Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AZQ6_LEIMU

TriTrypDb:

LmxM.28.0900

Length:

303

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AZQ6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AZQ6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	149	151	PF00675	0.653
CLV_NRD_NRD_1	227	229	PF00675	0.632
CLV_NRD_NRD_1	3	5	PF00675	0.698
CLV_NRD_NRD_1	38	40	PF00675	0.613
CLV_NRD_NRD_1	74	76	PF00675	0.672
CLV_PCSK_FUR_1	104	108	PF00082	0.633
CLV_PCSK_KEX2_1	106	108	PF00082	0.549
CLV_PCSK_KEX2_1	149	151	PF00082	0.658
CLV_PCSK_KEX2_1	2	4	PF00082	0.793
CLV_PCSK_KEX2_1	271	273	PF00082	0.553
CLV_PCSK_KEX2_1	278	280	PF00082	0.622
CLV_PCSK_KEX2_1	74	76	PF00082	0.672
CLV_PCSK_PC1ET2_1	106	108	PF00082	0.564
CLV_PCSK_PC1ET2_1	271	273	PF00082	0.553
CLV_PCSK_PC1ET2_1	278	280	PF00082	0.622
CLV_PCSK_PC7_1	102	108	PF00082	0.571
CLV_PCSK_SKI1_1	207	211	PF00082	0.371
CLV_PCSK_SKI1_1	39	43	PF00082	0.505
CLV_PCSK_SKI1_1	79	83	PF00082	0.507
DEG_APCC_DBOX_1	83	91	PF00400	0.550
DEG_Nend_UBRbox_1	1	4	PF02207	0.602
DOC_CYCLIN_RxL_1	263	273	PF00134	0.420
DOC_MAPK_gen_1	104	112	PF00069	0.554
DOC_MAPK_gen_1	186	196	PF00069	0.568
DOC_MAPK_gen_1	37	46	PF00069	0.557
DOC_MAPK_MEF2A_6	189	198	PF00069	0.579
DOC_MAPK_MEF2A_6	37	46	PF00069	0.557
DOC_MAPK_NFAT4_5	39	47	PF00069	0.629
DOC_PP1_RVXF_1	37	44	PF00149	0.550
DOC_USP7_MATH_1	10	14	PF00917	0.543
DOC_WW_Pin1_4	281	286	PF00397	0.459
LIG_14-3-3_CanoR_1	2	9	PF00244	0.717
LIG_14-3-3_CanoR_1	231	235	PF00244	0.653
LIG_Actin_WH2_2	123	141	PF00022	0.495
LIG_Actin_WH2_2	255	273	PF00022	0.554
LIG_APCC_ABBAyCdc20_2	39	45	PF00400	0.554
LIG_Clathr_ClatBox_1	41	45	PF01394	0.553
LIG_FHA_1	17	23	PF00498	0.630
LIG_FHA_2	197	203	PF00498	0.557
LIG_FHA_2	249	255	PF00498	0.572
LIG_FHA_2	25	31	PF00498	0.538
LIG_FHA_2	53	59	PF00498	0.618
LIG_LIR_Nem_3	236	242	PF02991	0.588
LIG_LIR_Nem_3	273	277	PF02991	0.573
LIG_LRP6_Inhibitor_1	31	37	PF00058	0.542
LIG_NRBOX	258	264	PF00104	0.509
LIG_SH2_CRK	239	243	PF00017	0.586
LIG_SH2_CRK	280	284	PF00017	0.531
LIG_SH2_GRB2like	97	100	PF00017	0.573
LIG_SH2_STAT5	275	278	PF00017	0.583
LIG_SH3_3	60	66	PF00018	0.719
LIG_SUMO_SIM_anti_2	27	33	PF11976	0.554
LIG_TRAF2_1	253	256	PF00917	0.552
LIG_TRAF2_1	56	59	PF00917	0.492
MOD_CK2_1	194	200	PF00069	0.462
MOD_CK2_1	218	224	PF00069	0.557
MOD_CK2_1	230	236	PF00069	0.627
MOD_CK2_1	248	254	PF00069	0.567
MOD_CK2_1	52	58	PF00069	0.604
MOD_GlcNHglycan	11	15	PF01048	0.629
MOD_GlcNHglycan	218	223	PF01048	0.503
MOD_GlcNHglycan	52	55	PF01048	0.677
MOD_GSK3_1	141	148	PF00069	0.658
MOD_GSK3_1	240	247	PF00069	0.359
MOD_NEK2_1	270	275	PF00069	0.490
MOD_PIKK_1	58	64	PF00454	0.495
MOD_PK_1	279	285	PF00069	0.441
MOD_PKA_1	2	8	PF00069	0.594
MOD_PKA_2	2	8	PF00069	0.704
MOD_PKA_2	230	236	PF00069	0.532
MOD_PKB_1	2	10	PF00069	0.596
MOD_Plk_1	58	64	PF00069	0.716
MOD_Plk_2-3	248	254	PF00069	0.345
MOD_ProDKin_1	281	287	PF00069	0.457
MOD_SUMO_for_1	162	165	PF00179	0.354
MOD_SUMO_rev_2	33	42	PF00179	0.542
MOD_SUMO_rev_2	85	90	PF00179	0.550
TRG_DiLeu_BaEn_4	171	177	PF01217	0.533
TRG_DiLeu_BaEn_4	254	260	PF01217	0.547
TRG_ENDOCYTIC_2	239	242	PF00928	0.587
TRG_ENDOCYTIC_2	274	277	PF00928	0.526
TRG_ENDOCYTIC_2	280	283	PF00928	0.606
TRG_ER_diArg_1	1	4	PF00400	0.602
TRG_ER_diArg_1	101	104	PF00400	0.632
TRG_ER_diArg_1	149	152	PF00400	0.587
TRG_ER_diArg_1	74	76	PF00400	0.677
TRG_NES_CRM1_1	171	182	PF08389	0.505

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IM76	Leptomonas seymouri	56%	97%
A0A1X0NYF4	Trypanosomatidae	32%	100%
A0A3S7X1C2	Leishmania donovani	86%	100%
A4HGD4	Leishmania braziliensis	68%	100%
A4I3G7	Leishmania infantum	86%	100%
Q4Q8H7	Leishmania major	83%	100%