Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AZS5_LEIMU

TriTrypDb:

LmxM.28.1080

Length:

723

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0020023	kinetoplast	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AZS5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AZS5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	126	128	PF00675	0.510
CLV_NRD_NRD_1	353	355	PF00675	0.463
CLV_NRD_NRD_1	426	428	PF00675	0.663
CLV_NRD_NRD_1	434	436	PF00675	0.438
CLV_NRD_NRD_1	575	577	PF00675	0.563
CLV_NRD_NRD_1	583	585	PF00675	0.551
CLV_NRD_NRD_1	693	695	PF00675	0.699
CLV_NRD_NRD_1	7	9	PF00675	0.648
CLV_NRD_NRD_1	84	86	PF00675	0.648
CLV_NRD_NRD_1	89	91	PF00675	0.496
CLV_PCSK_FUR_1	124	128	PF00082	0.617
CLV_PCSK_KEX2_1	124	126	PF00082	0.512
CLV_PCSK_KEX2_1	190	192	PF00082	0.488
CLV_PCSK_KEX2_1	386	388	PF00082	0.522
CLV_PCSK_KEX2_1	425	427	PF00082	0.640
CLV_PCSK_KEX2_1	455	457	PF00082	0.372
CLV_PCSK_KEX2_1	575	577	PF00082	0.563
CLV_PCSK_KEX2_1	583	585	PF00082	0.551
CLV_PCSK_KEX2_1	693	695	PF00082	0.652
CLV_PCSK_KEX2_1	7	9	PF00082	0.705
CLV_PCSK_KEX2_1	84	86	PF00082	0.752
CLV_PCSK_PC1ET2_1	190	192	PF00082	0.511
CLV_PCSK_PC1ET2_1	386	388	PF00082	0.446
CLV_PCSK_PC1ET2_1	455	457	PF00082	0.294
CLV_PCSK_SKI1_1	150	154	PF00082	0.437
CLV_PCSK_SKI1_1	162	166	PF00082	0.520
CLV_PCSK_SKI1_1	251	255	PF00082	0.567
CLV_PCSK_SKI1_1	355	359	PF00082	0.435
CLV_PCSK_SKI1_1	383	387	PF00082	0.332
CLV_PCSK_SKI1_1	435	439	PF00082	0.544
CLV_PCSK_SKI1_1	456	460	PF00082	0.422
CLV_PCSK_SKI1_1	465	469	PF00082	0.423
CLV_PCSK_SKI1_1	510	514	PF00082	0.587
CLV_PCSK_SKI1_1	644	648	PF00082	0.594
CLV_PCSK_SKI1_1	677	681	PF00082	0.503
DEG_Nend_Nbox_1	1	3	PF02207	0.673
DEG_SPOP_SBC_1	34	38	PF00917	0.599
DEG_SPOP_SBC_1	556	560	PF00917	0.655
DOC_CKS1_1	545	550	PF01111	0.542
DOC_CYCLIN_yCln2_LP_2	274	277	PF00134	0.472
DOC_CYCLIN_yCln2_LP_2	468	474	PF00134	0.605
DOC_MAPK_FxFP_2	472	475	PF00069	0.676
DOC_MAPK_gen_1	108	115	PF00069	0.542
DOC_MAPK_gen_1	116	123	PF00069	0.545
DOC_MAPK_gen_1	190	198	PF00069	0.422
DOC_MAPK_gen_1	296	305	PF00069	0.623
DOC_MAPK_gen_1	712	720	PF00069	0.668
DOC_MAPK_MEF2A_6	298	307	PF00069	0.611
DOC_MAPK_MEF2A_6	714	722	PF00069	0.658
DOC_PP1_RVXF_1	138	144	PF00149	0.527
DOC_PP1_RVXF_1	148	155	PF00149	0.429
DOC_PP2B_LxvP_1	20	23	PF13499	0.671
DOC_PP2B_LxvP_1	206	209	PF13499	0.513
DOC_PP2B_LxvP_1	274	277	PF13499	0.472
DOC_PP4_FxxP_1	143	146	PF00568	0.514
DOC_PP4_FxxP_1	217	220	PF00568	0.529
DOC_PP4_FxxP_1	472	475	PF00568	0.518
DOC_USP7_MATH_1	23	27	PF00917	0.698
