Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AZR6_LEIMU

TriTrypDb:

LmxM.28.1000

Length:

934

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AZR6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AZR6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	283	287	PF00656	0.505
CLV_C14_Caspase3-7	856	860	PF00656	0.678
CLV_NRD_NRD_1	191	193	PF00675	0.728
CLV_NRD_NRD_1	195	197	PF00675	0.618
CLV_NRD_NRD_1	493	495	PF00675	0.500
CLV_NRD_NRD_1	683	685	PF00675	0.280
CLV_NRD_NRD_1	746	748	PF00675	0.674
CLV_NRD_NRD_1	766	768	PF00675	0.285
CLV_NRD_NRD_1	785	787	PF00675	0.339
CLV_NRD_NRD_1	794	796	PF00675	0.272
CLV_PCSK_FUR_1	491	495	PF00082	0.610
CLV_PCSK_KEX2_1	191	193	PF00082	0.695
CLV_PCSK_KEX2_1	195	197	PF00082	0.622
CLV_PCSK_KEX2_1	493	495	PF00082	0.491
CLV_PCSK_KEX2_1	683	685	PF00082	0.280
CLV_PCSK_KEX2_1	716	718	PF00082	0.588
CLV_PCSK_KEX2_1	746	748	PF00082	0.674
CLV_PCSK_KEX2_1	766	768	PF00082	0.285
CLV_PCSK_KEX2_1	785	787	PF00082	0.339
CLV_PCSK_PC1ET2_1	716	718	PF00082	0.562
CLV_PCSK_PC7_1	191	197	PF00082	0.734
CLV_PCSK_PC7_1	742	748	PF00082	0.659
CLV_PCSK_PC7_1	762	768	PF00082	0.302
CLV_PCSK_SKI1_1	187	191	PF00082	0.801
CLV_PCSK_SKI1_1	211	215	PF00082	0.643
CLV_PCSK_SKI1_1	229	233	PF00082	0.575
CLV_PCSK_SKI1_1	300	304	PF00082	0.675
CLV_PCSK_SKI1_1	384	388	PF00082	0.513
CLV_PCSK_SKI1_1	472	476	PF00082	0.484
CLV_PCSK_SKI1_1	478	482	PF00082	0.407
CLV_PCSK_SKI1_1	530	534	PF00082	0.497
CLV_PCSK_SKI1_1	721	725	PF00082	0.479
CLV_PCSK_SKI1_1	786	790	PF00082	0.447
CLV_PCSK_SKI1_1	791	795	PF00082	0.470
CLV_PCSK_SKI1_1	850	854	PF00082	0.348
CLV_PCSK_SKI1_1	915	919	PF00082	0.609
DEG_APCC_DBOX_1	210	218	PF00400	0.646
DEG_APCC_DBOX_1	514	522	PF00400	0.426
DEG_APCC_DBOX_1	627	635	PF00400	0.464
DEG_Nend_Nbox_1	1	3	PF02207	0.599
DEG_SCF_FBW7_1	586	593	PF00400	0.454
DEG_SCF_FBW7_1	813	820	PF00400	0.568
DEG_SPOP_SBC_1	170	174	PF00917	0.606
DOC_CDC14_PxL_1	702	710	PF14671	0.568
DOC_CKS1_1	439	444	PF01111	0.582
DOC_CYCLIN_RxL_1	226	236	PF00134	0.698
DOC_CYCLIN_RxL_1	294	307	PF00134	0.603
DOC_CYCLIN_RxL_1	846	856	PF00134	0.312
DOC_MAPK_gen_1	384	392	PF00069	0.571
DOC_MAPK_gen_1	55	63	PF00069	0.598
DOC_MAPK_HePTP_8	390	402	PF00069	0.553
DOC_MAPK_MEF2A_6	384	392	PF00069	0.654
DOC_MAPK_MEF2A_6	393	402	PF00069	0.482
DOC_MAPK_MEF2A_6	515	523	PF00069	0.421
DOC_MAPK_MEF2A_6	567	574	PF00069	0.401
DOC_MAPK_MEF2A_6	628	635	PF00069	0.554
DOC_MAPK_MEF2A_6	83	92	PF00069	0.433
DOC_MAPK_NFAT4_5	628	636	PF00069	0.547
DOC_PP2B_LxvP_1	400	403	PF13499	0.552
DOC_PP2B_LxvP_1	572	575	PF13499	0.439
DOC_PP2B_LxvP_1	633	636	PF13499	0.409
DOC_PP2B_LxvP_1	657	660	PF13499	0.658
