IRS-type PTB domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AZS3_LEIMU

TriTrypDb:

LmxM.28.1060

Length:

408

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AZS3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AZS3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	13	17	PF00656	0.756
CLV_NRD_NRD_1	140	142	PF00675	0.598
CLV_NRD_NRD_1	145	147	PF00675	0.590
CLV_NRD_NRD_1	210	212	PF00675	0.681
CLV_NRD_NRD_1	24	26	PF00675	0.653
CLV_NRD_NRD_1	249	251	PF00675	0.760
CLV_NRD_NRD_1	350	352	PF00675	0.707
CLV_NRD_NRD_1	87	89	PF00675	0.648
CLV_PCSK_FUR_1	208	212	PF00082	0.715
CLV_PCSK_KEX2_1	140	142	PF00082	0.598
CLV_PCSK_KEX2_1	19	21	PF00082	0.639
CLV_PCSK_KEX2_1	210	212	PF00082	0.680
CLV_PCSK_KEX2_1	24	26	PF00082	0.634
CLV_PCSK_KEX2_1	350	352	PF00082	0.707
CLV_PCSK_KEX2_1	87	89	PF00082	0.643
CLV_PCSK_PC1ET2_1	19	21	PF00082	0.699
CLV_PCSK_PC7_1	15	21	PF00082	0.640
CLV_PCSK_SKI1_1	184	188	PF00082	0.615
DEG_COP1_1	130	137	PF00400	0.679
DEG_Nend_Nbox_1	1	3	PF02207	0.594
DOC_PP4_FxxP_1	258	261	PF00568	0.698
DOC_USP7_MATH_1	111	115	PF00917	0.627
DOC_USP7_MATH_1	119	123	PF00917	0.773
DOC_USP7_MATH_1	185	189	PF00917	0.643
DOC_USP7_MATH_1	225	229	PF00917	0.773
DOC_USP7_MATH_1	252	256	PF00917	0.696
DOC_USP7_UBL2_3	284	288	PF12436	0.689
DOC_WW_Pin1_4	213	218	PF00397	0.742
DOC_WW_Pin1_4	257	262	PF00397	0.630
DOC_WW_Pin1_4	289	294	PF00397	0.712
DOC_WW_Pin1_4	374	379	PF00397	0.742
LIG_14-3-3_CanoR_1	123	127	PF00244	0.718
LIG_14-3-3_CanoR_1	221	225	PF00244	0.633
LIG_14-3-3_CanoR_1	87	92	PF00244	0.509
LIG_APCC_ABBA_1	325	330	PF00400	0.564
LIG_BIR_III_2	398	402	PF00653	0.503
LIG_BRCT_BRCA1_1	254	258	PF00533	0.692
LIG_FHA_1	123	129	PF00498	0.674
LIG_FHA_1	176	182	PF00498	0.792
LIG_FHA_1	5	11	PF00498	0.725
LIG_FHA_1	91	97	PF00498	0.487
LIG_FHA_2	134	140	PF00498	0.605
LIG_FHA_2	148	154	PF00498	0.599
LIG_LIR_Apic_2	255	261	PF02991	0.685
LIG_LIR_Gen_1	153	163	PF02991	0.621
LIG_LIR_Nem_3	153	159	PF02991	0.614
LIG_MYND_1	401	405	PF01753	0.608
LIG_Rb_pABgroove_1	356	364	PF01858	0.486
LIG_SH2_GRB2like	302	305	PF00017	0.748
LIG_SH2_GRB2like	333	336	PF00017	0.515
LIG_SH2_SRC	302	305	PF00017	0.634
LIG_SH2_SRC	333	336	PF00017	0.648
LIG_SH2_STAP1	311	315	PF00017	0.585
LIG_SH2_STAP1	362	366	PF00017	0.676
LIG_SH2_STAP1	395	399	PF00017	0.692
LIG_SH2_STAT3	316	319	PF00017	0.606
LIG_SH2_STAT5	296	299	PF00017	0.672
LIG_SH3_1	201	207	PF00018	0.616
LIG_SH3_1	239	245	PF00018	0.521
LIG_SH3_3	201	207	PF00018	0.618
LIG_SH3_3	239	245	PF00018	0.526
LIG_SH3_3	277	283	PF00018	0.602
LIG_SH3_3	86	92	PF00018	0.544
LIG_SH3_4	284	291	PF00018	0.692
LIG_SH3_CIN85_PxpxPR_1	163	168	PF14604	0.525
LIG_WW_1	293	296	PF00397	0.606
MOD_CK1_1	122	128	PF00069	0.717
MOD_CK1_1	151	157	PF00069	0.538
MOD_CK1_1	219	225	PF00069	0.536
MOD_CK1_1	90	96	PF00069	0.521
MOD_CK2_1	147	153	PF00069	0.566
MOD_CK2_1	220	226	PF00069	0.767
MOD_CK2_1	374	380	PF00069	0.675
MOD_Cter_Amidation	208	211	PF01082	0.689
MOD_Cter_Amidation	22	25	PF01082	0.634
MOD_Cter_Amidation	85	88	PF01082	0.523
MOD_GlcNHglycan	119	122	PF01048	0.835
MOD_GlcNHglycan	153	156	PF01048	0.702
MOD_GlcNHglycan	181	184	PF01048	0.747
MOD_GlcNHglycan	21	24	PF01048	0.751
MOD_GlcNHglycan	226	230	PF01048	0.776
MOD_GlcNHglycan	75	78	PF01048	0.656
MOD_GlcNHglycan	80	83	PF01048	0.767
MOD_GlcNHglycan	89	92	PF01048	0.649
MOD_GSK3_1	147	154	PF00069	0.658
MOD_GSK3_1	175	182	PF00069	0.791
MOD_GSK3_1	215	222	PF00069	0.727
MOD_GSK3_1	310	317	PF00069	0.598
MOD_GSK3_1	34	41	PF00069	0.526
MOD_GSK3_1	97	104	PF00069	0.496
MOD_N-GLC_1	128	133	PF02516	0.635
MOD_N-GLC_1	219	224	PF02516	0.724
MOD_NEK2_1	361	366	PF00069	0.713
MOD_PIKK_1	122	128	PF00454	0.717
MOD_PIKK_1	314	320	PF00454	0.507
MOD_PIKK_1	38	44	PF00454	0.502
MOD_PKA_1	19	25	PF00069	0.636
MOD_PKA_1	87	93	PF00069	0.688
MOD_PKA_2	122	128	PF00069	0.717
MOD_PKA_2	157	163	PF00069	0.510
MOD_PKA_2	19	25	PF00069	0.643
MOD_PKA_2	220	226	PF00069	0.634
MOD_PKA_2	305	311	PF00069	0.702
MOD_PKA_2	87	93	PF00069	0.688
MOD_Plk_1	219	225	PF00069	0.702
MOD_Plk_4	63	69	PF00069	0.557
MOD_ProDKin_1	213	219	PF00069	0.742
MOD_ProDKin_1	257	263	PF00069	0.627
MOD_ProDKin_1	289	295	PF00069	0.715
MOD_ProDKin_1	374	380	PF00069	0.741
MOD_SUMO_rev_2	359	366	PF00179	0.487
TRG_ER_diArg_1	207	210	PF00400	0.703
TRG_ER_diArg_1	87	89	PF00400	0.757

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P454	Leptomonas seymouri	40%	100%
A0A3S7X1G1	Leishmania donovani	85%	100%
A4HGF0	Leishmania braziliensis	60%	100%
A4I3I1	Leishmania infantum	86%	100%
Q4Q8G1	Leishmania major	89%	100%