LeishMANIAdb
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Oxidoreductase-like protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Oxidoreductase-like protein
Gene product:
oxidoreductase-like protein
Species:
Leishmania mexicana
UniProt:
E9AZR0_LEIMU
TriTrypDb:
LmxM.28.0940
Length:
955

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 10
NetGPI no yes: 0, no: 10
Cellular components
Term Name Level Count
GO:0005654 nucleoplasm 2 1
GO:0005737 cytoplasm 2 1
GO:0110165 cellular anatomical entity 1 1

Expansion

Sequence features

E9AZR0
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AZR0

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 191 195 PF00656 0.677
CLV_C14_Caspase3-7 287 291 PF00656 0.580
CLV_C14_Caspase3-7 924 928 PF00656 0.316
CLV_NRD_NRD_1 117 119 PF00675 0.476
CLV_NRD_NRD_1 131 133 PF00675 0.505
CLV_NRD_NRD_1 496 498 PF00675 0.333
CLV_NRD_NRD_1 9 11 PF00675 0.671
CLV_NRD_NRD_1 913 915 PF00675 0.410
CLV_NRD_NRD_1 96 98 PF00675 0.515
CLV_PCSK_FUR_1 117 121 PF00082 0.450
CLV_PCSK_KEX2_1 100 102 PF00082 0.482
CLV_PCSK_KEX2_1 117 119 PF00082 0.392
CLV_PCSK_KEX2_1 131 133 PF00082 0.500
CLV_PCSK_KEX2_1 136 138 PF00082 0.615
CLV_PCSK_KEX2_1 496 498 PF00082 0.333
CLV_PCSK_KEX2_1 585 587 PF00082 0.347
CLV_PCSK_KEX2_1 9 11 PF00082 0.646
CLV_PCSK_KEX2_1 913 915 PF00082 0.410
CLV_PCSK_PC1ET2_1 100 102 PF00082 0.484
CLV_PCSK_PC1ET2_1 119 121 PF00082 0.368
CLV_PCSK_PC1ET2_1 136 138 PF00082 0.441
CLV_PCSK_PC1ET2_1 585 587 PF00082 0.347
CLV_PCSK_PC7_1 132 138 PF00082 0.471
CLV_PCSK_SKI1_1 104 108 PF00082 0.581
CLV_PCSK_SKI1_1 211 215 PF00082 0.540
CLV_PCSK_SKI1_1 349 353 PF00082 0.467
CLV_PCSK_SKI1_1 390 394 PF00082 0.488
CLV_PCSK_SKI1_1 50 54 PF00082 0.601
CLV_PCSK_SKI1_1 595 599 PF00082 0.314
CLV_PCSK_SKI1_1 673 677 PF00082 0.406
CLV_PCSK_SKI1_1 69 73 PF00082 0.362
CLV_PCSK_SKI1_1 873 877 PF00082 0.322
CLV_PCSK_SKI1_1 948 952 PF00082 0.342
CLV_Separin_Metazoa 212 216 PF03568 0.527
DEG_APCC_DBOX_1 402 410 PF00400 0.517
DEG_APCC_DBOX_1 646 654 PF00400 0.273
DEG_SCF_FBW7_1 686 693 PF00400 0.523
DEG_SCF_FBW7_2 401 408 PF00400 0.514
DEG_SPOP_SBC_1 518 522 PF00917 0.667
DOC_CKS1_1 372 377 PF01111 0.508
DOC_CKS1_1 402 407 PF01111 0.517
DOC_CYCLIN_RxL_1 387 396 PF00134 0.459
DOC_CYCLIN_RxL_1 441 452 PF00134 0.423
DOC_CYCLIN_RxL_1 928 938 PF00134 0.308
DOC_CYCLIN_yCln2_LP_2 701 707 PF00134 0.560
DOC_MAPK_DCC_7 505 514 PF00069 0.605
DOC_MAPK_gen_1 476 485 PF00069 0.473
DOC_MAPK_gen_1 590 599 PF00069 0.335
DOC_MAPK_gen_1 603 612 PF00069 0.273
