Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania mexicana

UniProt:

E9AZM0_LEIMU

TriTrypDb:

LmxM.28.0590

Length:

523

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AZM0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AZM0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	366	370	PF00656	0.671
CLV_MEL_PAP_1	473	479	PF00089	0.642
CLV_NRD_NRD_1	125	127	PF00675	0.463
CLV_NRD_NRD_1	15	17	PF00675	0.569
CLV_NRD_NRD_1	173	175	PF00675	0.661
CLV_NRD_NRD_1	418	420	PF00675	0.574
CLV_NRD_NRD_1	468	470	PF00675	0.655
CLV_NRD_NRD_1	512	514	PF00675	0.756
CLV_NRD_NRD_1	66	68	PF00675	0.704
CLV_PCSK_KEX2_1	125	127	PF00082	0.463
CLV_PCSK_KEX2_1	15	17	PF00082	0.569
CLV_PCSK_KEX2_1	173	175	PF00082	0.687
CLV_PCSK_KEX2_1	417	419	PF00082	0.629
CLV_PCSK_KEX2_1	468	470	PF00082	0.655
CLV_PCSK_KEX2_1	512	514	PF00082	0.756
CLV_PCSK_PC1ET2_1	417	419	PF00082	0.629
CLV_PCSK_PC7_1	169	175	PF00082	0.618
CLV_PCSK_SKI1_1	274	278	PF00082	0.581
CLV_PCSK_SKI1_1	323	327	PF00082	0.623
CLV_PCSK_SKI1_1	400	404	PF00082	0.680
CLV_PCSK_SKI1_1	419	423	PF00082	0.611
CLV_PCSK_SKI1_1	469	473	PF00082	0.691
CLV_Separin_Metazoa	97	101	PF03568	0.618
DEG_SPOP_SBC_1	72	76	PF00917	0.607
DOC_CKS1_1	462	467	PF01111	0.648
DOC_CYCLIN_RxL_1	135	145	PF00134	0.520
DOC_CYCLIN_yClb3_PxF_3	149	157	PF00134	0.483
DOC_CYCLIN_yCln2_LP_2	438	444	PF00134	0.597
DOC_MAPK_MEF2A_6	400	407	PF00069	0.461
DOC_PP2B_LxvP_1	92	95	PF13499	0.688
DOC_USP7_MATH_1	260	264	PF00917	0.658
DOC_USP7_MATH_1	5	9	PF00917	0.632
DOC_USP7_MATH_1	516	520	PF00917	0.751
DOC_USP7_MATH_1	66	70	PF00917	0.640
DOC_USP7_MATH_1	85	89	PF00917	0.715
DOC_WW_Pin1_4	164	169	PF00397	0.650
DOC_WW_Pin1_4	174	179	PF00397	0.622
DOC_WW_Pin1_4	182	187	PF00397	0.628
DOC_WW_Pin1_4	211	216	PF00397	0.743
DOC_WW_Pin1_4	250	255	PF00397	0.639
DOC_WW_Pin1_4	267	272	PF00397	0.639
DOC_WW_Pin1_4	274	279	PF00397	0.628
DOC_WW_Pin1_4	461	466	PF00397	0.670
DOC_WW_Pin1_4	493	498	PF00397	0.646
DOC_WW_Pin1_4	79	84	PF00397	0.537
DOC_WW_Pin1_4	86	91	PF00397	0.756
LIG_14-3-3_CanoR_1	238	246	PF00244	0.600
LIG_14-3-3_CanoR_1	265	270	PF00244	0.710
LIG_14-3-3_CanoR_1	418	424	PF00244	0.632
LIG_14-3-3_CanoR_1	468	472	PF00244	0.635
LIG_14-3-3_CanoR_1	512	520	PF00244	0.632
LIG_14-3-3_CanoR_1	55	64	PF00244	0.622
LIG_14-3-3_CanoR_1	67	71	PF00244	0.627
LIG_Actin_WH2_2	219	236	PF00022	0.536
LIG_BIR_II_1	1	5	PF00653	0.566
LIG_EVH1_2	428	432	PF00568	0.718
LIG_FHA_1	125	131	PF00498	0.686
