Type VI secretion protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AZR4_LEIMU

TriTrypDb:

LmxM.28.0980

Length:

240

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 18

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 16
NetGPI	no	yes: 0, no: 16

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	10
GO:0110165	cellular anatomical entity	1	10

Expansion

Sequence features

E9AZR4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AZR4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_SKI1_1	200	204	PF00082	0.706
DOC_CYCLIN_RxL_1	194	208	PF00134	0.411
DOC_PP1_RVXF_1	120	126	PF00149	0.416
DOC_PP1_RVXF_1	49	56	PF00149	0.622
DOC_PP1_RVXF_1	78	85	PF00149	0.642
DOC_PP2B_PxIxI_1	127	133	PF00149	0.324
DOC_PP4_FxxP_1	125	128	PF00568	0.431
DOC_USP7_MATH_1	233	237	PF00917	0.529
DOC_USP7_MATH_1	26	30	PF00917	0.562
LIG_14-3-3_CanoR_1	122	126	PF00244	0.458
LIG_BIR_II_1	1	5	PF00653	0.689
LIG_BRCT_BRCA1_1	28	32	PF00533	0.535
LIG_BRCT_BRCA1_1	68	72	PF00533	0.727
LIG_EH_1	29	33	PF12763	0.698
LIG_FHA_1	108	114	PF00498	0.281
LIG_FHA_1	170	176	PF00498	0.463
LIG_FHA_1	3	9	PF00498	0.701
LIG_IBAR_NPY_1	76	78	PF08397	0.664
LIG_LIR_Apic_2	124	128	PF02991	0.469
LIG_LIR_Gen_1	131	137	PF02991	0.517
LIG_LIR_LC3C_4	110	113	PF02991	0.221
LIG_LIR_Nem_3	116	121	PF02991	0.308
LIG_LIR_Nem_3	131	136	PF02991	0.469
LIG_LIR_Nem_3	187	192	PF02991	0.342
LIG_Pex14_1	55	59	PF04695	0.665
LIG_REV1ctd_RIR_1	70	76	PF16727	0.633
LIG_SH2_CRK	133	137	PF00017	0.351
LIG_SH2_CRK	61	65	PF00017	0.679
LIG_SH2_GRB2like	205	208	PF00017	0.400
LIG_SH2_STAP1	115	119	PF00017	0.323
LIG_SH2_STAT5	115	118	PF00017	0.188
LIG_SH2_STAT5	189	192	PF00017	0.411
LIG_SH2_STAT5	23	26	PF00017	0.652
LIG_SH2_STAT5	44	47	PF00017	0.663
LIG_SH2_STAT5	81	84	PF00017	0.658
LIG_SH3_4	141	148	PF00018	0.489
LIG_SUMO_SIM_anti_2	110	116	PF11976	0.394
LIG_SUMO_SIM_par_1	110	116	PF11976	0.316
LIG_TYR_ITSM	129	136	PF00017	0.349
MOD_CK1_1	2	8	PF00069	0.686
MOD_CK1_1	99	105	PF00069	0.562
MOD_CK2_1	85	91	PF00069	0.637
MOD_GlcNHglycan	224	229	PF01048	0.677
MOD_GlcNHglycan	235	238	PF01048	0.719
MOD_GlcNHglycan	48	51	PF01048	0.453
MOD_GlcNHglycan	8	11	PF01048	0.524
MOD_GSK3_1	113	120	PF00069	0.306
MOD_GSK3_1	2	9	PF00069	0.744
MOD_NEK2_1	137	142	PF00069	0.359
MOD_NEK2_1	85	90	PF00069	0.636
MOD_NEK2_2	128	133	PF00069	0.420
MOD_PIKK_1	207	213	PF00454	0.407
MOD_PKA_2	121	127	PF00069	0.464
MOD_PKA_2	2	8	PF00069	0.668
MOD_Plk_1	128	134	PF00069	0.420
MOD_Plk_1	167	173	PF00069	0.494
MOD_Plk_1	200	206	PF00069	0.480
MOD_Plk_1	85	91	PF00069	0.637
MOD_Plk_2-3	86	92	PF00069	0.637
MOD_Plk_4	107	113	PF00069	0.296
MOD_Plk_4	121	127	PF00069	0.368
MOD_Plk_4	200	206	PF00069	0.405
TRG_ENDOCYTIC_2	133	136	PF00928	0.515
TRG_ENDOCYTIC_2	160	163	PF00928	0.474
TRG_ENDOCYTIC_2	61	64	PF00928	0.684
TRG_NES_CRM1_1	173	187	PF08389	0.490

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HYK0	Leptomonas seymouri	62%	99%
A0A0S4IVH5	Bodo saltans	47%	99%
A0A0S4IXX7	Bodo saltans	47%	91%
A0A1X0NYZ9	Trypanosomatidae	62%	100%
A0A3Q8IGT4	Leishmania donovani	60%	99%
A0A422MZK8	Trypanosoma rangeli	60%	100%
A4HGE2	Leishmania braziliensis	80%	100%
A4HLG1	Leishmania braziliensis	57%	100%
A4I3H5	Leishmania infantum	91%	100%
A4I8X2	Leishmania infantum	60%	99%
E9B3U1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	61%	99%
I1ZAQ0	Leishmania donovani	91%	100%
Q4Q483	Leishmania major	58%	100%
Q4Q8G9	Leishmania major	88%	100%
V5AL49	Trypanosoma cruzi	61%	94%