Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein

Species:

Leishmania mexicana

UniProt:

E9AZQ2_LEIMU

TriTrypDb:

LmxM.28.0860

Length:

484

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 3, no: 2
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AZQ2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AZQ2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	133	135	PF00675	0.549
CLV_NRD_NRD_1	240	242	PF00675	0.603
CLV_NRD_NRD_1	379	381	PF00675	0.552
CLV_PCSK_FUR_1	238	242	PF00082	0.603
CLV_PCSK_KEX2_1	133	135	PF00082	0.549
CLV_PCSK_KEX2_1	240	242	PF00082	0.603
CLV_PCSK_KEX2_1	346	348	PF00082	0.753
CLV_PCSK_PC1ET2_1	346	348	PF00082	0.753
CLV_PCSK_SKI1_1	134	138	PF00082	0.752
CLV_PCSK_SKI1_1	250	254	PF00082	0.635
CLV_PCSK_SKI1_1	323	327	PF00082	0.771
CLV_PCSK_SKI1_1	84	88	PF00082	0.740
DEG_APCC_KENBOX_2	298	302	PF00400	0.571
DEG_SPOP_SBC_1	211	215	PF00917	0.759
DEG_SPOP_SBC_1	269	273	PF00917	0.812
DOC_CKS1_1	293	298	PF01111	0.681
DOC_CYCLIN_yCln2_LP_2	326	332	PF00134	0.829
DOC_CYCLIN_yCln2_LP_2	391	397	PF00134	0.519
DOC_PP2B_LxvP_1	175	178	PF13499	0.815
DOC_PP2B_LxvP_1	326	329	PF13499	0.827
DOC_USP7_MATH_1	107	111	PF00917	0.582
DOC_USP7_MATH_1	138	142	PF00917	0.601
DOC_USP7_MATH_1	211	215	PF00917	0.849
DOC_USP7_MATH_1	225	229	PF00917	0.836
DOC_USP7_MATH_1	257	261	PF00917	0.637
DOC_USP7_MATH_1	269	273	PF00917	0.644
DOC_USP7_MATH_1	337	341	PF00917	0.732
DOC_USP7_MATH_1	80	84	PF00917	0.667
DOC_WW_Pin1_4	103	108	PF00397	0.742
DOC_WW_Pin1_4	152	157	PF00397	0.776
DOC_WW_Pin1_4	265	270	PF00397	0.796
DOC_WW_Pin1_4	271	276	PF00397	0.742
DOC_WW_Pin1_4	287	292	PF00397	0.674
DOC_WW_Pin1_4	307	312	PF00397	0.568
DOC_WW_Pin1_4	386	391	PF00397	0.699
DOC_WW_Pin1_4	58	63	PF00397	0.775
DOC_WW_Pin1_4	6	11	PF00397	0.611
DOC_WW_Pin1_4	76	81	PF00397	0.556
LIG_14-3-3_CanoR_1	103	107	PF00244	0.733
LIG_14-3-3_CanoR_1	199	204	PF00244	0.664
LIG_14-3-3_CanoR_1	238	248	PF00244	0.552
LIG_14-3-3_CanoR_1	336	344	PF00244	0.550
LIG_14-3-3_CanoR_1	380	387	PF00244	0.674
LIG_14-3-3_CanoR_1	402	408	PF00244	0.587
LIG_BIR_III_2	77	81	PF00653	0.535
LIG_BRCT_BRCA1_1	349	353	PF00533	0.531
LIG_Clathr_ClatBox_1	86	90	PF01394	0.743
LIG_DLG_GKlike_1	199	207	PF00625	0.671
LIG_EVH1_2	47	51	PF00568	0.499
LIG_FHA_1	145	151	PF00498	0.741
LIG_FHA_1	170	176	PF00498	0.827
LIG_FHA_1	30	36	PF00498	0.772
LIG_FHA_1	315	321	PF00498	0.660
LIG_FHA_1	339	345	PF00498	0.585
