ATP-grasp domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

ATP-grasp domain containing protein, putative

Species:

Leishmania mexicana

UniProt:

E9AZS6_LEIMU

TriTrypDb:

LmxM.28.1090

Length:

871

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AZS6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AZS6

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	10
GO:0005488	binding	1	10
GO:0005524	ATP binding	5	10
GO:0017076	purine nucleotide binding	4	10
GO:0030554	adenyl nucleotide binding	5	10
GO:0032553	ribonucleotide binding	3	10
GO:0032555	purine ribonucleotide binding	4	10
GO:0032559	adenyl ribonucleotide binding	5	10
GO:0035639	purine ribonucleoside triphosphate binding	4	10
GO:0036094	small molecule binding	2	10
GO:0043167	ion binding	2	10
GO:0043168	anion binding	3	10
GO:0043169	cation binding	3	10
GO:0046872	metal ion binding	4	10
GO:0097159	organic cyclic compound binding	2	10
GO:0097367	carbohydrate derivative binding	2	10
GO:1901265	nucleoside phosphate binding	3	10
GO:1901363	heterocyclic compound binding	2	10

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	146	150	PF00656	0.503
CLV_C14_Caspase3-7	294	298	PF00656	0.529
CLV_C14_Caspase3-7	791	795	PF00656	0.604
CLV_NRD_NRD_1	470	472	PF00675	0.512
CLV_NRD_NRD_1	496	498	PF00675	0.410
CLV_NRD_NRD_1	52	54	PF00675	0.599
CLV_NRD_NRD_1	524	526	PF00675	0.559
CLV_NRD_NRD_1	537	539	PF00675	0.619
CLV_NRD_NRD_1	56	58	PF00675	0.593
CLV_PCSK_KEX2_1	496	498	PF00082	0.410
CLV_PCSK_KEX2_1	52	54	PF00082	0.599
CLV_PCSK_KEX2_1	537	539	PF00082	0.687
CLV_PCSK_KEX2_1	56	58	PF00082	0.593
CLV_PCSK_PC7_1	52	58	PF00082	0.523
CLV_PCSK_SKI1_1	390	394	PF00082	0.444
CLV_PCSK_SKI1_1	675	679	PF00082	0.507
CLV_PCSK_SKI1_1	731	735	PF00082	0.546
CLV_PCSK_SKI1_1	759	763	PF00082	0.462
DEG_SPOP_SBC_1	12	16	PF00917	0.765
DEG_SPOP_SBC_1	610	614	PF00917	0.541
DEG_SPOP_SBC_1	772	776	PF00917	0.664
DOC_CKS1_1	65	70	PF01111	0.569
DOC_CKS1_1	685	690	PF01111	0.559
DOC_CYCLIN_yCln2_LP_2	363	369	PF00134	0.485
DOC_CYCLIN_yCln2_LP_2	41	47	PF00134	0.572
DOC_MAPK_gen_1	467	475	PF00069	0.498
DOC_MAPK_MEF2A_6	152	159	PF00069	0.366
DOC_PP1_RVXF_1	388	394	PF00149	0.444
DOC_PP2B_LxvP_1	363	366	PF13499	0.569
DOC_PP2B_LxvP_1	80	83	PF13499	0.491
DOC_PP4_FxxP_1	685	688	PF00568	0.601
DOC_PP4_FxxP_1	696	699	PF00568	0.486
DOC_USP7_MATH_1	13	17	PF00917	0.757