LIG_FHA_1	279	285	PF00498	0.560
LIG_FHA_1	324	330	PF00498	0.650
LIG_FHA_1	468	474	PF00498	0.651
LIG_FHA_1	72	78	PF00498	0.718
LIG_FHA_2	20	26	PF00498	0.640
LIG_FHA_2	335	341	PF00498	0.718
LIG_FHA_2	37	43	PF00498	0.583
LIG_GBD_Chelix_1	140	148	PF00786	0.647
LIG_LIR_Gen_1	101	110	PF02991	0.664
LIG_LIR_Gen_1	200	207	PF02991	0.584
LIG_LIR_Gen_1	517	523	PF02991	0.723
LIG_LIR_Nem_3	200	205	PF02991	0.579
LIG_LIR_Nem_3	39	43	PF02991	0.634
LIG_LIR_Nem_3	485	491	PF02991	0.519
LIG_LIR_Nem_3	517	523	PF02991	0.699
LIG_SH2_CRK	488	492	PF00017	0.520
LIG_SH2_SRC	373	376	PF00017	0.573
LIG_SH2_STAT3	375	378	PF00017	0.740
LIG_SH2_STAT5	102	105	PF00017	0.507
LIG_SH2_STAT5	136	139	PF00017	0.524
LIG_SH2_STAT5	47	50	PF00017	0.584
LIG_SH3_1	146	152	PF00018	0.453
LIG_SH3_3	146	152	PF00018	0.453
LIG_SH3_3	439	445	PF00018	0.725
LIG_SH3_CIN85_PxpxPR_1	168	173	PF14604	0.612
LIG_SUMO_SIM_anti_2	228	235	PF11976	0.505
LIG_TRAF2_1	331	334	PF00917	0.553
LIG_WRC_WIRS_1	151	156	PF05994	0.566
LIG_WRC_WIRS_1	202	207	PF05994	0.474
MOD_CDK_SPK_2	164	169	PF00069	0.709
MOD_CDK_SPxxK_3	267	274	PF00069	0.589
MOD_CDK_SPxxK_3	461	468	PF00069	0.648
MOD_CK1_1	153	159	PF00069	0.739
MOD_CK1_1	177	183	PF00069	0.812
MOD_CK1_1	211	217	PF00069	0.737
MOD_CK1_1	27	33	PF00069	0.731
MOD_CK1_1	387	393	PF00069	0.560
MOD_CK1_1	4	10	PF00069	0.665
MOD_CK1_1	434	440	PF00069	0.800
MOD_CK1_1	478	484	PF00069	0.605
MOD_CK1_1	486	492	PF00069	0.650
MOD_CK1_1	496	502	PF00069	0.643
MOD_CK1_1	505	511	PF00069	0.704
MOD_CK1_1	88	94	PF00069	0.504
MOD_CK2_1	19	25	PF00069	0.638
MOD_CK2_1	206	212	PF00069	0.674
MOD_CK2_1	334	340	PF00069	0.765
MOD_CK2_1	36	42	PF00069	0.584
MOD_CK2_1	43	49	PF00069	0.606
MOD_GlcNHglycan	186	189	PF01048	0.781
MOD_GlcNHglycan	208	211	PF01048	0.738
MOD_GlcNHglycan	3	6	PF01048	0.670
MOD_GlcNHglycan	361	364	PF01048	0.564
MOD_GlcNHglycan	389	392	PF01048	0.544
MOD_GlcNHglycan	459	462	PF01048	0.676
MOD_GlcNHglycan	478	481	PF01048	0.624
MOD_GlcNHglycan	488	491	PF01048	0.652
MOD_GlcNHglycan	514	517	PF01048	0.671
MOD_GlcNHglycan	7	10	PF01048	0.681
MOD_GSK3_1	1	8	PF00069	0.682
MOD_GSK3_1	120	127	PF00069	0.611
MOD_GSK3_1	160	167	PF00069	0.664
MOD_GSK3_1	238	245	PF00069	0.547
MOD_GSK3_1	24	31	PF00069	0.731
MOD_GSK3_1	274	281	PF00069	0.606
MOD_GSK3_1	32	39	PF00069	0.627
MOD_GSK3_1	350	357	PF00069	0.643
MOD_GSK3_1	359	366	PF00069	0.701
MOD_GSK3_1	380	387	PF00069	0.530
MOD_GSK3_1	419	426	PF00069	0.497
