EF-hand domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

SNARE associated Golgi protein, putative

Species:

Leishmania mexicana

UniProt:

E9AZN3_LEIMU

TriTrypDb:

LmxM.28.0710

Length:

585

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	10
GO:0110165	cellular anatomical entity	1	10
GO:0005635	nuclear envelope	4	1
GO:0012505	endomembrane system	2	1
GO:0031967	organelle envelope	3	1
GO:0031975	envelope	2	1

Expansion

Sequence features

E9AZN3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AZN3

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	10
GO:0005509	calcium ion binding	5	10
GO:0043167	ion binding	2	10
GO:0043169	cation binding	3	10
GO:0046872	metal ion binding	4	10

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	141	145	PF00656	0.346
CLV_C14_Caspase3-7	464	468	PF00656	0.507
CLV_NRD_NRD_1	19	21	PF00675	0.427
CLV_NRD_NRD_1	309	311	PF00675	0.348
CLV_NRD_NRD_1	465	467	PF00675	0.391
CLV_NRD_NRD_1	480	482	PF00675	0.364
CLV_NRD_NRD_1	569	571	PF00675	0.671
CLV_PCSK_KEX2_1	19	21	PF00082	0.427
CLV_PCSK_KEX2_1	309	311	PF00082	0.314
CLV_PCSK_KEX2_1	414	416	PF00082	0.468
CLV_PCSK_KEX2_1	465	467	PF00082	0.375
CLV_PCSK_KEX2_1	479	481	PF00082	0.345
CLV_PCSK_KEX2_1	569	571	PF00082	0.671
CLV_PCSK_PC1ET2_1	414	416	PF00082	0.468
CLV_PCSK_PC7_1	565	571	PF00082	0.634
CLV_PCSK_SKI1_1	12	16	PF00082	0.299
CLV_PCSK_SKI1_1	126	130	PF00082	0.539
CLV_PCSK_SKI1_1	414	418	PF00082	0.448
CLV_PCSK_SKI1_1	494	498	PF00082	0.383
CLV_PCSK_SKI1_1	520	524	PF00082	0.427
CLV_PCSK_SKI1_1	53	57	PF00082	0.316
CLV_PCSK_SKI1_1	573	577	PF00082	0.572
DEG_APCC_DBOX_1	18	26	PF00400	0.604
DEG_SPOP_SBC_1	487	491	PF00917	0.477
DOC_CYCLIN_RxL_1	50	58	PF00134	0.497
DOC_MAPK_FxFP_2	191	194	PF00069	0.362
DOC_MAPK_gen_1	223	230	PF00069	0.575
DOC_MAPK_gen_1	27	36	PF00069	0.566
DOC_MAPK_gen_1	517	525	PF00069	0.440
DOC_MAPK_gen_1	569	576	PF00069	0.460
DOC_MAPK_MEF2A_6	223	230	PF00069	0.633
DOC_MAPK_MEF2A_6	352	359	PF00069	0.321
DOC_MAPK_MEF2A_6	517	525	PF00069	0.593
DOC_MAPK_MEF2A_6	540	548	PF00069	0.435
DOC_PP4_FxxP_1	191	194	PF00568	0.362
DOC_PP4_FxxP_1	219	222	PF00568	0.569
DOC_PP4_FxxP_1	337	340	PF00568	0.258
DOC_USP7_MATH_1	408	412	PF00917	0.598
DOC_USP7_MATH_1	504	508	PF00917	0.641
DOC_USP7_UBL2_3	352	356	PF12436	0.302
DOC_WW_Pin1_4	74	79	PF00397	0.406
LIG_14-3-3_CanoR_1	126	132	PF00244	0.367
LIG_14-3-3_CanoR_1	27	36	PF00244	0.586
LIG_14-3-3_CanoR_1	379	389	PF00244	0.640
LIG_14-3-3_CanoR_1	480	486	PF00244	0.527
