LeishMANIAdb
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DNA repair protein RAD51 homolog

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
DNA repair protein RAD51 homolog
Gene product:
DNA repair protein RAD51, putative
Species:
Leishmania mexicana
UniProt:
E9AZL6_LEIMU
TriTrypDb:
LmxM.28.0550
Length:
375

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 10
NetGPI no yes: 0, no: 10
Cellular components
Term Name Level Count
GO:0005634 nucleus 5 10
GO:0043226 organelle 2 11
GO:0043227 membrane-bounded organelle 3 10
GO:0043229 intracellular organelle 3 11
GO:0043231 intracellular membrane-bounded organelle 4 10
GO:0110165 cellular anatomical entity 1 11
GO:0000228 nuclear chromosome 6 1
GO:0000793 condensed chromosome 6 1
GO:0000794 condensed nuclear chromosome 7 1
GO:0005694 chromosome 5 1
GO:0043228 non-membrane-bounded organelle 3 1
GO:0043232 intracellular non-membrane-bounded organelle 4 1

Expansion

Sequence features

E9AZL6
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AZL6

PDB structure(s): 7qv8_A

Function

Biological processes
Term Name Level Count
GO:0000724 double-strand break repair via homologous recombination 7 10
GO:0000725 recombinational repair 6 10
GO:0006139 nucleobase-containing compound metabolic process 3 11
GO:0006259 DNA metabolic process 4 11
GO:0006281 DNA repair 5 10
GO:0006302 double-strand break repair 6 10
GO:0006310 DNA recombination 5 11
GO:0006725 cellular aromatic compound metabolic process 3 11
GO:0006807 nitrogen compound metabolic process 2 11
GO:0006950 response to stress 2 11
GO:0006974 DNA damage response 4 11
GO:0008152 metabolic process 1 11
GO:0009987 cellular process 1 11
GO:0022402 cell cycle process 2 11
GO:0031297 replication fork processing 6 11
GO:0033554 cellular response to stress 3 11
GO:0034641 cellular nitrogen compound metabolic process 3 11
GO:0043170 macromolecule metabolic process 3 11
GO:0044237 cellular metabolic process 2 11
GO:0044238 primary metabolic process 2 11
GO:0044260 obsolete cellular macromolecule metabolic process 3 11
GO:0045005 DNA-templated DNA replication maintenance of fidelity 5 11
GO:0046483 heterocycle metabolic process 3 11
GO:0050896 response to stimulus 1 11
GO:0051716 cellular response to stimulus 2 11
GO:0071704 organic substance metabolic process 2 11
GO:0090304 nucleic acid metabolic process 4 11
GO:1901360 organic cyclic compound metabolic process 3 11
GO:1902298 cell cycle DNA replication maintenance of fidelity 3 11
GO:1903047 mitotic cell cycle process 3 11
GO:1990426 mitotic recombination-dependent replication fork processing 5 11
GO:1990505 mitotic DNA replication maintenance of fidelity 4 11
GO:0000730 DNA recombinase assembly 7 1
GO:0006312 mitotic recombination 6 1
GO:0006996 organelle organization 4 1
GO:0007131 reciprocal meiotic recombination 3 1
GO:0016043 cellular component organization 3 1
GO:0022414 reproductive process 1 1
GO:0022607 cellular component assembly 4 1
GO:0035825 homologous recombination 6 1
GO:0042148 strand invasion 5 1
GO:0043933 protein-containing complex organization 4 1
GO:0051276 chromosome organization 5 1
GO:0065003 protein-containing complex assembly 5 1
GO:0065004 protein-DNA complex assembly 6 1
GO:0070192 chromosome organization involved in meiotic cell cycle 3 1
GO:0071824 protein-DNA complex subunit organization 5 1
GO:0071840 cellular component organization or biogenesis 2 1
GO:0090735 DNA repair complex assembly 6 1
GO:0140527 reciprocal homologous recombination 7 1
GO:1903046 meiotic cell cycle process 2 1
Molecular functions
Term Name Level Count
GO:0000150 DNA strand exchange activity 4 11
GO:0000166 nucleotide binding 3 11
GO:0003676 nucleic acid binding 3 11
GO:0003677 DNA binding 4 11
GO:0003690 double-stranded DNA binding 5 11
GO:0003697 single-stranded DNA binding 5 11
GO:0003824 catalytic activity 1 11
GO:0005488 binding 1 11
GO:0005524 ATP binding 5 11
GO:0008094 ATP-dependent activity, acting on DNA 2 11
GO:0017076 purine nucleotide binding 4 11
GO:0030554 adenyl nucleotide binding 5 11
GO:0032553 ribonucleotide binding 3 11
GO:0032555 purine ribonucleotide binding 4 11
GO:0032559 adenyl ribonucleotide binding 5 11
GO:0035639 purine ribonucleoside triphosphate binding 4 11
GO:0036094 small molecule binding 2 11
GO:0043167 ion binding 2 11
GO:0043168 anion binding 3 11
GO:0097159 organic cyclic compound binding 2 11
GO:0097367 carbohydrate derivative binding 2 11
GO:0140097 catalytic activity, acting on DNA 3 11
GO:0140299 small molecule sensor activity 1 11
GO:0140612 DNA damage sensor activity 2 11
GO:0140640 catalytic activity, acting on a nucleic acid 2 11
GO:0140657 ATP-dependent activity 1 11
GO:0140664 ATP-dependent DNA damage sensor activity 3 11
GO:1901265 nucleoside phosphate binding 3 11
GO:1901363 heterocyclic compound binding 2 11
GO:0016462 pyrophosphatase activity 5 1
GO:0016787 hydrolase activity 2 1
GO:0016817 hydrolase activity, acting on acid anhydrides 3 1
GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 4 1
GO:0016887 ATP hydrolysis activity 7 1
GO:0017111 ribonucleoside triphosphate phosphatase activity 6 1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 10 12 PF00675 0.678
CLV_NRD_NRD_1 130 132 PF00675 0.215
CLV_NRD_NRD_1 338 340 PF00675 0.246
CLV_PCSK_KEX2_1 10 12 PF00082 0.614
