Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AZP8_LEIMU

TriTrypDb:

LmxM.28.0830

Length:

532

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AZP8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AZP8

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	1
GO:0003723	RNA binding	4	1
GO:0005488	binding	1	3
GO:0097159	organic cyclic compound binding	2	1
GO:1901363	heterocyclic compound binding	2	1
GO:0043167	ion binding	2	2
GO:0043169	cation binding	3	2
GO:0046872	metal ion binding	4	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	111	115	PF00656	0.681
CLV_C14_Caspase3-7	2	6	PF00656	0.466
CLV_NRD_NRD_1	135	137	PF00675	0.518
CLV_NRD_NRD_1	204	206	PF00675	0.395
CLV_NRD_NRD_1	373	375	PF00675	0.552
CLV_NRD_NRD_1	406	408	PF00675	0.359
CLV_NRD_NRD_1	495	497	PF00675	0.543
CLV_NRD_NRD_1	499	501	PF00675	0.507
CLV_PCSK_KEX2_1	135	137	PF00082	0.518
CLV_PCSK_KEX2_1	204	206	PF00082	0.595
CLV_PCSK_KEX2_1	213	215	PF00082	0.536
CLV_PCSK_KEX2_1	375	377	PF00082	0.524
CLV_PCSK_KEX2_1	392	394	PF00082	0.485
CLV_PCSK_KEX2_1	406	408	PF00082	0.565
CLV_PCSK_KEX2_1	495	497	PF00082	0.545
CLV_PCSK_KEX2_1	499	501	PF00082	0.502
CLV_PCSK_PC1ET2_1	213	215	PF00082	0.490
CLV_PCSK_PC1ET2_1	375	377	PF00082	0.575
CLV_PCSK_PC1ET2_1	392	394	PF00082	0.485
CLV_PCSK_PC7_1	495	501	PF00082	0.520
CLV_PCSK_SKI1_1	213	217	PF00082	0.537
CLV_PCSK_SKI1_1	293	297	PF00082	0.510
DEG_APCC_DBOX_1	292	300	PF00400	0.452
DEG_SCF_FBW7_1	151	157	PF00400	0.369
DEG_SPOP_SBC_1	42	46	PF00917	0.662
DOC_CDC14_PxL_1	20	28	PF14671	0.750
DOC_CKS1_1	103	108	PF01111	0.425
DOC_CKS1_1	151	156	PF01111	0.482
DOC_CKS1_1	160	165	PF01111	0.607
DOC_CYCLIN_RxL_1	290	298	PF00134	0.545
DOC_CYCLIN_yCln2_LP_2	320	326	PF00134	0.504
DOC_MAPK_DCC_7	16	25	PF00069	0.738
DOC_MAPK_DCC_7	522	531	PF00069	0.401
DOC_MAPK_gen_1	16	25	PF00069	0.726
DOC_MAPK_gen_1	406	413	PF00069	0.544
DOC_MAPK_gen_1	441	450	PF00069	0.609
DOC_MAPK_gen_1	520	528	PF00069	0.288
DOC_MAPK_HePTP_8	403	415	PF00069	0.414
DOC_MAPK_MEF2A_6	16	25	PF00069	0.738
DOC_MAPK_MEF2A_6	406	415	PF00069	0.619
DOC_MAPK_MEF2A_6	458	467	PF00069	0.522
DOC_MAPK_MEF2A_6	520	528	PF00069	0.358
DOC_PP4_FxxP_1	300	303	PF00568	0.505
DOC_USP7_MATH_1	144	148	PF00917	0.577
DOC_USP7_MATH_1	154	158	PF00917	0.565