LIG_14-3-3_CanoR_1	540	545	PF00244	0.355
LIG_BIR_II_1	1	5	PF00653	0.664
LIG_BRCT_BRCA1_1	341	345	PF00533	0.342
LIG_CaM_NSCaTE_8	314	321	PF13499	0.346
LIG_deltaCOP1_diTrp_1	161	170	PF00928	0.400
LIG_FHA_1	102	108	PF00498	0.356
LIG_FHA_1	29	35	PF00498	0.549
LIG_FHA_1	3	9	PF00498	0.594
LIG_FHA_1	488	494	PF00498	0.570
LIG_FHA_1	545	551	PF00498	0.415
LIG_FHA_1	56	62	PF00498	0.367
LIG_FHA_2	139	145	PF00498	0.427
LIG_FHA_2	422	428	PF00498	0.737
LIG_FHA_2	468	474	PF00498	0.653
LIG_FHA_2	487	493	PF00498	0.468
LIG_FHA_2	93	99	PF00498	0.371
LIG_LIR_Apic_2	216	222	PF02991	0.578
LIG_LIR_Apic_2	71	76	PF02991	0.427
LIG_LIR_Gen_1	101	107	PF02991	0.351
LIG_LIR_Gen_1	224	232	PF02991	0.514
LIG_LIR_Nem_3	101	106	PF02991	0.352
LIG_LIR_Nem_3	166	172	PF02991	0.269
LIG_LIR_Nem_3	224	230	PF02991	0.595
LIG_LIR_Nem_3	32	38	PF02991	0.610
LIG_LIR_Nem_3	390	394	PF02991	0.609
LIG_LIR_Nem_3	71	75	PF02991	0.441
LIG_LYPXL_yS_3	518	521	PF13949	0.587
LIG_MLH1_MIPbox_1	341	345	PF16413	0.342
LIG_NRBOX	545	551	PF00104	0.388
LIG_PDZ_Class_2	580	585	PF00595	0.440
LIG_Pex14_2	134	138	PF04695	0.343
LIG_Pex14_2	337	341	PF04695	0.272
LIG_Pex14_2	364	368	PF04695	0.374
LIG_REV1ctd_RIR_1	389	397	PF16727	0.547
LIG_SH2_CRK	103	107	PF00017	0.384
LIG_SH2_NCK_1	46	50	PF00017	0.640
LIG_SH2_PTP2	73	76	PF00017	0.557
LIG_SH2_SRC	46	49	PF00017	0.533
LIG_SH2_SRC	582	585	PF00017	0.445
LIG_SH2_STAP1	103	107	PF00017	0.366
LIG_SH2_STAP1	271	275	PF00017	0.469
LIG_SH2_STAP1	46	50	PF00017	0.640
LIG_SH2_STAT3	38	41	PF00017	0.637
LIG_SH2_STAT3	535	538	PF00017	0.645
LIG_SH2_STAT5	103	106	PF00017	0.348
LIG_SH2_STAT5	148	151	PF00017	0.447
LIG_SH2_STAT5	248	251	PF00017	0.591
LIG_SH2_STAT5	553	556	PF00017	0.442
LIG_SH2_STAT5	582	585	PF00017	0.456
LIG_SH2_STAT5	73	76	PF00017	0.557
LIG_SH3_3	22	28	PF00018	0.487
LIG_SH3_3	56	62	PF00018	0.317
LIG_SH3_3	72	78	PF00018	0.363
LIG_TRAF2_1	461	464	PF00917	0.586
LIG_TYR_ITIM	580	585	PF00017	0.431
LIG_TYR_ITIM	70	75	PF00017	0.356
LIG_WRC_WIRS_1	341	346	PF05994	0.258
LIG_WRC_WIRS_1	388	393	PF05994	0.657
LIG_WRC_WIRS_1	455	460	PF05994	0.568
MOD_CK1_1	101	107	PF00069	0.457
MOD_CK1_1	140	146	PF00069	0.445
MOD_CK1_1	2	8	PF00069	0.460
MOD_CK1_1	241	247	PF00069	0.582
MOD_CK1_1	298	304	PF00069	0.543
MOD_CK1_1	539	545	PF00069	0.431
MOD_CK2_1	231	237	PF00069	0.666
MOD_CK2_1	241	247	PF00069	0.518
MOD_CK2_1	3	9	PF00069	0.631
MOD_CK2_1	421	427	PF00069	0.739
MOD_CK2_1	450	456	PF00069	0.534
MOD_CK2_1	458	464	PF00069	0.534
MOD_CK2_1	467	473	PF00069	0.535