DOC_USP7_MATH_1	183	187	PF00917	0.715
DOC_USP7_MATH_1	195	199	PF00917	0.543
DOC_USP7_MATH_1	240	244	PF00917	0.497
DOC_USP7_MATH_1	318	322	PF00917	0.478
DOC_USP7_MATH_1	35	39	PF00917	0.734
DOC_USP7_MATH_1	491	495	PF00917	0.549
DOC_USP7_MATH_1	633	637	PF00917	0.632
DOC_USP7_MATH_1	717	721	PF00917	0.503
DOC_USP7_MATH_1	772	776	PF00917	0.664
DOC_USP7_MATH_1	804	808	PF00917	0.561
DOC_USP7_MATH_1	840	844	PF00917	0.574
DOC_WW_Pin1_4	209	214	PF00397	0.475
DOC_WW_Pin1_4	568	573	PF00397	0.354
DOC_WW_Pin1_4	61	66	PF00397	0.824
DOC_WW_Pin1_4	684	689	PF00397	0.530
DOC_WW_Pin1_4	695	700	PF00397	0.406
LIG_14-3-3_CanoR_1	123	127	PF00244	0.565
LIG_14-3-3_CanoR_1	390	396	PF00244	0.485
LIG_14-3-3_CanoR_1	479	483	PF00244	0.461
LIG_14-3-3_CanoR_1	496	500	PF00244	0.458
LIG_14-3-3_CanoR_1	525	529	PF00244	0.508
LIG_14-3-3_CanoR_1	573	580	PF00244	0.449
LIG_14-3-3_CanoR_1	609	619	PF00244	0.664
LIG_14-3-3_CanoR_1	632	641	PF00244	0.417
LIG_14-3-3_CanoR_1	690	694	PF00244	0.497
LIG_14-3-3_CanoR_1	806	816	PF00244	0.585
LIG_Actin_WH2_2	445	463	PF00022	0.610
LIG_BIR_III_4	507	511	PF00653	0.466
LIG_Clathr_ClatBox_1	85	89	PF01394	0.425
LIG_CSL_BTD_1	623	626	PF09270	0.473
LIG_deltaCOP1_diTrp_1	436	441	PF00928	0.369
LIG_eIF4E_1	220	226	PF01652	0.542
LIG_eIF4E_1	477	483	PF01652	0.504
LIG_eIF4E_1	580	586	PF01652	0.400
LIG_EVH1_1	624	628	PF00568	0.462
LIG_EVH1_1	80	84	PF00568	0.428
LIG_EVH1_2	54	58	PF00568	0.580
LIG_FHA_1	107	113	PF00498	0.501
LIG_FHA_1	221	227	PF00498	0.576
LIG_FHA_1	229	235	PF00498	0.548
LIG_FHA_1	360	366	PF00498	0.483
LIG_FHA_1	447	453	PF00498	0.501
LIG_FHA_1	460	466	PF00498	0.490
LIG_FHA_1	573	579	PF00498	0.417
LIG_FHA_1	641	647	PF00498	0.429
LIG_FHA_1	672	678	PF00498	0.561
LIG_FHA_1	690	696	PF00498	0.247
LIG_FHA_1	698	704	PF00498	0.410
LIG_FHA_1	736	742	PF00498	0.571
LIG_FHA_1	818	824	PF00498	0.544
LIG_FHA_2	347	353	PF00498	0.516
LIG_FHA_2	383	389	PF00498	0.444
LIG_FHA_2	525	531	PF00498	0.481
LIG_FHA_2	648	654	PF00498	0.547
LIG_FHA_2	661	667	PF00498	0.523
LIG_FHA_2	738	744	PF00498	0.562
LIG_FHA_2	789	795	PF00498	0.753
LIG_LIR_Apic_2	439	444	PF02991	0.446
LIG_LIR_Apic_2	694	699	PF02991	0.493
LIG_LIR_Gen_1	200	211	PF02991	0.489
LIG_LIR_Gen_1	238	246	PF02991	0.476
LIG_LIR_Gen_1	248	258	PF02991	0.385
LIG_LIR_Gen_1	305	314	PF02991	0.614
LIG_LIR_Gen_1	377	386	PF02991	0.369
LIG_LIR_Gen_1	581	589	PF02991	0.396
LIG_LIR_Gen_1	669	678	PF02991	0.442
LIG_LIR_Gen_1	855	864	PF02991	0.495
LIG_LIR_Nem_3	200	206	PF02991	0.517
LIG_LIR_Nem_3	238	244	PF02991	0.456
LIG_LIR_Nem_3	248	253	PF02991	0.408
LIG_LIR_Nem_3	305	311	PF02991	0.634
LIG_LIR_Nem_3	377	382	PF02991	0.369
LIG_LIR_Nem_3	425	431	PF02991	0.399
LIG_LIR_Nem_3	581	586	PF02991	0.384
LIG_LIR_Nem_3	621	627	PF02991	0.512
LIG_LIR_Nem_3	669	673	PF02991	0.418
LIG_Rb_pABgroove_1	471	479	PF01858	0.477
LIG_SH2_CRK	241	245	PF00017	0.509
LIG_SH2_CRK	308	312	PF00017	0.617
LIG_SH2_CRK	428	432	PF00017	0.401
LIG_SH2_CRK	583	587	PF00017	0.432
LIG_SH2_GRB2like	237	240	PF00017	0.526
LIG_SH2_GRB2like	269	272	PF00017	0.452
LIG_SH2_GRB2like	850	853	PF00017	0.490
LIG_SH2_NCK_1	237	241	PF00017	0.553
LIG_SH2_NCK_1	308	312	PF00017	0.617
LIG_SH2_SRC	147	150	PF00017	0.502
LIG_SH2_SRC	237	240	PF00017	0.566
LIG_SH2_SRC	252	255	PF00017	0.538
LIG_SH2_SRC	269	272	PF00017	0.424
LIG_SH2_SRC	415	418	PF00017	0.344
LIG_SH2_STAP1	237	241	PF00017	0.442
LIG_SH2_STAP1	583	587	PF00017	0.438
LIG_SH2_STAT3	477	480	PF00017	0.506
LIG_SH2_STAT5	147	150	PF00017	0.437
LIG_SH2_STAT5	252	255	PF00017	0.503
LIG_SH2_STAT5	269	272	PF00017	0.308
LIG_SH2_STAT5	308	311	PF00017	0.597
LIG_SH2_STAT5	342	345	PF00017	0.434
LIG_SH2_STAT5	346	349	PF00017	0.446
LIG_SH2_STAT5	384	387	PF00017	0.419
LIG_SH2_STAT5	415	418	PF00017	0.325
LIG_SH2_STAT5	421	424	PF00017	0.325
LIG_SH2_STAT5	501	504	PF00017	0.401
LIG_SH2_STAT5	588	591	PF00017	0.356
LIG_SH2_STAT5	850	853	PF00017	0.474
LIG_SH3_1	63	69	PF00018	0.580
LIG_SH3_2	51	56	PF14604	0.592
LIG_SH3_3	25	31	PF00018	0.784
LIG_SH3_3	365	371	PF00018	0.457
LIG_SH3_3	41	47	PF00018	0.548
LIG_SH3_3	48	54	PF00018	0.706
LIG_SH3_3	62	68	PF00018	0.566
LIG_SH3_3	620	626	PF00018	0.491
LIG_SH3_3	677	683	PF00018	0.671
LIG_SH3_3	78	84	PF00018	0.548
LIG_SH3_5	265	269	PF00018	0.417
LIG_SUMO_SIM_par_1	557	562	PF11976	0.436
LIG_SUMO_SIM_par_1	691	698	PF11976	0.490
LIG_SUMO_SIM_par_1	83	89	PF11976	0.361
LIG_TRAF2_1	117	120	PF00917	0.634
LIG_TRAF2_1	455	458	PF00917	0.581
LIG_TRAF2_1	650	653	PF00917	0.564
LIG_TYR_ITIM	426	431	PF00017	0.401
LIG_WRC_WIRS_1	667	672	PF05994	0.443
LIG_WW_3	53	57	PF00397	0.595
MOD_CDC14_SPxK_1	212	215	PF00782	0.524
MOD_CDK_SPK_2	209	214	PF00069	0.511
MOD_CDK_SPK_2	568	573	PF00069	0.368
MOD_CDK_SPxK_1	209	215	PF00069	0.508
