TPR_REGION domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

TPR repeat, putative

Species:

Leishmania mexicana

UniProt:

E9AZL1_LEIMU

TriTrypDb:

LmxM.28.0500

Length:

712

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 10
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AZL1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AZL1

Function

Biological processes
Term	Name	Level	Count
GO:0006457	protein folding	2	12
GO:0009987	cellular process	1	12

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	12
GO:0005515	protein binding	2	12
GO:0030544	Hsp70 protein binding	4	12
GO:0031072	heat shock protein binding	3	12
GO:0051879	Hsp90 protein binding	4	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	170	174	PF00656	0.706
CLV_MEL_PAP_1	602	608	PF00089	0.515
CLV_NRD_NRD_1	208	210	PF00675	0.440
CLV_NRD_NRD_1	549	551	PF00675	0.445
CLV_NRD_NRD_1	86	88	PF00675	0.515
CLV_PCSK_FUR_1	332	336	PF00082	0.476
CLV_PCSK_KEX2_1	207	209	PF00082	0.455
CLV_PCSK_KEX2_1	224	226	PF00082	0.570
CLV_PCSK_KEX2_1	334	336	PF00082	0.438
CLV_PCSK_KEX2_1	348	350	PF00082	0.320
CLV_PCSK_KEX2_1	549	551	PF00082	0.558
CLV_PCSK_KEX2_1	85	87	PF00082	0.524
CLV_PCSK_PC1ET2_1	224	226	PF00082	0.448
CLV_PCSK_PC1ET2_1	334	336	PF00082	0.531
CLV_PCSK_PC1ET2_1	348	350	PF00082	0.396
CLV_PCSK_SKI1_1	291	295	PF00082	0.369
CLV_PCSK_SKI1_1	317	321	PF00082	0.425
CLV_PCSK_SKI1_1	366	370	PF00082	0.306
CLV_PCSK_SKI1_1	414	418	PF00082	0.465
CLV_PCSK_SKI1_1	550	554	PF00082	0.465
CLV_Separin_Metazoa	670	674	PF03568	0.521
DEG_APCC_DBOX_1	134	142	PF00400	0.684
DEG_COP1_1	22	30	PF00400	0.684
DEG_Nend_UBRbox_3	1	3	PF02207	0.551
DEG_SPOP_SBC_1	159	163	PF00917	0.525
DOC_ANK_TNKS_1	640	647	PF00023	0.487
DOC_CYCLIN_RxL_1	314	324	PF00134	0.437
DOC_CYCLIN_RxL_1	411	419	PF00134	0.580
DOC_CYCLIN_RxL_1	549	558	PF00134	0.249
DOC_CYCLIN_yCln2_LP_2	151	157	PF00134	0.641
DOC_MAPK_gen_1	332	341	PF00069	0.398
DOC_MAPK_gen_1	458	467	PF00069	0.479
DOC_MAPK_gen_1	586	594	PF00069	0.348
DOC_PP1_RVXF_1	57	64	PF00149	0.665
DOC_PP4_FxxP_1	81	84	PF00568	0.648
DOC_USP7_MATH_1	159	163	PF00917	0.767
DOC_USP7_MATH_1	178	182	PF00917	0.636
DOC_USP7_MATH_1	277	281	PF00917	0.454
DOC_USP7_MATH_1	428	432	PF00917	0.407
DOC_USP7_MATH_1	67	71	PF00917	0.643
DOC_USP7_UBL2_3	334	338	PF12436	0.514
DOC_WW_Pin1_4	480	485	PF00397	0.463
DOC_WW_Pin1_4	490	495	PF00397	0.569
DOC_WW_Pin1_4	615	620	PF00397	0.643
LIG_14-3-3_CanoR_1	110	116	PF00244	0.608
LIG_14-3-3_CanoR_1	117	123	PF00244	0.454
LIG_14-3-3_CanoR_1	129	138	PF00244	0.567
LIG_14-3-3_CanoR_1	207	212	PF00244	0.454
LIG_14-3-3_CanoR_1	247	256	PF00244	0.446
LIG_14-3-3_CanoR_1	504	514	PF00244	0.452
LIG_14-3-3_CanoR_1	521	527	PF00244	0.396
LIG_14-3-3_CanoR_1	605	613	PF00244	0.505
LIG_14-3-3_CanoR_1	689	694	PF00244	0.476
LIG_APCC_ABBA_1	1	6	PF00400	0.483
LIG_APCC_ABBA_1	577	582	PF00400	0.476
LIG_BRCT_BRCA1_1	369	373	PF00533	0.453
