_PCSK_PC7_1	243	249	PF00082	0.630
CLV_PCSK_SKI1_1	270	274	PF00082	0.609
CLV_PCSK_SKI1_1	380	384	PF00082	0.583
CLV_PCSK_SKI1_1	49	53	PF00082	0.622
CLV_PCSK_SKI1_1	593	597	PF00082	0.545
CLV_PCSK_SKI1_1	640	644	PF00082	0.533
CLV_PCSK_SKI1_1	670	674	PF00082	0.467
CLV_PCSK_SKI1_1	701	705	PF00082	0.423
CLV_PCSK_SKI1_1	71	75	PF00082	0.410
DEG_SCF_FBW7_1	254	260	PF00400	0.639
DEG_SPOP_SBC_1	249	253	PF00917	0.651
DEG_SPOP_SBC_1	300	304	PF00917	0.518
DOC_CDC14_PxL_1	51	59	PF14671	0.443
DOC_CKS1_1	254	259	PF01111	0.642
DOC_CKS1_1	496	501	PF01111	0.652
DOC_CYCLIN_RxL_1	66	77	PF00134	0.500
DOC_CYCLIN_yCln2_LP_2	22	28	PF00134	0.481
DOC_MAPK_gen_1	14	22	PF00069	0.434
DOC_MAPK_gen_1	4	11	PF00069	0.403
DOC_MAPK_gen_1	47	56	PF00069	0.445
DOC_MAPK_MEF2A_6	17	24	PF00069	0.425
DOC_MAPK_MEF2A_6	47	56	PF00069	0.440
DOC_MAPK_NFAT4_5	47	55	PF00069	0.443
DOC_PP1_RVXF_1	69	75	PF00149	0.483
DOC_PP2B_LxvP_1	22	25	PF13499	0.475
DOC_PP2B_LxvP_1	52	55	PF13499	0.454
DOC_PP4_FxxP_1	371	374	PF00568	0.492
DOC_USP7_MATH_1	112	116	PF00917	0.607
DOC_USP7_MATH_1	225	229	PF00917	0.696
DOC_USP7_MATH_1	257	261	PF00917	0.686
DOC_USP7_MATH_1	296	300	PF00917	0.680
DOC_USP7_MATH_1	310	314	PF00917	0.537
DOC_USP7_MATH_1	331	335	PF00917	0.710
DOC_USP7_MATH_1	393	397	PF00917	0.592
DOC_USP7_MATH_1	419	423	PF00917	0.594
DOC_USP7_MATH_1	587	591	PF00917	0.457
DOC_USP7_MATH_1	638	642	PF00917	0.356
DOC_USP7_MATH_1	739	743	PF00917	0.679
DOC_USP7_MATH_1	747	751	PF00917	0.587
DOC_USP7_MATH_1	804	808	PF00917	0.496
DOC_WW_Pin1_4	216	221	PF00397	0.648
DOC_WW_Pin1_4	250	255	PF00397	0.675
DOC_WW_Pin1_4	261	266	PF00397	0.687
DOC_WW_Pin1_4	315	320	PF00397	0.649
DOC_WW_Pin1_4	495	500	PF00397	0.636
DOC_WW_Pin1_4	719	724	PF00397	0.597
LIG_14-3-3_CanoR_1	133	137	PF00244	0.468
LIG_14-3-3_CanoR_1	248	254	PF00244	0.662
LIG_14-3-3_CanoR_1	347	355	PF00244	0.516
LIG_14-3-3_CanoR_1	446	451	PF00244	0.560
LIG_14-3-3_CanoR_1	514	522	PF00244	0.487
LIG_14-3-3_CanoR_1	649	657	PF00244	0.632
LIG_APCC_ABBAyCdc20_2	40	46	PF00400	0.349
LIG_BIR_II_1	1	5	PF00653	0.516
LIG_BIR_III_2	369	373	PF00653	0.635
LIG_BRCT_BRCA1_1	313	317	PF00533	0.715
LIG_BRCT_BRCA1_1	612	616	PF00533	0.555
LIG_BRCT_BRCA1_1	766	770	PF00533	0.483
LIG_FHA_1	112	118	PF00498	0.526
LIG_FHA_1	142	148	PF00498	0.408
LIG_FHA_1	250	256	PF00498	0.725
LIG_FHA_1	556	562	PF00498	0.405
LIG_FHA_1	653	659	PF00498	0.590
LIG_FHA_1	688	694	PF00498	0.569
LIG_FHA_1	74	80	PF00498	0.444
LIG_FHA_2	121	127	PF00498	0.500
LIG_FHA_2	148	154	PF00498	0.411
LIG_FHA_2	27	33	PF00498	0.498
LIG_GBD_Chelix_1	811	819	PF00786	0.566
LIG_Integrin_isoDGR_2	339	341	PF01839	0.667
LIG_KLC1_Yacidic_2	6	10	PF13176	0.382
LIG_LIR_Apic_2	369	374	PF02991	0.500
LIG_LIR_Gen_1	6	15	PF02991	0.387
