Tc-38 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AZQ0_LEIMU

TriTrypDb:

LmxM.28.0840

Length:

822

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AZQ0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AZQ0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	177	181	PF00656	0.503
CLV_C14_Caspase3-7	515	519	PF00656	0.304
CLV_C14_Caspase3-7	743	747	PF00656	0.635
CLV_NRD_NRD_1	152	154	PF00675	0.623
CLV_NRD_NRD_1	234	236	PF00675	0.489
CLV_NRD_NRD_1	242	244	PF00675	0.569
CLV_NRD_NRD_1	32	34	PF00675	0.432
CLV_NRD_NRD_1	43	45	PF00675	0.293
CLV_NRD_NRD_1	545	547	PF00675	0.566
CLV_NRD_NRD_1	631	633	PF00675	0.423
CLV_NRD_NRD_1	670	672	PF00675	0.615
CLV_PCSK_KEX2_1	152	154	PF00082	0.505
CLV_PCSK_KEX2_1	234	236	PF00082	0.548
CLV_PCSK_KEX2_1	242	244	PF00082	0.698
CLV_PCSK_KEX2_1	32	34	PF00082	0.432
CLV_PCSK_KEX2_1	545	547	PF00082	0.566
CLV_PCSK_KEX2_1	605	607	PF00082	0.433
CLV_PCSK_KEX2_1	631	633	PF00082	0.423
CLV_PCSK_PC1ET2_1	605	607	PF00082	0.433
CLV_PCSK_SKI1_1	12	16	PF00082	0.326
CLV_PCSK_SKI1_1	139	143	PF00082	0.507
CLV_PCSK_SKI1_1	237	241	PF00082	0.437
CLV_PCSK_SKI1_1	44	48	PF00082	0.432
CLV_PCSK_SKI1_1	457	461	PF00082	0.473
CLV_PCSK_SKI1_1	464	468	PF00082	0.425
CLV_PCSK_SKI1_1	684	688	PF00082	0.658
DEG_Nend_Nbox_1	1	3	PF02207	0.483
DEG_SPOP_SBC_1	553	557	PF00917	0.551
DOC_CDC14_PxL_1	370	378	PF14671	0.524
DOC_CYCLIN_RxL_1	454	462	PF00134	0.489
DOC_CYCLIN_yCln2_LP_2	507	513	PF00134	0.392
DOC_MAPK_gen_1	32	42	PF00069	0.330
DOC_MAPK_gen_1	416	424	PF00069	0.533
DOC_MAPK_gen_1	645	653	PF00069	0.411
DOC_MAPK_HePTP_8	289	301	PF00069	0.526
DOC_MAPK_MEF2A_6	292	301	PF00069	0.517
DOC_PP1_RVXF_1	406	413	PF00149	0.467
DOC_PP1_RVXF_1	455	462	PF00149	0.485
DOC_PP1_RVXF_1	489	496	PF00149	0.629
DOC_PP2B_LxvP_1	111	114	PF13499	0.680
DOC_PP4_FxxP_1	199	202	PF00568	0.580
DOC_PP4_FxxP_1	427	430	PF00568	0.487
DOC_PP4_FxxP_1	676	679	PF00568	0.658
DOC_USP7_MATH_1	178	182	PF00917	0.715
DOC_USP7_MATH_1	552	556	PF00917	0.574
DOC_USP7_MATH_1	559	563	PF00917	0.660
DOC_USP7_MATH_1	618	622	PF00917	0.426
DOC_USP7_MATH_1	724	728	PF00917	0.449
DOC_USP7_MATH_1	737	741	PF00917	0.746
DOC_WW_Pin1_4	109	114	PF00397	0.564
DOC_WW_Pin1_4	124	129	PF00397	0.602
DOC_WW_Pin1_4	181	186	PF00397	0.603
DOC_WW_Pin1_4	555	560	PF00397	0.673
DOC_WW_Pin1_4	631	636	PF00397	0.401
DOC_WW_Pin1_4	67	72	PF00397	0.287
DOC_WW_Pin1_4	675	680	PF00397	0.568
DOC_WW_Pin1_4	813	818	PF00397	0.507