DOC_USP7_MATH_1	31	35	PF00917	0.722
DOC_USP7_MATH_1	329	333	PF00917	0.443
DOC_USP7_MATH_1	378	382	PF00917	0.490
DOC_USP7_MATH_1	437	441	PF00917	0.615
DOC_USP7_MATH_2	31	37	PF00917	0.694
DOC_USP7_UBL2_3	483	487	PF12436	0.518
DOC_WW_Pin1_4	102	107	PF00397	0.436
DOC_WW_Pin1_4	135	140	PF00397	0.555
DOC_WW_Pin1_4	150	155	PF00397	0.453
DOC_WW_Pin1_4	159	164	PF00397	0.548
DOC_WW_Pin1_4	319	324	PF00397	0.406
DOC_WW_Pin1_4	46	51	PF00397	0.716
DOC_WW_Pin1_4	54	59	PF00397	0.672
LIG_14-3-3_CanoR_1	145	154	PF00244	0.546
LIG_14-3-3_CanoR_1	204	212	PF00244	0.574
LIG_14-3-3_CanoR_1	214	222	PF00244	0.492
LIG_14-3-3_CanoR_1	257	261	PF00244	0.486
LIG_14-3-3_CanoR_1	376	385	PF00244	0.511
LIG_14-3-3_CanoR_1	406	412	PF00244	0.593
LIG_14-3-3_CanoR_1	80	89	PF00244	0.572
LIG_Actin_WH2_2	208	225	PF00022	0.274
LIG_APCC_ABBA_1	189	194	PF00400	0.589
LIG_BIR_II_1	1	5	PF00653	0.659
LIG_BRCT_BRCA1_1	185	189	PF00533	0.572
LIG_BRCT_BRCA1_1	312	316	PF00533	0.367
LIG_BRCT_BRCA1_1	446	450	PF00533	0.410
LIG_BRCT_BRCA1_1	48	52	PF00533	0.606
LIG_deltaCOP1_diTrp_1	368	377	PF00928	0.550
LIG_deltaCOP1_diTrp_1	475	478	PF00928	0.407
LIG_EH1_1	268	276	PF00400	0.488
LIG_EH1_1	308	316	PF00400	0.542
LIG_FHA_1	122	128	PF00498	0.461
LIG_FHA_1	266	272	PF00498	0.420
LIG_FHA_1	392	398	PF00498	0.554
LIG_FHA_1	406	412	PF00498	0.530
LIG_FHA_1	513	519	PF00498	0.406
LIG_FHA_1	98	104	PF00498	0.677
LIG_FHA_2	285	291	PF00498	0.461
LIG_FHA_2	378	384	PF00498	0.520
LIG_FHA_2	55	61	PF00498	0.784
LIG_IRF3_LxIS_1	123	128	PF10401	0.531
LIG_LIR_Apic_2	298	303	PF02991	0.521
LIG_LIR_Gen_1	239	246	PF02991	0.508
LIG_LIR_Gen_1	280	289	PF02991	0.410
LIG_LIR_Gen_1	354	365	PF02991	0.402
LIG_LIR_Gen_1	379	390	PF02991	0.482
LIG_LIR_Gen_1	447	456	PF02991	0.388
LIG_LIR_Gen_1	475	486	PF02991	0.427
LIG_LIR_Nem_3	239	244	PF02991	0.541
LIG_LIR_Nem_3	280	285	PF02991	0.367
LIG_LIR_Nem_3	290	295	PF02991	0.396
LIG_LIR_Nem_3	336	340	PF02991	0.435
LIG_LIR_Nem_3	354	360	PF02991	0.180
LIG_LIR_Nem_3	379	385	PF02991	0.404
LIG_LIR_Nem_3	447	453	PF02991	0.400
LIG_LIR_Nem_3	475	481	PF02991	0.413
LIG_LIR_Nem_3	484	489	PF02991	0.398
LIG_MYND_1	159	163	PF01753	0.559
LIG_Pex14_2	48	52	PF04695	0.703
LIG_PTB_Apo_2	263	270	PF02174	0.438