DOC_PP2B_LxvP_1	88	91	PF13499	0.441
DOC_PP4_FxxP_1	44	47	PF00568	0.527
DOC_PP4_FxxP_1	881	884	PF00568	0.680
DOC_USP7_MATH_1	136	140	PF00917	0.627
DOC_USP7_MATH_1	351	355	PF00917	0.565
DOC_USP7_MATH_1	492	496	PF00917	0.620
DOC_USP7_MATH_1	550	554	PF00917	0.441
DOC_USP7_MATH_1	590	594	PF00917	0.452
DOC_USP7_MATH_1	922	926	PF00917	0.662
DOC_USP7_MATH_2	120	126	PF00917	0.627
DOC_WW_Pin1_4	335	340	PF00397	0.606
DOC_WW_Pin1_4	438	443	PF00397	0.534
DOC_WW_Pin1_4	586	591	PF00397	0.405
DOC_WW_Pin1_4	667	672	PF00397	0.445
DOC_WW_Pin1_4	813	818	PF00397	0.574
DOC_WW_Pin1_4	895	900	PF00397	0.803
DOC_WW_Pin1_4	916	921	PF00397	0.579
LIG_14-3-3_CanoR_1	148	153	PF00244	0.679
LIG_14-3-3_CanoR_1	491	500	PF00244	0.574
LIG_14-3-3_CanoR_1	567	571	PF00244	0.528
LIG_14-3-3_CanoR_1	58	64	PF00244	0.521
LIG_14-3-3_CanoR_1	647	657	PF00244	0.659
LIG_APCC_ABBA_1	685	690	PF00400	0.446
LIG_BRCT_BRCA1_1	552	556	PF00533	0.523
LIG_BRCT_BRCA1_1	6	10	PF00533	0.490
LIG_CtBP_PxDLS_1	120	124	PF00389	0.632
LIG_deltaCOP1_diTrp_1	844	847	PF00928	0.318
LIG_FHA_1	395	401	PF00498	0.395
LIG_FHA_1	466	472	PF00498	0.568
LIG_FHA_1	567	573	PF00498	0.469
LIG_FHA_1	818	824	PF00498	0.514
LIG_FHA_2	110	116	PF00498	0.596
LIG_FHA_2	136	142	PF00498	0.636
LIG_FHA_2	359	365	PF00498	0.547
LIG_FHA_2	412	418	PF00498	0.583
LIG_FHA_2	439	445	PF00498	0.574
LIG_FHA_2	695	701	PF00498	0.596
LIG_FHA_2	708	714	PF00498	0.428
LIG_FHA_2	814	820	PF00498	0.571
LIG_FHA_2	849	855	PF00498	0.555
LIG_LIR_Apic_2	42	47	PF02991	0.515
LIG_LIR_Apic_2	880	884	PF02991	0.680
LIG_LIR_Gen_1	207	217	PF02991	0.655
LIG_LIR_Gen_1	397	407	PF02991	0.560
LIG_LIR_Gen_1	553	560	PF02991	0.468
LIG_LIR_Gen_1	690	699	PF02991	0.451
LIG_LIR_Gen_1	816	826	PF02991	0.573
LIG_LIR_Nem_3	149	155	PF02991	0.771
LIG_LIR_Nem_3	207	212	PF02991	0.670
LIG_LIR_Nem_3	397	402	PF02991	0.508
LIG_LIR_Nem_3	482	487	PF02991	0.610
LIG_LIR_Nem_3	528	532	PF02991	0.473
LIG_LIR_Nem_3	553	559	PF02991	0.433
LIG_LIR_Nem_3	568	574	PF02991	0.425
LIG_LIR_Nem_3	732	737	PF02991	0.431
LIG_LIR_Nem_3	816	821	PF02991	0.546
LIG_LIR_Nem_3	844	848	PF02991	0.291
LIG_MYND_1	660	664	PF01753	0.372
LIG_PDZ_Class_1	929	934	PF00595	0.491
LIG_Pex14_1	40	44	PF04695	0.500
LIG_PTB_Apo_2	275	282	PF02174	0.803
LIG_PTB_Apo_2	523	530	PF02174	0.281
LIG_PTB_Phospho_1	275	281	PF10480	0.802
LIG_PTB_Phospho_1	523	529	PF10480	0.277
LIG_SH2_CRK	439	443	PF00017	0.585
LIG_SH2_CRK	755	759	PF00017	0.460
LIG_SH2_CRK	761	765	PF00017	0.549
LIG_SH2_SRC	27	30	PF00017	0.449
LIG_SH2_SRC	688	691	PF00017	0.486
LIG_SH2_SRC	803	806	PF00017	0.491
LIG_SH2_STAP1	27	31	PF00017	0.584
LIG_SH2_STAP1	298	302	PF00017	0.713
LIG_SH2_STAP1	329	333	PF00017	0.320
LIG_SH2_STAP1	396	400	PF00017	0.381
LIG_SH2_STAP1	449	453	PF00017	0.439
LIG_SH2_STAP1	551	555	PF00017	0.425
LIG_SH2_STAT5	356	359	PF00017	0.535
LIG_SH2_STAT5	396	399	PF00017	0.390
LIG_SH2_STAT5	558	561	PF00017	0.423
LIG_SH2_STAT5	571	574	PF00017	0.397
LIG_SH2_STAT5	584	587	PF00017	0.372
LIG_SH2_STAT5	639	642	PF00017	0.512
LIG_SH2_STAT5	751	754	PF00017	0.537
LIG_SH2_STAT5	803	806	PF00017	0.491
LIG_SH3_3	123	129	PF00018	0.514
LIG_SH3_3	287	293	PF00018	0.751
LIG_SH3_3	400	406	PF00018	0.458
LIG_SH3_3	460	466	PF00018	0.613
LIG_SH3_3	544	550	PF00018	0.390
LIG_SH3_3	567	573	PF00018	0.537
LIG_SH3_3	657	663	PF00018	0.622
LIG_SH3_3	859	865	PF00018	0.590
LIG_SH3_3	914	920	PF00018	0.731
LIG_SUMO_SIM_anti_2	531	537	PF11976	0.340
LIG_SUMO_SIM_par_1	119	125	PF11976	0.630
LIG_SUMO_SIM_par_1	467	473	PF11976	0.543
LIG_TRAF2_1	373	376	PF00917	0.581
LIG_TRAF2_1	414	417	PF00917	0.608
LIG_TRAF2_1	687	690	PF00917	0.496
LIG_TRAF2_1	884	887	PF00917	0.488
LIG_UBA3_1	301	308	PF00899	0.520
LIG_WRC_WIRS_1	41	46	PF05994	0.505
LIG_WRC_WIRS_1	511	516	PF05994	0.502
LIG_WRC_WIRS_1	540	545	PF05994	0.482
LIG_WW_1	671	674	PF00397	0.420
LIG_WW_2	660	663	PF00397	0.383
MOD_CDK_SPK_2	438	443	PF00069	0.513
MOD_CDK_SPxxK_3	335	342	PF00069	0.588
MOD_CK1_1	159	165	PF00069	0.764
MOD_CK1_1	171	177	PF00069	0.679
MOD_CK1_1	368	374	PF00069	0.595
MOD_CK1_1	6	12	PF00069	0.644
MOD_CK1_1	898	904	PF00069	0.760
MOD_CK2_1	109	115	PF00069	0.602
MOD_CK2_1	135	141	PF00069	0.566
MOD_CK2_1	246	252	PF00069	0.763
MOD_CK2_1	411	417	PF00069	0.583
MOD_CK2_1	438	444	PF00069	0.574
MOD_CK2_1	646	652	PF00069	0.622
MOD_Cter_Amidation	783	786	PF01082	0.447
MOD_GlcNHglycan	138	141	PF01048	0.585
MOD_GlcNHglycan	158	161	PF01048	0.455
MOD_GlcNHglycan	173	176	PF01048	0.690
MOD_GlcNHglycan	248	251	PF01048	0.695
MOD_GlcNHglycan	308	311	PF01048	0.645
MOD_GlcNHglycan	552	555	PF01048	0.473
MOD_GlcNHglycan	859	862	PF01048	0.523
MOD_GlcNHglycan	895	898	PF01048	0.760
MOD_GlcNHglycan	900	903	PF01048	0.762
MOD_GlcNHglycan	909	912	PF01048	0.668
MOD_GSK3_1	155	162	PF00069	0.797
MOD_GSK3_1	169	176	PF00069	0.719
MOD_GSK3_1	2	9	PF00069	0.595
MOD_GSK3_1	216	223	PF00069	0.671
MOD_GSK3_1	262	269	PF00069	0.599
MOD_GSK3_1	364	371	PF00069	0.547
MOD_GSK3_1	561	568	PF00069	0.518
MOD_GSK3_1	586	593	PF00069	0.413
MOD_GSK3_1	648	655	PF00069	0.544
MOD_GSK3_1	813	820	PF00069	0.545
MOD_GSK3_1	853	860	PF00069	0.445
MOD_GSK3_1	891	898	PF00069	0.796
MOD_NEK2_1	121	126	PF00069	0.627
MOD_NEK2_1	155	160	PF00069	0.784
MOD_NEK2_1	2	7	PF00069	0.720
MOD_NEK2_1	220	225	PF00069	0.677
MOD_NEK2_1	365	370	PF00069	0.509
MOD_NEK2_1	386	391	PF00069	0.626
MOD_NEK2_1	679	684	PF00069	0.550