DOC_MAPK_gen_1 794 803 PF00069 0.531
DOC_MAPK_MEF2A_6 605 614 PF00069 0.273
DOC_MAPK_MEF2A_6 766 773 PF00069 0.457
DOC_PP1_RVXF_1 67 73 PF00149 0.587
DOC_PP1_RVXF_1 775 782 PF00149 0.633
DOC_PP2B_LxvP_1 701 704 PF13499 0.552
DOC_PP4_FxxP_1 72 75 PF00568 0.448
DOC_PP4_MxPP_1 324 327 PF00568 0.573
DOC_SPAK_OSR1_1 846 850 PF12202 0.273
DOC_USP7_MATH_1 254 258 PF00917 0.702
DOC_USP7_MATH_1 272 276 PF00917 0.703
DOC_USP7_MATH_1 319 323 PF00917 0.398
DOC_USP7_MATH_1 378 382 PF00917 0.550
DOC_USP7_MATH_1 388 392 PF00917 0.459
DOC_USP7_MATH_1 426 430 PF00917 0.514
DOC_USP7_MATH_1 519 523 PF00917 0.702
DOC_USP7_MATH_1 788 792 PF00917 0.462
DOC_USP7_UBL2_3 115 119 PF12436 0.447
DOC_WD40_RPTOR_TOS_1 651 657 PF00400 0.316
DOC_WW_Pin1_4 14 19 PF00397 0.592
DOC_WW_Pin1_4 337 342 PF00397 0.519
DOC_WW_Pin1_4 371 376 PF00397 0.600
DOC_WW_Pin1_4 401 406 PF00397 0.450
DOC_WW_Pin1_4 507 512 PF00397 0.470
DOC_WW_Pin1_4 686 691 PF00397 0.524
DOC_WW_Pin1_4 818 823 PF00397 0.292
DOC_WW_Pin1_4 903 908 PF00397 0.273
LIG_14-3-3_CanoR_1 517 526 PF00244 0.494
LIG_14-3-3_CanoR_1 593 598 PF00244 0.406
LIG_14-3-3_CanoR_1 616 622 PF00244 0.406
LIG_14-3-3_CanoR_1 725 731 PF00244 0.523
LIG_14-3-3_CanoR_1 88 93 PF00244 0.487
LIG_14-3-3_CanoR_1 881 887 PF00244 0.296
LIG_14-3-3_CanoR_1 9 18 PF00244 0.510
LIG_Actin_WH2_2 385 400 PF00022 0.430
LIG_APCC_ABBA_1 744 749 PF00400 0.594
LIG_BIR_II_1 1 5 PF00653 0.695
LIG_BIR_III_2 839 843 PF00653 0.314
LIG_BRCT_BRCA1_1 275 279 PF00533 0.603
LIG_Clathr_ClatBox_1 223 227 PF01394 0.432
LIG_Clathr_ClatBox_1 448 452 PF01394 0.495
LIG_Clathr_ClatBox_1 650 654 PF01394 0.273
LIG_deltaCOP1_diTrp_1 51 58 PF00928 0.437
LIG_deltaCOP1_diTrp_1 642 651 PF00928 0.288
LIG_deltaCOP1_diTrp_1 657 664 PF00928 0.252
LIG_deltaCOP1_diTrp_1 719 724 PF00928 0.414
LIG_EVH1_2 325 329 PF00568 0.624
LIG_FAT_LD_1 439 447 PF03623 0.426
LIG_FHA_1 201 207 PF00498 0.636
LIG_FHA_1 307 313 PF00498 0.579
LIG_FHA_1 372 378 PF00498 0.578
LIG_FHA_1 382 388 PF00498 0.586
LIG_FHA_1 402 408 PF00498 0.525
LIG_FHA_1 42 48 PF00498 0.590
LIG_FHA_1 594 600 PF00498 0.315
LIG_FHA_1 623 629 PF00498 0.308
LIG_FHA_1 691 697 PF00498 0.431
LIG_FHA_1 727 733 PF00498 0.580
LIG_FHA_1 897 903 PF00498 0.273
LIG_FHA_2 10 16 PF00498 0.799
LIG_FHA_2 147 153 PF00498 0.582
LIG_FHA_2 264 270 PF00498 0.662
LIG_FHA_2 285 291 PF00498 0.731
LIG_FHA_2 394 400 PF00498 0.534
LIG_FHA_2 464 470 PF00498 0.618
LIG_FHA_2 784 790 PF00498 0.467
LIG_FHA_2 832 838 PF00498 0.347
LIG_FHA_2 880 886 PF00498 0.273
LIG_FHA_2 97 103 PF00498 0.485
