Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AZN6_LEIMU

TriTrypDb:

LmxM.28.0740

Length:

394

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AZN6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AZN6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	187	191	PF00656	0.638
CLV_C14_Caspase3-7	296	300	PF00656	0.626
CLV_NRD_NRD_1	104	106	PF00675	0.627
CLV_NRD_NRD_1	209	211	PF00675	0.549
CLV_NRD_NRD_1	37	39	PF00675	0.553
CLV_PCSK_KEX2_1	142	144	PF00082	0.459
CLV_PCSK_KEX2_1	208	210	PF00082	0.560
CLV_PCSK_PC1ET2_1	142	144	PF00082	0.459
CLV_PCSK_PC7_1	204	210	PF00082	0.678
CLV_PCSK_SKI1_1	108	112	PF00082	0.603
CLV_PCSK_SKI1_1	237	241	PF00082	0.640
CLV_PCSK_SKI1_1	274	278	PF00082	0.565
CLV_PCSK_SKI1_1	309	313	PF00082	0.654
CLV_PCSK_SKI1_1	334	338	PF00082	0.505
DEG_Nend_UBRbox_2	1	3	PF02207	0.548
DEG_SCF_FBW7_1	148	155	PF00400	0.520
DOC_CYCLIN_RxL_1	103	115	PF00134	0.620
DOC_MAPK_gen_1	105	112	PF00069	0.605
DOC_MAPK_JIP1_4	106	112	PF00069	0.670
DOC_PP2B_LxvP_1	381	384	PF13499	0.638
DOC_USP7_MATH_1	152	156	PF00917	0.620
DOC_USP7_MATH_1	266	270	PF00917	0.567
DOC_USP7_UBL2_3	330	334	PF12436	0.558
DOC_WW_Pin1_4	148	153	PF00397	0.634
DOC_WW_Pin1_4	361	366	PF00397	0.556
LIG_14-3-3_CanoR_1	108	113	PF00244	0.614
LIG_14-3-3_CanoR_1	163	172	PF00244	0.523
LIG_14-3-3_CanoR_1	212	218	PF00244	0.650
LIG_14-3-3_CanoR_1	219	224	PF00244	0.609
LIG_14-3-3_CanoR_1	229	233	PF00244	0.511
LIG_14-3-3_CanoR_1	281	287	PF00244	0.693
LIG_FHA_1	11	17	PF00498	0.560
LIG_FHA_1	275	281	PF00498	0.583
LIG_FHA_1	376	382	PF00498	0.705
LIG_FHA_2	163	169	PF00498	0.534
LIG_FHA_2	229	235	PF00498	0.701
LIG_FHA_2	254	260	PF00498	0.556
LIG_FHA_2	294	300	PF00498	0.604
LIG_FHA_2	302	308	PF00498	0.630
LIG_FHA_2	362	368	PF00498	0.605
LIG_LIR_Apic_2	349	353	PF02991	0.635
LIG_LIR_Apic_2	374	380	PF02991	0.693
LIG_LIR_Gen_1	166	177	PF02991	0.551
LIG_LIR_Gen_1	197	207	PF02991	0.547
LIG_LIR_Gen_1	53	64	PF02991	0.504
LIG_LIR_Nem_3	166	172	PF02991	0.623
LIG_LIR_Nem_3	197	202	PF02991	0.554
LIG_LIR_Nem_3	211	217	PF02991	0.540
LIG_LIR_Nem_3	53	59	PF02991	0.501
LIG_LYPXL_SIV_4	8	16	PF13949	0.519
LIG_Pex14_1	310	314	PF04695	0.526
LIG_PTB_Apo_2	279	286	PF02174	0.666
LIG_PTB_Phospho_1	279	285	PF10480	0.665
LIG_SH2_CRK	56	60	PF00017	0.535
LIG_SH2_GRB2like	56	59	PF00017	0.542
LIG_SH2_NCK_1	199	203	PF00017	0.559
LIG_SH2_NCK_1	263	267	PF00017	0.609
LIG_SH2_NCK_1	363	367	PF00017	0.624
LIG_SH2_NCK_1	56	60	PF00017	0.490
LIG_SH2_STAP1	373	377	PF00017	0.635
LIG_SH2_STAT3	30	33	PF00017	0.655
LIG_SH2_STAT5	169	172	PF00017	0.537
LIG_SH2_STAT5	193	196	PF00017	0.598
LIG_SH2_STAT5	344	347	PF00017	0.509
LIG_SH2_STAT5	363	366	PF00017	0.474
LIG_SH2_STAT5	373	376	PF00017	0.524
LIG_SH2_STAT5	377	380	PF00017	0.534
LIG_SH2_STAT5	56	59	PF00017	0.498
LIG_SH3_3	15	21	PF00018	0.593
LIG_SH3_3	38	44	PF00018	0.539
LIG_TRAF2_1	353	356	PF00917	0.454
LIG_TYR_ITIM	54	59	PF00017	0.496
LIG_WW_3	16	20	PF00397	0.592
MOD_CK2_1	227	233	PF00069	0.665
MOD_CK2_1	253	259	PF00069	0.606
MOD_CK2_1	361	367	PF00069	0.614
MOD_GlcNHglycan	154	157	PF01048	0.733
MOD_GlcNHglycan	247	250	PF01048	0.530
MOD_GlcNHglycan	315	318	PF01048	0.581
MOD_GlcNHglycan	320	324	PF01048	0.578
MOD_GlcNHglycan	6	9	PF01048	0.560
MOD_GSK3_1	108	115	PF00069	0.529
MOD_GSK3_1	148	155	PF00069	0.595
MOD_GSK3_1	219	226	PF00069	0.670
MOD_GSK3_1	228	235	PF00069	0.602
MOD_GSK3_1	309	316	PF00069	0.598
MOD_GSK3_1	371	378	PF00069	0.754
MOD_GSK3_1	383	390	PF00069	0.663
MOD_GSK3_1	46	53	PF00069	0.547
MOD_N-GLC_1	45	50	PF02516	0.681
MOD_N-GLC_1	75	80	PF02516	0.581
MOD_NEK2_1	112	117	PF00069	0.549
MOD_NEK2_1	232	237	PF00069	0.543
MOD_NEK2_1	253	258	PF00069	0.645
MOD_NEK2_1	280	285	PF00069	0.733
MOD_NEK2_1	293	298	PF00069	0.553
MOD_NEK2_1	4	9	PF00069	0.574
MOD_NEK2_1	54	59	PF00069	0.573
MOD_NEK2_1	75	80	PF00069	0.533
MOD_NEK2_1	93	98	PF00069	0.522
MOD_PIKK_1	223	229	PF00454	0.513
MOD_PIKK_1	285	291	PF00454	0.563
MOD_PIKK_1	293	299	PF00454	0.480
MOD_PIKK_1	75	81	PF00454	0.565
MOD_PIKK_1	93	99	PF00454	0.575
MOD_PKA_2	162	168	PF00069	0.526
MOD_PKA_2	228	234	PF00069	0.630
MOD_PKA_2	280	286	PF00069	0.696
MOD_PKB_1	208	216	PF00069	0.676
MOD_Plk_1	210	216	PF00069	0.672
MOD_Plk_1	223	229	PF00069	0.580
MOD_Plk_1	266	272	PF00069	0.619
MOD_Plk_1	274	280	PF00069	0.658
MOD_Plk_1	45	51	PF00069	0.539
MOD_Plk_1	75	81	PF00069	0.587
MOD_Plk_4	372	378	PF00069	0.681
MOD_Plk_4	383	389	PF00069	0.679
MOD_ProDKin_1	148	154	PF00069	0.637
MOD_ProDKin_1	361	367	PF00069	0.552
MOD_SUMO_for_1	141	144	PF00179	0.505
TRG_AP2beta_CARGO_1	211	221	PF09066	0.584
TRG_ENDOCYTIC_2	169	172	PF00928	0.571
TRG_ENDOCYTIC_2	199	202	PF00928	0.556
TRG_ENDOCYTIC_2	373	376	PF00928	0.570
TRG_ENDOCYTIC_2	56	59	PF00928	0.493
TRG_ER_diArg_1	207	210	PF00400	0.551
TRG_NLS_MonoCore_2	104	109	PF00514	0.666
TRG_Pf-PMV_PEXEL_1	108	113	PF00026	0.657
TRG_Pf-PMV_PEXEL_1	143	147	PF00026	0.348

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PDT5	Leptomonas seymouri	70%	92%
A0A0S4JAK0	Bodo saltans	29%	100%
A0A1X0NYG9	Trypanosomatidae	46%	93%
A0A3Q8IEQ6	Leishmania donovani	95%	100%
A0A3R7KQJ1	Trypanosoma rangeli	47%	92%
A4HGB5	Leishmania braziliensis	86%	99%
A4I3E9	Leishmania infantum	96%	100%
D0A7Z8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	48%	94%
Q4Q8J5	Leishmania major	94%	100%
V5BQC0	Trypanosoma cruzi	46%	91%