MOD_GSK3_1	457	464	PF00069	0.671
MOD_GSK3_1	478	485	PF00069	0.614
MOD_GSK3_1	507	514	PF00069	0.644
MOD_GSK3_1	56	63	PF00069	0.737
MOD_GSK3_1	71	78	PF00069	0.552
MOD_GSK3_1	86	93	PF00069	0.639
MOD_LATS_1	474	480	PF00433	0.626
MOD_N-GLC_1	36	41	PF02516	0.575
MOD_N-GLC_1	434	439	PF02516	0.671
MOD_N-GLC_1	5	10	PF02516	0.661
MOD_NEK2_1	1	6	PF00069	0.567
MOD_NEK2_1	206	211	PF00069	0.765
MOD_NEK2_1	24	29	PF00069	0.701
MOD_NEK2_1	345	350	PF00069	0.607
MOD_NEK2_1	423	428	PF00069	0.526
MOD_NEK2_1	43	48	PF00069	0.515
MOD_NEK2_2	120	125	PF00069	0.492
MOD_OFUCOSY	275	280	PF10250	0.603
MOD_PIKK_1	238	244	PF00454	0.541
MOD_PIKK_1	317	323	PF00454	0.523
MOD_PIKK_1	496	502	PF00454	0.746
MOD_PKA_1	512	518	PF00069	0.754
MOD_PKA_2	124	130	PF00069	0.692
MOD_PKA_2	242	248	PF00069	0.706
MOD_PKA_2	351	357	PF00069	0.612
MOD_PKA_2	359	365	PF00069	0.600
MOD_PKA_2	467	473	PF00069	0.635
MOD_PKA_2	475	481	PF00069	0.624
MOD_PKA_2	511	517	PF00069	0.699
MOD_PKA_2	66	72	PF00069	0.646
MOD_Plk_1	120	126	PF00069	0.486
MOD_Plk_1	36	42	PF00069	0.617
MOD_Plk_1	434	440	PF00069	0.673
MOD_Plk_1	48	54	PF00069	0.574
MOD_Plk_1	482	488	PF00069	0.633
MOD_Plk_2-3	334	340	PF00069	0.650
MOD_Plk_2-3	369	375	PF00069	0.537
MOD_Plk_4	19	25	PF00069	0.577
MOD_Plk_4	201	207	PF00069	0.708
MOD_Plk_4	43	49	PF00069	0.726
MOD_Plk_4	483	489	PF00069	0.690
MOD_ProDKin_1	164	170	PF00069	0.647
MOD_ProDKin_1	174	180	PF00069	0.621
MOD_ProDKin_1	182	188	PF00069	0.626
MOD_ProDKin_1	211	217	PF00069	0.769
MOD_ProDKin_1	250	256	PF00069	0.639
MOD_ProDKin_1	267	273	PF00069	0.637
MOD_ProDKin_1	274	280	PF00069	0.623
MOD_ProDKin_1	461	467	PF00069	0.666
MOD_ProDKin_1	493	499	PF00069	0.643
MOD_ProDKin_1	79	85	PF00069	0.538
MOD_ProDKin_1	86	92	PF00069	0.750
MOD_SUMO_for_1	105	108	PF00179	0.667
TRG_DiLeu_BaEn_1	228	233	PF01217	0.503
TRG_ENDOCYTIC_2	102	105	PF00928	0.649
TRG_ENDOCYTIC_2	202	205	PF00928	0.707
TRG_ENDOCYTIC_2	488	491	PF00928	0.522
TRG_ER_diArg_1	124	126	PF00400	0.469
TRG_ER_diArg_1	15	17	PF00400	0.569
TRG_ER_diArg_1	172	174	PF00400	0.640
TRG_ER_diArg_1	467	469	PF00400	0.813
TRG_Pf-PMV_PEXEL_1	238	242	PF00026	0.504
TRG_Pf-PMV_PEXEL_1	285	289	PF00026	0.594
TRG_Pf-PMV_PEXEL_1	299	303	PF00026	0.486

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P7S4	Leptomonas seymouri	42%	99%
A0A3Q8IHY9	Leishmania donovani	88%	100%
A4HG99	Leishmania braziliensis	70%	100%
A4I3D3	Leishmania infantum	88%	100%
Q4Q8L1	Leishmania major	88%	100%