Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AZS2_LEIMU

TriTrypDb:

LmxM.28.1050

Length:

408

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AZS2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AZS2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	195	197	PF00675	0.549
CLV_NRD_NRD_1	249	251	PF00675	0.415
CLV_NRD_NRD_1	286	288	PF00675	0.307
CLV_NRD_NRD_1	82	84	PF00675	0.467
CLV_PCSK_KEX2_1	195	197	PF00082	0.549
CLV_PCSK_KEX2_1	249	251	PF00082	0.415
CLV_PCSK_KEX2_1	286	288	PF00082	0.307
CLV_PCSK_SKI1_1	195	199	PF00082	0.396
DEG_APCC_DBOX_1	180	188	PF00400	0.401
DEG_APCC_DBOX_1	82	90	PF00400	0.427
DEG_SCF_FBW7_1	10	17	PF00400	0.497
DEG_SPOP_SBC_1	134	138	PF00917	0.625
DEG_SPOP_SBC_1	54	58	PF00917	0.473
DOC_CYCLIN_RxL_1	283	294	PF00134	0.334
DOC_MAPK_RevD_3	182	196	PF00069	0.411
DOC_PP1_RVXF_1	284	291	PF00149	0.367
DOC_PP2B_LxvP_1	378	381	PF13499	0.343
DOC_PP4_FxxP_1	20	23	PF00568	0.509
DOC_PP4_FxxP_1	226	229	PF00568	0.457
DOC_USP7_MATH_1	15	19	PF00917	0.674
DOC_USP7_MATH_1	159	163	PF00917	0.348
DOC_USP7_MATH_1	239	243	PF00917	0.418
DOC_USP7_MATH_1	312	316	PF00917	0.519
DOC_USP7_MATH_1	396	400	PF00917	0.500
DOC_USP7_MATH_1	54	58	PF00917	0.516
DOC_USP7_MATH_2	128	134	PF00917	0.583
DOC_WW_Pin1_4	10	15	PF00397	0.587
DOC_WW_Pin1_4	225	230	PF00397	0.733
DOC_WW_Pin1_4	293	298	PF00397	0.459
DOC_WW_Pin1_4	326	331	PF00397	0.445
DOC_WW_Pin1_4	345	350	PF00397	0.397
LIG_14-3-3_CanoR_1	331	336	PF00244	0.591
LIG_14-3-3_CanoR_1	386	394	PF00244	0.422
LIG_14-3-3_CanoR_1	400	404	PF00244	0.362
LIG_14-3-3_CanoR_1	9	16	PF00244	0.711
LIG_AP2alpha_1	222	226	PF02296	0.472
LIG_BIR_II_1	1	5	PF00653	0.680
LIG_BIR_III_4	49	53	PF00653	0.551
LIG_BRCT_BRCA1_1	16	20	PF00533	0.506
LIG_BRCT_BRCA1_1	218	222	PF00533	0.598
LIG_BRCT_BRCA1_1	314	318	PF00533	0.432
LIG_BRCT_BRCA1_1	331	335	PF00533	0.343
LIG_DLG_GKlike_1	331	338	PF00625	0.488
LIG_FHA_1	135	141	PF00498	0.474
LIG_FHA_2	166	172	PF00498	0.460
LIG_FHA_2	228	234	PF00498	0.430
LIG_LIR_Apic_2	17	23	PF02991	0.506
LIG_LIR_Apic_2	202	208	PF02991	0.483
LIG_LIR_Apic_2	224	229	PF02991	0.464
LIG_LIR_Apic_2	265	271	PF02991	0.465
LIG_LIR_Gen_1	219	229	PF02991	0.600
LIG_LIR_Nem_3	115	119	PF02991	0.496
LIG_LIR_Nem_3	219	225	PF02991	0.604
LIG_LIR_Nem_3	332	338	PF02991	0.462
LIG_LIR_Nem_3	97	102	PF02991	0.313
LIG_Pex14_2	222	226	PF04695	0.472
LIG_RPA_C_Fungi	395	407	PF08784	0.446
LIG_SH2_CRK	205	209	PF00017	0.490
LIG_SH2_NCK_1	205	209	PF00017	0.490
LIG_SH2_PTP2	268	271	PF00017	0.471
LIG_SH2_SRC	150	153	PF00017	0.375
LIG_SH2_STAP1	70	74	PF00017	0.377
LIG_SH2_STAT5	102	105	PF00017	0.372
LIG_SH2_STAT5	150	153	PF00017	0.375
LIG_SH2_STAT5	268	271	PF00017	0.471
LIG_SH2_STAT5	358	361	PF00017	0.383
LIG_SH3_2	101	106	PF14604	0.473
LIG_SH3_3	150	156	PF00018	0.377
LIG_SH3_3	98	104	PF00018	0.479
LIG_SUMO_SIM_anti_2	399	405	PF11976	0.434
LIG_SUMO_SIM_par_1	118	124	PF11976	0.459
LIG_TRAF2_1	230	233	PF00917	0.427
MOD_CDK_SPK_2	326	331	PF00069	0.438
MOD_CDK_SPxxK_3	326	333	PF00069	0.411
MOD_CK1_1	133	139	PF00069	0.657
MOD_CK1_1	228	234	PF00069	0.677
MOD_CK1_1	235	241	PF00069	0.469
MOD_CK1_1	329	335	PF00069	0.493
MOD_CK1_1	399	405	PF00069	0.480
MOD_CK1_1	57	63	PF00069	0.467
MOD_CK2_1	227	233	PF00069	0.438
MOD_GlcNHglycan	132	135	PF01048	0.582
MOD_GlcNHglycan	161	164	PF01048	0.424
MOD_GlcNHglycan	17	20	PF01048	0.687
MOD_GlcNHglycan	184	187	PF01048	0.326
MOD_GlcNHglycan	343	346	PF01048	0.389
MOD_GlcNHglycan	388	391	PF01048	0.364
MOD_GlcNHglycan	404	407	PF01048	0.377
MOD_GlcNHglycan	92	95	PF01048	0.499
MOD_GSK3_1	10	17	PF00069	0.652
MOD_GSK3_1	128	135	PF00069	0.601
MOD_GSK3_1	228	235	PF00069	0.624
MOD_GSK3_1	258	265	PF00069	0.391
MOD_GSK3_1	325	332	PF00069	0.659
MOD_GSK3_1	341	348	PF00069	0.283
MOD_GSK3_1	53	60	PF00069	0.514
MOD_GSK3_1	90	97	PF00069	0.439
MOD_N-GLC_1	396	401	PF02516	0.488
MOD_NEK2_1	262	267	PF00069	0.440
MOD_NEK2_1	313	318	PF00069	0.501
MOD_NEK2_1	341	346	PF00069	0.325
MOD_NEK2_1	79	84	PF00069	0.550
MOD_NEK2_2	281	286	PF00069	0.368
MOD_NEK2_2	94	99	PF00069	0.293
MOD_PIKK_1	239	245	PF00454	0.476
MOD_PKA_2	206	212	PF00069	0.485
MOD_PKA_2	399	405	PF00069	0.448
MOD_PKA_2	8	14	PF00069	0.753
MOD_Plk_4	112	118	PF00069	0.423
MOD_Plk_4	136	142	PF00069	0.556
MOD_Plk_4	380	386	PF00069	0.522
MOD_Plk_4	94	100	PF00069	0.297
MOD_ProDKin_1	10	16	PF00069	0.588
MOD_ProDKin_1	225	231	PF00069	0.729
MOD_ProDKin_1	293	299	PF00069	0.454
MOD_ProDKin_1	326	332	PF00069	0.434
MOD_ProDKin_1	345	351	PF00069	0.391
TRG_DiLeu_BaLyEn_6	153	158	PF01217	0.470
TRG_DiLeu_BaLyEn_6	373	378	PF01217	0.492
TRG_ENDOCYTIC_2	102	105	PF00928	0.372
TRG_ENDOCYTIC_2	150	153	PF00928	0.375
TRG_ER_diArg_1	194	196	PF00400	0.515
TRG_ER_diArg_1	248	250	PF00400	0.415
TRG_ER_diArg_1	285	287	PF00400	0.392
TRG_ER_diArg_1	330	333	PF00400	0.514
TRG_Pf-PMV_PEXEL_1	167	171	PF00026	0.467
TRG_Pf-PMV_PEXEL_1	286	291	PF00026	0.325
TRG_Pf-PMV_PEXEL_1	61	65	PF00026	0.522

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A1X0NYD6	Trypanosomatidae	32%	83%
A0A3S7X1C6	Leishmania donovani	88%	100%
A4HGE9	Leishmania braziliensis	70%	100%
A4I3I0	Leishmania infantum	87%	100%
Q4Q8G2	Leishmania major	85%	100%