LIG_Integrin_isoDGR_2 826 828 PF01839 0.341
LIG_LIR_Gen_1 276 285 PF02991 0.531
LIG_LIR_Gen_1 299 310 PF02991 0.428
LIG_LIR_Gen_1 57 65 PF02991 0.455
LIG_LIR_Gen_1 662 672 PF02991 0.273
LIG_LIR_Gen_1 719 724 PF02991 0.434
LIG_LIR_Gen_1 87 96 PF02991 0.475
LIG_LIR_Nem_3 105 110 PF02991 0.522
LIG_LIR_Nem_3 276 282 PF02991 0.606
LIG_LIR_Nem_3 299 305 PF02991 0.439
LIG_LIR_Nem_3 456 462 PF02991 0.593
LIG_LIR_Nem_3 527 532 PF02991 0.519
LIG_LIR_Nem_3 57 61 PF02991 0.449
LIG_LIR_Nem_3 662 667 PF02991 0.273
LIG_LIR_Nem_3 719 723 PF02991 0.435
LIG_LIR_Nem_3 778 784 PF02991 0.499
LIG_LIR_Nem_3 855 861 PF02991 0.273
LIG_LIR_Nem_3 87 93 PF02991 0.488
LIG_LIR_Nem_3 940 946 PF02991 0.333
LIG_LIR_Nem_3 949 953 PF02991 0.323
LIG_NRBOX 142 148 PF00104 0.641
LIG_PCNA_yPIPBox_3 548 561 PF02747 0.493
LIG_PCNA_yPIPBox_3 939 951 PF02747 0.394
LIG_Pex14_1 54 58 PF04695 0.593
LIG_Pex14_1 720 724 PF04695 0.407
LIG_Pex14_2 946 950 PF04695 0.302
LIG_REV1ctd_RIR_1 721 729 PF16727 0.454
LIG_SH2_CRK 313 317 PF00017 0.439
LIG_SH2_CRK 564 568 PF00017 0.330
LIG_SH2_CRK 672 676 PF00017 0.406
LIG_SH2_CRK 90 94 PF00017 0.468
LIG_SH2_GRB2like 893 896 PF00017 0.316
LIG_SH2_NCK_1 532 536 PF00017 0.607
LIG_SH2_NCK_1 90 94 PF00017 0.487
LIG_SH2_SRC 315 318 PF00017 0.496
LIG_SH2_SRC 532 535 PF00017 0.602
LIG_SH2_STAP1 41 45 PF00017 0.615
LIG_SH2_STAP1 608 612 PF00017 0.407
LIG_SH2_STAP1 692 696 PF00017 0.427
LIG_SH2_STAP1 784 788 PF00017 0.475
LIG_SH2_STAT3 121 124 PF00017 0.503
LIG_SH2_STAT3 320 323 PF00017 0.598
LIG_SH2_STAT3 354 357 PF00017 0.368
LIG_SH2_STAT3 784 787 PF00017 0.517
LIG_SH2_STAT5 121 124 PF00017 0.503
LIG_SH2_STAT5 315 318 PF00017 0.496
LIG_SH2_STAT5 347 350 PF00017 0.374
LIG_SH2_STAT5 354 357 PF00017 0.365
LIG_SH2_STAT5 529 532 PF00017 0.516
LIG_SH2_STAT5 692 695 PF00017 0.434
LIG_SH2_STAT5 78 81 PF00017 0.483
LIG_SH2_STAT5 83 86 PF00017 0.460
LIG_SH2_STAT5 90 93 PF00017 0.438
LIG_SH3_1 369 375 PF00018 0.442
LIG_SH3_3 164 170 PF00018 0.725
LIG_SH3_3 2 8 PF00018 0.629
LIG_SH3_3 257 263 PF00018 0.728
LIG_SH3_3 335 341 PF00018 0.616
LIG_SH3_3 369 375 PF00018 0.498
LIG_SH3_3 399 405 PF00018 0.578
LIG_SH3_3 432 438 PF00018 0.512
LIG_SH3_3 729 735 PF00018 0.526
LIG_SH3_3 76 82 PF00018 0.548
LIG_SH3_3 839 845 PF00018 0.341
LIG_Sin3_3 359 366 PF02671 0.477
LIG_SUMO_SIM_anti_2 447 452 PF11976 0.497
LIG_SUMO_SIM_par_1 159 165 PF11976 0.607
LIG_SUMO_SIM_par_1 202 207 PF11976 0.476
LIG_SUMO_SIM_par_1 404 411 PF11976 0.525
LIG_SUMO_SIM_par_1 42 49 PF11976 0.674
LIG_SUMO_SIM_par_1 447 452 PF11976 0.497