LIG_PTB_Phospho_1	263	269	PF10480	0.441
LIG_SH2_CRK	292	296	PF00017	0.521
LIG_SH2_CRK	486	490	PF00017	0.431
LIG_SH2_NCK_1	235	239	PF00017	0.522
LIG_SH2_SRC	352	355	PF00017	0.384
LIG_SH2_STAP1	409	413	PF00017	0.465
LIG_SH2_STAT3	131	134	PF00017	0.482
LIG_SH2_STAT3	251	254	PF00017	0.487
LIG_SH2_STAT5	126	129	PF00017	0.497
LIG_SH2_STAT5	150	153	PF00017	0.654
LIG_SH2_STAT5	251	254	PF00017	0.496
LIG_SH2_STAT5	269	272	PF00017	0.284
LIG_SH2_STAT5	352	355	PF00017	0.384
LIG_SH2_STAT5	455	458	PF00017	0.377
LIG_SH2_STAT5	466	469	PF00017	0.391
LIG_SH3_3	100	106	PF00018	0.703
LIG_SH3_3	148	154	PF00018	0.586
LIG_SH3_3	18	24	PF00018	0.716
LIG_SUMO_SIM_anti_2	429	434	PF11976	0.392
LIG_SUMO_SIM_par_1	341	348	PF11976	0.417
LIG_SUMO_SIM_par_1	417	423	PF11976	0.500
LIG_SxIP_EBH_1	16	26	PF03271	0.711
LIG_TRAF2_1	207	210	PF00917	0.512
LIG_UBA3_1	160	166	PF00899	0.645
LIG_UBA3_1	22	29	PF00899	0.682
LIG_UBA3_1	295	301	PF00899	0.520
LIG_WRC_WIRS_1	421	426	PF05994	0.248
MOD_CDK_SPxK_1	102	108	PF00069	0.425
MOD_CDK_SPxxK_3	159	166	PF00069	0.627
MOD_CK1_1	196	202	PF00069	0.600
MOD_CK1_1	319	325	PF00069	0.405
MOD_CK1_1	34	40	PF00069	0.758
MOD_CK1_1	342	348	PF00069	0.385
MOD_CK1_1	420	426	PF00069	0.450
MOD_CK1_1	44	50	PF00069	0.771
MOD_CK1_1	51	57	PF00069	0.535
MOD_CK1_1	84	90	PF00069	0.786
MOD_CK1_1	97	103	PF00069	0.634
MOD_CK2_1	204	210	PF00069	0.542
MOD_Cter_Amidation	390	393	PF01082	0.481
MOD_GlcNHglycan	185	188	PF01048	0.598
MOD_GlcNHglycan	198	201	PF01048	0.498
MOD_GlcNHglycan	206	209	PF01048	0.530
MOD_GlcNHglycan	347	350	PF01048	0.417
MOD_GlcNHglycan	53	56	PF01048	0.784
MOD_GlcNHglycan	66	69	PF01048	0.581
MOD_GlcNHglycan	96	99	PF01048	0.729
MOD_GSK3_1	11	18	PF00069	0.710
MOD_GSK3_1	121	128	PF00069	0.484
MOD_GSK3_1	150	157	PF00069	0.444
MOD_GSK3_1	213	220	PF00069	0.475
MOD_GSK3_1	31	38	PF00069	0.745
MOD_GSK3_1	407	414	PF00069	0.482
MOD_GSK3_1	42	49	PF00069	0.761
MOD_GSK3_1	80	87	PF00069	0.682
MOD_N-GLC_1	265	270	PF02516	0.469
MOD_N-GLC_1	42	47	PF02516	0.739
MOD_N-GLC_1	512	517	PF02516	0.430
MOD_N-GLC_1	84	89	PF02516	0.754
MOD_NEK2_1	125	130	PF00069	0.495
MOD_NEK2_1	316	321	PF00069	0.396
MOD_NEK2_1	405	410	PF00069	0.595
MOD_NEK2_1	481	486	PF00069	0.421
MOD_NEK2_2	121	126	PF00069	0.470
MOD_PIKK_1	213	219	PF00454	0.565