LIG_14-3-3_CanoR_1	139	146	PF00244	0.534
LIG_14-3-3_CanoR_1	242	247	PF00244	0.599
LIG_14-3-3_CanoR_1	296	302	PF00244	0.498
LIG_14-3-3_CanoR_1	307	313	PF00244	0.405
LIG_14-3-3_CanoR_1	396	403	PF00244	0.465
LIG_14-3-3_CanoR_1	527	531	PF00244	0.565
LIG_14-3-3_CanoR_1	566	575	PF00244	0.574
LIG_14-3-3_CanoR_1	648	654	PF00244	0.395
LIG_14-3-3_CanoR_1	773	777	PF00244	0.632
LIG_Actin_WH2_2	571	589	PF00022	0.410
LIG_BRCT_BRCA1_1	156	160	PF00533	0.709
LIG_CaM_IQ_9	410	425	PF13499	0.535
LIG_CaMK_CASK_1	39	44	PF00069	0.432
LIG_CSL_BTD_1	40	43	PF09270	0.326
LIG_deltaCOP1_diTrp_1	190	199	PF00928	0.568
LIG_deltaCOP1_diTrp_1	39	47	PF00928	0.432
LIG_EVH1_2	520	524	PF00568	0.511
LIG_FAT_LD_1	104	112	PF03623	0.409
LIG_FHA_1	13	19	PF00498	0.326
LIG_FHA_1	169	175	PF00498	0.715
LIG_FHA_1	214	220	PF00498	0.611
LIG_FHA_1	278	284	PF00498	0.466
LIG_FHA_1	308	314	PF00498	0.556
LIG_FHA_1	558	564	PF00498	0.645
LIG_FHA_1	77	83	PF00498	0.326
LIG_FHA_1	780	786	PF00498	0.492
LIG_FHA_2	110	116	PF00498	0.684
LIG_FHA_2	209	215	PF00498	0.442
LIG_FHA_2	350	356	PF00498	0.419
LIG_FHA_2	632	638	PF00498	0.508
LIG_FHA_2	68	74	PF00498	0.357
LIG_FHA_2	764	770	PF00498	0.392
LIG_HCF-1_HBM_1	290	293	PF13415	0.433
LIG_LIR_Gen_1	101	111	PF02991	0.606
LIG_LIR_Gen_1	190	199	PF02991	0.568
LIG_LIR_Gen_1	270	279	PF02991	0.512
LIG_LIR_Gen_1	295	304	PF02991	0.495
LIG_LIR_Gen_1	716	725	PF02991	0.314
LIG_LIR_Gen_1	800	808	PF02991	0.527
LIG_LIR_Nem_3	101	106	PF02991	0.478
LIG_LIR_Nem_3	190	196	PF02991	0.586
LIG_LIR_Nem_3	226	232	PF02991	0.529
LIG_LIR_Nem_3	245	249	PF02991	0.375
LIG_LIR_Nem_3	270	274	PF02991	0.474
LIG_LIR_Nem_3	295	301	PF02991	0.417
LIG_LIR_Nem_3	499	504	PF02991	0.359
LIG_LIR_Nem_3	639	644	PF02991	0.536
LIG_LIR_Nem_3	716	720	PF02991	0.294
LIG_LYPXL_yS_3	373	376	PF13949	0.516
LIG_LYPXL_yS_3	641	644	PF13949	0.411
LIG_MLH1_MIPbox_1	156	160	PF16413	0.709
LIG_MYND_1	185	189	PF01753	0.608
LIG_NRBOX	375	381	PF00104	0.535
LIG_Pex14_1	573	577	PF04695	0.476
LIG_Pex14_1	629	633	PF04695	0.522
LIG_Pex14_2	156	160	PF04695	0.495
LIG_Pex14_2	569	573	PF04695	0.483
LIG_PTB_Apo_2	120	127	PF02174	0.517
LIG_PTB_Apo_2	256	263	PF02174	0.513
LIG_PTB_Apo_2	270	277	PF02174	0.384
LIG_PTB_Apo_2	711	718	PF02174	0.556
LIG_REV1ctd_RIR_1	410	420	PF16727	0.541
LIG_REV1ctd_RIR_1	458	468	PF16727	0.488
LIG_SH2_CRK	271	275	PF00017	0.490
LIG_SH2_GRB2like	271	274	PF00017	0.479
LIG_SH2_NCK_1	271	275	PF00017	0.276