CLV_PCSK_SKI1_1 250 254 PF00082 0.269
CLV_PCSK_SKI1_1 346 350 PF00082 0.213
CLV_PCSK_SKI1_1 93 97 PF00082 0.358
DEG_APCC_DBOX_1 249 257 PF00400 0.469
DEG_Nend_UBRbox_3 1 3 PF02207 0.579
DOC_MAPK_gen_1 131 137 PF00069 0.413
DOC_MAPK_gen_1 92 98 PF00069 0.331
DOC_USP7_MATH_1 16 20 PF00917 0.591
DOC_USP7_MATH_1 329 333 PF00917 0.413
DOC_WW_Pin1_4 350 355 PF00397 0.413
LIG_14-3-3_CanoR_1 165 175 PF00244 0.413
LIG_14-3-3_CanoR_1 228 238 PF00244 0.413
LIG_14-3-3_CanoR_1 335 339 PF00244 0.413
LIG_APCC_ABBA_1 191 196 PF00400 0.413
LIG_APCC_ABBA_1 363 368 PF00400 0.413
LIG_Clathr_ClatBox_1 253 257 PF01394 0.469
LIG_EH1_1 56 64 PF00400 0.394
LIG_FHA_1 120 126 PF00498 0.422
LIG_FHA_1 152 158 PF00498 0.413
LIG_FHA_1 172 178 PF00498 0.371
LIG_FHA_1 299 305 PF00498 0.413
LIG_FHA_1 331 337 PF00498 0.439
LIG_IRF3_LxIS_1 177 184 PF10401 0.426
LIG_LIR_Gen_1 248 259 PF02991 0.418
LIG_LIR_Nem_3 158 164 PF02991 0.446
LIG_LIR_Nem_3 248 254 PF02991 0.419
LIG_LIR_Nem_3 360 366 PF02991 0.417
LIG_LIR_Nem_3 55 60 PF02991 0.489
LIG_LIR_Nem_3 78 84 PF02991 0.307
LIG_SH2_CRK 351 355 PF00017 0.413
LIG_SH2_SRC 366 369 PF00017 0.398
LIG_SH2_STAT5 194 197 PF00017 0.413
LIG_SH2_STAT5 82 85 PF00017 0.301
LIG_SUMO_SIM_anti_2 19 27 PF11976 0.649
LIG_SUMO_SIM_par_1 133 139 PF11976 0.413
LIG_SUMO_SIM_par_1 204 211 PF11976 0.426
LIG_SUMO_SIM_par_1 252 258 PF11976 0.413
LIG_TRAF2_1 18 21 PF00917 0.685
LIG_TRFH_1 213 217 PF08558 0.247
MOD_CK2_1 153 159 PF00069 0.290
MOD_GlcNHglycan 122 125 PF01048 0.260
MOD_GlcNHglycan 14 17 PF01048 0.630
MOD_GlcNHglycan 242 245 PF01048 0.261
MOD_GlcNHglycan 257 260 PF01048 0.213
MOD_GlcNHglycan 266 270 PF01048 0.247
MOD_GlcNHglycan 309 313 PF01048 0.258
MOD_GlcNHglycan 45 48 PF01048 0.682
MOD_GlcNHglycan 54 57 PF01048 0.517
MOD_GlcNHglycan 85 88 PF01048 0.411
MOD_GSK3_1 12 19 PF00069 0.583
MOD_GSK3_1 151 158 PF00069 0.247
MOD_GSK3_1 171 178 PF00069 0.126
MOD_GSK3_1 330 337 PF00069 0.247
MOD_N-GLC_1 52 57 PF02516 0.506
MOD_NEK2_1 119 124 PF00069 0.247
MOD_NEK2_1 136 141 PF00069 0.126
MOD_NEK2_1 171 176 PF00069 0.247
MOD_NEK2_1 240 245 PF00069 0.266
MOD_NEK2_1 283 288 PF00069 0.248
MOD_OFUCOSY 172 179 PF10250 0.247
MOD_PIKK_1 166 172 PF00454 0.247
MOD_PIKK_1 181 187 PF00454 0.247
MOD_PIKK_1 24 30 PF00454 0.663
MOD_PKA_2 12 18 PF00069 0.712
MOD_PKA_2 334 340 PF00069 0.247
MOD_Plk_2-3 153 159 PF00069 0.290
MOD_ProDKin_1 350 356 PF00069 0.247
MOD_SUMO_rev_2 102 106 PF00179 0.334
MOD_SUMO_rev_2 70 76 PF00179 0.308
TRG_DiLeu_BaEn_1 112 117 PF01217 0.333
TRG_DiLeu_BaEn_1 143 148 PF01217 0.247
TRG_ER_diArg_1 10 13 PF00400 0.707
TRG_NLS_MonoExtC_3 338 344 PF00514 0.247
TRG_Pf-PMV_PEXEL_1 74 78 PF00026 0.321

