PPM-type phosphatase domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Domain of unknown function (DUF4539), putative

Species:

Leishmania mexicana

UniProt:

E9AZN2_LEIMU

TriTrypDb:

LmxM.28.0705

Length:

250

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AZN2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AZN2

Function

Biological processes
Term	Name	Level	Count
GO:0000725	recombinational repair	6	7
GO:0006139	nucleobase-containing compound metabolic process	3	7
GO:0006259	DNA metabolic process	4	7
GO:0006281	DNA repair	5	7
GO:0006310	DNA recombination	5	7
GO:0006725	cellular aromatic compound metabolic process	3	7
GO:0006807	nitrogen compound metabolic process	2	7
GO:0006950	response to stress	2	7
GO:0006974	DNA damage response	4	7
GO:0008152	metabolic process	1	7
GO:0009987	cellular process	1	7
GO:0033554	cellular response to stress	3	7
GO:0034641	cellular nitrogen compound metabolic process	3	7
GO:0043170	macromolecule metabolic process	3	7
GO:0044237	cellular metabolic process	2	7
GO:0044238	primary metabolic process	2	7
GO:0044260	obsolete cellular macromolecule metabolic process	3	7
GO:0046483	heterocycle metabolic process	3	7
GO:0050896	response to stimulus	1	7
GO:0051716	cellular response to stimulus	2	7
GO:0071704	organic substance metabolic process	2	7
GO:0090304	nucleic acid metabolic process	4	7
GO:1901360	organic cyclic compound metabolic process	3	7

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	180	184	PF00656	0.470
CLV_C14_Caspase3-7	245	249	PF00656	0.648
CLV_C14_Caspase3-7	48	52	PF00656	0.309
CLV_PCSK_KEX2_1	220	222	PF00082	0.657
CLV_PCSK_PC1ET2_1	220	222	PF00082	0.675
CLV_PCSK_SKI1_1	30	34	PF00082	0.504
CLV_PCSK_SKI1_1	43	47	PF00082	0.192
DEG_Nend_UBRbox_2	1	3	PF02207	0.443
DOC_PP2B_LxvP_1	113	116	PF13499	0.324
DOC_USP7_MATH_1	126	130	PF00917	0.675
DOC_USP7_MATH_1	147	151	PF00917	0.724
DOC_USP7_MATH_1	187	191	PF00917	0.760
DOC_USP7_MATH_1	194	198	PF00917	0.620
DOC_USP7_MATH_1	49	53	PF00917	0.309
LIG_APCC_ABBA_1	84	89	PF00400	0.249
LIG_deltaCOP1_diTrp_1	161	168	PF00928	0.501
LIG_FHA_1	40	46	PF00498	0.328
LIG_FHA_1	79	85	PF00498	0.384
LIG_FHA_1	89	95	PF00498	0.316
LIG_FHA_2	156	162	PF00498	0.548
LIG_FHA_2	178	184	PF00498	0.609
LIG_FHA_2	3	9	PF00498	0.432
LIG_IRF3_LxIS_1	90	96	PF10401	0.334
LIG_LIR_Apic_2	189	194	PF02991	0.572
LIG_LIR_Gen_1	62	71	PF02991	0.309
LIG_LIR_Nem_3	62	67	PF02991	0.309
LIG_LIR_Nem_3	72	78	PF02991	0.309
LIG_LYPXL_yS_3	75	78	PF13949	0.309
LIG_MYND_2	100	104	PF01753	0.381
LIG_NRBOX	109	115	PF00104	0.309
LIG_SH2_CRK	64	68	PF00017	0.309
LIG_SH2_NCK_1	175	179	PF00017	0.471
LIG_SH2_STAP1	28	32	PF00017	0.464
LIG_SH2_STAT5	191	194	PF00017	0.479
LIG_SH2_STAT5	64	67	PF00017	0.352
LIG_SUMO_SIM_anti_2	242	248	PF11976	0.557
LIG_SUMO_SIM_anti_2	88	94	PF11976	0.309
LIG_SUMO_SIM_par_1	51	58	PF11976	0.309
LIG_SUMO_SIM_par_1	88	97	PF11976	0.309
LIG_WRC_WIRS_1	178	183	PF05994	0.599
MOD_CK1_1	157	163	PF00069	0.740
MOD_CK1_1	26	32	PF00069	0.395
MOD_CK2_1	187	193	PF00069	0.574
MOD_CK2_1	2	8	PF00069	0.437
MOD_GlcNHglycan	120	123	PF01048	0.559
MOD_GlcNHglycan	130	133	PF01048	0.545
MOD_GlcNHglycan	229	232	PF01048	0.637
MOD_GlcNHglycan	30	33	PF01048	0.395
MOD_GlcNHglycan	47	50	PF01048	0.309
MOD_GlcNHglycan	58	62	PF01048	0.330
MOD_GSK3_1	124	131	PF00069	0.595
MOD_GSK3_1	155	162	PF00069	0.628
MOD_GSK3_1	177	184	PF00069	0.593
MOD_GSK3_1	19	26	PF00069	0.364
MOD_GSK3_1	2	9	PF00069	0.444
MOD_GSK3_1	200	207	PF00069	0.672
MOD_GSK3_1	221	228	PF00069	0.615
MOD_GSK3_1	39	46	PF00069	0.482
MOD_N-GLC_1	181	186	PF02516	0.475
MOD_N-GLC_1	225	230	PF02516	0.618
MOD_NEK2_1	93	98	PF00069	0.309
MOD_NEK2_2	59	64	PF00069	0.309
MOD_PIKK_1	201	207	PF00454	0.496
MOD_PK_1	212	218	PF00069	0.578
MOD_PKA_2	147	153	PF00069	0.608
MOD_Plk_1	88	94	PF00069	0.348
MOD_Plk_2-3	2	8	PF00069	0.437
MOD_Plk_4	2	8	PF00069	0.469
MOD_Plk_4	49	55	PF00069	0.310
TRG_DiLeu_BaEn_1	242	247	PF01217	0.557
TRG_ENDOCYTIC_2	175	178	PF00928	0.468
TRG_ENDOCYTIC_2	64	67	PF00928	0.309
TRG_ENDOCYTIC_2	75	78	PF00928	0.309

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I1R0	Leptomonas seymouri	49%	97%
A0A3S7X1B4	Leishmania donovani	92%	100%
A4HGB1	Leishmania braziliensis	74%	99%
A4I3E5	Leishmania infantum	92%	100%
Q4Q8J9	Leishmania major	90%	100%