Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AZP5_LEIMU

TriTrypDb:

LmxM.28.0820

Length:

502

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AZP5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AZP5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	158	162	PF00656	0.483
CLV_C14_Caspase3-7	222	226	PF00656	0.736
CLV_C14_Caspase3-7	262	266	PF00656	0.665
CLV_NRD_NRD_1	123	125	PF00675	0.447
CLV_NRD_NRD_1	162	164	PF00675	0.465
CLV_NRD_NRD_1	275	277	PF00675	0.511
CLV_NRD_NRD_1	433	435	PF00675	0.524
CLV_NRD_NRD_1	75	77	PF00675	0.551
CLV_NRD_NRD_1	90	92	PF00675	0.469
CLV_PCSK_FUR_1	273	277	PF00082	0.640
CLV_PCSK_FUR_1	72	76	PF00082	0.658
CLV_PCSK_KEX2_1	273	275	PF00082	0.515
CLV_PCSK_KEX2_1	383	385	PF00082	0.765
CLV_PCSK_KEX2_1	433	435	PF00082	0.525
CLV_PCSK_KEX2_1	74	76	PF00082	0.557
CLV_PCSK_KEX2_1	90	92	PF00082	0.480
CLV_PCSK_PC1ET2_1	383	385	PF00082	0.473
CLV_PCSK_PC7_1	270	276	PF00082	0.585
CLV_PCSK_PC7_1	86	92	PF00082	0.616
CLV_PCSK_SKI1_1	107	111	PF00082	0.530
CLV_PCSK_SKI1_1	164	168	PF00082	0.530
CLV_PCSK_SKI1_1	359	363	PF00082	0.820
CLV_PCSK_SKI1_1	94	98	PF00082	0.525
CLV_Separin_Metazoa	340	344	PF03568	0.587
DEG_APCC_DBOX_1	136	144	PF00400	0.392
DEG_Nend_UBRbox_1	1	4	PF02207	0.548
DEG_SPOP_SBC_1	209	213	PF00917	0.504
DEG_SPOP_SBC_1	60	64	PF00917	0.738
DOC_CKS1_1	80	85	PF01111	0.615
DOC_MAPK_gen_1	484	492	PF00069	0.472
DOC_PP4_FxxP_1	185	188	PF00568	0.508
DOC_PP4_FxxP_1	338	341	PF00568	0.503
DOC_PP4_FxxP_1	388	391	PF00568	0.710
DOC_USP7_MATH_1	16	20	PF00917	0.588
DOC_USP7_MATH_1	178	182	PF00917	0.469
DOC_USP7_MATH_1	208	212	PF00917	0.771
DOC_USP7_MATH_1	235	239	PF00917	0.725
DOC_USP7_MATH_1	257	261	PF00917	0.632
DOC_USP7_MATH_1	396	400	PF00917	0.644
DOC_USP7_MATH_1	60	64	PF00917	0.728
DOC_USP7_UBL2_3	160	164	PF12436	0.536
DOC_WW_Pin1_4	18	23	PF00397	0.562
DOC_WW_Pin1_4	202	207	PF00397	0.739
DOC_WW_Pin1_4	215	220	PF00397	0.750
DOC_WW_Pin1_4	255	260	PF00397	0.510
DOC_WW_Pin1_4	296	301	PF00397	0.620
DOC_WW_Pin1_4	369	374	PF00397	0.793
DOC_WW_Pin1_4	390	395	PF00397	0.528
DOC_WW_Pin1_4	79	84	PF00397	0.609
LIG_14-3-3_CanoR_1	177	187	PF00244	0.494
LIG_14-3-3_CanoR_1	2	6	PF00244	0.700
LIG_14-3-3_CanoR_1	202	206	PF00244	0.665
LIG_14-3-3_CanoR_1	398	403	PF00244	0.582
LIG_14-3-3_CanoR_1	407	413	PF00244	0.480
LIG_14-3-3_CanoR_1	418	424	PF00244	0.381
LIG_14-3-3_CanoR_1	449	456	PF00244	0.612
LIG_14-3-3_CanoR_1	74	80	PF00244	0.546
LIG_Actin_WH2_2	133	151	PF00022	0.475
LIG_BIR_III_2	40	44	PF00653	0.600
LIG_BIR_III_4	225	229	PF00653	0.494
LIG_BIR_III_4	424	428	PF00653	0.446
LIG_BRCT_BRCA1_1	181	185	PF00533	0.576
LIG_deltaCOP1_diTrp_1	324	330	PF00928	0.469
LIG_eIF4E_1	5	11	PF01652	0.414
LIG_FHA_1	24	30	PF00498	0.733
LIG_FHA_1	390	396	PF00498	0.718
LIG_FHA_1	5	11	PF00498	0.535
LIG_FHA_2	111	117	PF00498	0.431
LIG_FHA_2	128	134	PF00498	0.431
LIG_FHA_2	314	320	PF00498	0.477
LIG_FHA_2	335	341	PF00498	0.607
LIG_FHA_2	409	415	PF00498	0.657
LIG_FHA_2	491	497	PF00498	0.548
LIG_FHA_2	80	86	PF00498	0.480
LIG_GBD_Chelix_1	140	148	PF00786	0.404
LIG_GSK3_LRP6_1	390	395	PF00069	0.474
LIG_LIR_Apic_2	182	188	PF02991	0.538
LIG_LIR_Apic_2	336	341	PF02991	0.483
LIG_LIR_Apic_2	386	391	PF02991	0.697
LIG_LIR_Gen_1	126	136	PF02991	0.406
LIG_LIR_Nem_3	103	109	PF02991	0.640
LIG_LIR_Nem_3	126	131	PF02991	0.422
LIG_LIR_Nem_3	302	307	PF02991	0.484
LIG_LIR_Nem_3	426	432	PF02991	0.430
LIG_Pex14_1	325	329	PF04695	0.467
LIG_SH2_CRK	165	169	PF00017	0.429
LIG_SH2_STAP1	30	34	PF00017	0.612
LIG_SH2_STAT5	114	117	PF00017	0.490
LIG_SH2_STAT5	147	150	PF00017	0.398
LIG_SH2_STAT5	30	33	PF00017	0.686
LIG_SH2_STAT5	329	332	PF00017	0.487
LIG_SH3_1	99	105	PF00018	0.503
LIG_SH3_2	102	107	PF14604	0.634
LIG_SH3_3	388	394	PF00018	0.600
LIG_SH3_3	460	466	PF00018	0.465
LIG_SH3_3	77	83	PF00018	0.566
LIG_SH3_3	99	105	PF00018	0.503
LIG_TRAF2_1	259	262	PF00917	0.623
LIG_TRAF2_1	365	368	PF00917	0.517
LIG_WW_3	340	344	PF00397	0.587
MOD_CDK_SPK_2	79	84	PF00069	0.624
MOD_CDK_SPxxK_3	79	86	PF00069	0.620
MOD_CK1_1	20	26	PF00069	0.594
MOD_CK1_1	204	210	PF00069	0.669
MOD_CK1_1	211	217	PF00069	0.626
MOD_CK1_1	296	302	PF00069	0.669
MOD_CK1_1	4	10	PF00069	0.631
MOD_CK1_1	479	485	PF00069	0.656
MOD_CK1_1	50	56	PF00069	0.735
MOD_CK1_1	64	70	PF00069	0.581
MOD_CK2_1	132	138	PF00069	0.534
MOD_CK2_1	257	263	PF00069	0.679
MOD_CK2_1	334	340	PF00069	0.612
MOD_CK2_1	354	360	PF00069	0.661
MOD_CK2_1	362	368	PF00069	0.618
MOD_CK2_1	433	439	PF00069	0.678
MOD_CK2_1	448	454	PF00069	0.621
MOD_CK2_1	490	496	PF00069	0.484
MOD_CK2_1	79	85	PF00069	0.487
MOD_Cter_Amidation	122	125	PF01082	0.407
MOD_Cter_Amidation	381	384	PF01082	0.598
MOD_DYRK1A_RPxSP_1	202	206	PF00069	0.540
MOD_GlcNHglycan	11	14	PF01048	0.512
MOD_GlcNHglycan	152	155	PF01048	0.409
MOD_GlcNHglycan	181	184	PF01048	0.516
MOD_GlcNHglycan	206	209	PF01048	0.582
MOD_GlcNHglycan	253	256	PF01048	0.742
MOD_GlcNHglycan	301	304	PF01048	0.497
MOD_GlcNHglycan	385	388	PF01048	0.674
MOD_GlcNHglycan	398	401	PF01048	0.560
MOD_GlcNHglycan	63	66	PF01048	0.681
MOD_GSK3_1	16	23	PF00069	0.639
MOD_GSK3_1	204	211	PF00069	0.587