DOC_USP7_MATH_1	34	38	PF00917	0.715
DOC_USP7_MATH_1	451	455	PF00917	0.318
DOC_USP7_MATH_1	475	479	PF00917	0.425
DOC_USP7_MATH_1	550	554	PF00917	0.625
DOC_USP7_MATH_1	556	560	PF00917	0.658
DOC_USP7_MATH_1	591	595	PF00917	0.766
DOC_USP7_MATH_1	654	658	PF00917	0.763
DOC_USP7_MATH_1	80	84	PF00917	0.642
DOC_USP7_MATH_2	277	283	PF00917	0.485
DOC_WW_Pin1_4	21	26	PF00397	0.645
DOC_WW_Pin1_4	544	549	PF00397	0.539
DOC_WW_Pin1_4	583	588	PF00397	0.710
DOC_WW_Pin1_4	652	657	PF00397	0.683
DOC_WW_Pin1_4	698	703	PF00397	0.683
LIG_14-3-3_CanoR_1	175	183	PF00244	0.416
LIG_14-3-3_CanoR_1	244	248	PF00244	0.542
LIG_14-3-3_CanoR_1	328	332	PF00244	0.572
LIG_14-3-3_CanoR_1	456	461	PF00244	0.459
LIG_14-3-3_CanoR_1	55	61	PF00244	0.674
LIG_14-3-3_CanoR_1	712	722	PF00244	0.566
LIG_14-3-3_CanoR_1	74	80	PF00244	0.571
LIG_14-3-3_CanoR_1	84	88	PF00244	0.604
LIG_APCC_ABBA_1	399	404	PF00400	0.448
LIG_BIR_III_2	649	653	PF00653	0.645
LIG_BRCT_BRCA1_1	281	285	PF00533	0.514
LIG_deltaCOP1_diTrp_1	212	217	PF00928	0.541
LIG_deltaCOP1_diTrp_1	279	285	PF00928	0.505
LIG_DLG_GKlike_1	179	187	PF00625	0.237
LIG_eIF4E_1	269	275	PF01652	0.487
LIG_FHA_1	175	181	PF00498	0.321
LIG_FHA_1	216	222	PF00498	0.478
LIG_FHA_1	357	363	PF00498	0.390
LIG_FHA_1	66	72	PF00498	0.594
LIG_FHA_1	680	686	PF00498	0.720
LIG_FHA_2	208	214	PF00498	0.404
LIG_FHA_2	337	343	PF00498	0.348
LIG_FHA_2	457	463	PF00498	0.373
LIG_FHA_2	522	528	PF00498	0.340
LIG_FHA_2	544	550	PF00498	0.704
LIG_FHA_2	55	61	PF00498	0.627
LIG_FHA_2	619	625	PF00498	0.675
LIG_FHA_2	653	659	PF00498	0.707
LIG_FHA_2	703	709	PF00498	0.676
LIG_LIR_Apic_2	215	220	PF02991	0.542
LIG_LIR_Apic_2	469	475	PF02991	0.620
LIG_LIR_Gen_1	178	188	PF02991	0.473
LIG_LIR_Gen_1	212	221	PF02991	0.537
LIG_LIR_Gen_1	259	270	PF02991	0.483
LIG_LIR_Gen_1	454	463	PF02991	0.520
LIG_LIR_Gen_1	483	493	PF02991	0.507
LIG_LIR_Gen_1	535	545	PF02991	0.556
LIG_LIR_Nem_3	178	184	PF02991	0.468
LIG_LIR_Nem_3	212	217	PF02991	0.414
LIG_LIR_Nem_3	259	265	PF02991	0.447
LIG_LIR_Nem_3	282	288	PF02991	0.527
LIG_LIR_Nem_3	378	382	PF02991	0.429
LIG_LIR_Nem_3	454	460	PF02991	0.499
LIG_LIR_Nem_3	469	473	PF02991	0.492
LIG_LIR_Nem_3	483	489	PF02991	0.358
LIG_LIR_Nem_3	495	500	PF02991	0.518
LIG_LIR_Nem_3	535	541	PF02991	0.548
LIG_PCNA_yPIPBox_3	328	341	PF02747	0.518
LIG_PDZ_Class_2	718	723	PF00595	0.719
LIG_Pex14_1	281	285	PF04695	0.514
LIG_Pex14_1	75	79	PF04695	0.584
LIG_Pex14_2	470	474	PF04695	0.613
LIG_PTB_Apo_2	506	513	PF02174	0.654
LIG_RPA_C_Fungi	113	125	PF08784	0.468
LIG_SH2_CRK	457	461	PF00017	0.500
LIG_SH2_CRK	497	501	PF00017	0.579
LIG_SH2_SRC	531	534	PF00017	0.583
LIG_SH2_STAP1	231	235	PF00017	0.473
LIG_SH2_STAP1	312	316	PF00017	0.452
LIG_SH2_STAT3	129	132	PF00017	0.585
LIG_SH2_STAT5	247	250	PF00017	0.581
LIG_SH2_STAT5	264	267	PF00017	0.432
LIG_SH2_STAT5	269	272	PF00017	0.411
LIG_SH2_STAT5	441	444	PF00017	0.551
LIG_SH2_STAT5	473	476	PF00017	0.596
LIG_SH2_STAT5	490	493	PF00017	0.288
LIG_SH2_STAT5	604	607	PF00017	0.608
LIG_SH2_STAT5	97	100	PF00017	0.546
LIG_SH3_3	149	155	PF00018	0.516
LIG_SH3_3	284	290	PF00018	0.496
LIG_SH3_3	539	545	PF00018	0.603
LIG_TRAF2_1	330	333	PF00917	0.542
LIG_TRAF2_1	413	416	PF00917	0.536
LIG_TRAF2_1	621	624	PF00917	0.576
LIG_TRFH_1	541	545	PF08558	0.606
LIG_UBA3_1	184	190	PF00899	0.475
MOD_CDK_SPxK_1	583	589	PF00069	0.688
MOD_CDK_SPxxK_3	21	28	PF00069	0.549
MOD_CK1_1	21	27	PF00069	0.749
MOD_CK1_1	237	243	PF00069	0.473
MOD_CK1_1	308	314	PF00069	0.446
MOD_CK1_1	327	333	PF00069	0.538
MOD_CK1_1	35	41	PF00069	0.589
MOD_CK1_1	480	486	PF00069	0.365
MOD_CK1_1	555	561	PF00069	0.650
MOD_CK1_1	563	569	PF00069	0.558
MOD_CK1_1	571	577	PF00069	0.629
MOD_CK1_1	710	716	PF00069	0.716
MOD_CK1_1	83	89	PF00069	0.613
MOD_CK2_1	327	333	PF00069	0.439
MOD_CK2_1	336	342	PF00069	0.411
MOD_CK2_1	365	371	PF00069	0.420
MOD_CK2_1	410	416	PF00069	0.539
MOD_CK2_1	521	527	PF00069	0.484
MOD_CK2_1	543	549	PF00069	0.673
MOD_CK2_1	556	562	PF00069	0.672
MOD_CK2_1	618	624	PF00069	0.687
MOD_CK2_1	652	658	PF00069	0.741
MOD_CK2_1	702	708	PF00069	0.721
MOD_Cter_Amidation	423	426	PF01082	0.536
MOD_Cter_Amidation	433	436	PF01082	0.440
MOD_GlcNHglycan	477	480	PF01048	0.406
MOD_GlcNHglycan	504	507	PF01048	0.607
MOD_GlcNHglycan	552	555	PF01048	0.658
MOD_GlcNHglycan	662	665	PF01048	0.615
MOD_GlcNHglycan	708	712	PF01048	0.616
MOD_GlcNHglycan	715	718	PF01048	0.540
MOD_GSK3_1	175	182	PF00069	0.544
MOD_GSK3_1	215	222	PF00069	0.485
MOD_GSK3_1	230	237	PF00069	0.437
MOD_GSK3_1	243	250	PF00069	0.392
MOD_GSK3_1	301	308	PF00069	0.510
MOD_GSK3_1	32	39	PF00069	0.558
MOD_GSK3_1	552	559	PF00069	0.636
MOD_GSK3_1	56	63	PF00069	0.631
MOD_GSK3_1	574	581	PF00069	0.739
MOD_GSK3_1	585	592	PF00069	0.705
MOD_GSK3_1	685	692	PF00069	0.630
MOD_GSK3_1	698	705	PF00069	0.746
MOD_GSK3_1	74	81	PF00069	0.602
MOD_N-GLC_1	158	163	PF02516	0.607
MOD_NEK2_1	157	162	PF00069	0.547
MOD_NEK2_1	229	234	PF00069	0.517
MOD_NEK2_1	245	250	PF00069	0.446
MOD_NEK2_1	270	275	PF00069	0.498
MOD_NEK2_1	32	37	PF00069	0.619
MOD_NEK2_1	499	504	PF00069	0.516
MOD_NEK2_1	65	70	PF00069	0.624
MOD_NEK2_2	257	262	PF00069	0.518
MOD_NEK2_2	418	423	PF00069	0.506
MOD_PIKK_1	679	685	PF00454	0.701
MOD_PKA_1	108	114	PF00069	0.623
MOD_PKA_1	426	432	PF00069	0.613
MOD_PKA_2	174	180	PF00069	0.464
MOD_PKA_2	243	249	PF00069	0.533
MOD_PKA_2	327	333	PF00069	0.573
MOD_PKA_2	426	432	PF00069	0.600
MOD_PKA_2	54	60	PF00069	0.772
MOD_PKA_2	574	580	PF00069	0.662
MOD_PKA_2	713	719	PF00069	0.507
MOD_PKA_2	73	79	PF00069	0.691
MOD_PKA_2	83	89	PF00069	0.738
MOD_PKB_1	694	702	PF00069	0.657
MOD_Plk_1	119	125	PF00069	0.625
MOD_Plk_1	158	164	PF00069	0.636
MOD_Plk_1	270	276	PF00069	0.477
MOD_Plk_1	308	314	PF00069	0.283
MOD_Plk_1	615	621	PF00069	0.694
MOD_Plk_2-3	336	342	PF00069	0.271
MOD_Plk_2-3	521	527	PF00069	0.582
MOD_Plk_4	230	236	PF00069	0.497
MOD_Plk_4	257	263	PF00069	0.509
MOD_Plk_4	336	342	PF00069	0.526
MOD_Plk_4	375	381	PF00069	0.518
MOD_Plk_4	60	66	PF00069	0.740
MOD_ProDKin_1	21	27	PF00069	0.644
MOD_ProDKin_1	544	550	PF00069	0.539
MOD_ProDKin_1	583	589	PF00069	0.711
MOD_ProDKin_1	652	658	PF00069	0.684
MOD_ProDKin_1	698	704	PF00069	0.684
MOD_SUMO_rev_2	101	111	PF00179	0.565
MOD_SUMO_rev_2	136	141	PF00179	0.528
MOD_SUMO_rev_2	351	357	PF00179	0.549
MOD_SUMO_rev_2	368	375	PF00179	0.395
MOD_SUMO_rev_2	378	388	PF00179	0.486
MOD_SUMO_rev_2	413	418	PF00179	0.496
MOD_SUMO_rev_2	638	643	PF00179	0.725
MOD_SUMO_rev_2	678	688	PF00179	0.494
TRG_DiLeu_BaEn_1	192	197	PF01217	0.337
TRG_DiLeu_BaEn_1	333	338	PF01217	0.432
TRG_DiLeu_BaLyEn_6	28	33	PF01217	0.471
TRG_DiLeu_BaLyEn_6	99	104	PF01217	0.589
TRG_ENDOCYTIC_2	242	245	PF00928	0.527
TRG_ENDOCYTIC_2	420	423	PF00928	0.445
TRG_ENDOCYTIC_2	457	460	PF00928	0.498
TRG_ENDOCYTIC_2	473	476	PF00928	0.403
TRG_ENDOCYTIC_2	490	493	PF00928	0.382
TRG_ENDOCYTIC_2	497	500	PF00928	0.565
TRG_ENDOCYTIC_2	538	541	PF00928	0.672
TRG_ER_diArg_1	115	118	PF00400	0.491
TRG_ER_diArg_1	123	126	PF00400	0.508
TRG_ER_diArg_1	425	427	PF00400	0.584
TRG_ER_diArg_1	6	8	PF00400	0.612
TRG_ER_diArg_1	693	696	PF00400	0.720
TRG_ER_diArg_1	87	90	PF00400	0.683
TRG_NES_CRM1_1	195	207	PF08389	0.515
TRG_NLS_MonoExtN_4	88	94	PF00514	0.488
TRG_Pf-PMV_PEXEL_1	194	199	PF00026	0.544
TRG_Pf-PMV_PEXEL_1	406	411	PF00026	0.337

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4J5	Leptomonas seymouri	42%	100%
A0A1X0NYQ6	Trypanosomatidae	30%	100%
A0A3Q8IAY3	Leishmania donovani	87%	100%
A0A3R7LLJ8	Trypanosoma rangeli	29%	100%
A4HGF2	Leishmania braziliensis	70%	100%
A4I3I3	Leishmania infantum	87%	100%
D0A7W0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	31%	100%
Q4Q8F9	Leishmania major	86%	100%
V5DAI7	Trypanosoma cruzi	30%	100%