LIG_FHA_1	373	379	PF00498	0.762
LIG_FHA_1	416	422	PF00498	0.531
LIG_FHA_2	188	194	PF00498	0.547
LIG_FHA_2	251	257	PF00498	0.723
LIG_FHA_2	295	301	PF00498	0.568
LIG_Integrin_RGD_1	96	98	PF01839	0.827
LIG_LIR_Apic_2	404	408	PF02991	0.712
LIG_LIR_Gen_1	478	484	PF02991	0.533
LIG_LIR_Nem_3	38	44	PF02991	0.661
LIG_LIR_Nem_3	464	470	PF02991	0.608
LIG_LIR_Nem_3	478	484	PF02991	0.578
LIG_PCNA_PIPBox_1	245	254	PF02747	0.686
LIG_PCNA_yPIPBox_3	238	252	PF02747	0.692
LIG_PDZ_Class_3	479	484	PF00595	0.614
LIG_Pex14_1	477	481	PF04695	0.617
LIG_SH2_CRK	44	48	PF00017	0.501
LIG_SH2_CRK	467	471	PF00017	0.557
LIG_SH2_GRB2like	41	44	PF00017	0.727
LIG_SH2_NCK_1	44	48	PF00017	0.704
LIG_SH2_SRC	44	47	PF00017	0.501
LIG_SH2_STAT5	183	186	PF00017	0.855
LIG_SH2_STAT5	405	408	PF00017	0.787
LIG_SH2_STAT5	467	470	PF00017	0.558
LIG_SH3_3	174	180	PF00018	0.739
LIG_SH3_3	204	210	PF00018	0.650
LIG_SH3_3	219	225	PF00018	0.673
LIG_SH3_3	228	234	PF00018	0.664
LIG_SH3_3	290	296	PF00018	0.688
LIG_SH3_3	59	65	PF00018	0.749
LIG_SUMO_SIM_par_1	435	442	PF11976	0.587
LIG_TRAF2_1	243	246	PF00917	0.607
LIG_TRAF2_1	253	256	PF00917	0.719
LIG_TYR_ITIM	465	470	PF00017	0.562
MOD_CDC14_SPxK_1	106	109	PF00782	0.730
MOD_CDC14_SPxK_1	274	277	PF00782	0.629
MOD_CDC14_SPxK_1	310	313	PF00782	0.554
MOD_CDK_SPxK_1	103	109	PF00069	0.741
MOD_CDK_SPxK_1	152	158	PF00069	0.644
MOD_CDK_SPxK_1	271	277	PF00069	0.627
MOD_CDK_SPxK_1	307	313	PF00069	0.585
MOD_CDK_SPxxK_3	287	294	PF00069	0.677
MOD_CK1_1	105	111	PF00069	0.558
MOD_CK1_1	182	188	PF00069	0.790
MOD_CK1_1	260	266	PF00069	0.801
MOD_CK1_1	268	274	PF00069	0.691
MOD_CK1_1	280	286	PF00069	0.519
MOD_CK1_1	287	293	PF00069	0.537
MOD_CK1_1	338	344	PF00069	0.774
MOD_CK1_1	345	351	PF00069	0.782
MOD_CK1_1	401	407	PF00069	0.754
MOD_CK1_1	413	419	PF00069	0.577
MOD_CK1_1	58	64	PF00069	0.787
MOD_CK1_1	79	85	PF00069	0.730
MOD_CK1_1	9	15	PF00069	0.691
MOD_CK2_1	142	148	PF00069	0.822
MOD_CK2_1	187	193	PF00069	0.551
MOD_CK2_1	23	29	PF00069	0.523
MOD_CK2_1	250	256	PF00069	0.672
MOD_CK2_1	294	300	PF00069	0.655
MOD_Cter_Amidation	238	241	PF01082	0.605
MOD_GlcNHglycan	11	14	PF01048	0.784
MOD_GlcNHglycan	144	147	PF01048	0.743
MOD_GlcNHglycan	17	20	PF01048	0.700
MOD_GlcNHglycan	196	199	PF01048	0.696
MOD_GlcNHglycan	203	206	PF01048	0.631
MOD_GlcNHglycan	259	262	PF01048	0.602
MOD_GlcNHglycan	278	282	PF01048	0.757
MOD_GlcNHglycan	286	289	PF01048	0.749
MOD_GlcNHglycan	337	340	PF01048	0.785
