Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania mexicana

UniProt:

E9AZM8_LEIMU

TriTrypDb:

LmxM.28.0670

Length:

360

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AZM8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AZM8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	105	109	PF00656	0.601
CLV_C14_Caspase3-7	111	115	PF00656	0.729
CLV_NRD_NRD_1	207	209	PF00675	0.704
CLV_NRD_NRD_1	212	214	PF00675	0.639
CLV_PCSK_KEX2_1	142	144	PF00082	0.538
CLV_PCSK_KEX2_1	212	214	PF00082	0.613
CLV_PCSK_PC1ET2_1	142	144	PF00082	0.538
CLV_PCSK_PC7_1	208	214	PF00082	0.580
CLV_PCSK_SKI1_1	200	204	PF00082	0.725
CLV_PCSK_SKI1_1	256	260	PF00082	0.382
DOC_CYCLIN_yCln2_LP_2	331	337	PF00134	0.475
DOC_MAPK_MEF2A_6	327	335	PF00069	0.422
DOC_PP1_RVXF_1	336	343	PF00149	0.574
DOC_PP2B_LxvP_1	235	238	PF13499	0.486
DOC_PP2B_LxvP_1	331	334	PF13499	0.489
DOC_PP4_FxxP_1	21	24	PF00568	0.346
DOC_PP4_FxxP_1	295	298	PF00568	0.505
DOC_USP7_MATH_1	115	119	PF00917	0.480
DOC_WW_Pin1_4	20	25	PF00397	0.495
DOC_WW_Pin1_4	241	246	PF00397	0.568
DOC_WW_Pin1_4	285	290	PF00397	0.692
LIG_14-3-3_CanoR_1	143	149	PF00244	0.513
LIG_14-3-3_CanoR_1	280	285	PF00244	0.647
LIG_14-3-3_CanoR_1	82	92	PF00244	0.461
LIG_Actin_WH2_2	159	177	PF00022	0.459
LIG_Actin_WH2_2	247	262	PF00022	0.428
LIG_BIR_III_2	69	73	PF00653	0.423
LIG_CaM_IQ_9	268	283	PF13499	0.496
LIG_eIF4E_1	263	269	PF01652	0.382
LIG_FHA_1	181	187	PF00498	0.525
LIG_FHA_1	264	270	PF00498	0.496
LIG_FHA_2	242	248	PF00498	0.514
LIG_FHA_2	272	278	PF00498	0.585
LIG_GBD_Chelix_1	170	178	PF00786	0.476
LIG_LIR_Apic_2	20	24	PF02991	0.342
LIG_LIR_Apic_2	292	298	PF02991	0.548
LIG_LIR_Gen_1	14	24	PF02991	0.578
LIG_LIR_Nem_3	129	134	PF02991	0.432
LIG_LIR_Nem_3	14	19	PF02991	0.509
LIG_LIR_Nem_3	247	251	PF02991	0.560
LIG_LIR_Nem_3	346	352	PF02991	0.420
LIG_LIR_Nem_3	355	359	PF02991	0.479
LIG_LIR_Nem_3	53	58	PF02991	0.465
LIG_PTB_Apo_2	133	140	PF02174	0.555
LIG_REV1ctd_RIR_1	129	139	PF16727	0.451
LIG_SH2_CRK	189	193	PF00017	0.477
LIG_SH2_SRC	189	192	PF00017	0.474
LIG_SH2_STAP1	263	267	PF00017	0.436
LIG_SH2_STAT3	138	141	PF00017	0.382
LIG_SH2_STAT3	38	41	PF00017	0.571
LIG_SH2_STAT5	130	133	PF00017	0.403
LIG_SH2_STAT5	138	141	PF00017	0.387
LIG_SH2_STAT5	352	355	PF00017	0.500
LIG_SH2_STAT5	58	61	PF00017	0.489
LIG_SH3_1	351	357	PF00018	0.550
LIG_SH3_3	181	187	PF00018	0.478
LIG_SH3_3	351	357	PF00018	0.612
LIG_TRFH_1	295	299	PF08558	0.495
LIG_TRFH_1	58	62	PF08558	0.487
MOD_CK1_1	233	239	PF00069	0.558
MOD_CK2_1	19	25	PF00069	0.605
MOD_CK2_1	241	247	PF00069	0.527
MOD_GlcNHglycan	105	108	PF01048	0.657
MOD_GlcNHglycan	110	113	PF01048	0.747
MOD_GlcNHglycan	121	124	PF01048	0.431
MOD_GlcNHglycan	232	235	PF01048	0.473
MOD_GlcNHglycan	247	251	PF01048	0.459
MOD_GlcNHglycan	318	321	PF01048	0.461
MOD_GlcNHglycan	322	325	PF01048	0.439
MOD_GSK3_1	115	122	PF00069	0.583
MOD_GSK3_1	20	27	PF00069	0.504
MOD_GSK3_1	246	253	PF00069	0.402
MOD_GSK3_1	259	266	PF00069	0.377
MOD_GSK3_1	280	287	PF00069	0.511
MOD_GSK3_1	289	296	PF00069	0.542
MOD_GSK3_1	316	323	PF00069	0.490
MOD_GSK3_1	98	105	PF00069	0.526
MOD_N-GLC_1	116	121	PF02516	0.547
MOD_NEK2_1	19	24	PF00069	0.598
MOD_NEK2_1	246	251	PF00069	0.386
MOD_NEK2_1	284	289	PF00069	0.405
MOD_NEK2_1	50	55	PF00069	0.480
MOD_NEK2_2	130	135	PF00069	0.320
MOD_PIKK_1	11	17	PF00454	0.450
MOD_PIKK_1	225	231	PF00454	0.473
MOD_PIKK_1	37	43	PF00454	0.520
MOD_PKA_2	103	109	PF00069	0.699
MOD_PKA_2	259	265	PF00069	0.436
MOD_Plk_1	180	186	PF00069	0.494
MOD_Plk_1	263	269	PF00069	0.446
MOD_Plk_2-3	159	165	PF00069	0.614
MOD_Plk_4	263	269	PF00069	0.442
MOD_ProDKin_1	20	26	PF00069	0.492
MOD_ProDKin_1	241	247	PF00069	0.558
MOD_ProDKin_1	285	291	PF00069	0.692
MOD_SUMO_rev_2	204	211	PF00179	0.660
TRG_DiLeu_BaEn_1	264	269	PF01217	0.386
TRG_ER_diArg_1	173	176	PF00400	0.449
TRG_ER_diArg_1	211	213	PF00400	0.615
TRG_Pf-PMV_PEXEL_1	200	204	PF00026	0.725
TRG_Pf-PMV_PEXEL_1	276	281	PF00026	0.514

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IA55	Leptomonas seymouri	51%	75%
A0A3Q8IQE0	Leishmania donovani	88%	71%
A4HGA7	Leishmania braziliensis	76%	100%
A4I3E1	Leishmania infantum	88%	100%
Q4Q8K3	Leishmania major	86%	100%