Gluconokinase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gluconokinase

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AZS7_LEIMU

TriTrypDb:

LmxM.28.1095

Length:

120

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 3
NetGPI	no	yes: 0, no: 3

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AZS7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AZS7

Function

Biological processes
Term	Name	Level	Count
GO:0005975	carbohydrate metabolic process	3	4
GO:0006082	organic acid metabolic process	3	4
GO:0006793	phosphorus metabolic process	3	4
GO:0006796	phosphate-containing compound metabolic process	4	4
GO:0008152	metabolic process	1	4
GO:0009056	catabolic process	2	4
GO:0009987	cellular process	1	4
GO:0016052	carbohydrate catabolic process	4	4
GO:0016054	organic acid catabolic process	4	4
GO:0016310	phosphorylation	5	4
GO:0019520	aldonic acid metabolic process	4	4
GO:0019521	D-gluconate metabolic process	5	4
GO:0019752	carboxylic acid metabolic process	5	4
GO:0032787	monocarboxylic acid metabolic process	6	4
GO:0043436	oxoacid metabolic process	4	4
GO:0044237	cellular metabolic process	2	4
GO:0044238	primary metabolic process	2	4
GO:0044248	cellular catabolic process	3	4
GO:0044262	obsolete cellular carbohydrate metabolic process	3	4
GO:0044275	obsolete cellular carbohydrate catabolic process	4	4
GO:0044281	small molecule metabolic process	2	4
GO:0044282	small molecule catabolic process	3	4
GO:0046176	aldonic acid catabolic process	5	4
GO:0046177	D-gluconate catabolic process	6	4
GO:0046395	carboxylic acid catabolic process	5	4
GO:0071704	organic substance metabolic process	2	4
GO:0072329	monocarboxylic acid catabolic process	6	4
GO:1901575	organic substance catabolic process	3	4

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	4
GO:0003824	catalytic activity	1	4
GO:0005488	binding	1	4
GO:0005524	ATP binding	5	4
GO:0016301	kinase activity	4	4
GO:0016740	transferase activity	2	4
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	4
GO:0017076	purine nucleotide binding	4	4
GO:0030554	adenyl nucleotide binding	5	4
GO:0032553	ribonucleotide binding	3	4
GO:0032555	purine ribonucleotide binding	4	4
GO:0032559	adenyl ribonucleotide binding	5	4
GO:0035639	purine ribonucleoside triphosphate binding	4	4
GO:0036094	small molecule binding	2	4
GO:0043167	ion binding	2	4
GO:0043168	anion binding	3	4
GO:0097159	organic cyclic compound binding	2	4
GO:0097367	carbohydrate derivative binding	2	4
GO:1901265	nucleoside phosphate binding	3	4
GO:1901363	heterocyclic compound binding	2	4
GO:0016773	phosphotransferase activity, alcohol group as acceptor	4	1
GO:0046316	gluconokinase activity	5	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_SKI1_1	113	117	PF00082	0.402
CLV_PCSK_SKI1_1	23	27	PF00082	0.447
CLV_PCSK_SKI1_1	33	37	PF00082	0.663
DEG_APCC_DBOX_1	22	30	PF00400	0.419
DEG_SPOP_SBC_1	115	119	PF00917	0.436
DOC_MAPK_MEF2A_6	6	13	PF00069	0.379
DOC_USP7_MATH_1	115	119	PF00917	0.643
DOC_USP7_MATH_1	7	11	PF00917	0.382
LIG_14-3-3_CanoR_1	113	120	PF00244	0.486
LIG_14-3-3_CanoR_1	6	12	PF00244	0.514
LIG_FHA_1	6	12	PF00498	0.435
LIG_FHA_1	92	98	PF00498	0.462
LIG_LIR_Gen_1	46	56	PF02991	0.610
LIG_LIR_Nem_3	45	51	PF02991	0.602
LIG_MYND_2	100	104	PF01753	0.421
LIG_PDZ_Class_1	115	120	PF00595	0.419
LIG_SUMO_SIM_anti_2	8	13	PF11976	0.409
LIG_SUMO_SIM_par_1	100	106	PF11976	0.377
LIG_SUMO_SIM_par_1	93	99	PF11976	0.410
MOD_GlcNHglycan	15	18	PF01048	0.394
MOD_GlcNHglycan	52	55	PF01048	0.410
MOD_GSK3_1	111	118	PF00069	0.390
MOD_GSK3_1	38	45	PF00069	0.555
MOD_GSK3_1	71	78	PF00069	0.685
MOD_NEK2_1	103	108	PF00069	0.333
MOD_NEK2_1	111	116	PF00069	0.338
MOD_NEK2_1	13	18	PF00069	0.360
MOD_NEK2_1	70	75	PF00069	0.491
MOD_PIKK_1	75	81	PF00454	0.482
MOD_PKA_2	5	11	PF00069	0.465
MOD_Plk_4	7	13	PF00069	0.467
MOD_SUMO_rev_2	53	59	PF00179	0.410
TRG_DiLeu_BaLyEn_6	98	103	PF01217	0.332
TRG_ENDOCYTIC_2	22	25	PF00928	0.349

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A4HGF4	Leishmania braziliensis	76%	100%
A4I3I5	Leishmania infantum	81%	77%