MOD_GlcNHglycan	349	352	PF01048	0.685
MOD_GlcNHglycan	362	365	PF01048	0.658
MOD_GlcNHglycan	57	60	PF01048	0.637
MOD_GSK3_1	107	114	PF00069	0.593
MOD_GSK3_1	138	145	PF00069	0.801
MOD_GSK3_1	158	165	PF00069	0.547
MOD_GSK3_1	179	186	PF00069	0.816
MOD_GSK3_1	187	194	PF00069	0.733
MOD_GSK3_1	265	272	PF00069	0.787
MOD_GSK3_1	280	287	PF00069	0.602
MOD_GSK3_1	29	36	PF00069	0.743
MOD_GSK3_1	307	314	PF00069	0.627
MOD_GSK3_1	328	335	PF00069	0.625
MOD_GSK3_1	338	345	PF00069	0.719
MOD_GSK3_1	368	375	PF00069	0.569
MOD_GSK3_1	403	410	PF00069	0.634
MOD_GSK3_1	47	54	PF00069	0.671
MOD_GSK3_1	76	83	PF00069	0.744
MOD_GSK3_1	98	105	PF00069	0.766
MOD_N-GLC_1	138	143	PF02516	0.740
MOD_N-GLC_1	162	167	PF02516	0.543
MOD_N-GLC_1	187	192	PF02516	0.554
MOD_N-GLC_1	332	337	PF02516	0.837
MOD_NEK2_1	169	174	PF00069	0.540
MOD_NEK2_1	226	231	PF00069	0.559
MOD_NEK2_1	244	249	PF00069	0.704
MOD_NEK2_1	55	60	PF00069	0.772
MOD_NEK2_2	107	112	PF00069	0.602
MOD_NEK2_2	171	176	PF00069	0.712
MOD_OFUCOSY	104	111	PF10250	0.636
MOD_PIKK_1	162	168	PF00454	0.599
MOD_PIKK_1	339	345	PF00454	0.550
MOD_PKA_2	102	108	PF00069	0.764
MOD_PKA_2	157	163	PF00069	0.694
MOD_PKA_2	23	29	PF00069	0.610
MOD_PKA_2	239	245	PF00069	0.526
MOD_PKA_2	33	39	PF00069	0.688
MOD_PKA_2	335	341	PF00069	0.618
MOD_PKA_2	368	374	PF00069	0.682
MOD_PKA_2	379	385	PF00069	0.651
MOD_PKA_2	401	407	PF00069	0.588
MOD_PKA_2	413	419	PF00069	0.573
MOD_Plk_4	116	122	PF00069	0.513
MOD_Plk_4	179	185	PF00069	0.837
MOD_Plk_4	368	374	PF00069	0.842
MOD_Plk_4	416	422	PF00069	0.629
MOD_Plk_4	90	96	PF00069	0.819
MOD_ProDKin_1	103	109	PF00069	0.741
MOD_ProDKin_1	152	158	PF00069	0.777
MOD_ProDKin_1	265	271	PF00069	0.795
MOD_ProDKin_1	287	293	PF00069	0.779
MOD_ProDKin_1	307	313	PF00069	0.569
MOD_ProDKin_1	386	392	PF00069	0.696
MOD_ProDKin_1	58	64	PF00069	0.775
MOD_ProDKin_1	6	12	PF00069	0.610
MOD_ProDKin_1	76	82	PF00069	0.555
MOD_SUMO_rev_2	401	411	PF00179	0.716
TRG_DiLeu_BaLyEn_6	81	86	PF01217	0.817
TRG_ENDOCYTIC_2	467	470	PF00928	0.558
TRG_ER_diArg_1	237	240	PF00400	0.722
TRG_ER_diArg_1	320	323	PF00400	0.834
TRG_NES_CRM1_1	447	461	PF08389	0.619
TRG_Pf-PMV_PEXEL_1	250	255	PF00026	0.803
TRG_Pf-PMV_PEXEL_1	84	88	PF00026	0.740

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8IER7	Leishmania donovani	83%	96%
A4HGD0	Leishmania braziliensis	57%	99%
A4I3G3	Leishmania infantum	83%	96%
Q4Q8I1	Leishmania major	84%	100%