Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AZP6_LEIMU

TriTrypDb:

LmxM.28.0822

Length:

252

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AZP6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AZP6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	131	135	PF00656	0.564
CLV_NRD_NRD_1	148	150	PF00675	0.496
CLV_PCSK_KEX2_1	148	150	PF00082	0.564
CLV_PCSK_KEX2_1	206	208	PF00082	0.695
CLV_PCSK_PC1ET2_1	206	208	PF00082	0.622
CLV_PCSK_SKI1_1	79	83	PF00082	0.582
DEG_Nend_Nbox_1	1	3	PF02207	0.650
DEG_SCF_FBW7_1	152	158	PF00400	0.480
DEG_SCF_TRCP1_1	234	239	PF00400	0.499
DOC_CKS1_1	152	157	PF01111	0.483
DOC_CYCLIN_yClb5_NLxxxL_5	219	228	PF00134	0.609
DOC_MAPK_gen_1	203	211	PF00069	0.456
DOC_USP7_MATH_1	155	159	PF00917	0.630
DOC_USP7_MATH_1	175	179	PF00917	0.513
DOC_USP7_MATH_1	45	49	PF00917	0.682
DOC_USP7_MATH_1	75	79	PF00917	0.674
DOC_WD40_RPTOR_TOS_1	214	220	PF00400	0.428
DOC_WW_Pin1_4	119	124	PF00397	0.608
DOC_WW_Pin1_4	151	156	PF00397	0.537
LIG_14-3-3_CanoR_1	11	16	PF00244	0.625
LIG_14-3-3_CanoR_1	244	252	PF00244	0.615
LIG_FHA_1	223	229	PF00498	0.551
LIG_FHA_1	235	241	PF00498	0.622
LIG_FHA_2	244	250	PF00498	0.763
LIG_FHA_2	90	96	PF00498	0.704
LIG_LIR_Gen_1	169	179	PF02991	0.541
LIG_LIR_Nem_3	169	174	PF02991	0.538
LIG_PDZ_Class_2	247	252	PF00595	0.489
LIG_Pex14_2	204	208	PF04695	0.435
LIG_SH2_CRK	171	175	PF00017	0.542
LIG_SH2_STAT5	110	113	PF00017	0.572
LIG_SH2_STAT5	151	154	PF00017	0.532
LIG_SH3_3	149	155	PF00018	0.536
LIG_SUMO_SIM_anti_2	215	220	PF11976	0.583
LIG_UBA3_1	221	226	PF00899	0.613
LIG_WRC_WIRS_1	211	216	PF05994	0.434
MOD_CDK_SPxK_1	151	157	PF00069	0.441
MOD_CK1_1	128	134	PF00069	0.690
MOD_CK1_1	239	245	PF00069	0.672
MOD_CK1_1	89	95	PF00069	0.614
MOD_CK2_1	243	249	PF00069	0.765
MOD_GlcNHglycan	234	237	PF01048	0.622
MOD_GlcNHglycan	241	244	PF01048	0.531
MOD_GlcNHglycan	25	28	PF01048	0.593
MOD_GlcNHglycan	30	33	PF01048	0.520
MOD_GlcNHglycan	48	51	PF01048	0.704
MOD_GlcNHglycan	83	86	PF01048	0.639
MOD_GlcNHglycan	88	91	PF01048	0.592
MOD_GSK3_1	151	158	PF00069	0.661
MOD_GSK3_1	232	239	PF00069	0.654
MOD_GSK3_1	41	48	PF00069	0.580
MOD_LATS_1	9	15	PF00433	0.631
MOD_N-GLC_1	222	227	PF02516	0.591
MOD_N-GLC_2	245	247	PF02516	0.617
MOD_NEK2_1	209	214	PF00069	0.615
MOD_NEK2_1	222	227	PF00069	0.657
MOD_NEK2_1	40	45	PF00069	0.722
MOD_NEK2_1	99	104	PF00069	0.610
MOD_PIKK_1	62	68	PF00454	0.558
MOD_PKA_2	243	249	PF00069	0.765
MOD_Plk_1	175	181	PF00069	0.563
MOD_Plk_4	11	17	PF00069	0.628
MOD_Plk_4	166	172	PF00069	0.699
MOD_ProDKin_1	119	125	PF00069	0.617
MOD_ProDKin_1	151	157	PF00069	0.548
MOD_SUMO_rev_2	128	138	PF00179	0.618
MOD_SUMO_rev_2	58	63	PF00179	0.499
TRG_DiLeu_BaEn_1	217	222	PF01217	0.598
TRG_ENDOCYTIC_2	171	174	PF00928	0.534
TRG_ER_diArg_1	147	149	PF00400	0.632

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8IGN7	Leishmania donovani	88%	100%
A4HGC5	Leishmania braziliensis	72%	100%
E9ADJ9	Leishmania major	85%	100%
E9AHH8	Leishmania infantum	88%	100%