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P957 Leptomonas seymouri 52% 100%
A0A0N1IA48 Leptomonas seymouri 92% 100%
A0A0S4IRW2 Bodo saltans 28% 99%
A0A0S4J9C6 Bodo saltans 56% 100%
A0A0S4JEJ8 Bodo saltans 81% 100%
A0A1X0NYJ1 Trypanosomatidae 94% 100%
A0A1X0P517 Trypanosomatidae 55% 100%
A0A3Q8ID02 Leishmania donovani 95% 100%
A0A3Q8IGQ5 Leishmania donovani 50% 100%
A0A3R7M9F0 Trypanosoma rangeli 56% 100%
A0A422P1N0 Trypanosoma rangeli 88% 100%
A2SR54 Methanocorpusculum labreanum (strain ATCC 43576 / DSM 4855 / Z) 38% 100%
A3CWU4 Methanoculleus marisnigri (strain ATCC 35101 / DSM 1498 / JR1) 38% 100%
A3MXX9 Pyrobaculum calidifontis (strain DSM 21063 / JCM 11548 / VA1) 45% 100%
A4FWV5 Methanococcus maripaludis (strain C5 / ATCC BAA-1333) 39% 100%
A4HG95 Leishmania braziliensis 95% 100%
A4HNF3 Leishmania braziliensis 50% 100%
A4I3C9 Leishmania infantum 95% 100%
A4IC25 Leishmania infantum 55% 100%
A4WN87 Pyrobaculum arsenaticum (strain DSM 13514 / JCM 11321 / PZ6) 45% 100%
A4YCN4 Metallosphaera sedula (strain ATCC 51363 / DSM 5348 / JCM 9185 / NBRC 15509 / TH2) 43% 100%
A5UMW0 Methanobrevibacter smithii (strain ATCC 35061 / DSM 861 / OCM 144 / PS) 42% 100%
A6VGG2 Methanococcus maripaludis (strain C7 / ATCC BAA-1331) 39% 100%
A8AB83 Ignicoccus hospitalis (strain KIN4/I / DSM 18386 / JCM 14125) 42% 100%
A9AA90 Methanococcus maripaludis (strain C6 / ATCC BAA-1332) 39% 100%
A9AXA6 Herpetosiphon aurantiacus (strain ATCC 23779 / DSM 785 / 114-95) 26% 100%
B0R7Y4 Halobacterium salinarum (strain ATCC 29341 / DSM 671 / R1) 38% 100%
B1MD17 Mycobacteroides abscessus (strain ATCC 19977 / DSM 44196 / CIP 104536 / JCM 13569 / NCTC 13031 / TMC 1543) 25% 100%
B1YC14 Pyrobaculum neutrophilum (strain DSM 2338 / JCM 9278 / NBRC 100436 / V24Sta) 43% 100%
B2GB15 Limosilactobacillus fermentum (strain NBRC 3956 / LMG 18251) 26% 100%
B5ED05 Citrifermentans bemidjiense (strain ATCC BAA-1014 / DSM 16622 / JCM 12645 / Bem) 23% 100%
B8BM09 Oryza sativa subsp. indica 52% 100%
B8D610 Desulfurococcus amylolyticus (strain DSM 18924 / JCM 16383 / VKM B-2413 / 1221n) 41% 100%
C3MRI1 Sulfolobus islandicus (strain L.S.2.15 / Lassen #1) 42% 100%
C3MY77 Sulfolobus islandicus (strain M.14.25 / Kamchatka #1) 42% 100%
C3MZK6 Sulfolobus islandicus (strain M.16.27) 42% 100%
C3N7M8 Sulfolobus islandicus (strain Y.G.57.14 / Yellowstone #1) 42% 100%
C3NFU5 Sulfolobus islandicus (strain Y.N.15.51 / Yellowstone #2) 42% 100%
C4KIT6 Sulfolobus islandicus (strain M.16.4 / Kamchatka #3) 42% 100%
C6E6X6 Geobacter sp. (strain M21) 23% 100%
C9ZYH4 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 57% 100%
E9B717 Leishmania mexicana (strain MHOM/GT/2001/U1103) 52% 100%
O15315 Homo sapiens 31% 98%
O27436 Methanothermobacter thermautotrophicus (strain ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H) 43% 100%
O29269 Archaeoglobus fulgidus (strain ATCC 49558 / DSM 4304 / JCM 9628 / NBRC 100126 / VC-16) 44% 100%
O35719 Mus musculus 31% 100%
O42634 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 47% 100%
O43502 Homo sapiens 28% 100%
O43542 Homo sapiens 27% 100%
O61127 Leishmania major 95% 100%
O61128 Leishmania major 50% 100%
O67905 Aquifex aeolicus (strain VF5) 27% 100%
O73948 Methanococcus voltae 40% 100%
O74036 Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1) 47% 100%
O77507 Oryctolagus cuniculus 71% 100%
O93748 Cenarchaeum symbiosum (strain A) 41% 94%
P0CW58 Methanococcus maripaludis 39% 100%
P0CW59 Methanococcus maripaludis (strain S2 / LL) 39% 100%
