Putative propionyl-coa carboxylase beta chain

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

propionyl-coa carboxylase beta chain, putative

Species:

Leishmania mexicana

UniProt:

E9AZL0_LEIMU

TriTrypDb:

LmxM.28.0490

Length:

522

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005739	mitochondrion	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AZL0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AZL0

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	7
GO:0004658	propionyl-CoA carboxylase activity	5	5
GO:0016421	CoA carboxylase activity	4	5
GO:0016874	ligase activity	2	7
GO:0016885	ligase activity, forming carbon-carbon bonds	3	5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	149	153	PF00656	0.337
CLV_C14_Caspase3-7	262	266	PF00656	0.312
CLV_C14_Caspase3-7	296	300	PF00656	0.337
CLV_NRD_NRD_1	253	255	PF00675	0.277
CLV_NRD_NRD_1	412	414	PF00675	0.277
CLV_NRD_NRD_1	480	482	PF00675	0.277
CLV_NRD_NRD_1	506	508	PF00675	0.298
CLV_NRD_NRD_1	80	82	PF00675	0.353
CLV_PCSK_KEX2_1	253	255	PF00082	0.277
CLV_PCSK_KEX2_1	45	47	PF00082	0.301
CLV_PCSK_KEX2_1	80	82	PF00082	0.305
CLV_PCSK_PC1ET2_1	45	47	PF00082	0.301
CLV_PCSK_PC1ET2_1	80	82	PF00082	0.305
CLV_PCSK_PC7_1	41	47	PF00082	0.359
CLV_PCSK_SKI1_1	218	222	PF00082	0.254
CLV_PCSK_SKI1_1	45	49	PF00082	0.356
CLV_PCSK_SKI1_1	65	69	PF00082	0.144
CLV_PCSK_SKI1_1	98	102	PF00082	0.337
DEG_COP1_1	265	273	PF00400	0.359
DOC_CKS1_1	473	478	PF01111	0.277
DOC_MAPK_DCC_7	131	139	PF00069	0.337
DOC_MAPK_gen_1	253	261	PF00069	0.337
DOC_MAPK_gen_1	515	522	PF00069	0.277
DOC_MAPK_MEF2A_6	131	139	PF00069	0.277
DOC_PP1_RVXF_1	355	362	PF00149	0.277
DOC_PP4_FxxP_1	365	368	PF00568	0.277
DOC_PP4_FxxP_1	473	476	PF00568	0.277
DOC_PP4_FxxP_1	56	59	PF00568	0.337
DOC_PP4_FxxP_1	96	99	PF00568	0.277
DOC_USP7_MATH_1	232	236	PF00917	0.337
DOC_USP7_MATH_1	37	41	PF00917	0.514
DOC_USP7_UBL2_3	218	222	PF12436	0.277
DOC_WW_Pin1_4	185	190	PF00397	0.289
DOC_WW_Pin1_4	472	477	PF00397	0.350
LIG_14-3-3_CanoR_1	163	167	PF00244	0.290
LIG_14-3-3_CanoR_1	253	259	PF00244	0.280
LIG_14-3-3_CanoR_1	46	53	PF00244	0.356
LIG_Actin_WH2_2	147	165	PF00022	0.277
LIG_AP2alpha_1	361	365	PF02296	0.277
LIG_APCC_ABBA_1	53	58	PF00400	0.277
LIG_APCC_ABBAyCdc20_2	52	58	PF00400	0.277
LIG_BRCT_BRCA1_1	103	107	PF00533	0.277
LIG_BRCT_BRCA1_1	201	205	PF00533	0.337
LIG_FHA_1	18	24	PF00498	0.354
LIG_FHA_1	193	199	PF00498	0.279
LIG_FHA_1	90	96	PF00498	0.224
LIG_FHA_2	205	211	PF00498	0.279
LIG_FHA_2	219	225	PF00498	0.293
LIG_FHA_2	33	39	PF00498	0.497
LIG_FHA_2	369	375	PF00498	0.277
LIG_FHA_2	46	52	PF00498	0.231
LIG_FHA_2	59	65	PF00498	0.277
LIG_Integrin_RGD_1	429	431	PF01839	0.277
LIG_LIR_Apic_2	363	368	PF02991	0.277
LIG_LIR_Apic_2	431	437	PF02991	0.277
LIG_LIR_Apic_2	470	476	PF02991	0.277
LIG_LIR_Gen_1	104	114	PF02991	0.277
LIG_LIR_Gen_1	192	198	PF02991	0.277
LIG_LIR_Gen_1	201	211	PF02991	0.277
LIG_LIR_Gen_1	371	380	PF02991	0.277
LIG_LIR_Nem_3	104	110	PF02991	0.337
LIG_LIR_Nem_3	165	170	PF02991	0.359
LIG_LIR_Nem_3	201	206	PF02991	0.337
LIG_LIR_Nem_3	257	261	PF02991	0.337
LIG_LIR_Nem_3	274	280	PF02991	0.337
LIG_LIR_Nem_3	308	313	PF02991	0.271
LIG_LIR_Nem_3	371	375	PF02991	0.277
LIG_LIR_Nem_3	385	389	PF02991	0.277
LIG_PCNA_PIPBox_1	249	258	PF02747	0.312
LIG_PCNA_yPIPBox_3	360	373	PF02747	0.277
LIG_PDZ_Class_2	517	522	PF00595	0.277
LIG_Pex14_2	103	107	PF04695	0.277
LIG_Pex14_2	361	365	PF04695	0.277
LIG_PTB_Apo_2	161	168	PF02174	0.359
LIG_PTB_Apo_2	197	204	PF02174	0.337
LIG_PTB_Phospho_1	197	203	PF10480	0.337
LIG_SH2_CRK	203	207	PF00017	0.337
LIG_SH2_CRK	256	260	PF00017	0.337
LIG_SH2_CRK	386	390	PF00017	0.277
LIG_SH2_NCK_1	157	161	PF00017	0.277
LIG_SH2_NCK_1	400	404	PF00017	0.277
LIG_SH2_NCK_1	469	473	PF00017	0.312
LIG_SH2_SRC	157	160	PF00017	0.277
LIG_SH2_SRC	398	401	PF00017	0.277
LIG_SH2_STAP1	157	161	PF00017	0.277
LIG_SH2_STAP1	469	473	PF00017	0.277
LIG_SH2_STAT5	258	261	PF00017	0.277
LIG_SH3_3	183	189	PF00018	0.286
LIG_SH3_3	203	209	PF00018	0.277
LIG_SH3_3	265	271	PF00018	0.277
LIG_SH3_3	370	376	PF00018	0.277
LIG_SH3_3	485	491	PF00018	0.277
LIG_SUMO_SIM_anti_2	440	445	PF11976	0.277
LIG_SUMO_SIM_par_1	287	293	PF11976	0.435
LIG_SUMO_SIM_par_1	345	352	PF11976	0.337
LIG_TRAF2_1	36	39	PF00917	0.435
LIG_WRC_WIRS_1	369	374	PF05994	0.277
MOD_CK1_1	21	27	PF00069	0.446
MOD_CK1_1	235	241	PF00069	0.277
MOD_CK1_1	282	288	PF00069	0.337
MOD_CK1_1	455	461	PF00069	0.371
MOD_CK2_1	204	210	PF00069	0.277
MOD_CK2_1	218	224	PF00069	0.277
MOD_CK2_1	306	312	PF00069	0.277
MOD_CK2_1	32	38	PF00069	0.509
MOD_CK2_1	45	51	PF00069	0.236
MOD_CK2_1	58	64	PF00069	0.277
MOD_GlcNHglycan	114	117	PF01048	0.277
MOD_GlcNHglycan	141	144	PF01048	0.277
MOD_GlcNHglycan	167	170	PF01048	0.295
MOD_GlcNHglycan	212	215	PF01048	0.304
MOD_GlcNHglycan	234	237	PF01048	0.292
MOD_GlcNHglycan	265	268	PF01048	0.359
MOD_GlcNHglycan	477	480	PF01048	0.354
MOD_GlcNHglycan	9	12	PF01048	0.613
MOD_GSK3_1	101	108	PF00069	0.337
MOD_GSK3_1	110	117	PF00069	0.337
MOD_GSK3_1	17	24	PF00069	0.471
MOD_GSK3_1	185	192	PF00069	0.284
MOD_GSK3_1	259	266	PF00069	0.297
MOD_GSK3_1	278	285	PF00069	0.207
MOD_GSK3_1	28	35	PF00069	0.486
MOD_LATS_1	427	433	PF00433	0.304
MOD_N-GLC_1	139	144	PF02516	0.277
MOD_N-GLC_1	199	204	PF02516	0.354
MOD_NEK2_1	110	115	PF00069	0.277
MOD_NEK2_1	139	144	PF00069	0.277
MOD_NEK2_1	162	167	PF00069	0.277
MOD_NEK2_1	18	23	PF00069	0.540
MOD_NEK2_1	204	209	PF00069	0.277
MOD_PIKK_1	18	24	PF00454	0.543
MOD_PIKK_1	489	495	PF00454	0.171
MOD_PKA_1	45	51	PF00069	0.361
MOD_PKA_2	162	168	PF00069	0.277
MOD_PKA_2	263	269	PF00069	0.359
MOD_PKA_2	28	34	PF00069	0.590
MOD_PKA_2	45	51	PF00069	0.169
MOD_PKA_2	503	509	PF00069	0.413
MOD_PKB_1	276	284	PF00069	0.277
MOD_Plk_1	105	111	PF00069	0.337
MOD_Plk_1	192	198	PF00069	0.277
MOD_Plk_1	199	205	PF00069	0.277
MOD_Plk_1	278	284	PF00069	0.291
MOD_Plk_1	349	355	PF00069	0.283
MOD_Plk_1	401	407	PF00069	0.281
MOD_Plk_2-3	306	312	PF00069	0.277
MOD_Plk_2-3	58	64	PF00069	0.277
MOD_Plk_4	162	168	PF00069	0.359
MOD_Plk_4	199	205	PF00069	0.337
MOD_Plk_4	254	260	PF00069	0.277
MOD_Plk_4	282	288	PF00069	0.277
MOD_Plk_4	306	312	PF00069	0.277
MOD_Plk_4	406	412	PF00069	0.312
MOD_ProDKin_1	185	191	PF00069	0.289
MOD_ProDKin_1	472	478	PF00069	0.350
TRG_DiLeu_BaEn_1	64	69	PF01217	0.277
TRG_ENDOCYTIC_2	157	160	PF00928	0.277
TRG_ENDOCYTIC_2	203	206	PF00928	0.337
TRG_ENDOCYTIC_2	256	259	PF00928	0.337
TRG_ENDOCYTIC_2	277	280	PF00928	0.238
TRG_ENDOCYTIC_2	386	389	PF00928	0.277
TRG_ENDOCYTIC_2	420	423	PF00928	0.277
TRG_ER_diArg_1	252	254	PF00400	0.277
TRG_ER_diArg_1	495	498	PF00400	0.277
TRG_NES_CRM1_1	251	265	PF08389	0.337
TRG_NLS_MonoCore_2	42	47	PF00514	0.359
TRG_NLS_MonoExtN_4	41	48	PF00514	0.359

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4K5	Leptomonas seymouri	86%	100%
A0A0N1IIF0	Leptomonas seymouri	30%	78%
A0A0S4IW40	Bodo saltans	27%	77%
A0A0S4J7G9	Bodo saltans	74%	100%
A0A1X0NV46	Trypanosomatidae	32%	84%
A0A3Q8I921	Leishmania donovani	31%	97%
A0A3R7M923	Trypanosoma rangeli	32%	84%
A0A3S7X171	Leishmania donovani	96%	100%
A4F5Q5	Saccharopolyspora erythraea (strain ATCC 11635 / DSM 40517 / JCM 4748 / NBRC 13426 / NCIMB 8594 / NRRL 2338)	24%	92%
A4H6I5	Leishmania braziliensis	32%	100%
A4HG89	Leishmania braziliensis	93%	100%
A4HUX0	Leishmania infantum	31%	97%
A4X7V1	Salinispora tropica (strain ATCC BAA-916 / DSM 44818 / CNB-440)	24%	92%
B2A865	Natranaerobius thermophilus (strain ATCC BAA-1301 / DSM 18059 / JW/NM-WN-LF)	23%	86%
D0A7I1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	31%	85%
E9ANK4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	31%	100%
I3R7F1	Haloferax mediterranei (strain ATCC 33500 / DSM 1411 / JCM 8866 / NBRC 14739 / NCIMB 2177 / R-4)	56%	100%
I6YDK7	Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)	31%	99%
O31825	Bacillus subtilis (strain 168)	35%	100%
O53578	Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)	46%	100%
O54028	Propionigenium modestum	53%	100%
O86318	Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)	28%	99%
P05166	Homo sapiens	62%	97%
P07633	Rattus norvegicus	61%	96%
P34385	Caenorhabditis elegans	30%	86%
P53002	Mycobacterium leprae (strain TN)	49%	95%
P53003	Saccharopolyspora erythraea (strain ATCC 11635 / DSM 40517 / JCM 4748 / NBRC 13426 / NCIMB 8594 / NRRL 2338)	51%	96%
P54541	Bacillus subtilis (strain 168)	48%	100%
P63408	Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97)	39%	100%
P79384	Sus scrofa	62%	97%
P9WQH4	Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)	39%	100%
P9WQH5	Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)	39%	100%
P9WQH6	Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)	50%	95%
P9WQH7	Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)	50%	95%
Q06101	Rhodococcus erythropolis	40%	100%
Q06700	Acidaminococcus fermentans (strain ATCC 25085 / DSM 20731 / CCUG 9996 / CIP 106432 / VR4)	22%	89%
Q168G2	Roseobacter denitrificans (strain ATCC 33942 / OCh 114)	58%	100%
Q2TBR0	Bos taurus	62%	97%
Q3J4E3	Cereibacter sphaeroides (strain ATCC 17023 / DSM 158 / JCM 6121 / CCUG 31486 / LMG 2827 / NBRC 12203 / NCIMB 8253 / ATH 2.4.1.)	61%	100%
Q3ULD5	Mus musculus	29%	93%
Q4Q8M1	Leishmania major	96%	100%
Q4QH21	Leishmania major	31%	100%
Q57079	Veillonella parvula	54%	100%
Q5XIT9	Rattus norvegicus	30%	93%
Q899N5	Clostridium tetani (strain Massachusetts / E88)	24%	91%
Q8GBW6	Propionibacterium freudenreichii subsp. shermanii	49%	100%
Q8T2J9	Dictyostelium discoideum	31%	89%
Q99MN9	Mus musculus	62%	96%
Q9HCC0	Homo sapiens	30%	93%
Q9LDD8	Arabidopsis thaliana	30%	89%
Q9V9A7	Drosophila melanogaster	30%	90%
V5BWB7	Trypanosoma cruzi	31%	85%