MOD_PIKK_1	35	41	PF00454	0.703
MOD_PK_1	310	316	PF00069	0.367
MOD_PK_1	407	413	PF00069	0.617
MOD_PKA_1	204	210	PF00069	0.523
MOD_PKA_1	213	219	PF00069	0.546
MOD_PKA_2	144	150	PF00069	0.424
MOD_PKA_2	204	210	PF00069	0.496
MOD_PKA_2	213	219	PF00069	0.497
MOD_PKA_2	222	228	PF00069	0.354
MOD_PKA_2	256	262	PF00069	0.483
MOD_PKA_2	405	411	PF00069	0.454
MOD_PKA_2	79	85	PF00069	0.741
MOD_PKB_1	374	382	PF00069	0.501
MOD_PKB_1	441	449	PF00069	0.585
MOD_Plk_1	265	271	PF00069	0.467
MOD_Plk_1	31	37	PF00069	0.616
MOD_Plk_1	443	449	PF00069	0.445
MOD_Plk_1	512	518	PF00069	0.436
MOD_Plk_4	121	127	PF00069	0.497
MOD_Plk_4	256	262	PF00069	0.451
MOD_Plk_4	310	316	PF00069	0.402
MOD_Plk_4	329	335	PF00069	0.449
MOD_Plk_4	339	345	PF00069	0.446
MOD_Plk_4	426	432	PF00069	0.427
MOD_Plk_4	459	465	PF00069	0.488
MOD_Plk_4	85	91	PF00069	0.476
MOD_ProDKin_1	102	108	PF00069	0.437
MOD_ProDKin_1	135	141	PF00069	0.549
MOD_ProDKin_1	150	156	PF00069	0.453
MOD_ProDKin_1	159	165	PF00069	0.545
MOD_ProDKin_1	319	325	PF00069	0.405
MOD_ProDKin_1	46	52	PF00069	0.719
MOD_ProDKin_1	54	60	PF00069	0.672
MOD_SUMO_for_1	285	288	PF00179	0.494
MOD_SUMO_rev_2	207	215	PF00179	0.542
MOD_SUMO_rev_2	368	377	PF00179	0.363
TRG_DiLeu_BaEn_4	210	216	PF01217	0.540
TRG_DiLeu_BaLyEn_6	156	161	PF01217	0.579
TRG_ENDOCYTIC_2	176	179	PF00928	0.572
TRG_ENDOCYTIC_2	235	238	PF00928	0.448
TRG_ENDOCYTIC_2	282	285	PF00928	0.400
TRG_ENDOCYTIC_2	292	295	PF00928	0.417
TRG_ENDOCYTIC_2	486	489	PF00928	0.419
TRG_ER_diArg_1	203	205	PF00400	0.527
TRG_ER_diArg_1	374	377	PF00400	0.482
TRG_ER_diArg_1	405	407	PF00400	0.369
TRG_ER_diArg_1	494	496	PF00400	0.525
TRG_ER_diArg_1	498	500	PF00400	0.513
TRG_ER_diArg_1	519	522	PF00400	0.450
TRG_NES_CRM1_1	354	369	PF08389	0.514
TRG_Pf-PMV_PEXEL_1	293	298	PF00026	0.527

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I6Z5	Leptomonas seymouri	68%	100%
A0A0S4IP32	Bodo saltans	39%	100%
A0A1X0NYG7	Trypanosomatidae	52%	100%
A0A3Q8IDT7	Leishmania donovani	94%	100%
A0A3R7LMJ5	Trypanosoma rangeli	54%	100%
A4HGC7	Leishmania braziliensis	85%	100%
A4I3F9	Leishmania infantum	94%	100%
D0A7X9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	54%	100%
Q4Q8I5	Leishmania major	92%	100%
V5DH50	Trypanosoma cruzi	54%	100%