ANK_REP_REGION domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Ankyrin repeats (3 copies), putative

Species:

Leishmania mexicana

UniProt:

E9AZM9_LEIMU

TriTrypDb:

LmxM.28.0680

Length:

235

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AZM9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AZM9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	16	20	PF00656	0.456
CLV_C14_Caspase3-7	45	49	PF00656	0.384
CLV_NRD_NRD_1	187	189	PF00675	0.746
CLV_PCSK_KEX2_1	199	201	PF00082	0.727
CLV_PCSK_PC1ET2_1	199	201	PF00082	0.698
CLV_PCSK_SKI1_1	121	125	PF00082	0.413
DEG_APCC_DBOX_1	11	19	PF00400	0.541
DEG_Nend_UBRbox_2	1	3	PF02207	0.586
DEG_SPOP_SBC_1	219	223	PF00917	0.640
DOC_PP4_FxxP_1	11	14	PF00568	0.564
DOC_USP7_MATH_1	203	207	PF00917	0.688
DOC_USP7_MATH_1	219	223	PF00917	0.527
LIG_APCC_ABBA_1	1	6	PF00400	0.632
LIG_FHA_1	221	227	PF00498	0.585
LIG_FHA_2	14	20	PF00498	0.497
LIG_LIR_Apic_2	147	152	PF02991	0.594
LIG_LIR_Apic_2	2	7	PF02991	0.633
LIG_LIR_Apic_2	8	14	PF02991	0.602
LIG_LIR_Gen_1	129	140	PF02991	0.502
LIG_MYND_3	67	71	PF01753	0.364
LIG_RPA_C_Fungi	94	106	PF08784	0.384
LIG_SH2_NCK_1	27	31	PF00017	0.456
LIG_SH2_PTP2	149	152	PF00017	0.572
LIG_SH2_SRC	149	152	PF00017	0.572
LIG_SH2_STAP1	128	132	PF00017	0.503
LIG_SH2_STAT3	128	131	PF00017	0.485
LIG_SH2_STAT5	149	152	PF00017	0.517
LIG_SH2_STAT5	39	42	PF00017	0.327
LIG_SH3_1	188	194	PF00018	0.649
LIG_SH3_2	194	199	PF14604	0.616
LIG_SH3_3	188	194	PF00018	0.695
LIG_SH3_3	210	216	PF00018	0.653
LIG_SH3_3	77	83	PF00018	0.269
LIG_SUMO_SIM_anti_2	32	37	PF11976	0.384
LIG_TRAF2_1	178	181	PF00917	0.613
MOD_CK1_1	153	159	PF00069	0.441
MOD_CK2_1	109	115	PF00069	0.257
MOD_CK2_1	138	144	PF00069	0.510
MOD_CK2_1	159	165	PF00069	0.550
MOD_GlcNHglycan	111	114	PF01048	0.360
MOD_GlcNHglycan	161	164	PF01048	0.557
MOD_GlcNHglycan	203	206	PF01048	0.677
MOD_GlcNHglycan	227	230	PF01048	0.566
MOD_GlcNHglycan	23	26	PF01048	0.437
MOD_GSK3_1	134	141	PF00069	0.509
MOD_N-GLC_1	159	164	PF02516	0.497
MOD_NEK2_1	119	124	PF00069	0.472
MOD_NEK2_1	21	26	PF00069	0.467
MOD_NEK2_1	225	230	PF00069	0.670
MOD_PIKK_1	150	156	PF00454	0.674
MOD_PIKK_1	220	226	PF00454	0.588
MOD_Plk_1	142	148	PF00069	0.607
MOD_Plk_2-3	13	19	PF00069	0.472
MOD_Plk_2-3	176	182	PF00069	0.798
MOD_Plk_4	134	140	PF00069	0.373
MOD_Plk_4	145	151	PF00069	0.490
MOD_Plk_4	153	159	PF00069	0.635
MOD_SUMO_rev_2	169	179	PF00179	0.672
MOD_SUMO_rev_2	180	185	PF00179	0.572
TRG_DiLeu_BaEn_1	134	139	PF01217	0.429
TRG_ENDOCYTIC_2	132	135	PF00928	0.494

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I8F3	Leptomonas seymouri	72%	100%
A0A1X0NYH9	Trypanosomatidae	40%	96%
A0A3R7KXF5	Trypanosoma rangeli	45%	100%
A0A3S7X195	Leishmania donovani	94%	100%
A4HGA8	Leishmania braziliensis	84%	99%
A4I3E2	Leishmania infantum	93%	100%
Q4Q8K2	Leishmania major	92%	99%
Q6NSI1	Homo sapiens	24%	73%
V5BQC3	Trypanosoma cruzi	44%	99%