LIG_SUMO_SIM_par_1 595 600 PF11976 0.305
LIG_SUMO_SIM_par_1 734 739 PF11976 0.609
LIG_TRAF2_1 522 525 PF00917 0.670
LIG_TRAF2_1 759 762 PF00917 0.525
LIG_TRFH_1 918 922 PF08558 0.512
LIG_TYR_ITIM 562 567 PF00017 0.353
LIG_UBA3_1 106 115 PF00899 0.415
LIG_WW_3 6 10 PF00397 0.636
MOD_CDK_SPK_2 903 908 PF00069 0.273
MOD_CDK_SPxxK_3 14 21 PF00069 0.505
MOD_CDK_SPxxK_3 903 910 PF00069 0.273
MOD_CK1_1 181 187 PF00069 0.651
MOD_CK1_1 273 279 PF00069 0.694
MOD_CK1_1 381 387 PF00069 0.563
MOD_CK1_1 425 431 PF00069 0.489
MOD_CK1_1 896 902 PF00069 0.273
MOD_CK2_1 146 152 PF00069 0.470
MOD_CK2_1 204 210 PF00069 0.581
MOD_CK2_1 263 269 PF00069 0.659
MOD_CK2_1 414 420 PF00069 0.595
MOD_CK2_1 518 524 PF00069 0.537
MOD_CK2_1 54 60 PF00069 0.469
MOD_CK2_1 783 789 PF00069 0.459
MOD_CK2_1 831 837 PF00069 0.327
MOD_CK2_1 849 855 PF00069 0.247
MOD_CK2_1 96 102 PF00069 0.487
MOD_GlcNHglycan 143 146 PF01048 0.675
MOD_GlcNHglycan 183 186 PF01048 0.741
MOD_GlcNHglycan 190 193 PF01048 0.723
MOD_GlcNHglycan 194 198 PF01048 0.670
MOD_GlcNHglycan 206 209 PF01048 0.413
MOD_GlcNHglycan 241 244 PF01048 0.730
MOD_GlcNHglycan 251 254 PF01048 0.630
MOD_GlcNHglycan 271 275 PF01048 0.691
MOD_GlcNHglycan 290 294 PF01048 0.535
MOD_GlcNHglycan 380 383 PF01048 0.511
MOD_GlcNHglycan 422 427 PF01048 0.470
MOD_GlcNHglycan 500 503 PF01048 0.500
MOD_GlcNHglycan 62 65 PF01048 0.573
MOD_GlcNHglycan 766 769 PF01048 0.730
MOD_GlcNHglycan 851 854 PF01048 0.273
MOD_GlcNHglycan 882 885 PF01048 0.273
MOD_GSK3_1 200 207 PF00069 0.469
MOD_GSK3_1 241 248 PF00069 0.527
MOD_GSK3_1 273 280 PF00069 0.738
MOD_GSK3_1 37 44 PF00069 0.485
MOD_GSK3_1 377 384 PF00069 0.745
MOD_GSK3_1 388 395 PF00069 0.567
MOD_GSK3_1 422 429 PF00069 0.593
MOD_GSK3_1 56 63 PF00069 0.357
MOD_GSK3_1 593 600 PF00069 0.406
MOD_GSK3_1 617 624 PF00069 0.429
MOD_GSK3_1 682 689 PF00069 0.273
MOD_GSK3_1 703 710 PF00069 0.607
MOD_GSK3_1 771 778 PF00069 0.459
MOD_GSK3_1 84 91 PF00069 0.474
MOD_GSK3_1 862 869 PF00069 0.273
MOD_GSK3_1 896 903 PF00069 0.273
MOD_N-GLC_1 172 177 PF02516 0.718
MOD_N-GLC_1 849 854 PF02516 0.287
MOD_NEK2_1 146 151 PF00069 0.571
MOD_NEK2_1 204 209 PF00069 0.651
MOD_NEK2_1 303 308 PF00069 0.428
MOD_NEK2_1 392 397 PF00069 0.565
MOD_NEK2_1 610 615 PF00069 0.307
MOD_NEK2_1 622 627 PF00069 0.342
MOD_NEK2_1 707 712 PF00069 0.479
MOD_NEK2_1 747 752 PF00069 0.649
MOD_NEK2_1 84 89 PF00069 0.466
MOD_NEK2_1 861 866 PF00069 0.381
MOD_NEK2_1 879 884 PF00069 0.171
MOD_NEK2_1 935 940 PF00069 0.347
MOD_NEK2_2 178 183 PF00069 0.497
MOD_NEK2_2 486 491 PF00069 0.379
MOD_PIKK_1 303 309 PF00454 0.406
MOD_PIKK_1 319 325 PF00454 0.428
MOD_PIKK_1 426 432 PF00454 0.614
MOD_PIKK_1 659 665 PF00454 0.273
MOD_PIKK_1 748 754 PF00454 0.532
MOD_PIKK_1 783 789 PF00454 0.502
MOD_PKA_1 9 15 PF00069 0.640
MOD_PKA_2 130 136 PF00069 0.453
MOD_PKA_2 880 886 PF00069 0.273
MOD_PKA_2 9 15 PF00069 0.640
MOD_PKA_2 96 102 PF00069 0.470
MOD_Plk_1 178 184 PF00069 0.672
MOD_Plk_1 37 43 PF00069 0.610
MOD_Plk_1 486 492 PF00069 0.321
MOD_Plk_1 775 781 PF00069 0.627
MOD_Plk_1 849 855 PF00069 0.283
MOD_Plk_2-3 452 458 PF00069 0.473
MOD_Plk_2-3 757 763 PF00069 0.462
MOD_Plk_4 593 599 PF00069 0.377
MOD_Plk_4 610 616 PF00069 0.278
MOD_Plk_4 617 623 PF00069 0.304
MOD_Plk_4 795 801 PF00069 0.435
MOD_Plk_4 88 94 PF00069 0.608
MOD_ProDKin_1 14 20 PF00069 0.592
MOD_ProDKin_1 337 343 PF00069 0.517
MOD_ProDKin_1 371 377 PF00069 0.599
MOD_ProDKin_1 401 407 PF00069 0.459
MOD_ProDKin_1 507 513 PF00069 0.480
MOD_ProDKin_1 686 692 PF00069 0.524
MOD_ProDKin_1 818 824 PF00069 0.292
MOD_ProDKin_1 903 909 PF00069 0.273
MOD_SUMO_for_1 135 138 PF00179 0.429
TRG_DiLeu_BaEn_1 212 217 PF01217 0.521
TRG_DiLeu_BaEn_1 299 304 PF01217 0.493
TRG_DiLeu_BaEn_4 30 36 PF01217 0.700
TRG_DiLeu_BaLyEn_6 157 162 PF01217 0.607
TRG_ENDOCYTIC_2 313 316 PF00928 0.412
TRG_ENDOCYTIC_2 532 535 PF00928 0.535
TRG_ENDOCYTIC_2 564 567 PF00928 0.333
TRG_ENDOCYTIC_2 571 574 PF00928 0.314
TRG_ENDOCYTIC_2 672 675 PF00928 0.406
TRG_ENDOCYTIC_2 90 93 PF00928 0.468
TRG_ENDOCYTIC_2 943 946 PF00928 0.312
TRG_ENDOCYTIC_2 947 950 PF00928 0.308
TRG_ER_diArg_1 117 120 PF00400 0.450
TRG_ER_diArg_1 130 132 PF00400 0.495
TRG_ER_diArg_1 496 498 PF00400 0.333
TRG_ER_diArg_1 668 671 PF00400 0.382
TRG_ER_diArg_1 8 10 PF00400 0.644
TRG_NES_CRM1_1 440 452 PF08389 0.502
TRG_NLS_Bipartite_1 100 122 PF00514 0.469
TRG_NLS_MonoExtC_3 282 288 PF00514 0.702
TRG_NLS_MonoExtN_4 115 122 PF00514 0.444
TRG_NLS_MonoExtN_4 281 287 PF00514 0.472
TRG_Pf-PMV_PEXEL_1 120 124 PF00026 0.507
TRG_Pf-PMV_PEXEL_1 416 420 PF00026 0.501
TRG_Pf-PMV_PEXEL_1 626 630 PF00026 0.406
TRG_Pf-PMV_PEXEL_1 777 782 PF00026 0.622

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P863 Leptomonas seymouri 69% 95%
A0A1X0NZS2 Trypanosomatidae 54% 100%
A0A3R7KME7 Trypanosoma rangeli 54% 100%
A0A3S7X1C4 Leishmania donovani 90% 98%
A4HGD8 Leishmania braziliensis 80% 99%
A4I3H1 Leishmania infantum 90% 98%
D0A7W5 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 49% 100%
Q4Q8H3 Leishmania major 90% 100%
V5BG64 Trypanosoma cruzi 51% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS