Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania mexicana

UniProt:

E9AZS1_LEIMU

TriTrypDb:

LmxM.28.1040

Length:

841

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AZS1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AZS1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	304	308	PF00656	0.532
CLV_C14_Caspase3-7	430	434	PF00656	0.549
CLV_C14_Caspase3-7	577	581	PF00656	0.653
CLV_C14_Caspase3-7	729	733	PF00656	0.560
CLV_C14_Caspase3-7	817	821	PF00656	0.507
CLV_NRD_NRD_1	282	284	PF00675	0.652
CLV_NRD_NRD_1	299	301	PF00675	0.607
CLV_NRD_NRD_1	366	368	PF00675	0.642
CLV_NRD_NRD_1	833	835	PF00675	0.524
CLV_PCSK_KEX2_1	282	284	PF00082	0.652
CLV_PCSK_KEX2_1	299	301	PF00082	0.607
CLV_PCSK_KEX2_1	365	367	PF00082	0.641
CLV_PCSK_KEX2_1	55	57	PF00082	0.699
CLV_PCSK_KEX2_1	833	835	PF00082	0.524
CLV_PCSK_KEX2_1	84	86	PF00082	0.508
CLV_PCSK_PC1ET2_1	365	367	PF00082	0.523
CLV_PCSK_PC1ET2_1	55	57	PF00082	0.631
CLV_PCSK_PC1ET2_1	84	86	PF00082	0.503
CLV_PCSK_PC7_1	829	835	PF00082	0.539
CLV_PCSK_SKI1_1	212	216	PF00082	0.516
CLV_PCSK_SKI1_1	251	255	PF00082	0.505
CLV_PCSK_SKI1_1	27	31	PF00082	0.783
CLV_PCSK_SKI1_1	381	385	PF00082	0.479
CLV_PCSK_SKI1_1	390	394	PF00082	0.429
CLV_PCSK_SKI1_1	56	60	PF00082	0.678
CLV_PCSK_SKI1_1	737	741	PF00082	0.648
CLV_Separin_Metazoa	807	811	PF03568	0.507
DEG_APCC_DBOX_1	389	397	PF00400	0.459
DEG_Nend_UBRbox_1	1	4	PF02207	0.610
DEG_SPOP_SBC_1	523	527	PF00917	0.628
DEG_SPOP_SBC_1	712	716	PF00917	0.660
DOC_CKS1_1	541	546	PF01111	0.639
DOC_CKS1_1	593	598	PF01111	0.617
DOC_CYCLIN_RxL_1	387	394	PF00134	0.353
DOC_MAPK_gen_1	299	305	PF00069	0.436
DOC_PP2B_LxvP_1	170	173	PF13499	0.570
DOC_PP2B_LxvP_1	674	677	PF13499	0.645
DOC_PP2B_LxvP_1	740	743	PF13499	0.640
DOC_PP2B_LxvP_1	767	770	PF13499	0.645
DOC_PP4_MxPP_1	695	698	PF00568	0.536
DOC_USP7_MATH_1	103	107	PF00917	0.516
DOC_USP7_MATH_1	190	194	PF00917	0.507
DOC_USP7_MATH_1	23	27	PF00917	0.625
DOC_USP7_MATH_1	285	289	PF00917	0.598
DOC_USP7_MATH_1	29	33	PF00917	0.590
DOC_USP7_MATH_1	295	299	PF00917	0.609
DOC_USP7_MATH_1	36	40	PF00917	0.511
DOC_USP7_MATH_1	447	451	PF00917	0.487
DOC_USP7_MATH_1	523	527	PF00917	0.628
DOC_USP7_MATH_1	633	637	PF00917	0.669
DOC_USP7_MATH_1	639	643	PF00917	0.627
DOC_USP7_MATH_1	646	650	PF00917	0.621
DOC_USP7_MATH_1	704	708	PF00917	0.630
DOC_USP7_MATH_1	712	716	PF00917	0.577
DOC_USP7_MATH_1	821	825	PF00917	0.579
DOC_USP7_MATH_1	837	841	PF00917	0.538
DOC_USP7_UBL2_3	80	84	PF12436	0.536
DOC_WW_Pin1_4	101	106	PF00397	0.614
DOC_WW_Pin1_4	406	411	PF00397	0.659
DOC_WW_Pin1_4	540	545	PF00397	0.579
DOC_WW_Pin1_4	592	597	PF00397	0.615
DOC_WW_Pin1_4	598	603	PF00397	0.643
DOC_WW_Pin1_4	663	668	PF00397	0.532
LIG_14-3-3_CanoR_1	155	165	PF00244	0.561
LIG_14-3-3_CanoR_1	299	304	PF00244	0.694
LIG_14-3-3_CanoR_1	381	386	PF00244	0.382
LIG_14-3-3_CanoR_1	4	9	PF00244	0.610
LIG_14-3-3_CanoR_1	537	542	PF00244	0.566
LIG_14-3-3_CanoR_1	85	90	PF00244	0.519
LIG_14-3-3_CanoR_1	97	102	PF00244	0.537
LIG_BIR_III_2	685	689	PF00653	0.538
LIG_BIR_III_2	703	707	PF00653	0.535
LIG_BIR_III_2	820	824	PF00653	0.523
LIG_BIR_III_4	225	229	PF00653	0.367
LIG_BRCT_BRCA1_1	378	382	PF00533	0.480
LIG_Clathr_ClatBox_1	165	169	PF01394	0.616
LIG_EVH1_1	708	712	PF00568	0.538
LIG_EVH1_1	740	744	PF00568	0.528
LIG_FHA_1	269	275	PF00498	0.472
LIG_FHA_1	396	402	PF00498	0.423
LIG_FHA_1	466	472	PF00498	0.517
LIG_FHA_1	498	504	PF00498	0.516
LIG_FHA_1	599	605	PF00498	0.696
LIG_FHA_1	627	633	PF00498	0.658
LIG_FHA_1	804	810	PF00498	0.501
LIG_FHA_1	84	90	PF00498	0.560
LIG_FHA_2	105	111	PF00498	0.569
LIG_FHA_2	255	261	PF00498	0.463
LIG_FHA_2	302	308	PF00498	0.588
LIG_FHA_2	422	428	PF00498	0.737
LIG_FHA_2	461	467	PF00498	0.552
LIG_FHA_2	516	522	PF00498	0.609
LIG_FHA_2	553	559	PF00498	0.628
LIG_FHA_2	652	658	PF00498	0.547
LIG_FHA_2	727	733	PF00498	0.563
LIG_FHA_2	815	821	PF00498	0.505
LIG_LIR_Apic_2	707	711	PF02991	0.580
LIG_LIR_Gen_1	379	389	PF02991	0.492
LIG_LIR_Gen_1	516	523	PF02991	0.610
LIG_LIR_Gen_1	525	535	PF02991	0.598
LIG_LIR_Nem_3	313	317	PF02991	0.474
LIG_LIR_Nem_3	379	385	PF02991	0.490
LIG_LIR_Nem_3	516	522	PF02991	0.613
LIG_LIR_Nem_3	525	531	PF02991	0.602
LIG_LIR_Nem_3	559	565	PF02991	0.615
LIG_MYND_1	602	606	PF01753	0.639
LIG_MYND_1	755	759	PF01753	0.657
LIG_NRBOX	388	394	PF00104	0.353
LIG_RPA_C_Fungi	792	804	PF08784	0.498
LIG_SH2_CRK	375	379	PF00017	0.494
LIG_SH2_CRK	562	566	PF00017	0.511
LIG_SH2_STAT3	315	318	PF00017	0.494
LIG_SH2_STAT3	374	377	PF00017	0.507
LIG_SH3_1	62	68	PF00018	0.571
LIG_SH3_3	404	410	PF00018	0.605
LIG_SH3_3	538	544	PF00018	0.623
LIG_SH3_3	582	588	PF00018	0.629
LIG_SH3_3	615	621	PF00018	0.558
LIG_SH3_3	62	68	PF00018	0.571
LIG_SH3_3	703	709	PF00018	0.689
LIG_SH3_3	718	724	PF00018	0.583
LIG_SH3_3	736	742	PF00018	0.568
LIG_SH3_3	746	752	PF00018	0.620
LIG_SH3_3	755	761	PF00018	0.628
LIG_SH3_3	775	781	PF00018	0.560
LIG_Sin3_3	457	464	PF02671	0.567
LIG_SUMO_SIM_anti_2	456	463	PF11976	0.568
LIG_SUMO_SIM_par_1	466	472	PF11976	0.546
LIG_SUMO_SIM_par_1	499	505	PF11976	0.518
LIG_TRAF2_1	284	287	PF00917	0.470
LIG_TRAF2_1	518	521	PF00917	0.648
LIG_TRAF2_1	623	626	PF00917	0.548
LIG_UBA3_1	215	224	PF00899	0.507
LIG_WW_3	696	700	PF00397	0.539
MOD_CDC14_SPxK_1	409	412	PF00782	0.669
MOD_CDK_SPxK_1	406	412	PF00069	0.663
MOD_CK1_1	104	110	PF00069	0.554
MOD_CK1_1	298	304	PF00069	0.575
MOD_CK1_1	554	560	PF00069	0.629
MOD_CK1_1	589	595	PF00069	0.565
MOD_CK1_1	642	648	PF00069	0.663
MOD_CK2_1	104	110	PF00069	0.577
MOD_CK2_1	254	260	PF00069	0.462
MOD_CK2_1	421	427	PF00069	0.634
MOD_CK2_1	460	466	PF00069	0.547
MOD_CK2_1	479	485	PF00069	0.496
MOD_CK2_1	515	521	PF00069	0.622
MOD_CK2_1	523	529	PF00069	0.599
MOD_CK2_1	624	630	PF00069	0.651
MOD_Cter_Amidation	831	834	PF01082	0.538
MOD_DYRK1A_RPxSP_1	406	410	PF00069	0.614
MOD_GlcNHglycan	14	17	PF01048	0.565
MOD_GlcNHglycan	152	155	PF01048	0.613
MOD_GlcNHglycan	21	24	PF01048	0.521
MOD_GlcNHglycan	33	36	PF01048	0.656
MOD_GlcNHglycan	378	381	PF01048	0.434
MOD_GlcNHglycan	38	41	PF01048	0.795
MOD_GlcNHglycan	385	388	PF01048	0.398
MOD_GlcNHglycan	43	46	PF01048	0.747
MOD_GlcNHglycan	481	484	PF01048	0.578
MOD_GlcNHglycan	588	591	PF01048	0.646
MOD_GlcNHglycan	6	9	PF01048	0.610
MOD_GlcNHglycan	635	638	PF01048	0.666
MOD_GlcNHglycan	647	651	PF01048	0.589
MOD_GlcNHglycan	669	672	PF01048	0.686
MOD_GlcNHglycan	746	749	PF01048	0.614
MOD_GlcNHglycan	773	776	PF01048	0.578
MOD_GlcNHglycan	817	820	PF01048	0.542
MOD_GSK3_1	134	141	PF00069	0.523
MOD_GSK3_1	17	24	PF00069	0.623
MOD_GSK3_1	290	297	PF00069	0.531
MOD_GSK3_1	381	388	PF00069	0.425
MOD_GSK3_1	447	454	PF00069	0.590
MOD_GSK3_1	460	467	PF00069	0.538
MOD_GSK3_1	536	543	PF00069	0.529
MOD_GSK3_1	638	645	PF00069	0.625
MOD_GSK3_1	651	658	PF00069	0.560
MOD_GSK3_1	661	668	PF00069	0.554
MOD_GSK3_1	712	719	PF00069	0.702
MOD_GSK3_1	84	91	PF00069	0.626
MOD_GSK3_1	97	104	PF00069	0.604
MOD_N-GLC_1	260	265	PF02516	0.469
MOD_NEK2_1	109	114	PF00069	0.597
MOD_NEK2_1	12	17	PF00069	0.665
MOD_NEK2_1	254	259	PF00069	0.461
MOD_NEK2_1	460	465	PF00069	0.567
MOD_NEK2_1	713	718	PF00069	0.666
MOD_NEK2_2	285	290	PF00069	0.488
MOD_PIKK_1	21	27	PF00454	0.605
MOD_PIKK_1	29	35	PF00454	0.597
MOD_PIKK_1	307	313	PF00454	0.512
MOD_PIKK_1	349	355	PF00454	0.442
MOD_PIKK_1	415	421	PF00454	0.561
MOD_PIKK_1	48	54	PF00454	0.638
MOD_PIKK_1	513	519	PF00454	0.537
MOD_PIKK_1	589	595	PF00454	0.549
MOD_PKA_1	299	305	PF00069	0.436
MOD_PKA_1	84	90	PF00069	0.515
MOD_PKA_2	142	148	PF00069	0.644
MOD_PKA_2	254	260	PF00069	0.462
MOD_PKA_2	298	304	PF00069	0.631
MOD_PKA_2	428	434	PF00069	0.567
MOD_PKA_2	536	542	PF00069	0.566
MOD_PKA_2	704	710	PF00069	0.654
MOD_PKA_2	84	90	PF00069	0.552
MOD_PKB_1	2	10	PF00069	0.612
MOD_Plk_1	109	115	PF00069	0.527
MOD_Plk_1	168	174	PF00069	0.694
MOD_Plk_1	210	216	PF00069	0.520
MOD_Plk_1	260	266	PF00069	0.469
MOD_Plk_1	285	291	PF00069	0.537
MOD_Plk_1	421	427	PF00069	0.599
MOD_Plk_1	465	471	PF00069	0.532
MOD_Plk_1	486	492	PF00069	0.524
MOD_Plk_1	624	630	PF00069	0.658
MOD_Plk_2-3	552	558	PF00069	0.531
MOD_Plk_2-3	624	630	PF00069	0.658
MOD_Plk_4	109	115	PF00069	0.483
MOD_Plk_4	228	234	PF00069	0.583
MOD_Plk_4	497	503	PF00069	0.514
MOD_ProDKin_1	101	107	PF00069	0.606
MOD_ProDKin_1	406	412	PF00069	0.663
MOD_ProDKin_1	540	546	PF00069	0.581
MOD_ProDKin_1	592	598	PF00069	0.616
MOD_ProDKin_1	663	669	PF00069	0.533
TRG_DiLeu_BaEn_1	211	216	PF01217	0.517
TRG_DiLeu_BaLyEn_6	270	275	PF01217	0.473
TRG_DiLeu_BaLyEn_6	54	59	PF01217	0.631
TRG_ENDOCYTIC_2	314	317	PF00928	0.498
TRG_ENDOCYTIC_2	375	378	PF00928	0.494
TRG_ENDOCYTIC_2	562	565	PF00928	0.514
TRG_ER_diArg_1	281	283	PF00400	0.657
TRG_Pf-PMV_PEXEL_1	273	278	PF00026	0.474
TRG_Pf-PMV_PEXEL_1	348	353	PF00026	0.477
TRG_Pf-PMV_PEXEL_1	390	394	PF00026	0.357
TRG_Pf-PMV_PEXEL_1	73	78	PF00026	0.563

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S7X1D3	Leishmania donovani	80%	100%
A4HGE8	Leishmania braziliensis	50%	100%
A4I3H9	Leishmania infantum	81%	87%
Q4Q8G3	Leishmania major	77%	100%