MOD_NEK2_1	853	858	PF00069	0.613
MOD_NEK2_2	566	571	PF00069	0.442
MOD_PIKK_1	412	418	PF00454	0.542
MOD_PIKK_1	561	567	PF00454	0.525
MOD_PKA_2	351	357	PF00069	0.538
MOD_PKA_2	358	364	PF00069	0.526
MOD_PKA_2	492	498	PF00069	0.598
MOD_PKA_2	566	572	PF00069	0.389
MOD_PKA_2	627	633	PF00069	0.432
MOD_PKA_2	646	652	PF00069	0.340
MOD_Plk_1	121	127	PF00069	0.547
MOD_Plk_1	365	371	PF00069	0.529
MOD_Plk_1	590	596	PF00069	0.448
MOD_Plk_1	853	859	PF00069	0.603
MOD_Plk_2-3	465	471	PF00069	0.626
MOD_Plk_2-3	707	713	PF00069	0.359
MOD_Plk_4	220	226	PF00069	0.687
MOD_Plk_4	328	334	PF00069	0.489
MOD_Plk_4	386	392	PF00069	0.551
MOD_Plk_4	394	400	PF00069	0.467
MOD_Plk_4	531	537	PF00069	0.247
MOD_Plk_4	566	572	PF00069	0.377
MOD_Plk_4	590	596	PF00069	0.532
MOD_Plk_4	635	641	PF00069	0.498
MOD_ProDKin_1	335	341	PF00069	0.600
MOD_ProDKin_1	438	444	PF00069	0.533
MOD_ProDKin_1	586	592	PF00069	0.401
MOD_ProDKin_1	667	673	PF00069	0.436
MOD_ProDKin_1	813	819	PF00069	0.580
MOD_ProDKin_1	895	901	PF00069	0.804
MOD_ProDKin_1	916	922	PF00069	0.572
MOD_SUMO_rev_2	465	474	PF00179	0.634
MOD_SUMO_rev_2	49	57	PF00179	0.525
MOD_SUMO_rev_2	525	532	PF00179	0.454
MOD_SUMO_rev_2	713	718	PF00179	0.547
MOD_SUMO_rev_2	840	848	PF00179	0.279
TRG_DiLeu_BaEn_1	528	533	PF01217	0.464
TRG_DiLeu_BaEn_1	629	634	PF01217	0.560
TRG_DiLeu_BaLyEn_6	14	19	PF01217	0.614
TRG_DiLeu_BaLyEn_6	227	232	PF01217	0.698
TRG_DiLeu_BaLyEn_6	454	459	PF01217	0.583
TRG_ENDOCYTIC_2	298	301	PF00928	0.632
TRG_ENDOCYTIC_2	529	532	PF00928	0.406
TRG_ENDOCYTIC_2	571	574	PF00928	0.438
TRG_ENDOCYTIC_2	674	677	PF00928	0.485
TRG_ENDOCYTIC_2	688	691	PF00928	0.484
TRG_ENDOCYTIC_2	761	764	PF00928	0.488
TRG_ER_diArg_1	190	192	PF00400	0.690
TRG_ER_diArg_1	195	197	PF00400	0.613
TRG_ER_diArg_1	490	493	PF00400	0.633
TRG_ER_diArg_1	666	669	PF00400	0.358
TRG_ER_diArg_1	683	685	PF00400	0.245
TRG_ER_diArg_1	766	768	PF00400	0.351
TRG_ER_diArg_1	785	787	PF00400	0.339
TRG_NES_CRM1_1	29	45	PF08389	0.525
TRG_NES_CRM1_1	421	432	PF08389	0.432
TRG_NES_CRM1_1	693	707	PF08389	0.324
TRG_Pf-PMV_PEXEL_1	102	107	PF00026	0.603
TRG_Pf-PMV_PEXEL_1	229	233	PF00026	0.787
TRG_Pf-PMV_PEXEL_1	342	346	PF00026	0.485
TRG_Pf-PMV_PEXEL_1	478	482	PF00026	0.504
TRG_Pf-PMV_PEXEL_1	709	713	PF00026	0.356
TRG_Pf-PMV_PEXEL_1	850	854	PF00026	0.309

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2W5	Leptomonas seymouri	49%	88%
A0A1X0NZW9	Trypanosomatidae	35%	95%
A0A3Q8IDR2	Leishmania donovani	90%	99%
A0A3R7M3D8	Trypanosoma rangeli	34%	100%
A4HGE4	Leishmania braziliensis	75%	100%
A4I3H7	Leishmania infantum	90%	99%
Q4Q8G7	Leishmania major	90%	100%
V5D1P8	Trypanosoma cruzi	35%	99%