P0CW91 Aeropyrum pernix 43% 100%
P0CW92 Aeropyrum pernix (strain ATCC 700893 / DSM 11879 / JCM 9820 / NBRC 100138 / K1) 43% 100%
P25453 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 48% 100%
P25454 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 59% 94%
P33542 Aquifex pyrophilus 27% 100%
P36601 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 63% 100%
P37383 Gallus gallus 73% 100%
P37384 Lilium longiflorum 51% 100%
P50265 Candida albicans 48% 100%
P70099 Cricetulus griseus 72% 100%
P94102 Arabidopsis thaliana 65% 100%
Q06609 Homo sapiens 72% 100%
Q08297 Mus musculus 70% 100%
Q08DH8 Bos taurus 28% 100%
Q0AHX4 Nitrosomonas eutropha (strain DSM 101675 / C91 / Nm57) 24% 100%
Q12UG7 Methanococcoides burtonii (strain DSM 6242 / NBRC 107633 / OCM 468 / ACE-M) 41% 100%
Q14565 Homo sapiens 53% 100%
Q18EU1 Haloquadratum walsbyi (strain DSM 16790 / HBSQ001) 36% 100%
Q27297 Drosophila melanogaster 63% 100%
Q2KJ94 Bos taurus 72% 100%
Q2NE95 Methanosphaera stadtmanae (strain ATCC 43021 / DSM 3091 / JCM 11832 / MCB-3) 41% 100%
Q39009 Arabidopsis thaliana 50% 100%
Q40134 Solanum lycopersicum 63% 100%
Q46A31 Methanosarcina barkeri (strain Fusaro / DSM 804) 41% 100%
Q48328 Haloferax volcanii (strain ATCC 29605 / DSM 3757 / JCM 8879 / NBRC 14742 / NCIMB 2012 / VKM B-1768 / DS2) 35% 100%
Q49593 Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) 42% 100%
Q4JAT5 Sulfolobus acidocaldarius (strain ATCC 33909 / DSM 639 / JCM 8929 / NBRC 15157 / NCIMB 11770) 41% 100%
Q54PJ7 Dictyostelium discoideum 29% 98%
Q55075 Saccharolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2) 42% 100%
Q59560 Mycolicibacterium smegmatis (strain ATCC 700084 / mc(2)155) 25% 100%
Q59595 Neisseria cinerea 27% 100%
Q5YT00 Nocardia farcinica (strain IFM 10152) 25% 100%
Q61880 Mus musculus 51% 100%
Q67EU8 Zea mays 66% 100%
Q6L126 Picrophilus torridus (strain ATCC 700027 / DSM 9790 / JCM 10055 / NBRC 100828) 40% 100%
Q74MX9 Nanoarchaeum equitans (strain Kin4-M) 44% 100%
Q7EAG4 Oryza sativa subsp. indica 52% 100%
Q7GBF7 Oryza sativa subsp. japonica 52% 100%
Q7GBF8 Oryza sativa subsp. japonica 52% 100%
Q8MKI8 Canis lupus familiaris 72% 100%
Q8PZN5 Methanosarcina mazei (strain ATCC BAA-159 / DSM 3647 / Goe1 / Go1 / JCM 11833 / OCM 88) 41% 100%
Q8R2J9 Cricetulus griseus 28% 100%
Q8TK71 Methanosarcina acetivorans (strain ATCC 35395 / DSM 2834 / JCM 12185 / C2A) 42% 100%
Q8ZYR9 Pyrobaculum aerophilum (strain ATCC 51768 / DSM 7523 / JCM 9630 / CIP 104966 / NBRC 100827 / IM2) 42% 100%
Q91917 Xenopus laevis 72% 100%
Q91918 Xenopus laevis 72% 100%
Q924H5 Mus musculus 27% 100%
Q96449 Glycine max 49% 100%
Q975Y1 Sulfurisphaera tokodaii (strain DSM 16993 / JCM 10545 / NBRC 100140 / 7) 41% 100%
Q97BJ9 Thermoplasma volcanium (strain ATCC 51530 / DSM 4299 / JCM 9571 / NBRC 15438 / GSS1) 43% 100%
Q99133 Ustilago maydis (strain 521 / FGSC 9021) 66% 100%
Q9HJ68 Thermoplasma acidophilum (strain ATCC 25905 / DSM 1728 / JCM 9062 / NBRC 15155 / AMRC-C165) 43% 100%
Q9HMM4 Halobacterium salinarum (strain ATCC 700922 / JCM 11081 / NRC-1) 38% 100%
Q9SK02 Arabidopsis thaliana 32% 100%
Q9UUL2 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 30% 100%
Q9UWR5 Pyrobaculum islandicum (strain DSM 4184 / JCM 9189 / GEO3) 43% 100%
Q9V233 Pyrococcus abyssi (strain GE5 / Orsay) 47% 100%
Q9XED7 Zea mays 67% 100%
Q9Y8J4 Desulfurococcus amylolyticus 41% 100%
V5B714 Trypanosoma cruzi 56% 100%
V5BKV4 Trypanosoma cruzi 84% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS