ER lumen protein-retaining receptor

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

ER lumen retaining receptor-like protein

Species:

Leishmania mexicana

UniProt:

E9AZM4_LEIMU

TriTrypDb:

LmxM.28.0630

Length:

219

Annotations

LeishMANIAdb annotations

Corresponds to the highly conserved KDEL receptor (ERD2) of all other Eukaryotic organisms. . Localization: ER (by homology)

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005789	endoplasmic reticulum membrane	4	11
GO:0016020	membrane	2	11
GO:0031090	organelle membrane	3	11
GO:0110165	cellular anatomical entity	1	11
GO:0005783	endoplasmic reticulum	5	1
GO:0005801	cis-Golgi network	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1

Expansion

Sequence features

E9AZM4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AZM4

Function

Biological processes
Term	Name	Level	Count
GO:0006621	protein retention in ER lumen	6	11
GO:0006810	transport	3	11
GO:0008104	protein localization	4	11
GO:0009987	cellular process	1	11
GO:0015031	protein transport	4	11
GO:0032507	maintenance of protein location in cell	3	11
GO:0033036	macromolecule localization	2	11
GO:0035437	maintenance of protein localization in endoplasmic reticulum	5	11
GO:0045184	establishment of protein localization	3	11
GO:0045185	maintenance of protein location	3	11
GO:0051179	localization	1	11
GO:0051234	establishment of localization	2	11
GO:0051235	maintenance of location	2	11
GO:0051641	cellular localization	2	11
GO:0051651	maintenance of location in cell	2	11
GO:0070727	cellular macromolecule localization	3	11
GO:0071702	organic substance transport	4	11
GO:0071705	nitrogen compound transport	4	11
GO:0072595	maintenance of protein localization in organelle	4	11
GO:0006888	endoplasmic reticulum to Golgi vesicle-mediated transport	4	1
GO:0016192	vesicle-mediated transport	4	1
GO:0046907	intracellular transport	3	1
GO:0048193	Golgi vesicle transport	5	1
GO:0051649	establishment of localization in cell	3	1

Molecular functions
Term	Name	Level	Count
GO:0005048	signal sequence binding	4	11
GO:0005488	binding	1	11
GO:0033218	amide binding	2	11
GO:0042277	peptide binding	3	11
GO:0046923	ER retention sequence binding	5	11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	116	118	PF00675	0.400
CLV_NRD_NRD_1	208	210	PF00675	0.283
CLV_PCSK_KEX2_1	116	118	PF00082	0.400
CLV_PCSK_SKI1_1	209	213	PF00082	0.278
CLV_PCSK_SKI1_1	64	68	PF00082	0.235
DOC_MAPK_gen_1	116	123	PF00069	0.276
DOC_MAPK_gen_1	25	34	PF00069	0.412
DOC_MAPK_MEF2A_6	116	123	PF00069	0.329
DOC_PP1_RVXF_1	178	184	PF00149	0.308
DOC_PP1_RVXF_1	62	68	PF00149	0.215
DOC_PP2B_LxvP_1	100	103	PF13499	0.235
DOC_PP4_FxxP_1	80	83	PF00568	0.450
DOC_USP7_MATH_1	115	119	PF00917	0.167
DOC_USP7_MATH_1	151	155	PF00917	0.399
DOC_USP7_UBL2_3	81	85	PF12436	0.399
DOC_WW_Pin1_4	111	116	PF00397	0.368
DOC_WW_Pin1_4	79	84	PF00397	0.399
LIG_14-3-3_CanoR_1	182	187	PF00244	0.294
LIG_14-3-3_CanoR_1	25	34	PF00244	0.430
LIG_BIR_II_1	1	5	PF00653	0.369
LIG_BRCT_BRCA1_1	107	111	PF00533	0.305
LIG_Clathr_ClatBox_1	194	198	PF01394	0.368
LIG_deltaCOP1_diTrp_1	122	127	PF00928	0.239
LIG_FHA_1	44	50	PF00498	0.258
LIG_FHA_1	60	66	PF00498	0.296
LIG_FHA_1	69	75	PF00498	0.315
LIG_FHA_1	92	98	PF00498	0.402
LIG_LIR_Gen_1	146	157	PF02991	0.399
LIG_LIR_Gen_1	193	204	PF02991	0.265
LIG_LIR_Gen_1	38	48	PF02991	0.273
LIG_LIR_Gen_1	50	59	PF02991	0.189
LIG_LIR_Nem_3	126	130	PF02991	0.333
LIG_LIR_Nem_3	146	152	PF02991	0.309
LIG_LIR_Nem_3	193	199	PF02991	0.252
LIG_LIR_Nem_3	38	43	PF02991	0.273
LIG_LIR_Nem_3	46	51	PF02991	0.200
LIG_LIR_Nem_3	54	58	PF02991	0.243
LIG_Pex14_1	171	175	PF04695	0.235
LIG_Pex14_1	84	88	PF04695	0.426
LIG_Pex14_2	40	44	PF04695	0.254
LIG_Pex14_2	80	84	PF04695	0.450
LIG_SH2_CRK	149	153	PF00017	0.455
LIG_SH2_CRK	178	182	PF00017	0.319
LIG_SH2_CRK	201	205	PF00017	0.237
LIG_SH2_SRC	130	133	PF00017	0.235
LIG_SH2_SRC	176	179	PF00017	0.363
LIG_SH2_SRC	48	51	PF00017	0.435
LIG_SH2_SRC	99	102	PF00017	0.276
LIG_SH2_STAP1	145	149	PF00017	0.420
LIG_SH2_STAT3	203	206	PF00017	0.295
LIG_SH2_STAT5	130	133	PF00017	0.235
LIG_SH2_STAT5	145	148	PF00017	0.399
LIG_SH2_STAT5	156	159	PF00017	0.235
LIG_SH2_STAT5	176	179	PF00017	0.219
LIG_SH2_STAT5	196	199	PF00017	0.249
LIG_SH2_STAT5	203	206	PF00017	0.295
LIG_SH2_STAT5	48	51	PF00017	0.235
LIG_SH2_STAT5	76	79	PF00017	0.254
LIG_SH2_STAT5	99	102	PF00017	0.258
LIG_SUMO_SIM_anti_2	132	138	PF11976	0.235
LIG_SUMO_SIM_anti_2	14	21	PF11976	0.368
LIG_SUMO_SIM_par_1	14	21	PF11976	0.368
LIG_TYR_ITIM	97	102	PF00017	0.254
LIG_TYR_ITSM	44	51	PF00017	0.307
LIG_UBA3_1	16	22	PF00899	0.243
LIG_WRC_WIRS_1	52	57	PF05994	0.279
MOD_CDC14_SPxK_1	82	85	PF00782	0.399
MOD_CDK_SPK_2	111	116	PF00069	0.368
MOD_CDK_SPxK_1	111	117	PF00069	0.237
MOD_CDK_SPxK_1	79	85	PF00069	0.399
MOD_CK1_1	185	191	PF00069	0.368
MOD_CK1_1	33	39	PF00069	0.406
MOD_GlcNHglycan	13	16	PF01048	0.318
MOD_GlcNHglycan	187	190	PF01048	0.368
MOD_GlcNHglycan	27	30	PF01048	0.202
MOD_GSK3_1	111	118	PF00069	0.444
MOD_N-GLC_1	59	64	PF02516	0.494
MOD_N-GLC_1	91	96	PF02516	0.216
MOD_NEK2_1	11	16	PF00069	0.368
MOD_NEK2_1	123	128	PF00069	0.422
MOD_NEK2_1	190	195	PF00069	0.332
MOD_NEK2_1	67	72	PF00069	0.323
MOD_NEK2_2	30	35	PF00069	0.399
MOD_NEK2_2	59	64	PF00069	0.294
MOD_PIKK_1	125	131	PF00454	0.254
MOD_PK_1	182	188	PF00069	0.294
MOD_PKA_2	115	121	PF00069	0.253
MOD_Plk_1	59	65	PF00069	0.294
MOD_Plk_1	91	97	PF00069	0.412
MOD_Plk_4	105	111	PF00069	0.411
MOD_Plk_4	190	196	PF00069	0.249
MOD_ProDKin_1	111	117	PF00069	0.368
MOD_ProDKin_1	79	85	PF00069	0.399
TRG_ENDOCYTIC_2	149	152	PF00928	0.399
TRG_ENDOCYTIC_2	163	166	PF00928	0.235
TRG_ENDOCYTIC_2	178	181	PF00928	0.379
TRG_ENDOCYTIC_2	196	199	PF00928	0.109
TRG_ENDOCYTIC_2	201	204	PF00928	0.254
TRG_ENDOCYTIC_2	48	51	PF00928	0.242
TRG_ENDOCYTIC_2	99	102	PF00928	0.254
TRG_ER_diArg_1	115	117	PF00400	0.109
TRG_ER_diArg_1	24	27	PF00400	0.496
TRG_ER_diArg_1	95	98	PF00400	0.436

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I068	Leptomonas seymouri	81%	100%
A0A0S4JT51	Bodo saltans	66%	100%
A0A1X0NYI5	Trypanosomatidae	66%	100%
A0A3Q8IGM8	Leishmania donovani	96%	100%
A0A422P1Q5	Trypanosoma rangeli	66%	100%
A4HGA3	Leishmania braziliensis	91%	100%
A4I3D7	Leishmania infantum	96%	100%
D0A810	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	62%	100%
O42580	Xenopus laevis	49%	100%
O43731	Homo sapiens	45%	100%
O44017	Entamoeba histolytica	44%	100%
O76767	Drosophila melanogaster	47%	100%
O94270	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	41%	100%
P18413	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)	43%	100%
P18414	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	42%	100%
P24390	Homo sapiens	47%	100%
P33946	Bos taurus	46%	100%
P33947	Homo sapiens	48%	100%
P33948	Plasmodium falciparum	42%	99%
P35402	Arabidopsis thaliana	48%	100%
P48583	Caenorhabditis elegans	46%	100%
Q09473	Caenorhabditis elegans	50%	100%
Q2KJ37	Bos taurus	48%	100%
Q4Q8K7	Leishmania major	96%	100%
Q569A6	Rattus norvegicus	47%	100%
Q5U305	Rattus norvegicus	48%	100%
Q5XHA2	Xenopus tropicalis	50%	100%
Q5ZKX9	Gallus gallus	50%	100%
Q611C8	Caenorhabditis briggsae	46%	100%
Q66JF2	Xenopus tropicalis	48%	100%
Q68ES4	Xenopus laevis	50%	100%
Q6P257	Xenopus tropicalis	48%	100%
Q6PAB8	Xenopus laevis	49%	100%
Q6PEH1	Danio rerio	48%	100%
Q6PFS5	Danio rerio	44%	100%
Q76NM1	Plasmodium falciparum (isolate 3D7)	42%	99%
Q7ZXS5	Xenopus laevis	47%	100%
Q86JE5	Dictyostelium discoideum	46%	100%
Q8R1L4	Mus musculus	47%	100%
Q8VWI1	Arabidopsis thaliana	47%	100%
Q99JH8	Mus musculus	46%	100%
Q9CQM2	Mus musculus	48%	100%
Q9ZTN2	Petunia hybrida	49%	100%