LIG_BRCT_BRCA1_1	563	567	PF00533	0.404
LIG_FHA_1	217	223	PF00498	0.456
LIG_FHA_1	284	290	PF00498	0.418
LIG_FHA_1	367	373	PF00498	0.356
LIG_FHA_1	404	410	PF00498	0.536
LIG_FHA_1	411	417	PF00498	0.489
LIG_FHA_1	501	507	PF00498	0.447
LIG_FHA_1	574	580	PF00498	0.428
LIG_FHA_1	645	651	PF00498	0.391
LIG_FHA_1	96	102	PF00498	0.551
LIG_FHA_2	161	167	PF00498	0.781
LIG_FHA_2	168	174	PF00498	0.722
LIG_FHA_2	612	618	PF00498	0.621
LIG_FHA_2	665	671	PF00498	0.527
LIG_FHA_2	678	684	PF00498	0.529
LIG_Integrin_isoDGR_2	384	386	PF01839	0.442
LIG_LIR_Apic_2	78	84	PF02991	0.643
LIG_LIR_Gen_1	106	116	PF02991	0.529
LIG_LIR_Gen_1	128	138	PF02991	0.677
LIG_LIR_Gen_1	558	567	PF02991	0.362
LIG_LIR_Gen_1	576	584	PF02991	0.286
LIG_LIR_Gen_1	60	67	PF02991	0.659
LIG_LIR_Gen_1	94	105	PF02991	0.535
LIG_LIR_Nem_3	106	111	PF02991	0.560
LIG_LIR_Nem_3	128	134	PF02991	0.677
LIG_LIR_Nem_3	210	214	PF02991	0.514
LIG_LIR_Nem_3	370	376	PF02991	0.396
LIG_LIR_Nem_3	377	383	PF02991	0.498
LIG_LIR_Nem_3	558	563	PF02991	0.351
LIG_LIR_Nem_3	576	580	PF02991	0.295
LIG_LIR_Nem_3	597	602	PF02991	0.357
LIG_LIR_Nem_3	60	66	PF02991	0.577
LIG_LIR_Nem_3	70	76	PF02991	0.478
LIG_LIR_Nem_3	703	709	PF02991	0.499
LIG_LIR_Nem_3	94	100	PF02991	0.525
LIG_RPA_C_Fungi	247	259	PF08784	0.485
LIG_SH2_CRK	131	135	PF00017	0.678
LIG_SH2_CRK	380	384	PF00017	0.474
LIG_SH2_CRK	560	564	PF00017	0.384
LIG_SH2_CRK	97	101	PF00017	0.496
LIG_SH2_GRB2like	233	236	PF00017	0.498
LIG_SH2_SRC	343	346	PF00017	0.533
LIG_SH2_STAP1	303	307	PF00017	0.334
LIG_SH2_STAP1	343	347	PF00017	0.511
LIG_SH2_STAP1	97	101	PF00017	0.472
LIG_SH2_STAT5	256	259	PF00017	0.409
LIG_SH2_STAT5	283	286	PF00017	0.314
LIG_SH2_STAT5	437	440	PF00017	0.341
LIG_SH2_STAT5	97	100	PF00017	0.478
LIG_SH3_3	25	31	PF00018	0.588
LIG_SH3_3	39	45	PF00018	0.459
LIG_SH3_3	668	674	PF00018	0.544
LIG_TRAF2_1	10	13	PF00917	0.541
LIG_TRAF2_1	237	240	PF00917	0.503
LIG_TRAF2_1	242	245	PF00917	0.534
LIG_TRAF2_1	484	487	PF00917	0.534
LIG_TRAF2_1	528	531	PF00917	0.458
LIG_TRAF2_1	697	700	PF00917	0.424
LIG_WRC_WIRS_1	16	21	PF05994	0.453
LIG_WRC_WIRS_1	678	683	PF05994	0.557
MOD_CK1_1	133	139	PF00069	0.677
MOD_CK1_1	189	195	PF00069	0.617
MOD_CK1_1	250	256	PF00069	0.344
MOD_CK1_1	431	437	PF00069	0.393
MOD_CK1_1	480	486	PF00069	0.615
MOD_CK1_1	561	567	PF00069	0.403
MOD_CK1_1	569	575	PF00069	0.351
MOD_CK1_1	659	665	PF00069	0.398
MOD_CK2_1	136	142	PF00069	0.604
MOD_CK2_1	160	166	PF00069	0.689
MOD_CK2_1	480	486	PF00069	0.502
MOD_CK2_1	650	656	PF00069	0.416
MOD_CK2_1	664	670	PF00069	0.454
MOD_CK2_1	677	683	PF00069	0.542
MOD_CK2_1	68	74	PF00069	0.552
MOD_Cter_Amidation	222	225	PF01082	0.450
MOD_GlcNHglycan	135	138	PF01048	0.710
MOD_GlcNHglycan	194	197	PF01048	0.703
MOD_GlcNHglycan	201	204	PF01048	0.557
MOD_GlcNHglycan	310	313	PF01048	0.405
MOD_GlcNHglycan	433	436	PF01048	0.486
MOD_GlcNHglycan	479	482	PF01048	0.519
MOD_GlcNHglycan	564	567	PF01048	0.409
MOD_GlcNHglycan	683	686	PF01048	0.455
