Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AZK9_LEIMU

TriTrypDb:

LmxM.28.0485

Length:

213

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	7
GO:0110165	cellular anatomical entity	1	7

Expansion

Sequence features

E9AZK9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AZK9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	25	29	PF00656	0.369
CLV_NRD_NRD_1	193	195	PF00675	0.441
DEG_SCF_FBW7_1	168	175	PF00400	0.681
DEG_SPOP_SBC_1	172	176	PF00917	0.743
DEG_SPOP_SBC_1	205	209	PF00917	0.649
DEG_SPOP_SBC_1	76	80	PF00917	0.472
DEG_SPOP_SBC_1	90	94	PF00917	0.424
DOC_USP7_MATH_1	172	176	PF00917	0.781
DOC_USP7_MATH_1	205	209	PF00917	0.701
DOC_USP7_MATH_1	47	51	PF00917	0.402
DOC_USP7_MATH_1	60	64	PF00917	0.472
DOC_WW_Pin1_4	168	173	PF00397	0.701
DOC_WW_Pin1_4	196	201	PF00397	0.618
DOC_WW_Pin1_4	206	211	PF00397	0.688
DOC_WW_Pin1_4	3	8	PF00397	0.467
LIG_14-3-3_CanoR_1	21	30	PF00244	0.489
LIG_14-3-3_CanoR_1	40	48	PF00244	0.402
LIG_14-3-3_CanoR_1	77	84	PF00244	0.490
LIG_eIF4E_1	106	112	PF01652	0.208
LIG_FHA_1	114	120	PF00498	0.343
LIG_FHA_1	4	10	PF00498	0.364
LIG_FHA_1	78	84	PF00498	0.489
LIG_FHA_1	90	96	PF00498	0.443
LIG_FHA_2	23	29	PF00498	0.431
LIG_GBD_Chelix_1	104	112	PF00786	0.499
LIG_LYPXL_SIV_4	105	113	PF13949	0.201
LIG_NRBOX	107	113	PF00104	0.268
LIG_Pex14_1	110	114	PF04695	0.315
LIG_SH2_GRB2like	11	14	PF00017	0.420
LIG_SH2_STAT5	106	109	PF00017	0.292
LIG_SUMO_SIM_anti_2	120	126	PF11976	0.248
LIG_SUMO_SIM_par_1	115	121	PF11976	0.452
MOD_CDK_SPK_2	196	201	PF00069	0.573
MOD_CK1_1	12	18	PF00069	0.547
MOD_CK1_1	135	141	PF00069	0.670
MOD_CK1_1	157	163	PF00069	0.677
MOD_CK1_1	173	179	PF00069	0.665
MOD_CK1_1	193	199	PF00069	0.592
MOD_CK1_1	50	56	PF00069	0.492
MOD_GlcNHglycan	134	137	PF01048	0.448
MOD_GlcNHglycan	168	171	PF01048	0.476
MOD_GlcNHglycan	42	45	PF01048	0.594
MOD_GlcNHglycan	52	55	PF01048	0.691
MOD_GlcNHglycan	62	65	PF01048	0.643
MOD_GlcNHglycan	95	98	PF01048	0.629
MOD_GSK3_1	113	120	PF00069	0.298
MOD_GSK3_1	128	135	PF00069	0.670
MOD_GSK3_1	166	173	PF00069	0.729
MOD_GSK3_1	195	202	PF00069	0.665
MOD_GSK3_1	36	43	PF00069	0.419
MOD_GSK3_1	71	78	PF00069	0.554
MOD_GSK3_1	89	96	PF00069	0.489
MOD_GSK3_1	9	16	PF00069	0.401
MOD_N-GLC_1	12	17	PF02516	0.614
MOD_N-GLC_1	23	28	PF02516	0.619
MOD_N-GLC_1	30	35	PF02516	0.649
MOD_N-GLC_1	50	55	PF02516	0.672
MOD_N-GLC_1	71	76	PF02516	0.698
MOD_N-GLC_1	88	93	PF02516	0.755
MOD_N-GLC_2	126	128	PF02516	0.429
MOD_NEK2_1	113	118	PF00069	0.298
MOD_NEK2_1	156	161	PF00069	0.695
MOD_NEK2_1	178	183	PF00069	0.636
MOD_NEK2_1	190	195	PF00069	0.637
MOD_NEK2_1	88	93	PF00069	0.537
MOD_PIKK_1	157	163	PF00454	0.659
MOD_PKA_2	193	199	PF00069	0.701
MOD_PKA_2	76	82	PF00069	0.474
MOD_Plk_1	23	29	PF00069	0.433
MOD_Plk_1	30	36	PF00069	0.432
MOD_ProDKin_1	168	174	PF00069	0.699
MOD_ProDKin_1	196	202	PF00069	0.622
MOD_ProDKin_1	206	212	PF00069	0.687
MOD_ProDKin_1	3	9	PF00069	0.466
TRG_DiLeu_BaLyEn_6	174	179	PF01217	0.647
TRG_ER_FFAT_2	70	79	PF00635	0.484

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4Z6	Leptomonas seymouri	41%	93%
A0A3Q8IQC4	Leishmania donovani	82%	94%
A4HG88	Leishmania braziliensis	55%	100%
E9AHH3	Leishmania infantum	82%	76%
Q4Q8M2	Leishmania major	79%	100%