MOD_CDK_SPxK_1	684	690	PF00069	0.567
MOD_CK1_1	197	203	PF00069	0.592
MOD_CK1_1	278	284	PF00069	0.518
MOD_CK1_1	321	327	PF00069	0.573
MOD_CK1_1	345	351	PF00069	0.462
MOD_CK1_1	36	42	PF00069	0.577
MOD_CK1_1	402	408	PF00069	0.408
MOD_CK1_1	697	703	PF00069	0.514
MOD_CK1_1	720	726	PF00069	0.543
MOD_CK1_1	807	813	PF00069	0.555
MOD_CK1_1	814	820	PF00069	0.565
MOD_CK2_1	391	397	PF00069	0.387
MOD_CK2_1	452	458	PF00069	0.505
MOD_CK2_1	524	530	PF00069	0.531
MOD_CK2_1	632	638	PF00069	0.412
MOD_CK2_1	647	653	PF00069	0.520
MOD_CK2_1	660	666	PF00069	0.481
MOD_CK2_1	737	743	PF00069	0.566
MOD_CK2_1	772	778	PF00069	0.596
MOD_CMANNOS	438	441	PF00535	0.369
MOD_GlcNHglycan	103	106	PF01048	0.495
MOD_GlcNHglycan	167	170	PF01048	0.548
MOD_GlcNHglycan	185	188	PF01048	0.711
MOD_GlcNHglycan	197	200	PF01048	0.598
MOD_GlcNHglycan	258	261	PF01048	0.471
MOD_GlcNHglycan	372	375	PF01048	0.401
MOD_GlcNHglycan	4	7	PF01048	0.574
MOD_GlcNHglycan	454	457	PF01048	0.585
MOD_GlcNHglycan	48	51	PF01048	0.697
MOD_GlcNHglycan	493	496	PF01048	0.563
MOD_GlcNHglycan	722	725	PF01048	0.541
MOD_GlcNHglycan	727	730	PF01048	0.522
MOD_GlcNHglycan	768	771	PF01048	0.642
MOD_GSK3_1	107	114	PF00069	0.527
MOD_GSK3_1	191	198	PF00069	0.707
MOD_GSK3_1	29	36	PF00069	0.706
MOD_GSK3_1	302	309	PF00069	0.592
MOD_GSK3_1	317	324	PF00069	0.549
MOD_GSK3_1	342	349	PF00069	0.486
MOD_GSK3_1	370	377	PF00069	0.344
MOD_GSK3_1	378	385	PF00069	0.344
MOD_GSK3_1	398	405	PF00069	0.288
MOD_GSK3_1	446	453	PF00069	0.496
MOD_GSK3_1	491	498	PF00069	0.405
MOD_GSK3_1	568	575	PF00069	0.340
MOD_GSK3_1	597	604	PF00069	0.610
MOD_GSK3_1	67	74	PF00069	0.746
MOD_GSK3_1	694	701	PF00069	0.512
MOD_GSK3_1	7	14	PF00069	0.723
MOD_GSK3_1	720	727	PF00069	0.458
MOD_GSK3_1	737	744	PF00069	0.590
MOD_GSK3_1	773	780	PF00069	0.667
MOD_GSK3_1	804	811	PF00069	0.556
MOD_LATS_1	536	542	PF00433	0.440
MOD_N-GLC_1	165	170	PF02516	0.551
MOD_N-GLC_1	191	196	PF02516	0.788
MOD_N-GLC_1	2	7	PF02516	0.618
MOD_N-GLC_1	36	41	PF02516	0.595
MOD_N-GLC_1	541	546	PF02516	0.474
MOD_N-GLC_1	610	615	PF02516	0.464
MOD_N-GLC_2	178	180	PF02516	0.389
MOD_N-GLC_2	513	515	PF02516	0.460
MOD_NEK2_1	1	6	PF00069	0.799
MOD_NEK2_1	165	170	PF00069	0.548
MOD_NEK2_1	673	678	PF00069	0.539
MOD_NEK2_1	735	740	PF00069	0.553
MOD_NEK2_1	805	810	PF00069	0.586
MOD_NEK2_2	147	152	PF00069	0.487
MOD_NMyristoyl	1	7	PF02799	0.553
