LeishMANIAdb
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Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
hypothetical protein, conserved
Species:
Leishmania mexicana
UniProt:
E9AZP9_LEIMU
TriTrypDb:
LmxM.28.0835
Length:
174

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 9
NetGPI no yes: 0, no: 9
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AZP9
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AZP9

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 131 133 PF00675 0.488
CLV_NRD_NRD_1 75 77 PF00675 0.526
CLV_PCSK_FUR_1 73 77 PF00082 0.593
CLV_PCSK_KEX2_1 131 133 PF00082 0.468
CLV_PCSK_KEX2_1 75 77 PF00082 0.516
CLV_PCSK_PC7_1 71 77 PF00082 0.593
CLV_PCSK_SKI1_1 120 124 PF00082 0.369
CLV_PCSK_SKI1_1 136 140 PF00082 0.424
DEG_Nend_UBRbox_3 1 3 PF02207 0.550
DOC_MAPK_MEF2A_6 146 154 PF00069 0.531
DOC_USP7_MATH_1 81 85 PF00917 0.699
DOC_WW_Pin1_4 94 99 PF00397 0.710
LIG_14-3-3_CanoR_1 120 125 PF00244 0.283
LIG_14-3-3_CanoR_1 146 154 PF00244 0.578
LIG_Actin_WH2_2 25 42 PF00022 0.447
LIG_BIR_III_2 95 99 PF00653 0.770
LIG_FHA_2 121 127 PF00498 0.285
LIG_LIR_Nem_3 29 34 PF02991 0.487
LIG_SH2_STAP1 114 118 PF00017 0.392
LIG_SH2_STAT3 21 24 PF00017 0.574
LIG_SH2_STAT5 6 9 PF00017 0.569
MOD_CK1_1 153 159 PF00069 0.575
MOD_CK2_1 120 126 PF00069 0.285
MOD_Cter_Amidation 73 76 PF01082 0.599
MOD_GlcNHglycan 58 61 PF01048 0.684
MOD_GlcNHglycan 78 81 PF01048 0.713
MOD_GSK3_1 102 109 PF00069 0.501
MOD_GSK3_1 120 127 PF00069 0.288
MOD_GSK3_1 7 14 PF00069 0.446
MOD_N-GLC_1 102 107 PF02516 0.582
MOD_NEK2_1 7 12 PF00069 0.625
MOD_NEK2_2 82 87 PF00069 0.735
MOD_PKA_1 56 62 PF00069 0.560
MOD_PKA_2 145 151 PF00069 0.574
MOD_ProDKin_1 94 100 PF00069 0.710
TRG_DiLeu_BaEn_2 2 8 PF01217 0.648
TRG_ER_diArg_1 73 76 PF00400 0.615
TRG_Pf-PMV_PEXEL_1 26 30 PF00026 0.471

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1PFQ6 Leptomonas seymouri 57% 95%
A0A1X0NYP6 Trypanosomatidae 29% 100%
A0A3Q8IQF9 Leishmania donovani 85% 99%
A0A422N3V4 Trypanosoma rangeli 33% 100%
A4HGC8 Leishmania braziliensis 68% 100%
A4I3G0 Leishmania infantum 85% 99%
D0A7X8 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 29% 100%
Q4Q8I4 Leishmania major 84% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS