ANK_REP_REGION domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AZN9_LEIMU

TriTrypDb:

LmxM.28.0770

Length:

479

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AZN9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AZN9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	227	229	PF00675	0.629
CLV_NRD_NRD_1	367	369	PF00675	0.805
CLV_NRD_NRD_1	45	47	PF00675	0.379
CLV_NRD_NRD_1	89	91	PF00675	0.611
CLV_PCSK_KEX2_1	167	169	PF00082	0.731
CLV_PCSK_KEX2_1	367	369	PF00082	0.805
CLV_PCSK_KEX2_1	463	465	PF00082	0.689
CLV_PCSK_PC1ET2_1	167	169	PF00082	0.731
CLV_PCSK_PC1ET2_1	463	465	PF00082	0.734
CLV_PCSK_SKI1_1	112	116	PF00082	0.512
CLV_PCSK_SKI1_1	162	166	PF00082	0.739
CLV_PCSK_SKI1_1	185	189	PF00082	0.695
CLV_PCSK_SKI1_1	329	333	PF00082	0.795
CLV_PCSK_SKI1_1	98	102	PF00082	0.343
DEG_APCC_DBOX_1	333	341	PF00400	0.413
DOC_CYCLIN_RxL_1	109	116	PF00134	0.512
DOC_CYCLIN_yCln2_LP_2	203	209	PF00134	0.283
DOC_CYCLIN_yCln2_LP_2	96	102	PF00134	0.546
DOC_PP1_RVXF_1	110	116	PF00149	0.512
DOC_PP1_RVXF_1	221	228	PF00149	0.497
DOC_PP2B_LxvP_1	100	103	PF13499	0.411
DOC_PP4_FxxP_1	35	38	PF00568	0.757
DOC_USP7_MATH_1	139	143	PF00917	0.528
DOC_USP7_MATH_1	55	59	PF00917	0.766
DOC_USP7_UBL2_3	474	478	PF12436	0.498
DOC_WW_Pin1_4	1	6	PF00397	0.767
DOC_WW_Pin1_4	202	207	PF00397	0.449
DOC_WW_Pin1_4	373	378	PF00397	0.467
LIG_14-3-3_CanoR_1	168	175	PF00244	0.534
LIG_14-3-3_CanoR_1	223	228	PF00244	0.457
LIG_14-3-3_CanoR_1	351	355	PF00244	0.488
LIG_14-3-3_CanoR_1	449	455	PF00244	0.543
LIG_APCC_ABBA_1	422	427	PF00400	0.621
LIG_BIR_II_1	1	5	PF00653	0.768
LIG_BRCT_BRCA1_1	123	127	PF00533	0.461
LIG_BRCT_BRCA1_1	223	227	PF00533	0.504
LIG_BRCT_BRCA1_2	223	229	PF00533	0.462
LIG_Clathr_ClatBox_1	207	211	PF01394	0.423
LIG_Clathr_ClatBox_1	56	60	PF01394	0.758
LIG_deltaCOP1_diTrp_1	128	137	PF00928	0.467
LIG_DLG_GKlike_1	311	318	PF00625	0.350
LIG_FHA_1	124	130	PF00498	0.534
LIG_FHA_1	139	145	PF00498	0.509
LIG_FHA_1	156	162	PF00498	0.369
LIG_FHA_1	437	443	PF00498	0.536
LIG_FHA_1	449	455	PF00498	0.522
LIG_FHA_1	48	54	PF00498	0.777
LIG_FHA_1	77	83	PF00498	0.775
LIG_FHA_2	123	129	PF00498	0.406
LIG_FHA_2	210	216	PF00498	0.415
LIG_GBD_Chelix_1	106	114	PF00786	0.512
LIG_HP1_1	55	59	PF01393	0.720
LIG_LIR_Apic_2	33	38	PF02991	0.755
LIG_LIR_Apic_2	372	377	PF02991	0.472
LIG_LIR_Gen_1	25	34	PF02991	0.676
LIG_LIR_Gen_1	291	299	PF02991	0.464
LIG_LIR_Gen_1	386	397	PF02991	0.494
LIG_LIR_Gen_1	429	437	PF02991	0.540
LIG_LIR_Nem_3	25	29	PF02991	0.679
LIG_LIR_Nem_3	265	270	PF02991	0.482
LIG_LIR_Nem_3	291	295	PF02991	0.472
LIG_LIR_Nem_3	303	307	PF02991	0.434
LIG_LIR_Nem_3	313	319	PF02991	0.481
LIG_LIR_Nem_3	358	364	PF02991	0.584
LIG_LIR_Nem_3	386	392	PF02991	0.534
LIG_LIR_Nem_3	429	434	PF02991	0.432
LIG_MYND_1	99	103	PF01753	0.411
LIG_NRBOX	105	111	PF00104	0.512
LIG_NRBOX	58	64	PF00104	0.668
LIG_Pex14_2	213	217	PF04695	0.269
LIG_Pex14_2	263	267	PF04695	0.423
LIG_PTB_Apo_2	29	36	PF02174	0.674
LIG_REV1ctd_RIR_1	264	272	PF16727	0.481
LIG_SH2_CRK	389	393	PF00017	0.588
LIG_SH2_GRB2like	431	434	PF00017	0.401
LIG_SH2_NCK_1	389	393	PF00017	0.427
LIG_SH2_STAP1	431	435	PF00017	0.401
LIG_SH2_STAT3	20	23	PF00017	0.771
LIG_SH2_STAT5	34	37	PF00017	0.685
LIG_SH2_STAT5	348	351	PF00017	0.484
LIG_SH2_STAT5	453	456	PF00017	0.461
LIG_SH3_3	203	209	PF00018	0.317
LIG_SH3_3	376	382	PF00018	0.388
LIG_SH3_4	37	44	PF00018	0.778
LIG_SUMO_SIM_par_1	55	60	PF11976	0.719
LIG_TRAF2_1	212	215	PF00917	0.485
LIG_TRAF2_1	456	459	PF00917	0.576
LIG_UBA3_1	109	117	PF00899	0.450
LIG_WRC_WIRS_1	210	215	PF05994	0.286
LIG_WRC_WIRS_1	263	268	PF05994	0.482
MOD_CK1_1	123	129	PF00069	0.461
MOD_CK1_1	166	172	PF00069	0.422
MOD_CK1_1	202	208	PF00069	0.394
MOD_CK1_1	233	239	PF00069	0.500
MOD_CK1_1	353	359	PF00069	0.525
MOD_CK1_1	362	368	PF00069	0.468
MOD_CK1_1	373	379	PF00069	0.555
MOD_CK1_1	390	396	PF00069	0.421
MOD_CK1_1	4	10	PF00069	0.798
MOD_CK1_1	417	423	PF00069	0.595
MOD_CK2_1	209	215	PF00069	0.401
MOD_CK2_1	353	359	PF00069	0.558
MOD_CK2_1	453	459	PF00069	0.469
MOD_GlcNHglycan	168	171	PF01048	0.706
MOD_GlcNHglycan	236	239	PF01048	0.611
MOD_GlcNHglycan	286	289	PF01048	0.659
MOD_GlcNHglycan	307	310	PF01048	0.774
MOD_GlcNHglycan	361	364	PF01048	0.709
MOD_GlcNHglycan	443	447	PF01048	0.758
MOD_GlcNHglycan	455	458	PF01048	0.781
MOD_GlcNHglycan	6	9	PF01048	0.509
MOD_GlcNHglycan	64	67	PF01048	0.534
MOD_GSK3_1	166	173	PF00069	0.506
MOD_GSK3_1	230	237	PF00069	0.482
MOD_GSK3_1	284	291	PF00069	0.475
MOD_GSK3_1	350	357	PF00069	0.562
MOD_GSK3_1	388	395	PF00069	0.582
MOD_N-GLC_1	284	289	PF02516	0.734
MOD_N-GLC_1	387	392	PF02516	0.748
MOD_N-GLC_2	194	196	PF02516	0.508
MOD_NEK2_1	121	126	PF00069	0.438
MOD_NEK2_1	129	134	PF00069	0.401
MOD_NEK2_1	156	161	PF00069	0.493
MOD_NEK2_1	199	204	PF00069	0.393
MOD_NEK2_1	284	289	PF00069	0.514
MOD_NEK2_1	318	323	PF00069	0.500
MOD_NEK2_1	387	392	PF00069	0.477
MOD_PIKK_1	215	221	PF00454	0.472
MOD_PIKK_1	448	454	PF00454	0.542
MOD_PKA_1	370	376	PF00069	0.605
MOD_PKA_2	139	145	PF00069	0.434
MOD_PKA_2	305	311	PF00069	0.569
MOD_PKA_2	350	356	PF00069	0.559
MOD_PKA_2	448	454	PF00069	0.542
MOD_PKB_1	368	376	PF00069	0.605
MOD_Plk_1	156	162	PF00069	0.571
MOD_Plk_1	221	227	PF00069	0.398
MOD_Plk_1	387	393	PF00069	0.505
MOD_Plk_1	435	441	PF00069	0.557
MOD_Plk_1	76	82	PF00069	0.769
MOD_Plk_4	194	200	PF00069	0.463
MOD_Plk_4	262	268	PF00069	0.429
MOD_Plk_4	311	317	PF00069	0.460
MOD_Plk_4	350	356	PF00069	0.465
MOD_Plk_4	436	442	PF00069	0.534
MOD_ProDKin_1	1	7	PF00069	0.765
MOD_ProDKin_1	202	208	PF00069	0.446
MOD_ProDKin_1	373	379	PF00069	0.465
MOD_SUMO_for_1	150	153	PF00179	0.495
MOD_SUMO_rev_2	226	236	PF00179	0.466
MOD_SUMO_rev_2	330	340	PF00179	0.568
TRG_DiLeu_BaEn_1	77	82	PF01217	0.701
TRG_DiLeu_BaEn_1	97	102	PF01217	0.383
TRG_DiLeu_BaEn_4	13	19	PF01217	0.673
TRG_DiLeu_BaLyEn_6	203	208	PF01217	0.446
TRG_DiLeu_BaLyEn_6	314	319	PF01217	0.507
TRG_DiLeu_BaLyEn_6	96	101	PF01217	0.687
TRG_ENDOCYTIC_2	316	319	PF00928	0.505
TRG_ENDOCYTIC_2	389	392	PF00928	0.592
TRG_ENDOCYTIC_2	431	434	PF00928	0.426
TRG_ER_diArg_1	367	370	PF00400	0.607
TRG_Pf-PMV_PEXEL_1	112	116	PF00026	0.512
TRG_Pf-PMV_PEXEL_1	40	44	PF00026	0.545

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PES7	Leptomonas seymouri	38%	100%
A0A3Q8ID12	Leishmania donovani	88%	100%
A4HGB8	Leishmania braziliensis	75%	100%
A4I3F2	Leishmania infantum	89%	100%
Q4Q8J2	Leishmania major	90%	100%