MOD_GSK3_1	235	242	PF00069	0.661
MOD_GSK3_1	251	258	PF00069	0.694
MOD_GSK3_1	314	321	PF00069	0.522
MOD_GSK3_1	448	455	PF00069	0.511
MOD_GSK3_1	50	57	PF00069	0.699
MOD_GSK3_1	60	67	PF00069	0.600
MOD_GSK3_1	75	82	PF00069	0.444
MOD_N-GLC_1	313	318	PF02516	0.425
MOD_NEK2_1	1	6	PF00069	0.589
MOD_NEK2_1	148	153	PF00069	0.495
MOD_NEK2_1	167	172	PF00069	0.459
MOD_NEK2_1	282	287	PF00069	0.570
MOD_NEK2_1	29	34	PF00069	0.636
MOD_NEK2_1	408	413	PF00069	0.522
MOD_NEK2_1	61	66	PF00069	0.726
MOD_PIKK_1	257	263	PF00454	0.677
MOD_PIKK_1	64	70	PF00454	0.633
MOD_PK_1	398	404	PF00069	0.498
MOD_PKA_1	124	130	PF00069	0.490
MOD_PKA_1	383	389	PF00069	0.771
MOD_PKA_1	433	439	PF00069	0.631
MOD_PKA_1	74	80	PF00069	0.528
MOD_PKA_2	1	7	PF00069	0.597
MOD_PKA_2	148	154	PF00069	0.553
MOD_PKA_2	201	207	PF00069	0.662
MOD_PKA_2	383	389	PF00069	0.682
MOD_PKA_2	419	425	PF00069	0.507
MOD_PKA_2	433	439	PF00069	0.530
MOD_PKA_2	448	454	PF00069	0.482
MOD_PKA_2	490	496	PF00069	0.484
MOD_PKA_2	74	80	PF00069	0.472
MOD_PKB_1	72	80	PF00069	0.634
MOD_Plk_1	132	138	PF00069	0.513
MOD_Plk_1	313	319	PF00069	0.507
MOD_Plk_1	333	339	PF00069	0.378
MOD_Plk_2-3	132	138	PF00069	0.529
MOD_Plk_2-3	334	340	PF00069	0.607
MOD_Plk_4	110	116	PF00069	0.549
MOD_Plk_4	235	241	PF00069	0.662
MOD_Plk_4	318	324	PF00069	0.473
MOD_ProDKin_1	18	24	PF00069	0.565
MOD_ProDKin_1	202	208	PF00069	0.744
MOD_ProDKin_1	215	221	PF00069	0.750
MOD_ProDKin_1	255	261	PF00069	0.506
MOD_ProDKin_1	296	302	PF00069	0.609
MOD_ProDKin_1	369	375	PF00069	0.792
MOD_ProDKin_1	390	396	PF00069	0.525
MOD_ProDKin_1	79	85	PF00069	0.607
MOD_SUMO_rev_2	153	162	PF00179	0.294
MOD_SUMO_rev_2	88	96	PF00179	0.588
TRG_ENDOCYTIC_2	165	168	PF00928	0.409
TRG_ENDOCYTIC_2	429	432	PF00928	0.578
TRG_ER_diArg_1	273	276	PF00400	0.500
TRG_ER_diArg_1	307	310	PF00400	0.475
TRG_ER_diArg_1	342	345	PF00400	0.603
TRG_ER_diArg_1	405	408	PF00400	0.529
TRG_ER_diArg_1	432	434	PF00400	0.509
TRG_ER_diArg_1	73	76	PF00400	0.591
TRG_ER_diArg_1	89	91	PF00400	0.503
TRG_Pf-PMV_PEXEL_1	410	414	PF00026	0.652
TRG_Pf-PMV_PEXEL_1	99	103	PF00026	0.595

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I8G0	Leptomonas seymouri	64%	100%
A0A0S4IT28	Bodo saltans	34%	100%
A0A1X0NYF9	Trypanosomatidae	47%	100%
A0A3Q8IDQ0	Leishmania donovani	94%	100%
A0A3R7M5S0	Trypanosoma rangeli	46%	100%
A4HGC4	Leishmania braziliensis	79%	100%
A4I3F7	Leishmania infantum	94%	100%
D0A7Y3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	45%	100%
Q4Q8I7	Leishmania major	94%	100%
V5BKT5	Trypanosoma cruzi	46%	100%