MOD_CK2_1	486	492	PF00069	0.470
MOD_CK2_1	92	98	PF00069	0.410
MOD_GlcNHglycan	186	189	PF01048	0.320
MOD_GlcNHglycan	289	292	PF01048	0.379
MOD_GlcNHglycan	345	348	PF01048	0.427
MOD_GlcNHglycan	368	371	PF01048	0.372
MOD_GlcNHglycan	382	385	PF01048	0.347
MOD_GlcNHglycan	402	405	PF01048	0.443
MOD_GlcNHglycan	513	516	PF01048	0.308
MOD_GlcNHglycan	83	86	PF01048	0.602
MOD_GSK3_1	180	187	PF00069	0.316
MOD_GSK3_1	339	346	PF00069	0.342
MOD_GSK3_1	450	457	PF00069	0.593
MOD_GSK3_1	536	543	PF00069	0.436
MOD_GSK3_1	98	105	PF00069	0.419
MOD_N-GLC_1	301	306	PF02516	0.348
MOD_NEK2_1	238	243	PF00069	0.602
MOD_NEK2_1	287	292	PF00069	0.581
MOD_NEK2_1	34	39	PF00069	0.533
MOD_NEK2_1	345	350	PF00069	0.302
MOD_NEK2_1	380	385	PF00069	0.585
MOD_NEK2_1	450	455	PF00069	0.555
MOD_NEK2_1	544	549	PF00069	0.378
MOD_NEK2_1	55	60	PF00069	0.362
MOD_NEK2_2	340	345	PF00069	0.258
MOD_PIKK_1	231	237	PF00454	0.589
MOD_PKA_2	29	35	PF00069	0.532
MOD_PKA_2	408	414	PF00069	0.581
MOD_PKA_2	539	545	PF00069	0.432
MOD_PKB_1	479	487	PF00069	0.496
MOD_Plk_1	301	307	PF00069	0.535
MOD_Plk_2-3	467	473	PF00069	0.567
MOD_Plk_4	241	247	PF00069	0.542
MOD_Plk_4	29	35	PF00069	0.615
MOD_Plk_4	340	346	PF00069	0.276
MOD_Plk_4	387	393	PF00069	0.605
MOD_Plk_4	430	436	PF00069	0.593
MOD_Plk_4	443	449	PF00069	0.558
MOD_Plk_4	450	456	PF00069	0.425
MOD_Plk_4	467	473	PF00069	0.535
MOD_Plk_4	544	550	PF00069	0.342
MOD_Plk_4	55	61	PF00069	0.323
MOD_Plk_4	68	74	PF00069	0.287
MOD_Plk_4	98	104	PF00069	0.412
MOD_ProDKin_1	74	80	PF00069	0.406
MOD_SUMO_rev_2	491	496	PF00179	0.512
TRG_DiLeu_BaEn_1	430	435	PF01217	0.651
TRG_DiLeu_BaLyEn_6	517	522	PF01217	0.642
TRG_ENDOCYTIC_2	103	106	PF00928	0.359
TRG_ENDOCYTIC_2	169	172	PF00928	0.427
TRG_ENDOCYTIC_2	294	297	PF00928	0.458
TRG_ENDOCYTIC_2	518	521	PF00928	0.613
TRG_ENDOCYTIC_2	582	585	PF00928	0.485
TRG_ENDOCYTIC_2	72	75	PF00928	0.356
TRG_ER_diArg_1	308	310	PF00400	0.548
TRG_ER_diArg_1	406	409	PF00400	0.646
TRG_ER_diArg_1	478	481	PF00400	0.630
TRG_ER_diArg_1	568	570	PF00400	0.430
TRG_Pf-PMV_PEXEL_1	552	557	PF00026	0.646

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P7S3	Leptomonas seymouri	64%	100%
A0A1X0NYV6	Trypanosomatidae	47%	100%
A0A3Q8IAW4	Leishmania donovani	93%	100%
A0A422P1M7	Trypanosoma rangeli	47%	100%
A4HGB2	Leishmania braziliensis	82%	100%
A4I3E6	Leishmania infantum	93%	100%
D0A801	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	44%	100%
Q4Q8J8	Leishmania major	91%	100%
V5B0S4	Trypanosoma cruzi	45%	100%