MOD_GSK3_1	125	132	PF00069	0.673
MOD_GSK3_1	517	524	PF00069	0.349
MOD_GSK3_1	555	562	PF00069	0.452
MOD_GSK3_1	565	572	PF00069	0.424
MOD_GSK3_1	611	618	PF00069	0.555
MOD_GSK3_1	656	663	PF00069	0.438
MOD_GSK3_1	677	684	PF00069	0.499
MOD_GSK3_1	91	98	PF00069	0.638
MOD_N-GLC_1	167	172	PF02516	0.734
MOD_N-GLC_1	431	436	PF02516	0.342
MOD_N-GLC_1	664	669	PF02516	0.529
MOD_N-GLC_2	664	666	PF02516	0.504
MOD_NEK2_1	302	307	PF00069	0.439
MOD_NEK2_1	33	38	PF00069	0.677
MOD_NEK2_1	375	380	PF00069	0.347
MOD_NEK2_1	416	421	PF00069	0.493
MOD_NEK2_1	522	527	PF00069	0.433
MOD_NEK2_1	555	560	PF00069	0.410
MOD_NEK2_1	660	665	PF00069	0.392
MOD_NEK2_1	677	682	PF00069	0.561
MOD_NEK2_2	130	135	PF00069	0.680
MOD_NEK2_2	186	191	PF00069	0.432
MOD_NEK2_2	343	348	PF00069	0.384
MOD_PIKK_1	453	459	PF00454	0.438
MOD_PK_1	588	594	PF00069	0.390
MOD_PKA_1	207	213	PF00069	0.520
MOD_PKA_1	216	222	PF00069	0.507
MOD_PKA_2	207	213	PF00069	0.534
MOD_PKA_2	248	254	PF00069	0.477
MOD_PKA_2	277	283	PF00069	0.441
MOD_PKA_2	604	610	PF00069	0.459
MOD_PKA_2	91	97	PF00069	0.561
MOD_Plk_1	167	173	PF00069	0.663
MOD_Plk_1	343	349	PF00069	0.527
MOD_Plk_1	431	437	PF00069	0.538
MOD_Plk_1	625	631	PF00069	0.506
MOD_Plk_1	68	74	PF00069	0.700
MOD_Plk_1	95	101	PF00069	0.528
MOD_Plk_2-3	573	579	PF00069	0.407
MOD_Plk_4	111	117	PF00069	0.610
MOD_Plk_4	375	381	PF00069	0.334
MOD_Plk_4	522	528	PF00069	0.519
MOD_Plk_4	588	594	PF00069	0.373
MOD_Plk_4	656	662	PF00069	0.452
MOD_Plk_4	95	101	PF00069	0.514
MOD_ProDKin_1	480	486	PF00069	0.472
MOD_ProDKin_1	490	496	PF00069	0.557
MOD_ProDKin_1	615	621	PF00069	0.644
MOD_SUMO_for_1	697	700	PF00179	0.505
MOD_SUMO_rev_2	121	125	PF00179	0.549
TRG_DiLeu_BaEn_1	12	17	PF01217	0.553
TRG_DiLeu_BaEn_1	656	661	PF01217	0.442
TRG_DiLeu_BaLyEn_6	371	376	PF01217	0.293
TRG_DiLeu_BaLyEn_6	467	472	PF01217	0.460
TRG_ENDOCYTIC_2	131	134	PF00928	0.677
TRG_ENDOCYTIC_2	336	339	PF00928	0.452
TRG_ENDOCYTIC_2	380	383	PF00928	0.465
TRG_ENDOCYTIC_2	536	539	PF00928	0.392
TRG_ENDOCYTIC_2	560	563	PF00928	0.322
TRG_ENDOCYTIC_2	97	100	PF00928	0.502
TRG_ER_diArg_1	207	209	PF00400	0.467
TRG_ER_diArg_1	458	461	PF00400	0.456
TRG_ER_diArg_1	688	691	PF00400	0.458
TRG_ER_diArg_1	84	87	PF00400	0.668
TRG_NLS_MonoExtC_3	333	338	PF00514	0.446
TRG_NLS_MonoExtN_4	332	338	PF00514	0.448
TRG_Pf-PMV_PEXEL_1	236	240	PF00026	0.508
TRG_Pf-PMV_PEXEL_1	264	268	PF00026	0.405
TRG_Pf-PMV_PEXEL_1	317	321	PF00026	0.476
TRG_Pf-PMV_PEXEL_1	470	474	PF00026	0.478

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I228	Leptomonas seymouri	70%	100%
A0A0S4JB35	Bodo saltans	29%	96%
A0A1X0NZW8	Trypanosomatidae	30%	92%
A0A3Q8IAV8	Leishmania donovani	95%	100%
A0A3R7KXE4	Trypanosoma rangeli	32%	100%
A4HG90	Leishmania braziliensis	85%	100%
A4I3C4	Leishmania infantum	95%	100%
D0A822	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	30%	97%
Q4Q8M0	Leishmania major	94%	100%
V5DH70	Trypanosoma cruzi	31%	95%