MOD_PIKK_1	18	24	PF00454	0.772
MOD_PIKK_1	399	405	PF00454	0.344
MOD_PIKK_1	541	547	PF00454	0.667
MOD_PIKK_1	67	73	PF00454	0.780
MOD_PIKK_1	795	801	PF00454	0.635
MOD_PIKK_1	840	846	PF00454	0.594
MOD_PK_1	471	477	PF00069	0.475
MOD_PKA_1	471	477	PF00069	0.475
MOD_PKA_2	122	128	PF00069	0.590
MOD_PKA_2	321	327	PF00069	0.577
MOD_PKA_2	399	405	PF00069	0.423
MOD_PKA_2	478	484	PF00069	0.506
MOD_PKA_2	495	501	PF00069	0.507
MOD_PKA_2	524	530	PF00069	0.468
MOD_PKA_2	572	578	PF00069	0.452
MOD_PKA_2	59	65	PF00069	0.621
MOD_PKA_2	633	639	PF00069	0.644
MOD_PKA_2	671	677	PF00069	0.476
MOD_PKA_2	689	695	PF00069	0.239
MOD_PKA_2	765	771	PF00069	0.588
MOD_PKA_2	805	811	PF00069	0.561
MOD_PKB_1	189	197	PF00069	0.485
MOD_PKB_1	757	765	PF00069	0.582
MOD_Plk_1	36	42	PF00069	0.596
MOD_Plk_1	499	505	PF00069	0.459
MOD_Plk_1	814	820	PF00069	0.569
MOD_Plk_1	854	860	PF00069	0.563
MOD_Plk_2-3	788	794	PF00069	0.711
MOD_Plk_4	111	117	PF00069	0.544
MOD_Plk_4	240	246	PF00069	0.494
MOD_Plk_4	359	365	PF00069	0.508
MOD_Plk_4	478	484	PF00069	0.427
MOD_Plk_4	581	587	PF00069	0.494
MOD_Plk_4	641	647	PF00069	0.453
MOD_Plk_4	814	820	PF00069	0.511
MOD_ProDKin_1	209	215	PF00069	0.471
MOD_ProDKin_1	568	574	PF00069	0.347
MOD_ProDKin_1	61	67	PF00069	0.823
MOD_ProDKin_1	684	690	PF00069	0.528
MOD_ProDKin_1	695	701	PF00069	0.402
MOD_SUMO_for_1	548	551	PF00179	0.706
TRG_DiLeu_BaEn_1	89	94	PF01217	0.530
TRG_DiLeu_BaLyEn_6	206	211	PF01217	0.468
TRG_DiLeu_BaLyEn_6	41	46	PF01217	0.580
TRG_DiLeu_BaLyEn_6	81	86	PF01217	0.655
TRG_ENDOCYTIC_2	241	244	PF00928	0.425
TRG_ENDOCYTIC_2	308	311	PF00928	0.611
TRG_ENDOCYTIC_2	428	431	PF00928	0.369
TRG_ENDOCYTIC_2	583	586	PF00928	0.357
TRG_ENDOCYTIC_2	853	856	PF00928	0.545
TRG_ER_diArg_1	206	209	PF00400	0.470
TRG_ER_diArg_1	51	53	PF00400	0.821
TRG_ER_diArg_1	537	539	PF00400	0.694
TRG_ER_diArg_1	55	57	PF00400	0.571
TRG_ER_diArg_1	631	634	PF00400	0.588
TRG_Pf-PMV_PEXEL_1	662	666	PF00026	0.488
TRG_Pf-PMV_PEXEL_1	784	788	PF00026	0.517

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P453	Leptomonas seymouri	48%	100%
A0A0S4IPI1	Bodo saltans	31%	100%
A0A3S7X1H2	Leishmania donovani	92%	100%
A4HGF3	Leishmania braziliensis	78%	100%
A4I3I4	Leishmania infantum	92%	100%
D0A7V8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	35%	100%
Q4Q8F8	Leishmania major	91%	100%
V5BEJ5	Trypanosoma cruzi	33%	100%