LIG_SH2_NCK_1	633	637	PF00017	0.382
LIG_SH2_PTP2	57	60	PF00017	0.432
LIG_SH2_PTP2	595	598	PF00017	0.593
LIG_SH2_SRC	266	269	PF00017	0.400
LIG_SH2_SRC	383	386	PF00017	0.626
LIG_SH2_STAT5	159	162	PF00017	0.717
LIG_SH2_STAT5	266	269	PF00017	0.550
LIG_SH2_STAT5	271	274	PF00017	0.371
LIG_SH2_STAT5	293	296	PF00017	0.434
LIG_SH2_STAT5	324	327	PF00017	0.446
LIG_SH2_STAT5	338	341	PF00017	0.436
LIG_SH2_STAT5	436	439	PF00017	0.456
LIG_SH2_STAT5	57	60	PF00017	0.432
LIG_SH2_STAT5	577	580	PF00017	0.568
LIG_SH2_STAT5	595	598	PF00017	0.364
LIG_SH2_STAT5	633	636	PF00017	0.380
LIG_SH3_3	183	189	PF00018	0.612
LIG_SH3_3	37	43	PF00018	0.326
LIG_SH3_3	591	597	PF00018	0.437
LIG_SH3_3	702	708	PF00018	0.518
LIG_SH3_3	742	748	PF00018	0.525
LIG_SUMO_SIM_anti_2	721	727	PF11976	0.346
LIG_SUMO_SIM_par_1	184	190	PF11976	0.498
LIG_TYR_ITIM	593	598	PF00017	0.571
MOD_CK1_1	109	115	PF00069	0.567
MOD_CK1_1	173	179	PF00069	0.560
MOD_CK1_1	181	187	PF00069	0.610
MOD_CK1_1	208	214	PF00069	0.452
MOD_CK1_1	245	251	PF00069	0.595
MOD_CK1_1	555	561	PF00069	0.700
MOD_CK1_1	767	773	PF00069	0.621
MOD_CK2_1	109	115	PF00069	0.655
MOD_CK2_1	144	150	PF00069	0.523
MOD_CK2_1	349	355	PF00069	0.383
MOD_CK2_1	737	743	PF00069	0.770
MOD_CK2_1	763	769	PF00069	0.500
MOD_CK2_1	772	778	PF00069	0.662
MOD_CK2_1	800	806	PF00069	0.521
MOD_GlcNHglycan	146	149	PF01048	0.716
MOD_GlcNHglycan	160	163	PF01048	0.526
MOD_GlcNHglycan	390	393	PF01048	0.592
MOD_GlcNHglycan	569	572	PF01048	0.510
MOD_GlcNHglycan	692	695	PF01048	0.683
MOD_GlcNHglycan	700	704	PF01048	0.543
MOD_GlcNHglycan	739	742	PF01048	0.773
MOD_GlcNHglycan	753	756	PF01048	0.497
MOD_GlcNHglycan	761	764	PF01048	0.463
MOD_GlcNHglycan	766	769	PF01048	0.424
MOD_GlcNHglycan	811	814	PF01048	0.732
MOD_GSK3_1	154	161	PF00069	0.602
MOD_GSK3_1	169	176	PF00069	0.530
MOD_GSK3_1	208	215	PF00069	0.469
MOD_GSK3_1	223	230	PF00069	0.455
MOD_GSK3_1	245	252	PF00069	0.590
MOD_GSK3_1	480	487	PF00069	0.378
MOD_GSK3_1	553	560	PF00069	0.566
MOD_GSK3_1	759	766	PF00069	0.458
MOD_GSK3_1	772	779	PF00069	0.653
MOD_GSK3_1	809	816	PF00069	0.734
MOD_N-GLC_1	122	127	PF02516	0.517
MOD_N-GLC_1	154	159	PF02516	0.706
MOD_N-GLC_1	205	210	PF02516	0.571
MOD_N-GLC_1	272	277	PF02516	0.288
MOD_N-GLC_1	502	507	PF02516	0.462
MOD_N-GLC_1	567	572	PF02516	0.561
MOD_N-GLC_1	65	70	PF02516	0.218
MOD_N-GLC_2	537	539	PF02516	0.478
MOD_NEK2_1	106	111	PF00069	0.510
MOD_NEK2_1	205	210	PF00069	0.571
MOD_NEK2_1	297	302	PF00069	0.443
MOD_NEK2_1	308	313	PF00069	0.383
MOD_NEK2_1	332	337	PF00069	0.570
MOD_NEK2_1	437	442	PF00069	0.455
MOD_NEK2_1	459	464	PF00069	0.473
MOD_NEK2_1	502	507	PF00069	0.462
MOD_NEK2_1	579	584	PF00069	0.525
MOD_NEK2_1	698	703	PF00069	0.584
MOD_NEK2_1	750	755	PF00069	0.598
MOD_NEK2_1	772	777	PF00069	0.578
MOD_NEK2_1	785	790	PF00069	0.643
MOD_NEK2_2	618	623	PF00069	0.510
MOD_PIKK_1	131	137	PF00454	0.711
MOD_PIKK_1	502	508	PF00454	0.474
MOD_PKA_1	242	248	PF00069	0.614
MOD_PKA_2	227	233	PF00069	0.454
MOD_PKA_2	242	248	PF00069	0.584
MOD_PKA_2	395	401	PF00069	0.480
MOD_PKA_2	526	532	PF00069	0.558
MOD_PKA_2	737	743	PF00069	0.579
MOD_PKA_2	772	778	PF00069	0.680
MOD_Plk_1	122	128	PF00069	0.512
MOD_Plk_1	179	185	PF00069	0.503
MOD_Plk_1	272	278	PF00069	0.300
MOD_Plk_1	332	338	PF00069	0.513
MOD_Plk_1	502	508	PF00069	0.474
MOD_Plk_1	618	624	PF00069	0.515
MOD_Plk_1	65	71	PF00069	0.326
MOD_Plk_1	699	705	PF00069	0.432
MOD_Plk_2-3	800	806	PF00069	0.536
MOD_Plk_4	170	176	PF00069	0.505
MOD_Plk_4	205	211	PF00069	0.542
MOD_Plk_4	242	248	PF00069	0.614
MOD_Plk_4	308	314	PF00069	0.519
MOD_Plk_4	767	773	PF00069	0.621
MOD_ProDKin_1	109	115	PF00069	0.571
MOD_ProDKin_1	124	130	PF00069	0.601
MOD_ProDKin_1	181	187	PF00069	0.604
MOD_ProDKin_1	555	561	PF00069	0.674
MOD_ProDKin_1	631	637	PF00069	0.399
MOD_ProDKin_1	67	73	PF00069	0.287
MOD_ProDKin_1	675	681	PF00069	0.570
MOD_ProDKin_1	813	819	PF00069	0.505
MOD_SUMO_rev_2	381	389	PF00179	0.638
TRG_DiLeu_BaEn_1	721	726	PF01217	0.337
TRG_DiLeu_BaEn_2	638	644	PF01217	0.541
TRG_DiLeu_BaLyEn_6	371	376	PF01217	0.416
TRG_DiLeu_BaLyEn_6	676	681	PF01217	0.646
TRG_DiLeu_BaLyEn_6	694	699	PF01217	0.432
TRG_DiLeu_BaLyEn_6	745	750	PF01217	0.598
TRG_DiLeu_BaLyEn_6	814	819	PF01217	0.601
TRG_ENDOCYTIC_2	271	274	PF00928	0.407
TRG_ENDOCYTIC_2	373	376	PF00928	0.516
TRG_ENDOCYTIC_2	595	598	PF00928	0.593
TRG_ENDOCYTIC_2	633	636	PF00928	0.380
TRG_ENDOCYTIC_2	641	644	PF00928	0.411
TRG_ENDOCYTIC_2	802	805	PF00928	0.527
TRG_ER_diArg_1	233	235	PF00400	0.480
TRG_ER_diArg_1	284	287	PF00400	0.425
TRG_ER_diArg_1	471	474	PF00400	0.405
TRG_ER_diArg_1	545	547	PF00400	0.468
TRG_ER_diArg_1	630	632	PF00400	0.426
TRG_Pf-PMV_PEXEL_1	378	382	PF00026	0.459

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P7T3	Leptomonas seymouri	44%	98%
A0A3S7X1B1	Leishmania donovani	86%	94%
A4I3G1	Leishmania infantum	86%	94%
Q4Q8I3	Leishmania major	86%	100%