LIG_LIR_Gen_1	641	650	PF02991	0.610
LIG_LIR_Gen_1	772	781	PF02991	0.532
LIG_LIR_Nem_3	537	543	PF02991	0.524
LIG_LIR_Nem_3	554	560	PF02991	0.410
LIG_LIR_Nem_3	6	11	PF02991	0.376
LIG_LIR_Nem_3	641	646	PF02991	0.608
LIG_LIR_Nem_3	772	778	PF02991	0.525
LIG_LIR_Nem_3	800	805	PF02991	0.478
LIG_Pex14_1	180	184	PF04695	0.542
LIG_Pex14_2	7	11	PF04695	0.364
LIG_PTB_Apo_2	686	693	PF02174	0.474
LIG_REV1ctd_RIR_1	689	699	PF16727	0.487
LIG_SH2_CRK	217	221	PF00017	0.542
LIG_SH2_NCK_1	217	221	PF00017	0.542
LIG_SH2_STAP1	762	766	PF00017	0.512
LIG_SH2_STAT3	140	143	PF00017	0.444
LIG_SH2_STAT3	564	567	PF00017	0.474
LIG_SH2_STAT3	581	584	PF00017	0.372
LIG_SH2_STAT5	140	143	PF00017	0.444
LIG_SH2_STAT5	146	149	PF00017	0.378
LIG_SH2_STAT5	415	418	PF00017	0.519
LIG_SH2_STAT5	564	567	PF00017	0.474
LIG_SH2_STAT5	797	800	PF00017	0.562
LIG_SH2_STAT5	8	11	PF00017	0.367
LIG_SH3_2	254	259	PF14604	0.642
LIG_SH3_3	196	202	PF00018	0.600
LIG_SH3_3	251	257	PF00018	0.655
LIG_SH3_3	318	324	PF00018	0.655
LIG_SH3_3	370	376	PF00018	0.570
LIG_SH3_3	404	410	PF00018	0.617
LIG_SH3_3	475	481	PF00018	0.367
LIG_SUMO_SIM_par_1	18	23	PF11976	0.427
LIG_TRAF2_1	751	754	PF00917	0.530
LIG_UBA3_1	50	58	PF00899	0.451
LIG_WW_2	373	376	PF00397	0.551
MOD_CDK_SPK_2	253	258	PF00069	0.644
MOD_CDK_SPxK_1	253	259	PF00069	0.645
MOD_CDK_SPxK_1	495	501	PF00069	0.649
MOD_CK1_1	102	108	PF00069	0.535
MOD_CK1_1	115	121	PF00069	0.570
MOD_CK1_1	218	224	PF00069	0.603
MOD_CK1_1	253	259	PF00069	0.662
MOD_CK1_1	260	266	PF00069	0.674
MOD_CK1_1	299	305	PF00069	0.654
MOD_CK1_1	315	321	PF00069	0.768
MOD_CK1_1	349	355	PF00069	0.594
MOD_CK1_1	726	732	PF00069	0.574
MOD_CK2_1	120	126	PF00069	0.510
MOD_CK2_1	225	231	PF00069	0.580
MOD_CK2_1	747	753	PF00069	0.584
MOD_CK2_1	804	810	PF00069	0.468
MOD_Cter_Amidation	344	347	PF01082	0.706
MOD_Cter_Amidation	845	848	PF01082	0.587
MOD_DYRK1A_RPxSP_1	250	254	PF00069	0.645
MOD_GlcNHglycan	101	104	PF01048	0.502
MOD_GlcNHglycan	223	226	PF01048	0.769
MOD_GlcNHglycan	227	230	PF01048	0.661
MOD_GlcNHglycan	26	29	PF01048	0.422
MOD_GlcNHglycan	266	269	PF01048	0.639
MOD_GlcNHglycan	290	293	PF01048	0.545
MOD_GlcNHglycan	298	301	PF01048	0.710
MOD_GlcNHglycan	314	317	PF01048	0.633
MOD_GlcNHglycan	335	338	PF01048	0.628
MOD_GlcNHglycan	589	592	PF01048	0.436
MOD_GlcNHglycan	601	604	PF01048	0.583
MOD_GlcNHglycan	606	609	PF01048	0.546
MOD_GlcNHglycan	640	643	PF01048	0.462
MOD_GlcNHglycan	713	716	PF01048	0.548
MOD_GlcNHglycan	749	752	PF01048	0.641
MOD_GlcNHglycan	95	98	PF01048	0.422
MOD_GSK3_1	111	118	PF00069	0.570
MOD_GSK3_1	221	228	PF00069	0.612
MOD_GSK3_1	249	256	PF00069	0.677
MOD_GSK3_1	257	264	PF00069	0.689
MOD_GSK3_1	296	303	PF00069	0.650
MOD_GSK3_1	311	318	PF00069	0.571
MOD_GSK3_1	331	338	PF00069	0.738
MOD_GSK3_1	393	400	PF00069	0.779
MOD_GSK3_1	434	441	PF00069	0.457
MOD_GSK3_1	442	449	PF00069	0.425
MOD_GSK3_1	626	633	PF00069	0.484
MOD_GSK3_1	648	655	PF00069	0.648
MOD_GSK3_1	719	726	PF00069	0.609
MOD_GSK3_1	735	742	PF00069	0.633
MOD_GSK3_1	811	818	PF00069	0.562
MOD_N-GLC_1	652	657	PF02516	0.612
MOD_N-GLC_2	80	82	PF02516	0.458
MOD_NEK2_1	120	125	PF00069	0.524
MOD_NEK2_1	141	146	PF00069	0.415
MOD_NEK2_1	15	20	PF00069	0.434
MOD_NEK2_1	434	439	PF00069	0.464
MOD_NEK2_1	463	468	PF00069	0.490
MOD_NEK2_1	632	637	PF00069	0.438
MOD_NEK2_1	687	692	PF00069	0.451
MOD_NEK2_1	815	820	PF00069	0.580
MOD_NEK2_2	26	31	PF00069	0.416
MOD_NEK2_2	668	673	PF00069	0.467
MOD_OFUCOSY	432	438	PF10250	0.440
MOD_PIKK_1	189	195	PF00454	0.522
MOD_PIKK_1	301	307	PF00454	0.702
MOD_PIKK_1	804	810	PF00454	0.622
MOD_PIKK_1	813	819	PF00454	0.603
MOD_PKA_1	346	352	PF00069	0.648
MOD_PKA_2	132	138	PF00069	0.472
MOD_PKA_2	141	147	PF00069	0.430
MOD_PKA_2	242	248	PF00069	0.666
MOD_PKA_2	249	255	PF00069	0.636
MOD_PKA_2	260	266	PF00069	0.604
MOD_PKA_2	346	352	PF00069	0.615
MOD_PKA_2	513	519	PF00069	0.523
MOD_PKA_2	648	654	PF00069	0.674
MOD_PKA_2	711	717	PF00069	0.529
MOD_PKB_1	246	254	PF00069	0.647
MOD_Plk_1	115	121	PF00069	0.539
MOD_Plk_1	38	44	PF00069	0.460
MOD_Plk_1	535	541	PF00069	0.574
MOD_Plk_1	687	693	PF00069	0.459
MOD_Plk_1	771	777	PF00069	0.425
MOD_Plk_2-3	536	542	PF00069	0.571
MOD_Plk_4	15	21	PF00069	0.416
MOD_Plk_4	393	399	PF00069	0.597
MOD_Plk_4	463	469	PF00069	0.433
MOD_Plk_4	65	71	PF00069	0.505
MOD_Plk_4	687	693	PF00069	0.441
MOD_ProDKin_1	216	222	PF00069	0.650
MOD_ProDKin_1	250	256	PF00069	0.674
MOD_ProDKin_1	261	267	PF00069	0.688
MOD_ProDKin_1	315	321	PF00069	0.648
MOD_ProDKin_1	495	501	PF00069	0.649
MOD_ProDKin_1	719	725	PF00069	0.600
MOD_SUMO_rev_2	32	41	PF00179	0.376
MOD_SUMO_rev_2	6	15	PF00179	0.387
TRG_DiLeu_BaEn_1	116	121	PF01217	0.551
TRG_DiLeu_BaLyEn_6	46	51	PF01217	0.555
TRG_DiLeu_BaLyEn_6	68	73	PF01217	0.492
TRG_ENDOCYTIC_2	452	455	PF00928	0.418
TRG_ENDOCYTIC_2	458	461	PF00928	0.416
TRG_ENDOCYTIC_2	618	621	PF00928	0.492
TRG_ENDOCYTIC_2	8	11	PF00928	0.367
TRG_ER_diArg_1	452	454	PF00400	0.424
TRG_NES_CRM1_1	776	788	PF08389	0.481
TRG_NLS_Bipartite_1	246	262	PF00514	0.644
TRG_NLS_MonoExtC_3	245	250	PF00514	0.641
TRG_NLS_MonoExtN_4	243	250	PF00514	0.634
TRG_NLS_MonoExtN_4	257	262	PF00514	0.636
TRG_Pf-PMV_PEXEL_1	238	242	PF00026	0.530
TRG_Pf-PMV_PEXEL_1	701	706	PF00026	0.506

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HU94	Leptomonas seymouri	63%	99%
A0A3S7X1F3	Leishmania donovani	92%	100%
A4HGF5	Leishmania braziliensis	77%	100%
A4I3I6	Leishmania infantum	93%	100%
Q4Q8F6	Leishmania major	92%	100%