LeishMANIAdb
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PAP-associated domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
PAP-associated domain-containing protein
Gene product:
kinetoplast poly(A) polymerase 1
Species:
Leishmania mexicana
UniProt:
E9AZP1_LEIMU
TriTrypDb:
LmxM.28.0780
Length:
455

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 21
NetGPI no yes: 0, no: 21
Cellular components
Term Name Level Count
GO:0005737 cytoplasm 2 20
GO:0110165 cellular anatomical entity 1 21
GO:0016020 membrane 2 3
GO:0005739 mitochondrion 5 1
GO:0043226 organelle 2 1
GO:0043227 membrane-bounded organelle 3 1
GO:0043229 intracellular organelle 3 1
GO:0043231 intracellular membrane-bounded organelle 4 1
GO:0031019 mitochondrial mRNA editing complex 3 1
GO:0032991 protein-containing complex 1 1
GO:0045293 mRNA editing complex 3 1
GO:0098798 mitochondrial protein-containing complex 2 1
GO:1902494 catalytic complex 2 1

Expansion

Sequence features

E9AZP1
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AZP1

Function

Biological processes
Term Name Level Count
GO:0006139 nucleobase-containing compound metabolic process 3 22
GO:0006396 RNA processing 6 22
GO:0006725 cellular aromatic compound metabolic process 3 22
GO:0006807 nitrogen compound metabolic process 2 22
GO:0008152 metabolic process 1 22
GO:0009987 cellular process 1 22
GO:0016070 RNA metabolic process 5 22
GO:0031123 RNA 3'-end processing 7 22
GO:0034641 cellular nitrogen compound metabolic process 3 22
GO:0043170 macromolecule metabolic process 3 22
GO:0044237 cellular metabolic process 2 22
GO:0044238 primary metabolic process 2 22
GO:0046483 heterocycle metabolic process 3 22
GO:0071076 RNA 3' uridylation 8 22
GO:0071704 organic substance metabolic process 2 22
GO:0090304 nucleic acid metabolic process 4 22
GO:1901360 organic cyclic compound metabolic process 3 22
GO:0006378 mRNA polyadenylation 7 1
GO:0006397 mRNA processing 7 1
GO:0016071 mRNA metabolic process 6 1
GO:0031124 mRNA 3'-end processing 8 1
GO:0043631 RNA polyadenylation 6 1
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 22
GO:0005488 binding 1 22
GO:0016740 transferase activity 2 22
GO:0016772 transferase activity, transferring phosphorus-containing groups 3 22
GO:0016779 nucleotidyltransferase activity 4 22
GO:0043167 ion binding 2 22
GO:0043169 cation binding 3 22
GO:0046872 metal ion binding 4 22
GO:0050265 RNA uridylyltransferase activity 4 22
GO:0070569 uridylyltransferase activity 5 22
GO:0140098 catalytic activity, acting on RNA 3 22
GO:0140640 catalytic activity, acting on a nucleic acid 2 22
GO:0004652 obsolete polynucleotide adenylyltransferase activity 6 4
GO:0070566 adenylyltransferase activity 5 4

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 378 380 PF00675 0.437
CLV_NRD_NRD_1 416 418 PF00675 0.513
CLV_NRD_NRD_1 45 47 PF00675 0.420
CLV_NRD_NRD_1 52 54 PF00675 0.363
CLV_PCSK_KEX2_1 418 420 PF00082 0.523
CLV_PCSK_KEX2_1 45 47 PF00082 0.408
CLV_PCSK_KEX2_1 52 54 PF00082 0.375
CLV_PCSK_PC1ET2_1 418 420 PF00082 0.605
CLV_PCSK_SKI1_1 198 202 PF00082 0.329
CLV_PCSK_SKI1_1 406 410 PF00082 0.550
CLV_PCSK_SKI1_1 427 431 PF00082 0.626
CLV_PCSK_SKI1_1 443 447 PF00082 0.485
CLV_Separin_Metazoa 42 46 PF03568 0.511
DEG_APCC_DBOX_1 197 205 PF00400 0.313
DEG_APCC_DBOX_1 405 413 PF00400 0.585
DOC_CYCLIN_yClb1_LxF_4 409 414 PF00134 0.607
DOC_CYCLIN_yCln2_LP_2 155 161 PF00134 0.396
DOC_MAPK_MEF2A_6 146 155 PF00069 0.361
DOC_MAPK_MEF2A_6 351 359 PF00069 0.530
DOC_PP1_RVXF_1 409 415 PF00149 0.571
DOC_PP2B_LxvP_1 155 158 PF13499 0.370
DOC_PP4_FxxP_1 364 367 PF00568 0.389
DOC_USP7_MATH_1 82 86 PF00917 0.573
DOC_USP7_UBL2_3 376 380 PF12436 0.553
DOC_WW_Pin1_4 253 258 PF00397 0.483
DOC_WW_Pin1_4 78 83 PF00397 0.418
LIG_14-3-3_CanoR_1 383 389 PF00244 0.495
LIG_14-3-3_CanoR_1 391 399 PF00244 0.489
LIG_14-3-3_CanoR_1 417 422 PF00244 0.582
LIG_14-3-3_CanoR_1 45 54 PF00244 0.520
LIG_14-3-3_CanoR_1 73 79 PF00244 0.485
LIG_BIR_III_2 266 270 PF00653 0.354
LIG_BRCT_BRCA1_1 123 127 PF00533 0.480
LIG_deltaCOP1_diTrp_1 120 127 PF00928 0.389
LIG_eIF4E_1 8 14 PF01652 0.433
LIG_FHA_1 13 19 PF00498 0.462
LIG_FHA_1 133 139 PF00498 0.378
LIG_FHA_1 225 231 PF00498 0.329
LIG_FHA_1 344 350 PF00498 0.345
LIG_FHA_1 366 372 PF00498 0.533
LIG_FHA_1 440 446 PF00498 0.577
LIG_FHA_2 115 121 PF00498 0.444
LIG_FHA_2 279 285 PF00498 0.306
LIG_FHA_2 435 441 PF00498 0.479
LIG_LIR_Apic_2 166 171 PF02991 0.368
LIG_LIR_Apic_2 362 367 PF02991 0.394
LIG_LIR_Gen_1 124 132 PF02991 0.437
LIG_LIR_Gen_1 81 91 PF02991 0.507
LIG_LIR_Nem_3 124 130 PF02991 0.427
LIG_LIR_Nem_3 24 30 PF02991 0.332
LIG_LIR_Nem_3 260 264 PF02991 0.416
LIG_LIR_Nem_3 281 285 PF02991 0.305
LIG_LIR_Nem_3 81 86 PF02991 0.494
LIG_Pex14_1 121 125 PF04695 0.515
LIG_Pex14_2 170 174 PF04695 0.343
LIG_Pex14_2 282 286 PF04695 0.450
LIG_PTB_Apo_2 255 262 PF02174 0.567
LIG_PTB_Phospho_1 255 261 PF10480 0.570
LIG_SH2_CRK 168 172 PF00017 0.343
LIG_SH2_STAP1 224 228 PF00017 0.308
LIG_SH2_STAP1 3 7 PF00017 0.383
LIG_SH2_STAT5 277 280 PF00017 0.383
LIG_SH2_STAT5 285 288 PF00017 0.383
LIG_SH2_STAT5 348 351 PF00017 0.394
LIG_SH2_STAT5 8 11 PF00017 0.349
LIG_SH3_1 76 82 PF00018 0.419
LIG_SH3_2 378 383 PF14604 0.430
LIG_SH3_3 148 154 PF00018 0.349
LIG_SH3_3 315 321 PF00018 0.295
LIG_SH3_3 375 381 PF00018 0.396
LIG_SH3_3 76 82 PF00018 0.419
LIG_SUMO_SIM_anti_2 227 232 PF11976 0.367
LIG_SUMO_SIM_par_1 29 34 PF11976 0.461
LIG_UBA3_1 138 146 PF00899 0.380
LIG_UBA3_1 200 206 PF00899 0.335
LIG_WRC_WIRS_1 279 284 PF05994 0.279
LIG_WW_3 380 384 PF00397 0.487
MOD_CK1_1 372 378 PF00069 0.476
MOD_CK1_1 436 442 PF00069 0.545
MOD_CK2_1 114 120 PF00069 0.472
MOD_CK2_1 278 284 PF00069 0.306
MOD_CK2_1 44 50 PF00069 0.550
MOD_GlcNHglycan 210 213 PF01048 0.329
MOD_GlcNHglycan 371 374 PF01048 0.408
MOD_GSK3_1 126 133 PF00069 0.266
MOD_GSK3_1 176 183 PF00069 0.443
MOD_GSK3_1 220 227 PF00069 0.326
MOD_GSK3_1 365 372 PF00069 0.549
MOD_GSK3_1 74 81 PF00069 0.428
MOD_N-GLC_1 114 119 PF02516 0.455
MOD_N-GLC_1 121 126 PF02516 0.408
MOD_N-GLC_1 433 438 PF02516 0.639
MOD_NEK2_1 13 18 PF00069 0.427
MOD_NEK2_1 132 137 PF00069 0.377
MOD_NEK2_1 174 179 PF00069 0.325
MOD_NEK2_1 181 186 PF00069 0.324
MOD_NEK2_1 220 225 PF00069 0.333
MOD_NEK2_1 278 283 PF00069 0.289
MOD_NEK2_1 302 307 PF00069 0.330
MOD_NEK2_1 343 348 PF00069 0.512
MOD_NEK2_1 369 374 PF00069 0.505
MOD_NEK2_1 44 49 PF00069 0.544
MOD_NEK2_1 92 97 PF00069 0.334
MOD_NEK2_2 3 8 PF00069 0.431
MOD_PKA_1 417 423 PF00069 0.541
MOD_PKA_1 45 51 PF00069 0.511
MOD_PKA_2 181 187 PF00069 0.332
MOD_PKA_2 208 214 PF00069 0.296
MOD_PKA_2 44 50 PF00069 0.371
MOD_PKA_2 72 78 PF00069 0.423
MOD_PKB_1 107 115 PF00069 0.370
MOD_Plk_1 114 120 PF00069 0.424
MOD_Plk_1 121 127 PF00069 0.416
MOD_Plk_1 3 9 PF00069 0.422
MOD_Plk_1 343 349 PF00069 0.436
MOD_Plk_2-3 330 336 PF00069 0.163
MOD_Plk_4 134 140 PF00069 0.485
MOD_Plk_4 224 230 PF00069 0.313
MOD_Plk_4 232 238 PF00069 0.338
MOD_Plk_4 278 284 PF00069 0.450
MOD_Plk_4 3 9 PF00069 0.412
MOD_Plk_4 343 349 PF00069 0.415
MOD_Plk_4 365 371 PF00069 0.486
MOD_ProDKin_1 253 259 PF00069 0.481
MOD_ProDKin_1 78 84 PF00069 0.413
TRG_DiLeu_BaEn_1 274 279 PF01217 0.368
TRG_ENDOCYTIC_2 261 264 PF00928 0.405
TRG_ER_diArg_1 106 109 PF00400 0.478
TRG_ER_diArg_1 44 46 PF00400 0.408
TRG_ER_diArg_1 51 53 PF00400 0.363
TRG_ER_diArg_1 56 59 PF00400 0.293
TRG_NLS_MonoExtC_3 416 422 PF00514 0.645
TRG_Pf-PMV_PEXEL_1 262 266 PF00026 0.440
TRG_Pf-PMV_PEXEL_1 339 344 PF00026 0.395
TRG_Pf-PMV_PEXEL_1 386 390 PF00026 0.605

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P857 Leptomonas seymouri 75% 87%
A0A0N1IJQ4 Leptomonas seymouri 27% 90%
A0A0S4JJT6 Bodo saltans 43% 78%
A0A1X0NSS0 Trypanosomatidae 23% 93%
A0A1X0NZU6 Trypanosomatidae 59% 87%
A0A3Q8IC11 Leishmania donovani 26% 89%
A0A3Q8IHZ8 Leishmania donovani 96% 100%
A0A3R7K3P5 Trypanosoma rangeli 56% 86%
A0A422NVH7 Trypanosoma rangeli 24% 93%
A4HEP5 Leishmania braziliensis 26% 100%
A4HGC0 Leishmania braziliensis 91% 100%
A4I1X5 Leishmania infantum 26% 89%
A4I3F3 Leishmania infantum 96% 100%
C9ZS45 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 24% 93%
D0A7Y7 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 58% 86%
E9AY21 Leishmania mexicana (strain MHOM/GT/2001/U1103) 26% 100%
Q4Q8J1 Leishmania major 96% 100%
Q4Q9F2 Leishmania major 26% 100%
Q86MV5 Trypanosoma brucei brucei 24% 93%
V5BG78 Trypanosoma cruzi 56% 86%
V5BQ07 Trypanosoma cruzi 24% 94%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS