Sas10 domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Sas10/Utp3/C1D family/Sas10 C-terminal domain containing protein, putative

Species:

Leishmania mexicana

UniProt:

E9AZN4_LEIMU

TriTrypDb:

LmxM.28.0720

Length:

560

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005730	nucleolus	5	1
GO:0030684	preribosome	3	1
GO:0032040	small-subunit processome	4	1
GO:0032991	protein-containing complex	1	1
GO:0043226	organelle	2	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1
GO:1990904	ribonucleoprotein complex	2	1

Expansion

Sequence features

E9AZN4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AZN4

Function

Biological processes
Term	Name	Level	Count
GO:0000462	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	10	1
GO:0006139	nucleobase-containing compound metabolic process	3	1
GO:0006364	rRNA processing	8	1
GO:0006396	RNA processing	6	1
GO:0006725	cellular aromatic compound metabolic process	3	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0009987	cellular process	1	1
GO:0016070	RNA metabolic process	5	1
GO:0016072	rRNA metabolic process	7	1
GO:0030490	maturation of SSU-rRNA	9	1
GO:0034470	ncRNA processing	7	1
GO:0034641	cellular nitrogen compound metabolic process	3	1
GO:0034660	ncRNA metabolic process	6	1
GO:0043170	macromolecule metabolic process	3	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0046483	heterocycle metabolic process	3	1
GO:0071704	organic substance metabolic process	2	1
GO:0090304	nucleic acid metabolic process	4	1
GO:1901360	organic cyclic compound metabolic process	3	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	117	121	PF00656	0.507
CLV_C14_Caspase3-7	126	130	PF00656	0.508
CLV_C14_Caspase3-7	15	19	PF00656	0.698
CLV_C14_Caspase3-7	443	447	PF00656	0.724
CLV_NRD_NRD_1	118	120	PF00675	0.545
CLV_NRD_NRD_1	12	14	PF00675	0.610
CLV_NRD_NRD_1	190	192	PF00675	0.234
CLV_NRD_NRD_1	228	230	PF00675	0.335
CLV_NRD_NRD_1	303	305	PF00675	0.461
CLV_NRD_NRD_1	389	391	PF00675	0.522
CLV_NRD_NRD_1	46	48	PF00675	0.594
CLV_NRD_NRD_1	469	471	PF00675	0.570
CLV_NRD_NRD_1	490	492	PF00675	0.230
CLV_NRD_NRD_1	510	512	PF00675	0.183
CLV_NRD_NRD_1	519	521	PF00675	0.334
CLV_NRD_NRD_1	96	98	PF00675	0.462
CLV_PCSK_FUR_1	301	305	PF00082	0.610
CLV_PCSK_KEX2_1	10	12	PF00082	0.613
CLV_PCSK_KEX2_1	118	120	PF00082	0.546
CLV_PCSK_KEX2_1	303	305	PF00082	0.568
CLV_PCSK_KEX2_1	388	390	PF00082	0.503
CLV_PCSK_KEX2_1	405	407	PF00082	0.616
CLV_PCSK_KEX2_1	490	492	PF00082	0.235
CLV_PCSK_KEX2_1	519	521	PF00082	0.314
CLV_PCSK_PC1ET2_1	10	12	PF00082	0.613
CLV_PCSK_PC1ET2_1	405	407	PF00082	0.634
CLV_PCSK_PC7_1	515	521	PF00082	0.314
CLV_PCSK_SKI1_1	165	169	PF00082	0.540
CLV_PCSK_SKI1_1	3	7	PF00082	0.704
CLV_PCSK_SKI1_1	308	312	PF00082	0.550
CLV_PCSK_SKI1_1	47	51	PF00082	0.639
CLV_PCSK_SKI1_1	501	505	PF00082	0.281
CLV_Separin_Metazoa	385	389	PF03568	0.619
DEG_APCC_DBOX_1	243	251	PF00400	0.431
DEG_APCC_DBOX_1	303	311	PF00400	0.469
DOC_CYCLIN_RxL_1	162	172	PF00134	0.372
DOC_CYCLIN_yClb5_NLxxxL_5	198	204	PF00134	0.456
DOC_MAPK_gen_1	519	528	PF00069	0.314
DOC_MAPK_RevD_3	105	119	PF00069	0.545
DOC_USP7_MATH_1	108	112	PF00917	0.531
DOC_USP7_MATH_1	113	117	PF00917	0.412
DOC_USP7_MATH_1	123	127	PF00917	0.445
DOC_USP7_MATH_1	280	284	PF00917	0.659
DOC_USP7_MATH_1	288	292	PF00917	0.651
DOC_USP7_MATH_1	412	416	PF00917	0.772
DOC_USP7_MATH_1	465	469	PF00917	0.508
DOC_USP7_MATH_1	476	480	PF00917	0.503
DOC_USP7_UBL2_3	405	409	PF12436	0.718
DOC_USP7_UBL2_3	492	496	PF12436	0.281
DOC_USP7_UBL2_3	6	10	PF12436	0.593
DOC_USP7_UBL2_3	94	98	PF12436	0.525
DOC_WW_Pin1_4	157	162	PF00397	0.400
DOC_WW_Pin1_4	191	196	PF00397	0.446
LIG_14-3-3_CanoR_1	400	407	PF00244	0.690
LIG_14-3-3_CanoR_1	97	107	PF00244	0.496
LIG_APCC_ABBA_1	243	248	PF00400	0.431
LIG_BIR_II_1	1	5	PF00653	0.713
LIG_BIR_III_2	132	136	PF00653	0.556
LIG_BRCT_BRCA1_1	532	536	PF00533	0.411
LIG_eIF4E_1	259	265	PF01652	0.389
LIG_FHA_1	217	223	PF00498	0.431
LIG_FHA_2	146	152	PF00498	0.472
LIG_FHA_2	48	54	PF00498	0.726
LIG_FHA_2	99	105	PF00498	0.525
LIG_LIR_Gen_1	141	150	PF02991	0.448
LIG_LIR_Gen_1	219	227	PF02991	0.431
LIG_LIR_Gen_1	355	365	PF02991	0.547
LIG_LIR_Gen_1	450	460	PF02991	0.526
LIG_LIR_Gen_1	58	68	PF02991	0.607
LIG_LIR_Nem_3	141	147	PF02991	0.456
LIG_LIR_Nem_3	219	224	PF02991	0.431
LIG_LIR_Nem_3	355	361	PF02991	0.535
LIG_LIR_Nem_3	450	456	PF02991	0.529
LIG_LIR_Nem_3	541	547	PF02991	0.281
LIG_LIR_Nem_3	58	64	PF02991	0.619
LIG_NRBOX	162	168	PF00104	0.502
LIG_PCNA_yPIPBox_3	256	265	PF02747	0.377
LIG_PDZ_Class_1	555	560	PF00595	0.411
LIG_REV1ctd_RIR_1	355	364	PF16727	0.638
LIG_RPA_C_Fungi	465	477	PF08784	0.495
LIG_SH2_STAP1	189	193	PF00017	0.433
LIG_SH2_STAP1	453	457	PF00017	0.522
LIG_SH2_STAT5	214	217	PF00017	0.266
LIG_SH2_STAT5	221	224	PF00017	0.266
LIG_SH2_STAT5	246	249	PF00017	0.266
LIG_SH3_3	404	410	PF00018	0.609
LIG_SUMO_SIM_anti_2	111	117	PF11976	0.350
LIG_SUMO_SIM_anti_2	151	157	PF11976	0.482
LIG_SUMO_SIM_anti_2	378	385	PF11976	0.605
LIG_SUMO_SIM_anti_2	84	93	PF11976	0.509
LIG_SUMO_SIM_par_1	166	172	PF11976	0.287
LIG_TRAF2_1	252	255	PF00917	0.370
LIG_TRAF2_1	349	352	PF00917	0.687
LIG_TRAF2_1	483	486	PF00917	0.677
LIG_UBA3_1	163	171	PF00899	0.382
LIG_UBA3_1	383	392	PF00899	0.582
LIG_WRC_WIRS_1	200	205	PF05994	0.411
MOD_CDK_SPxxK_3	191	198	PF00069	0.287
MOD_CK1_1	266	272	PF00069	0.532
MOD_CK2_1	145	151	PF00069	0.431
MOD_CK2_1	199	205	PF00069	0.460
MOD_CK2_1	346	352	PF00069	0.693
MOD_CK2_1	379	385	PF00069	0.530
MOD_CK2_1	9	15	PF00069	0.616
MOD_Cter_Amidation	227	230	PF01082	0.281
MOD_GlcNHglycan	265	268	PF01048	0.460
MOD_GlcNHglycan	282	285	PF01048	0.594
MOD_GlcNHglycan	332	335	PF01048	0.511
MOD_GlcNHglycan	473	476	PF01048	0.565
MOD_GlcNHglycan	478	481	PF01048	0.604
MOD_GSK3_1	199	206	PF00069	0.443
MOD_GSK3_1	263	270	PF00069	0.480
MOD_GSK3_1	322	329	PF00069	0.531
MOD_GSK3_1	335	342	PF00069	0.498
MOD_GSK3_1	396	403	PF00069	0.710
MOD_GSK3_1	43	50	PF00069	0.784
MOD_GSK3_1	528	535	PF00069	0.411
MOD_N-GLC_1	335	340	PF02516	0.606
MOD_N-GLC_1	446	451	PF02516	0.453
MOD_N-GLC_2	43	45	PF02516	0.591
MOD_NEK2_1	114	119	PF00069	0.546
MOD_NEK2_1	203	208	PF00069	0.288
MOD_NEK2_1	210	215	PF00069	0.271
MOD_NEK2_1	216	221	PF00069	0.266
MOD_NEK2_1	257	262	PF00069	0.384
MOD_NEK2_1	289	294	PF00069	0.663
MOD_NEK2_1	335	340	PF00069	0.608
MOD_PIKK_1	528	534	PF00454	0.360
MOD_PKA_1	124	130	PF00069	0.696
MOD_PKA_1	330	336	PF00069	0.625
MOD_PKA_1	405	411	PF00069	0.698
MOD_PKA_1	47	53	PF00069	0.728
MOD_PKA_1	97	103	PF00069	0.532
MOD_PKA_2	401	407	PF00069	0.777
MOD_PKA_2	43	49	PF00069	0.607
MOD_Plk_1	379	385	PF00069	0.531
MOD_Plk_2-3	379	385	PF00069	0.651
MOD_Plk_2-3	446	452	PF00069	0.675
MOD_Plk_4	169	175	PF00069	0.420
MOD_Plk_4	199	205	PF00069	0.371
MOD_Plk_4	216	222	PF00069	0.174
MOD_Plk_4	379	385	PF00069	0.561
MOD_ProDKin_1	157	163	PF00069	0.391
MOD_ProDKin_1	191	197	PF00069	0.287
MOD_SUMO_for_1	156	159	PF00179	0.453
MOD_SUMO_for_1	224	227	PF00179	0.266
MOD_SUMO_for_1	538	541	PF00179	0.331
MOD_SUMO_rev_2	186	194	PF00179	0.399
MOD_SUMO_rev_2	202	208	PF00179	0.373
MOD_SUMO_rev_2	248	257	PF00179	0.361
TRG_DiLeu_BaEn_1	159	164	PF01217	0.401
TRG_DiLeu_BaEn_1	379	384	PF01217	0.619
TRG_DiLeu_BaLyEn_6	260	265	PF01217	0.383
TRG_ENDOCYTIC_2	221	224	PF00928	0.266
TRG_ENDOCYTIC_2	453	456	PF00928	0.559
TRG_ER_diArg_1	387	390	PF00400	0.542
TRG_ER_diArg_1	505	508	PF00400	0.347
TRG_NES_CRM1_1	22	37	PF08389	0.433
TRG_NLS_MonoExtC_3	9	14	PF00514	0.614
TRG_NLS_MonoExtC_3	96	102	PF00514	0.585
TRG_NLS_MonoExtN_4	94	101	PF00514	0.574
TRG_PTS1	557	560	PF00515	0.411

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PDH2	Leptomonas seymouri	72%	100%
A0A0S4JBP1	Bodo saltans	39%	100%
A0A1X0NYI2	Trypanosomatidae	48%	100%
A0A3S7X1D4	Leishmania donovani	94%	100%
A0A422P1Q1	Trypanosoma rangeli	51%	100%
A4HGB3	Leishmania braziliensis	83%	98%
A4I3E7	Leishmania infantum	94%	100%
D0A800	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	48%	100%
Q4Q8J7	Leishmania major	93%	100%
V5BG83	Trypanosoma cruzi	49%	100%