Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AZN5_LEIMU

TriTrypDb:

LmxM.28.0730

Length:

185

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AZN5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AZN5

PDB structure(s): 7aih_Au , 7am2_Au , 7ane_Au

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	137	139	PF00675	0.456
CLV_NRD_NRD_1	27	29	PF00675	0.640
CLV_NRD_NRD_1	9	11	PF00675	0.599
CLV_PCSK_FUR_1	135	139	PF00082	0.559
CLV_PCSK_KEX2_1	125	127	PF00082	0.494
CLV_PCSK_KEX2_1	137	139	PF00082	0.399
CLV_PCSK_KEX2_1	27	29	PF00082	0.662
CLV_PCSK_PC1ET2_1	125	127	PF00082	0.529
CLV_PCSK_PC7_1	23	29	PF00082	0.649
CLV_PCSK_SKI1_1	10	14	PF00082	0.736
CLV_PCSK_SKI1_1	116	120	PF00082	0.464
CLV_PCSK_SKI1_1	43	47	PF00082	0.568
DEG_Nend_Nbox_1	1	3	PF02207	0.579
DOC_CKS1_1	112	117	PF01111	0.463
DOC_MAPK_gen_1	100	110	PF00069	0.502
DOC_PP1_RVXF_1	114	120	PF00149	0.472
DOC_PP4_FxxP_1	50	53	PF00568	0.610
DOC_USP7_MATH_1	51	55	PF00917	0.513
DOC_USP7_UBL2_3	63	67	PF12436	0.566
DOC_WW_Pin1_4	111	116	PF00397	0.468
DOC_WW_Pin1_4	76	81	PF00397	0.485
LIG_14-3-3_CanoR_1	27	37	PF00244	0.613
LIG_14-3-3_CanoR_1	4	8	PF00244	0.611
LIG_BRCT_BRCA1_1	37	41	PF00533	0.627
LIG_deltaCOP1_diTrp_1	147	151	PF00928	0.422
LIG_EVH1_1	16	20	PF00568	0.585
LIG_FHA_1	112	118	PF00498	0.461
LIG_FHA_1	3	9	PF00498	0.567
LIG_IBAR_NPY_1	35	37	PF08397	0.586
LIG_LIR_Apic_2	48	53	PF02991	0.540
LIG_LIR_Gen_1	34	45	PF02991	0.584
LIG_LIR_Nem_3	147	152	PF02991	0.404
LIG_MAD2	93	101	PF02301	0.496
LIG_PDZ_Wminus1_1	183	185	PF00595	0.478
LIG_Pex14_1	56	60	PF04695	0.423
LIG_PTB_Apo_2	44	51	PF02174	0.537
LIG_SH2_CRK	152	156	PF00017	0.408
LIG_SH2_STAP1	129	133	PF00017	0.598
LIG_SH2_STAP1	25	29	PF00017	0.685
LIG_SH2_STAP1	37	41	PF00017	0.560
LIG_SH2_STAT5	64	67	PF00017	0.461
LIG_SH3_1	106	112	PF00018	0.493
LIG_SH3_3	106	112	PF00018	0.493
LIG_SH3_3	14	20	PF00018	0.589
LIG_SH3_3	170	176	PF00018	0.474
LIG_SH3_3	74	80	PF00018	0.514
LIG_WW_3	18	22	PF00397	0.680
MOD_CDK_SPK_2	111	116	PF00069	0.468
MOD_CK1_1	31	37	PF00069	0.652
MOD_GSK3_1	27	34	PF00069	0.624
MOD_GSK3_1	51	58	PF00069	0.422
MOD_NEK2_1	2	7	PF00069	0.631
MOD_NEK2_1	41	46	PF00069	0.522
MOD_PKA_1	27	33	PF00069	0.617
MOD_PKA_2	102	108	PF00069	0.514
MOD_PKA_2	27	33	PF00069	0.640
MOD_PKA_2	3	9	PF00069	0.564
MOD_PKA_2	51	57	PF00069	0.432
MOD_Plk_4	3	9	PF00069	0.676
MOD_Plk_4	51	57	PF00069	0.432
MOD_ProDKin_1	111	117	PF00069	0.464
MOD_ProDKin_1	76	82	PF00069	0.490
TRG_ENDOCYTIC_2	152	155	PF00928	0.412
TRG_ENDOCYTIC_2	37	40	PF00928	0.530
TRG_ENDOCYTIC_2	85	88	PF00928	0.435
TRG_ER_diArg_1	137	139	PF00400	0.536
TRG_ER_diArg_1	158	161	PF00400	0.427
TRG_ER_diArg_1	20	23	PF00400	0.622
TRG_ER_diArg_1	27	29	PF00400	0.609
TRG_Pf-PMV_PEXEL_1	137	141	PF00026	0.521

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I6Y9	Leptomonas seymouri	90%	100%
A0A0S4J812	Bodo saltans	72%	100%
A0A1X0NYE8	Trypanosomatidae	77%	100%
A0A3R7RRY1	Trypanosoma rangeli	77%	100%
A0A3S7X1D1	Leishmania donovani	99%	100%
A4HGB4	Leishmania braziliensis	97%	100%
A4I3E8	Leishmania infantum	98%	100%
D0A7Z9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	76%	100%
Q4Q8J6	Leishmania major	98%	100%