CNH domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AZQ3_LEIMU

TriTrypDb:

LmxM.28.0870

Length:

577

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 5

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 8

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	8
GO:0110165	cellular anatomical entity	1	8

Expansion

Sequence features

E9AZQ3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AZQ3

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	2
GO:0016874	ligase activity	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	118	120	PF00675	0.452
CLV_NRD_NRD_1	194	196	PF00675	0.512
CLV_NRD_NRD_1	233	235	PF00675	0.316
CLV_PCSK_FUR_1	231	235	PF00082	0.317
CLV_PCSK_KEX2_1	117	119	PF00082	0.469
CLV_PCSK_KEX2_1	194	196	PF00082	0.512
CLV_PCSK_KEX2_1	233	235	PF00082	0.314
CLV_PCSK_PC1ET2_1	117	119	PF00082	0.469
CLV_PCSK_PC1ET2_1	233	235	PF00082	0.314
CLV_PCSK_PC7_1	113	119	PF00082	0.379
CLV_PCSK_SKI1_1	205	209	PF00082	0.371
CLV_PCSK_SKI1_1	257	261	PF00082	0.393
CLV_PCSK_SKI1_1	383	387	PF00082	0.307
CLV_PCSK_SKI1_1	502	506	PF00082	0.396
CLV_PCSK_SKI1_1	566	570	PF00082	0.357
CLV_Separin_Metazoa	499	503	PF03568	0.545
DEG_Nend_Nbox_1	1	3	PF02207	0.450
DEG_SPOP_SBC_1	265	269	PF00917	0.433
DEG_SPOP_SBC_1	359	363	PF00917	0.580
DOC_CKS1_1	429	434	PF01111	0.543
DOC_CKS1_1	463	468	PF01111	0.579
DOC_CYCLIN_yClb3_PxF_3	432	440	PF00134	0.616
DOC_MAPK_gen_1	421	429	PF00069	0.481
DOC_MAPK_gen_1	479	488	PF00069	0.458
DOC_MAPK_MEF2A_6	209	216	PF00069	0.581
DOC_MAPK_MEF2A_6	440	447	PF00069	0.480
DOC_PP1_SILK_1	205	210	PF00149	0.593
DOC_PP4_FxxP_1	429	432	PF00568	0.625
DOC_PP4_FxxP_1	568	571	PF00568	0.585
DOC_USP7_MATH_1	136	140	PF00917	0.588
DOC_USP7_MATH_1	153	157	PF00917	0.640
DOC_USP7_MATH_1	165	169	PF00917	0.626
DOC_USP7_MATH_1	221	225	PF00917	0.565
DOC_USP7_MATH_1	359	363	PF00917	0.618
DOC_USP7_MATH_1	52	56	PF00917	0.379
DOC_USP7_MATH_1	73	77	PF00917	0.293
DOC_USP7_UBL2_3	117	121	PF12436	0.673
DOC_USP7_UBL2_3	122	126	PF12436	0.718
DOC_USP7_UBL2_3	155	159	PF12436	0.663
DOC_USP7_UBL2_3	366	370	PF12436	0.543
DOC_WW_Pin1_4	193	198	PF00397	0.690
DOC_WW_Pin1_4	217	222	PF00397	0.492
DOC_WW_Pin1_4	428	433	PF00397	0.527
DOC_WW_Pin1_4	462	467	PF00397	0.583
DOC_WW_Pin1_4	569	574	PF00397	0.607
LIG_14-3-3_CanoR_1	234	239	PF00244	0.535
LIG_14-3-3_CanoR_1	257	266	PF00244	0.652
LIG_14-3-3_CanoR_1	295	303	PF00244	0.477
LIG_14-3-3_CanoR_1	308	314	PF00244	0.511
LIG_14-3-3_CanoR_1	325	331	PF00244	0.540
LIG_14-3-3_CanoR_1	332	336	PF00244	0.524
LIG_14-3-3_CanoR_1	423	430	PF00244	0.496
LIG_14-3-3_CanoR_1	566	571	PF00244	0.494
LIG_AP2alpha_1	296	300	PF02296	0.550
LIG_APCC_ABBA_1	443	448	PF00400	0.488
LIG_APCC_ABBA_1	469	474	PF00400	0.430
LIG_APCC_ABBAyCdc20_2	19	25	PF00400	0.407
LIG_BRCT_BRCA1_1	279	283	PF00533	0.429
LIG_FHA_1	24	30	PF00498	0.417
LIG_FHA_1	265	271	PF00498	0.594
LIG_FHA_1	286	292	PF00498	0.600
LIG_FHA_1	346	352	PF00498	0.563
LIG_FHA_2	194	200	PF00498	0.692
LIG_FHA_2	347	353	PF00498	0.518
LIG_FHA_2	362	368	PF00498	0.601
LIG_FHA_2	451	457	PF00498	0.513
LIG_FHA_2	510	516	PF00498	0.536
LIG_GBD_Chelix_1	70	78	PF00786	0.258
LIG_LIR_Gen_1	256	266	PF02991	0.513
LIG_LIR_Gen_1	297	305	PF02991	0.538
LIG_LIR_Gen_1	439	447	PF02991	0.475
LIG_LIR_Gen_1	60	69	PF02991	0.363
LIG_LIR_Nem_3	224	228	PF02991	0.493
LIG_LIR_Nem_3	256	262	PF02991	0.501
LIG_LIR_Nem_3	297	303	PF02991	0.469
LIG_LIR_Nem_3	439	445	PF02991	0.480
LIG_LIR_Nem_3	60	64	PF02991	0.295
LIG_PCNA_PIPBox_1	527	536	PF02747	0.499
LIG_PCNA_yPIPBox_3	308	317	PF02747	0.555
LIG_Pex14_2	296	300	PF04695	0.625
LIG_Rb_pABgroove_1	528	536	PF01858	0.539
LIG_SH2_CRK	442	446	PF00017	0.508
LIG_SH2_SRC	21	24	PF00017	0.323
LIG_SH2_STAP1	279	283	PF00017	0.538
LIG_SH2_STAT3	279	282	PF00017	0.541
LIG_SH2_STAT3	455	458	PF00017	0.544
LIG_SH2_STAT3	534	537	PF00017	0.531
LIG_SH2_STAT5	21	24	PF00017	0.420
LIG_SH2_STAT5	225	228	PF00017	0.500
LIG_SH3_3	429	435	PF00018	0.584
LIG_SH3_3	479	485	PF00018	0.585
LIG_SUMO_SIM_anti_2	339	346	PF11976	0.506
LIG_SUMO_SIM_anti_2	348	355	PF11976	0.476
LIG_SUMO_SIM_anti_2	60	66	PF11976	0.400
LIG_SUMO_SIM_par_1	339	346	PF11976	0.520
LIG_SUMO_SIM_par_1	70	76	PF11976	0.298
LIG_TRAF2_1	109	112	PF00917	0.545
LIG_UBA3_1	567	575	PF00899	0.600
MOD_CDC14_SPxK_1	572	575	PF00782	0.611
MOD_CDK_SPxK_1	569	575	PF00069	0.577
MOD_CK1_1	168	174	PF00069	0.671
MOD_CK1_1	193	199	PF00069	0.733
MOD_CK1_1	306	312	PF00069	0.580
MOD_CK1_1	340	346	PF00069	0.630
MOD_CK2_1	106	112	PF00069	0.654
MOD_CK2_1	346	352	PF00069	0.486
MOD_CK2_1	509	515	PF00069	0.535
MOD_GlcNHglycan	150	153	PF01048	0.570
MOD_GlcNHglycan	155	158	PF01048	0.624
MOD_GlcNHglycan	170	173	PF01048	0.392
MOD_GlcNHglycan	279	282	PF01048	0.257
MOD_GlcNHglycan	3	6	PF01048	0.620
MOD_GlcNHglycan	305	308	PF01048	0.370
MOD_GlcNHglycan	372	375	PF01048	0.396
MOD_GlcNHglycan	39	42	PF01048	0.537
MOD_GlcNHglycan	424	427	PF01048	0.308
MOD_GlcNHglycan	50	53	PF01048	0.605
MOD_GlcNHglycan	515	519	PF01048	0.436
MOD_GlcNHglycan	54	57	PF01048	0.573
MOD_GlcNHglycan	556	559	PF01048	0.323
MOD_GSK3_1	136	143	PF00069	0.641
MOD_GSK3_1	189	196	PF00069	0.749
MOD_GSK3_1	217	224	PF00069	0.639
MOD_GSK3_1	277	284	PF00069	0.500
MOD_GSK3_1	311	318	PF00069	0.532
MOD_GSK3_1	458	465	PF00069	0.668
MOD_GSK3_1	48	55	PF00069	0.362
MOD_GSK3_1	569	576	PF00069	0.546
MOD_LATS_1	564	570	PF00433	0.493
MOD_N-GLC_1	309	314	PF02516	0.264
MOD_N-GLC_1	509	514	PF02516	0.276
MOD_NEK2_1	1	6	PF00069	0.426
MOD_NEK2_1	189	194	PF00069	0.685
MOD_NEK2_1	216	221	PF00069	0.522
MOD_NEK2_1	285	290	PF00069	0.546
MOD_NEK2_1	296	301	PF00069	0.475
MOD_NEK2_1	303	308	PF00069	0.450
MOD_NEK2_1	326	331	PF00069	0.558
MOD_NEK2_1	35	40	PF00069	0.436
MOD_NEK2_1	386	391	PF00069	0.547
MOD_NEK2_1	422	427	PF00069	0.508
MOD_NEK2_1	554	559	PF00069	0.513
MOD_NEK2_2	450	455	PF00069	0.533
MOD_NEK2_2	509	514	PF00069	0.553
MOD_PIKK_1	311	317	PF00454	0.507
MOD_PIKK_1	459	465	PF00454	0.604
MOD_PKA_1	234	240	PF00069	0.556
MOD_PKA_2	294	300	PF00069	0.482
MOD_PKA_2	331	337	PF00069	0.525
MOD_PKA_2	394	400	PF00069	0.610
MOD_PKA_2	422	428	PF00069	0.496
MOD_Plk_1	285	291	PF00069	0.545
MOD_Plk_1	309	315	PF00069	0.464
MOD_Plk_1	509	515	PF00069	0.487
MOD_Plk_2-3	346	352	PF00069	0.486
MOD_Plk_4	203	209	PF00069	0.533
MOD_Plk_4	221	227	PF00069	0.495
MOD_Plk_4	234	240	PF00069	0.557
MOD_Plk_4	296	302	PF00069	0.523
MOD_Plk_4	337	343	PF00069	0.576
MOD_Plk_4	386	392	PF00069	0.538
MOD_Plk_4	450	456	PF00069	0.545
MOD_Plk_4	467	473	PF00069	0.485
MOD_Plk_4	509	515	PF00069	0.513
MOD_ProDKin_1	193	199	PF00069	0.691
MOD_ProDKin_1	217	223	PF00069	0.491
MOD_ProDKin_1	428	434	PF00069	0.540
MOD_ProDKin_1	462	468	PF00069	0.582
MOD_ProDKin_1	569	575	PF00069	0.616
MOD_SUMO_rev_2	123	128	PF00179	0.587
MOD_SUMO_rev_2	269	276	PF00179	0.476
TRG_DiLeu_BaEn_1	213	218	PF01217	0.544
TRG_DiLeu_BaEn_2	123	129	PF01217	0.658
TRG_DiLeu_BaLyEn_6	286	291	PF01217	0.454
TRG_ENDOCYTIC_2	225	228	PF00928	0.500
TRG_ENDOCYTIC_2	442	445	PF00928	0.462
TRG_ENDOCYTIC_2	497	500	PF00928	0.591
TRG_ER_diArg_1	479	482	PF00400	0.468
TRG_ER_diArg_1	98	101	PF00400	0.702
TRG_NLS_MonoCore_2	116	121	PF00514	0.635
TRG_NLS_MonoExtC_3	116	121	PF00514	0.558
TRG_NLS_MonoExtN_4	231	237	PF00514	0.505
TRG_Pf-PMV_PEXEL_1	133	137	PF00026	0.356
TRG_Pf-PMV_PEXEL_1	252	256	PF00026	0.334

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P7S9	Leptomonas seymouri	62%	100%
A0A1X0NYG1	Trypanosomatidae	43%	100%
A0A3S7X1B3	Leishmania donovani	89%	100%
A0A422N3T8	Trypanosoma rangeli	44%	100%
A4HGD1	Leishmania braziliensis	76%	99%
Q4Q8I0	Leishmania major	87%	100%